| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry knockout validation; mouse; 1:400; loading ...; fig 4a
- western blot knockout validation; mouse; 1:1000; loading ...; fig 4b
| Shen Z, Zheng Y, Wu J, Chen Y, Wu X, Zhou Y, et al. PARK2-dependent mitophagy induced by acidic postconditioning protects against focal cerebral ischemia and extends the reperfusion window. Autophagy. 2017;13:473-485 pubmed publisher |
- western blot knockout validation; rat; 1:1000; fig 1a
| Gemechu J, Sharma A, Yu D, Xie Y, Merkel O, Moszczynska A. Characterization of Dopaminergic System in the Striatum of Young Adult Park2-/- Knockout Rats. Sci Rep. 2018;8:1517 pubmed publisher |
- western blot knockout validation; mouse; 1:1000; fig 4
| Gong G, Song M, Csordás G, Kelly D, Matkovich S, Dorn G. Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science. 2015;350:aad2459 pubmed publisher |
- western blot knockout validation; mouse; 1:1000
| Song M, Gong G, Burelle Y, Gustafsson Ã, Kitsis R, Matkovich S, et al. Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts. Circ Res. 2015;117:346-51 pubmed publisher |
- immunohistochemistry; human; fig 2
- western blot; human; fig 2
| Kobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, et al. Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis. J Immunol. 2016;197:504-16 pubmed publisher |
- immunoprecipitation; human; 1:800; loading ...; fig 3
- western blot; human; 1:800; loading ...; fig 3a
- immunoprecipitation; mouse; 1:800; loading ...; fig 3
- western blot; mouse; 1:800; loading ...; fig 3b
| Halbach M, Stehning T, Damrath E, Jendrach M, Åžen N, BaÅŸak A, et al. Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated. PLoS ONE. 2015;10:e0121089 pubmed publisher |
- western blot; human; 1:500; fig 2
| Ambrosi G, Ghezzi C, Sepe S, Milanese C, Payan Gomez C, Bombardieri C, et al. Bioenergetic and proteolytic defects in fibroblasts from patients with sporadic Parkinson's disease. Biochim Biophys Acta. 2014;1842:1385-94 pubmed publisher |
| Borzęcka Solarz K, Dembińska J, Hromada Judycka A, Traczyk G, Ciesielska A, Ziemlinska E, et al. Association of Lyn kinase with membrane rafts determines its negative influence on LPS-induced signaling. Mol Biol Cell. 2017;28:1147-1159 pubmed publisher |
| Gong Y, Schumacher S, Wu W, Tang F, Beroukhim R, Chan T. Pan-Cancer Analysis Links PARK2 to BCL-XL-Dependent Control of Apoptosis. Neoplasia. 2017;19:75-83 pubmed publisher |
| Taneike M, Nishida K, Omiya S, Zarrinpashneh E, Misaka T, Kitazume Taneike R, et al. mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy. PLoS ONE. 2016;11:e0152628 pubmed publisher |
| Liu K, Li F, Han H, Chen Y, Mao Z, Luo J, et al. Parkin Regulates the Activity of Pyruvate Kinase M2. J Biol Chem. 2016;291:10307-17 pubmed publisher |
| Song P, Li S, Wu H, Gao R, Rao G, Wang D, et al. Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease. Protein Cell. 2016;7:114-29 pubmed publisher |
| Tanaka T, Terai Y, Kogata Y, Ashihara K, Maeda K, Fujiwara S, et al. CD24 expression as a marker for predicting clinical outcome and invasive activity in uterine cervical cancer. Oncol Rep. 2015;34:2282-8 pubmed publisher |
| Shakiba N, White C, Lipsitz Y, Yachie Kinoshita A, Tonge P, Hussein S, et al. CD24 tracks divergent pluripotent states in mouse and human cells. Nat Commun. 2015;6:7329 pubmed publisher |
| Ahmad T, Sundar I, Lerner C, Gerloff J, Tormos A, Yao H, et al. Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease. FASEB J. 2015;29:2912-29 pubmed publisher |
| Ito S, Araya J, Kurita Y, Kobayashi K, Takasaka N, Yoshida M, et al. PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. Autophagy. 2015;11:547-59 pubmed publisher |
| Drew B, Ribas V, Le J, Henstridge D, Phun J, Zhou Z, et al. HSP72 is a mitochondrial stress sensor critical for Parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle. Diabetes. 2014;63:1488-505 pubmed publisher |
| Meng F, Yao D, Shi Y, Kabakoff J, Wu W, Reicher J, et al. Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation. Mol Neurodegener. 2011;6:34 pubmed publisher |
| Okatsu K, Saisho K, Shimanuki M, Nakada K, Shitara H, Sou Y, et al. p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. Genes Cells. 2010;15:887-900 pubmed publisher |
| Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, Gautier C, et al. PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol. 2010;189:211-21 pubmed publisher |
