product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
ATGL Antibody
catalog :
2138
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, western blot knockout validation
citations: 38
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; fig 1
Alsted T, Nybo L, Schweiger M, Fledelius C, Jacobsen P, Zimmermann R, et al. Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training. Am J Physiol Endocrinol Metab. 2009;296:E445-53 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5b
Zuo Z, Liu Z, Gao T, Yin Y, Wang Z, Hou Y, et al. Prolonged inorganic arsenic exposure via drinking water impairs brown adipose tissue function in mice. Sci Total Environ. 2019;668:310-317 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s2c
Li T, Song L, Sun Y, Li J, Yi C, Lam S, et al. Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. Nat Commun. 2018;9:1916 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 3c
Song Z, Xiaoli A, Zhang Q, Zhang Y, Yang E, Wang S, et al. Cyclin C regulates adipogenesis by stimulating transcriptional activity of CCAAT/enhancer-binding protein ?. J Biol Chem. 2017;292:8918-8932 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Kuo T, Chen T, Lee R, Nguyen N, Broughton A, Zhang D, et al. Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis. Diabetes. 2017;66:1601-1610 pubmed publisher
  • western blot; human; fig 5
Christensen B, Nellemann B, Jørgensen J, Pedersen S, Jessen N. Erythropoietin does not activate erythropoietin receptor signaling or lipolytic pathways in human subcutaneous white adipose tissue in vivo. Lipids Health Dis. 2016;15:160 pubmed publisher
  • western blot; human; fig 3
  • western blot; mouse; fig 5
Laurens C, Badin P, Louche K, Mairal A, Tavernier G, Marette A, et al. G0/G1 Switch Gene 2 controls adipose triglyceride lipase activity and lipid metabolism in skeletal muscle. Mol Metab. 2016;5:527-537 pubmed publisher
  • western blot; mouse; fig 3
Park J, Xu X, Cho S, Hur K, Lee M, Kersten S, et al. CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis. Sci Rep. 2016;6:27938 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 7g
Schrul B, Kopito R. Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains. Nat Cell Biol. 2016;18:740-51 pubmed publisher
  • western blot; human; loading ...; fig 2e
Barquissau V, Beuzelin D, Pisani D, Beranger G, Mairal A, Montagner A, et al. White-to-brite conversion in human adipocytes promotes metabolic reprogramming towards fatty acid anabolic and catabolic pathways. Mol Metab. 2016;5:352-365 pubmed publisher
  • western blot; human; loading ...; fig 3f
Vigelso A, Prats C, Ploug T, Dela F, Helge J. Higher muscle content of perilipin 5 and endothelial lipase protein in trained than untrained middle-aged men. Physiol Res. 2016;65:293-302 pubmed
  • western blot; human; 1:1000; fig 1
Iglesias J, Lamontagne J, Erb H, Gezzar S, Zhao S, Joly E, et al. Simplified assays of lipolysis enzymes for drug discovery and specificity assessment of known inhibitors. J Lipid Res. 2016;57:131-41 pubmed publisher
  • western blot; mouse; fig 1b
Das S, Stadelmeyer E, Schauer S, Schwarz A, Strohmaier H, Claudel T, et al. Micro RNA-124a regulates lipolysis via adipose triglyceride lipase and comparative gene identification 58. Int J Mol Sci. 2015;16:8555-68 pubmed publisher
  • western blot; rat; loading ...
Rogers R, Beaudoin M, Wheatley J, Wright D, Geiger P. Heat shock proteins: in vivo heat treatments reveal adipose tissue depot-specific effects. J Appl Physiol (1985). 2015;118:98-106 pubmed publisher
  • western blot; human
Li S, Zhou T, Li C, Dai Z, Che D, Yao Y, et al. High metastaticgastric and breast cancer cells consume oleic acid in an AMPK dependent manner. PLoS ONE. 2014;9:e97330 pubmed publisher
  • western blot; mouse
Lakeland T, Borg M, Matzaris M, Abdelkader A, Evans R, Watt M. Augmented expression and secretion of adipose-derived pigment epithelium-derived factor does not alter local angiogenesis or contribute to the development of systemic metabolic derangements. Am J Physiol Endocrinol Metab. 2014;306:E1367-77 pubmed publisher
  • western blot; mouse; fig 1
Pulinilkunnil T, Kienesberger P, Nagendran J, Sharma N, Young M, Dyck J. Cardiac-specific adipose triglyceride lipase overexpression protects from cardiac steatosis and dilated cardiomyopathy following diet-induced obesity. Int J Obes (Lond). 2014;38:205-15 pubmed publisher
Schweiger M, Romauch M, Schreiber R, Grabner G, Hutter S, Kotzbeck P, et al. Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice. Nat Commun. 2017;8:14859 pubmed publisher
Gao S, Li C, Zhu Y, Wang Y, Sui A, Zhong Y, et al. PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy. Sci Rep. 2017;7:42846 pubmed publisher
Gemmink A, Bakker L, Guigas B, Kornips E, Schaart G, Meinders A, et al. Lipid droplet dynamics and insulin sensitivity upon a 5-day high-fat diet in Caucasians and South Asians. Sci Rep. 2017;7:42393 pubmed publisher
Chung H, Ryu D, Kim K, Chang J, Kim Y, Yi H, et al. Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. J Cell Biol. 2017;216:149-165 pubmed publisher
Gallardo Montejano V, Saxena G, Kusminski C, Yang C, McAfee J, Hahner L, et al. Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1?/SIRT1-dependent transcriptional regulation of mitochondrial function. Nat Commun. 2016;7:12723 pubmed publisher
Oropeza D, Jouvet N, Bouyakdan K, Perron G, Ringuette L, Philipson L, et al. PGC-1 coactivators in ?-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids. Mol Metab. 2015;4:811-22 pubmed publisher
Barrett H, Kubala M, Scholz Romero K, Denny K, Woodruff T, McIntyre H, et al. Placental lipase expression in pregnancies complicated by preeclampsia: a case-control study. Reprod Biol Endocrinol. 2015;13:100 pubmed publisher
Newsom S, Everett A, Park S, Van Pelt D, Hinko A, Horowitz J. Lipid mixtures containing a very high proportion of saturated fatty acids only modestly impair insulin signaling in cultured muscle cells. PLoS ONE. 2015;10:e0120871 pubmed publisher
Bakke S, Feng Y, Nikolić N, Kase E, Moro C, Stensrud C, et al. Myotubes from severely obese type 2 diabetic subjects accumulate less lipids and show higher lipolytic rate than myotubes from severely obese non-diabetic subjects. PLoS ONE. 2015;10:e0119556 pubmed publisher
Grabek K, Diniz Behn C, Barsh G, Hesselberth J, Martin S. Enhanced stability and polyadenylation of select mRNAs support rapid thermogenesis in the brown fat of a hibernator. elife. 2015;4: pubmed publisher
Sheshachalam A, Srivastava N, Mitchell T, Lacy P, Eitzen G. Granule protein processing and regulated secretion in neutrophils. Front Immunol. 2014;5:448 pubmed publisher
Barrett H, Kubala M, Scholz Romero K, Denny K, Woodruff T, McIntyre H, et al. Placental lipases in pregnancies complicated by gestational diabetes mellitus (GDM). PLoS ONE. 2014;9:e104826 pubmed publisher
Mason R, Meex R, Russell A, Canny B, Watt M. Cellular localization and associations of the major lipolytic proteins in human skeletal muscle at rest and during exercise. PLoS ONE. 2014;9:e103062 pubmed publisher
Okumura T, Harada K, Oue K, Zhang J, Asano S, Hayashiuchi M, et al. Phospholipase C-related catalytically inactive protein (PRIP) regulates lipolysis in adipose tissue by modulating the phosphorylation of hormone-sensitive lipase. PLoS ONE. 2014;9:e100559 pubmed publisher
Huang Y, Morales Rosado J, Ray J, Myers T, Kho T, Lu M, et al. Toll-like receptor agonists promote prolonged triglyceride storage in macrophages. J Biol Chem. 2014;289:3001-12 pubmed publisher
Bouwman F, Wang P, van Baak M, Saris W, Mariman E. Increased ?-oxidation with improved glucose uptake capacity in adipose tissue from obese after weight loss and maintenance. Obesity (Silver Spring). 2014;22:819-27 pubmed publisher
Verhoef S, Camps S, Bouwman F, Mariman E, Westerterp K. Physiological response of adipocytes to weight loss and maintenance. PLoS ONE. 2013;8:e58011 pubmed publisher
Timmers S, de Vogel van den Bosch J, de Wit N, Schaart G, van Beurden D, Hesselink M, et al. Differential effects of saturated versus unsaturated dietary fatty acids on weight gain and myocellular lipid profiles in mice. Nutr Diabetes. 2011;1:e11 pubmed publisher
McIlroy G, Delibegovic M, Owen C, Stoney P, Shearer K, McCaffery P, et al. Fenretinide treatment prevents diet-induced obesity in association with major alterations in retinoid homeostatic gene expression in adipose, liver, and hypothalamus. Diabetes. 2013;62:825-36 pubmed publisher
Li H, Song Y, Zhang L, Gu Y, Li F, Pan S, et al. LSDP5 enhances triglyceride storage in hepatocytes by influencing lipolysis and fatty acid ?-oxidation of lipid droplets. PLoS ONE. 2012;7:e36712 pubmed publisher
Timmers S, de Vogel van den Bosch J, Hesselink M, van Beurden D, Schaart G, Ferraz M, et al. Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscle. PLoS ONE. 2011;6:e14503 pubmed publisher
product information
SKU :
2138S
Product-Name :
ATGL Antibody
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
M, (R)
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Metabolism
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
54
Host :
Rabbit
Target :
ATGL
Primary-Protein :
PNPLA2
Alt-Names :
1110001C14Rik,ATGL,Adipose triglyceride lipase,Calcium-independent phospholipase A2,DKFZp667M109,Desnutrin,FP17548,IPLA2-zeta,PEDF-R,PLPL2,PNPLA2,Patatin-like phospholipase domain-containing protein 2,Pigment epithelium-derived factor,TTS-2.2,TTS2,TTS2.2,Transport-secretion protein 2,patatin-like phospholipase domain containing 2,transport-secretion protein 2.2,triglyceride hydrolase
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.