| Published Application/Species/Sample/Dilution | Reference | 
|---|
| western blot knockout validation; human; 1:200; fig 1a
 | Chen Y, Wang R, Huang S, Henson E, Bi J, Gibson S. Erb-b2 Receptor Tyrosine Kinase 2 (ERBB2) Promotes ATG12-Dependent Autophagy Contributing to Treatment Resistance of Breast Cancer Cells. Cancers (Basel). 2021;13: pubmed  publisher | 
| western blot; human; 1:1000; loading ...; fig 3b, s4cwestern blot; mouse; 1:1000; loading ...; fig 3a
 | Goyette M, Elkholi I, Apcher C, Kuasne H, Rothlin C, Muller W, et al . Targeting Axl favors an antitumorigenic microenvironment that enhances immunotherapy responses by decreasing Hif-1α levels. Proc Natl Acad Sci U S A. 2021;118: pubmed  publisher | 
| immunohistochemistry; mouse; 1:500; loading ...; fig 1g
 | Prokakis E, Dyas A, Grün R, Fritzsche S, Bedi U, Kazerouni Z, et al . USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response. Oncogene. 2021;40:4004-4018 pubmed  publisher | 
| immunocytochemistry; human; loading ...; fig 2bwestern blot; human; loading ...; fig 2c
 | Bi Y, Chen X, Wei B, Wang L, Gong L, Li H, et al . DEPTOR stabilizes ErbB2 to promote the proliferation and survival of ErbB2-positive breast cancer cells. Theranostics. 2021;11:6355-6369 pubmed  publisher | 
| immunohistochemistry; mouse; loading ...; fig s2awestern blot; mouse; loading ...; fig s2b
 | Yang Y, Leonard M, Luo Z, Yeo S, Bick G, Hao M, et al . Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer. Cell Rep. 2021;34:108822 pubmed  publisher | 
| western blot; human; loading ...; fig 1b, 2b
 | Liu Q, Borcherding N, Shao P, Maina P, Zhang W, Qi H. Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance. EBioMedicine. 2020;51:102612 pubmed  publisher | 
| western blot; human; loading ...; fig 1a
 | Jiang S, Zhang M, Zhang Y, Zhou W, Zhu T, Ruan Q, et al . WNT5B governs the phenotype of basal-like breast cancer by activating WNT signaling. Cell Commun Signal. 2019;17:109 pubmed  publisher | 
| western blot; human; loading ...; fig s3b
 | Zhao H, Martin E, Matalkah F, Shah N, Ivanov A, Ruppert J, et al . Conditional knockout of SHP2 in ErbB2 transgenic mice or inhibition in HER2-amplified breast cancer cell lines blocks oncogene expression and tumorigenesis. Oncogene. 2019;38:2275-2290 pubmed  publisher | 
| western blot; mouse; 1:1000; loading ...; fig 1g
 | Schumacher M, Hedl M, Abraham C, Bernard J, Lozano P, Hsieh J, et al . ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation. Cell Death Dis. 2017;8:e2622 pubmed  publisher | 
| western blot; human; 1:1000; loading ...; fig 3
 | Kneissl J, Hartmann A, Pfarr N, Erlmeier F, Lorber T, Keller S, et al . Influence of the HER receptor ligand system on sensitivity to cetuximab and trastuzumab in gastric cancer cell lines. J Cancer Res Clin Oncol. 2017;143:573-600 pubmed  publisher | 
| western blot; human; 1:1000; loading ...; fig 4g
 | Mitra S, Ghosh B, Gayen N, Roy J, Mandal A. Bipartite Role of Heat Shock Protein 90 (Hsp90) Keeps CRAF Kinase Poised for Activation. J Biol Chem. 2016;291:24579-24593 pubmed | 
| flow cytometry; human; loading ...; fig 1aimmunocytochemistry; humanimmunohistochemistry; human
 | Jordan N, Bardia A, Wittner B, Benes C, Ligorio M, Zheng Y, et al . HER2 expression identifies dynamic functional states within circulating breast cancer cells. Nature. 2016;537:102-106 pubmed  publisher | 
| western blot; human; loading ...; fig 2a
 | LAW M, Ferreira R, Davis B, Higgins P, Kim J, Castellano R, et al . CUB domain-containing protein 1 and the epidermal growth factor receptor cooperate to induce cell detachment. Breast Cancer Res. 2016;18:80 pubmed  publisher | 
| immunoprecipitation; human; loading ...; fig s8
 | Szymanska M, Fosdahl A, Nikolaysen F, Pedersen M, Grandal M, Stang E, et al . A combination of two antibodies recognizing non-overlapping epitopes of HER2 induces kinase activity-dependent internalization of HER2. J Cell Mol Med. 2016;20:1999-2011 pubmed  publisher | 
| western blot; human; loading ...; fig 1a
 | Saisana M, Griffin S, May F. Importance of the type I insulin-like growth factor receptor in HER2, FGFR2 and MET-unamplified gastric cancer with and without Ras pathway activation. Oncotarget. 2016;7:54445-54462 pubmed  publisher | 
| western blot; human; 1:500; fig 2
 | Gschweitl M, Ulbricht A, Barnes C, Enchev R, Stoffel Studer I, Meyer Schaller N, et al . A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes. elife. 2016;5:e13841 pubmed  publisher | 
| western blot; human; fig 1b
 | Stindt S, Cebula P, Albrecht U, Keitel V, Schulte Am Esch J, Knoefel W, et al . Hepatitis C Virus Activates a Neuregulin-Driven Circuit to Modify Surface Expression of Growth Factor Receptors of the ErbB Family. PLoS ONE. 2016;11:e0148711 pubmed  publisher | 
| western blot; human; fig 1
 | Kim D, Helfman D. Loss of MLCK leads to disruption of cell-cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK/JNK signaling. Oncogene. 2016;35:4495-508 pubmed  publisher | 
| immunocytochemistry; human; fig 2western blot; human; fig 2
 | Khalil H, Langdon S, Kankia I, Bown J, Deeni Y. NRF2 Regulates HER2 and HER3 Signaling Pathway to Modulate Sensitivity to Targeted Immunotherapies. Oxid Med Cell Longev. 2016;2016:4148791 pubmed  publisher | 
| western blot; human; 1:200; loading ...; fig 2b
 | Yamaguchi T, Lu C, Ida L, Yanagisawa K, Usukura J, Cheng J, et al . ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1. Nat Commun. 2016;7:10060 pubmed  publisher | 
| western blot; human; 1:1000; fig 7e
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| western blot; human; 1:1000; loading ...; fig 5C; S6B
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| immunocytochemistry; human; fig 4
 | RodrÃguez C, Reidel S, Bal de Kier Joffé E, Jasnis M, Fiszman G. Autophagy Protects from Trastuzumab-Induced Cytotoxicity in HER2 Overexpressing Breast Tumor Spheroids. PLoS ONE. 2015;10:e0137920 pubmed  publisher | 
| immunohistochemistry - paraffin section; human; loading ...; fig 1f
 | Wang D, Pang Z, Clarke G, Nofech Mozes S, Liu K, Cheung A, et al . Ki-67 Membranous Staining: Biologically Relevant or an Artifact of Multiplexed Immunofluorescent Staining. Appl Immunohistochem Mol Morphol. 2016;24:447-52 pubmed  publisher | 
| western blot; human; fig 4
 | Yang L, Li Y, Bhattacharya A, Zhang Y. Inhibition of ERBB2-overexpressing Tumors by Recombinant Human Prolidase and Its Enzymatically Inactive Mutant. EBioMedicine. 2015;2:396-405 pubmed | 
| immunohistochemistry - paraffin section; human; 1:25
 | Jäger W, Xue H, Hayashi T, Janssen C, Awrey S, Wyatt A, et al . Patient-derived bladder cancer xenografts in the preclinical development of novel targeted therapies. Oncotarget. 2015;6:21522-32 pubmed | 
| western blot; human; 1:100
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| western blot; mouse; 1:1000; loading ...; fig 5b
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| western blot; human; loading ...; fig 4f, 4g, 4h
 | Ferreira R, Law M, Jahn S, Davis B, Heldermon C, Reinhard M, et al . Novel agents that downregulate EGFR, HER2, and HER3 in parallel. Oncotarget. 2015;6:10445-59 pubmed | 
|  | Yoo J, Kim T, Kong S, Lee J, Choi W, Kim K, et al . Role of Mig-6 in hepatic glucose metabolism. J Diabetes. 2016;8:86-97 pubmed  publisher | 
| immunocytochemistry; human; fig 3western blot; human; fig 1
 | Blanchard Z, Paul B, Craft B, ElShamy W. BRCA1-IRIS inactivation overcomes paclitaxel resistance in triple negative breast cancers. Breast Cancer Res. 2015;17:5 pubmed  publisher | 
| western blot; human; fig s1
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| immunocytochemistry; humanwestern blot; human
 | Asp N, Pust S, Sandvig K. Flotillin depletion affects ErbB protein levels in different human breast cancer cells. Biochim Biophys Acta. 2014;1843:1987-96 pubmed  publisher | 
| western blot; human; loading ...; fig 1a
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| western blot; dogs; loading ...; fig 1b
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| western blot; human; fig 2
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| immunocytochemistry; mouse; 1:200western blot; mouse; 1:1000
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| immunocytochemistry; human; 1:150
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