product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Ku80 (C48E7) Rabbit mAb
catalog :
2180
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C48E7
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section, reverse phase protein lysate microarray
more info or order :
Cell Signaling Technology product webpage
citations: 22
Published Application/Species/Sample/DilutionReference
  • reverse phase protein lysate microarray; human; loading ...; fig st6
Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher
  • reverse phase protein lysate microarray; human; loading ...; fig 3a
. Integrated genomic and molecular characterization of cervical cancer. Nature. 2017;543:378-384 pubmed publisher
  • western blot; human; 1:1000; fig 2d
Chang V, Tsai Y, Tsai Y, Peng S, Chen S, Chang T, et al. Krüpple-like factor 10 regulates radio-sensitivity of pancreatic cancer via UV radiation resistance-associated gene. Radiother Oncol. 2017;122:476-484 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:100; fig s5a
Lee I, Koo K, Jung K, Kim M, Kim I, Hwang K, et al. Neurogenin-2-transduced human neural progenitor cells attenuate neonatal hypoxic-ischemic brain injury. Transl Res. 2017;183:121-136.e9 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5c
Guo J, Wang X, Lu X, Jing R, Li J, Li C, et al. Unraveling molecular effects of ADAR1 overexpression in HEK293T cells by label-free quantitative proteomics. Cell Cycle. 2016;15:1591-601 pubmed publisher
  • western blot; human; fig 4
Son J, Hwang E, Kim J. Systematic analyses of the ultraviolet radiation resistance-associated gene product (UVRAG) protein interactome by tandem affinity purification. Arch Pharm Res. 2016;39:370-9 pubmed publisher
  • immunoprecipitation; human; 1:1000; fig 7
He S, Zhao Z, Yang Y, O Connell D, Zhang X, Oh S, et al. Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers. Nat Commun. 2015;6:7839 pubmed publisher
  • immunocytochemistry; human; fig s4
Van Sluis M, McStay B. A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage. Genes Dev. 2015;29:1151-63 pubmed publisher
  • western blot; human; fig 4
Nakajima N, Hagiwara Y, Oike T, Okayasu R, Murakami T, Nakano T, et al. Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair. PLoS ONE. 2015;10:e0122582 pubmed publisher
  • western blot; human; fig 5
Chen Y, Wei M, Wang C, Lee H, Pan S, Gao M, et al. Dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor is an effective radiosensitizer for colorectal cancer. Cancer Lett. 2015;357:582-90 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Owonikoko T, Zhang G, Deng X, Rossi M, Switchenko J, Doho G, et al. Poly (ADP) ribose polymerase enzyme inhibitor, veliparib, potentiates chemotherapy and radiation in vitro and in vivo in small cell lung cancer. Cancer Med. 2014;3:1579-94 pubmed publisher
  • western blot; human
Prensner J, Chen W, Iyer M, Cao Q, Ma T, Han S, et al. PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer. Cancer Res. 2014;74:1651-60 pubmed publisher
  • immunocytochemistry; human; fig 2c
  • western blot; human; fig 7b
Shibata A, Moiani D, Arvai A, Perry J, Harding S, Genois M, et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014;53:7-18 pubmed publisher
Oh L, Hainaut P, Blanchet S, Ariffin H. Expression of p53 N-terminal isoforms in B-cell precursor acute lymphoblastic leukemia and its correlation with clinicopathological profiles. BMC Cancer. 2020;20:110 pubmed publisher
Xia Y, Pfeifer C, Zhu K, Irianto J, Liu D, Pannell K, et al. Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. J Cell Biol. 2019;: pubmed publisher
Tu W, Shiah Y, Lourenco C, Mullen P, Dingar D, Redel C, et al. MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis. Cancer Cell. 2018;34:579-595.e8 pubmed publisher
Xia Y, Ivanovska I, Zhu K, Smith L, Irianto J, Pfeifer C, et al. Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. J Cell Biol. 2018;217:3796-3808 pubmed publisher
Rushing A, Hoang K, Polakowski N, Lemasson I. The Human T-Cell Leukemia Virus Type 1 Basic Leucine Zipper Factor Attenuates Repair of Double-Stranded DNA Breaks via Nonhomologous End Joining. J Virol. 2018;92: pubmed publisher
Bütepage M, Preisinger C, von Kriegsheim A, Scheufen A, Lausberg E, Li J, et al. Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription. Sci Rep. 2018;8:6748 pubmed publisher
Young L, Marzio A, Pérez Durán P, Reid D, Meredith D, Roberti D, et al. TIMELESS Forms a Complex with PARP1 Distinct from Its Complex with TIPIN and Plays a Role in the DNA Damage Response. Cell Rep. 2015;13:451-459 pubmed publisher
Banerjee R, Russo N, Liu M, Basrur V, Bellile E, Palanisamy N, et al. TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer. Nat Commun. 2014;5:4527 pubmed publisher
Zhu W, Zhang W, Shou W, Field L. P53 inhibition exacerbates late-stage anthracycline cardiotoxicity. Cardiovasc Res. 2014;103:81-9 pubmed publisher
product information
SKU :
2180S
Product-Name :
Ku80 (C48E7) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, Mk
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Cell Cycle / Checkpoint Control
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
86
Host :
Rabbit
Target :
Ku80
Primary-Protein :
Ku80
Alt-Names :
86 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 2,ATP-dependent DNA helicase II 80 kDa subunit,CTC box-binding factor 85 kDa subunit,CTC85,CTCBF,DNA repair protein XRCC5,FLJ39089,G22P2,KARP-1,KARP1,KUB2,Ku autoantigen, 80kD),Ku autoantigen, 80kDa,Ku80,Ku86,Ku86 autoantigen related protein 1,Lupus Ku autoantigen protein p86,NFIV,Nuclear factor IV,TLAA,Thyroid-lupus autoantigen,X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining,X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining),X-ray repair cross-complementing protein 5,X-ray repair, complementing defective, repair in Chinese hamster,XRCC5
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.