product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
LSD1 (C69G12) Rabbit mAb
catalog :
2184
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C69G12
reactivity :
human, mouse, brown rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
Cell Signaling Technology product webpage
citations: 18
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 3b
Volkman H, Cambier S, Gray E, Stetson D. Tight nuclear tethering of cGAS is essential for preventing autoreactivity. elife. 2019;8: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5d
Wobser M, Weber A, Glunz A, Tauch S, Seitz K, Butelmann T, et al. Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells. J Hematol Oncol. 2019;12:30 pubmed publisher
  • western blot; mouse; loading ...; fig 1b
Raso F, Sagadiev S, Du S, Gage E, Arkatkar T, Metzler G, et al. αv Integrins regulate germinal center B cell responses through noncanonical autophagy. J Clin Invest. 2018;128:4163-4178 pubmed publisher
  • western blot; mouse; loading ...; fig 5b
  • western blot; human; loading ...; fig 1c
Shin C, Ito Y, Ichikawa S, Tokunaga M, Sakata Sogawa K, Tanaka T. MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-κB and negatively regulates inflammatory responses. Sci Rep. 2017;7:46097 pubmed publisher
  • western blot; mouse; 1:1000; fig 11
Smagris E, Gilyard S, BasuRay S, Cohen J, Hobbs H. Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins. J Biol Chem. 2016;291:10659-76 pubmed publisher
  • western blot; mouse; 1:1000; fig 5
Acharya M, Sokolovska A, Tam J, Conway K, Stefani C, Raso F, et al. αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells. Nat Commun. 2016;7:10917 pubmed publisher
  • western blot; mouse; fig 6
Ono R, Kaisho T, Tanaka T. PDLIM1 inhibits NF-κB-mediated inflammatory signaling by sequestering the p65 subunit of NF-κB in the cytoplasm. Sci Rep. 2015;5:18327 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:400; loading ...; fig 5
  • western blot; human; 1:2000; loading ...; fig 3d
Hsu H, Liu Y, Tseng K, Yang T, Yeh C, You J, et al. CBB1003, a lysine-specific demethylase 1 inhibitor, suppresses colorectal cancer cells growth through down-regulation of leucine-rich repeat-containing G-protein-coupled receptor 5 expression. J Cancer Res Clin Oncol. 2015;141:11-21 pubmed publisher
  • immunocytochemistry; human; 1:400
Sankar S, Theisen E, Bearss J, Mulvihill T, Hoffman L, Sorna V, et al. Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth. Clin Cancer Res. 2014;20:4584-97 pubmed publisher
  • western blot; human
Sankar S, Bell R, Stephens B, Zhuo R, Sharma S, Bearss D, et al. Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma. Oncogene. 2013;32:5089-100 pubmed publisher
  • immunocytochemistry; mouse; 1:100
  • western blot; mouse; 1:2000
Ma P, Pan H, Montgomery R, Olson E, Schultz R. Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development. Proc Natl Acad Sci U S A. 2012;109:E481-9 pubmed publisher
Engel M, Gee Y, Cross D, Maccarone A, Heng B, Hulme A, et al. Novel dual-action prodrug triggers apoptosis in glioblastoma cells by releasing a glutathione quencher and lysine-specific histone demethylase 1A inhibitor. J Neurochem. 2019;149:535-550 pubmed publisher
Velinder M, Singer J, Bareyan D, Meznarich J, Tracy C, Fulcher J, et al. GFI1 functions in transcriptional control and cell fate determination require SNAG domain methylation to recruit LSD1. Biochem J. 2016;473:3355-69 pubmed publisher
Roth M, Wang Z, Chen W. SIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cells. Oncotarget. 2016;7:50195-50214 pubmed publisher
McGrath J, Williamson K, Balasubramanian S, Odate S, Arora S, Hatton C, et al. Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes. Cancer Res. 2016;76:1975-88 pubmed publisher
Theisen E, Gajiwala S, Bearss J, Sorna V, Sharma S, JANAT AMSBURY M. Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma. BMC Cancer. 2014;14:752 pubmed publisher
Miura S, Maesawa C, Shibazaki M, Yasuhira S, Kasai S, Tsunoda K, et al. Immunohistochemistry for histone h3 lysine 9 methyltransferase and demethylase proteins in human melanomas. Am J Dermatopathol. 2014;36:211-6 pubmed publisher
Rudra D, deRoos P, Chaudhry A, Niec R, Arvey A, Samstein R, et al. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Nat Immunol. 2012;13:1010-9 pubmed publisher
product information
SKU :
2184S
Product-Name :
LSD1 (C69G12) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Chromatin Regulation / Nuclear Function
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
110
Host :
Rabbit
Target :
LSD1
Primary-Protein :
LSD1
Alt-Names :
AOF2,BHC110,BRAF35-HDAC complex protein BHC110,FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit,Flavin-containing amine oxidase domain-containing protein 2,KDM1,KDM1A,KIAA0601,LSD1,Lysine-specific histone demethylase 1A,amine oxidase (flavin containing) domain 2,lysine (K)-specific demethylase 1,lysine (K)-specific demethylase 1A,lysine-specific histone demethylase 1
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.