product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
α-Tubulin (11H10) Rabbit mAb
catalog :
2125
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
11H10
reactivity :
human, mouse, brown rat, dogs, bovine, Drosophila melanogaster
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
citations: 75
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:200; loading ...; fig 6s4b
Cohen Katsenelson K, Stender J, Kawashima A, Lordén G, Uchiyama S, Nizet V, et al. PHLPP1 counter-regulates STAT1-mediated inflammatory signaling. elife. 2019;8: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6c
Giurisato E, Xu Q, Lonardi S, Telfer B, Russo I, Pearson A, et al. Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition. Proc Natl Acad Sci U S A. 2018;115:E2801-E2810 pubmed publisher
  • western blot; human; 1:1000; fig 6
Dirks M, Wall B, Kramer I, Zorenc A, Goessens J, Gijsen A, et al. A single session of neuromuscular electrical stimulation does not augment postprandial muscle protein accretion. Am J Physiol Endocrinol Metab. 2016;311:E278-85 pubmed publisher
  • western blot; human; 1:1000; fig 4
Wang J, Hu K, Guo J, Cheng F, Lv J, Jiang W, et al. Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK. Nat Commun. 2016;7:11363 pubmed publisher
  • western blot; human; 1:1000; fig 4
Keasey M, Lemos R, Hagg T, Oliveira J. Vitamin-D receptor agonist calcitriol reduces calcification in vitro through selective upregulation of SLC20A2 but not SLC20A1 or XPR1. Sci Rep. 2016;6:25802 pubmed publisher
  • western blot; human; 1:1000; fig 2
Wei T, Zhang H, Cetin N, Miller E, Moak T, Suen J, et al. Elevated Expression of Matrix Metalloproteinase-9 not Matrix Metalloproteinase-2 Contributes to Progression of Extracranial Arteriovenous Malformation. Sci Rep. 2016;6:24378 pubmed publisher
  • western blot; human; 1:1000; fig 3
Jung Y, Decker A, Wang J, Lee E, Kana L, Yumoto K, et al. Endogenous GAS6 and Mer receptor signaling regulate prostate cancer stem cells in bone marrow. Oncotarget. 2016;7:25698-711 pubmed publisher
  • western blot; Drosophila melanogaster; 1:2000; fig 4
Gorsky M, Burnouf S, Dols J, Mandelkow E, Partridge L. Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo. Sci Rep. 2016;6:22685 pubmed publisher
  • western blot; human; 1:1000; fig 2
Gao S, Chen X, Jin H, Ren S, Liu Z, Fang X, et al. Overexpression of ErbB2 renders breast cancer cells susceptible to 3-BrPA through the increased dissociation of hexokinase II from mitochondrial outer membrane. Oncol Lett. 2016;11:1567-1573 pubmed
  • western blot; mouse; fig s2
Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, et al. Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders. Nat Commun. 2016;7:10594 pubmed publisher
  • western blot; mouse; fig 5
Ge W, Yuan M, Ceylan A, Wang X, Ren J. Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism. Biochim Biophys Acta. 2016;1862:622-634 pubmed publisher
  • western blot; mouse; 1:100; fig 5
Hunt L, Xu B, Finkelstein D, Fan Y, Carroll P, Cheng P, et al. The glucose-sensing transcription factor MLX promotes myogenesis via myokine signaling. Genes Dev. 2015;29:2475-89 pubmed publisher
  • western blot; human; 1:1000; fig 3
Suwei D, Liang Z, Zhimin L, Ruilei L, Yingying Z, Zhen L, et al. NLK functions to maintain proliferation and stemness of NSCLC and is a target of metformin. J Hematol Oncol. 2015;8:120 pubmed publisher
  • western blot; mouse; fig 6
  • western blot; brown rat; fig 3
Sabirzhanov B, Stoica B, Zhao Z, Loane D, Wu J, Dorsey S, et al. miR-711 upregulation induces neuronal cell death after traumatic brain injury. Cell Death Differ. 2016;23:654-68 pubmed publisher
  • western blot; human; 1:1000; fig 3
Widder M, Lützkendorf J, Caysa H, Unverzagt S, Wickenhauser C, Benndorf R, et al. Multipotent mesenchymal stromal cells promote tumor growth in distinct colorectal cancer cells by a β1-integrin-dependent mechanism. Int J Cancer. 2016;138:964-75 pubmed publisher
  • western blot; brown rat; 1:10,000; fig 3
Geletu M, Guy S, Greer S, Raptis L. Differential effects of polyoma virus middle tumor antigen mutants upon gap junctional, intercellular communication. Exp Cell Res. 2015;336:223-31 pubmed publisher
  • western blot; mouse; fig 4f
Munson M, Allen G, Toth R, Campbell D, Lucocq J, Ganley I. mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival. EMBO J. 2015;34:2272-90 pubmed publisher
  • immunocytochemistry; mouse; fig 4a
Zhang T, Zhou Y, Qi S, Wang Z, Qian W, Ouyang Y, et al. Nuf2 is required for chromosome segregation during mouse oocyte meiotic maturation. Cell Cycle. 2015;14:2701-10 pubmed publisher
  • western blot; human; fig 2
Grikscheit K, Frank T, Wang Y, Grosse R. Junctional actin assembly is mediated by Formin-like 2 downstream of Rac1. J Cell Biol. 2015;209:367-76 pubmed publisher
  • western blot; mouse; 1:1000; fig 7a
Qi S, Wang Z, Huang L, Liang L, Xian Y, Ouyang Y, et al. Casein kinase 1 (α, δ and ε) localize at the spindle poles, but may not be essential for mammalian oocyte meiotic progression. Cell Cycle. 2015;14:1675-85 pubmed publisher
  • western blot; mouse; 1:1000; fig 2
Zhang R, Huang M, Cao Z, Qi J, Qiu Z, Chiang L. MeCP2 plays an analgesic role in pain transmission through regulating CREB / miR-132 pathway. Mol Pain. 2015;11:19 pubmed publisher
  • western blot; brown rat; fig 1
Lee H, Jeong H, Park S, Yoo W, Choi S, Choi K, et al. Fusion protein of retinol-binding protein and albumin domain III reduces liver fibrosis. EMBO Mol Med. 2015;7:819-30 pubmed publisher
  • western blot; mouse; 1:1000
Tian E, Stevens S, Guan Y, Springer D, Anderson S, Starost M, et al. Galnt1 is required for normal heart valve development and cardiac function. PLoS ONE. 2015;10:e0115861 pubmed publisher
  • western blot; human; 1:500
Daniëls V, Smans K, Royaux I, Chypre M, Swinnen J, Zaidi N. Cancer cells differentially activate and thrive on de novo lipid synthesis pathways in a low-lipid environment. PLoS ONE. 2014;9:e106913 pubmed publisher
  • western blot; human; 1:10000
Balmer N, Klima S, Rempel E, Ivanova V, Kolde R, Weng M, et al. From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014;88:1451-68 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500
Li R, Tan J, Chen L, Feng J, Liang W, Guo X, et al. Iqcg is essential for sperm flagellum formation in mice. PLoS ONE. 2014;9:e98053 pubmed publisher
  • western blot; human
Ding Z, German P, Bai S, Reddy A, Liu X, Sun M, et al. Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein. Cancer Res. 2014;74:3127-36 pubmed publisher
  • western blot; human
Liu B, Cao Y, Huizinga T, Hafler D, Toes R. TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells. Eur J Immunol. 2014;44:2121-9 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Khotskaya Y, Beck B, Hurst D, Han Z, Xia W, Hung M, et al. Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix. Mol Carcinog. 2014;53:1011-26 pubmed publisher
  • western blot; mouse; 1:2,000
Mietzsch U, McKenna J, Reith R, Way S, Gambello M. Comparative analysis of Tsc1 and Tsc2 single and double radial glial cell mutants. J Comp Neurol. 2013;521:3817-31 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Arun V, Wiley J, Kaur H, Kaplan D, Guha A. A novel neurofibromin (NF1) interaction with the leucine-rich pentatricopeptide repeat motif-containing protein links neurofibromatosis type 1 and the French Canadian variant of Leigh's syndrome in a common molecular complex. J Neurosci Res. 2013;91:494-505 pubmed publisher
  • western blot; mouse; 1:10 000
Xu X, Wang Q, Long Y, Zhang R, Wei X, Xing M, et al. Stress-mediated p38 activation promotes somatic cell reprogramming. Cell Res. 2013;23:131-41 pubmed publisher
  • western blot; human
Lindberg K, Helguero L, Omoto Y, Gustafsson J, Haldosén L. Estrogen receptor ? represses Akt signaling in breast cancer cells via downregulation of HER2/HER3 and upregulation of PTEN: implications for tamoxifen sensitivity. Breast Cancer Res. 2011;13:R43 pubmed publisher
Zhang B, Shetti D, Fan C, Wei K. miR-29b-3p promotes progression of MDA-MB-231 triple-negative breast cancer cells through downregulating TRAF3. Biol Res. 2019;52:38 pubmed publisher
Tsarouhas V, Liu D, Tsikala G, Fedoseienko A, Zinn K, Matsuda R, et al. WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis. Nat Commun. 2019;10:2193 pubmed publisher
Mason Osann E, Dai A, Floro J, Lock Y, Reiss M, Gali H, et al. Identification of a novel gene fusion in ALT positive osteosarcoma. Oncotarget. 2018;9:32868-32880 pubmed publisher
Sonnenschein H, Lawrence K, Wittenberg K, Slykas F, Dohleman E, Knoublauch J, et al. Suppressor of IKKepsilon forms direct interactions with cytoskeletal proteins, tubulin and α-actinin, linking innate immunity to the cytoskeleton. FEBS Open Bio. 2018;8:1064-1082 pubmed publisher
Nandy A, Mondal A, Pandey R, Arumugam P, Dawa S, Jaisinghani N, et al. Adipocyte Model of Mycobacterium tuberculosis Infection Reveals Differential Availability of Iron to Bacilli in the Lipid-Rich Caseous Environment. Infect Immun. 2018;86: pubmed publisher
Grobe H, Wüstenhagen A, Baarlink C, Grosse R, Grikscheit K. A Rac1-FMNL2 signaling module affects cell-cell contact formation independent of Cdc42 and membrane protrusions. PLoS ONE. 2018;13:e0194716 pubmed publisher
Kolluri K, Alifrangis C, Kumar N, Ishii Y, Price S, Michaut M, et al. Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells. elife. 2018;7: pubmed publisher
Wu J, Xiang S, Zhang M, Fang B, Huang H, Kwon O, et al. Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity. J Biol Chem. 2018;293:1976-1993 pubmed publisher
Capece T, Walling B, Lim K, Kim K, Bae S, Chung H, et al. A novel intracellular pool of LFA-1 is critical for asymmetric CD8+ T cell activation and differentiation. J Cell Biol. 2017;216:3817-3829 pubmed publisher
Nazari M, Serrill J, Wan X, Nguyen M, Anklin C, Gallegos D, et al. New Mandelalides Expand a Macrolide Series of Mitochondrial Inhibitors. J Med Chem. 2017;60:7850-7862 pubmed publisher
Conforti F, Zhang X, Rao G, De Pas T, Yonemori Y, Rodriguez J, et al. Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors. Cancer Res. 2017;77:5614-5627 pubmed publisher
Miyamoto T, Lo P, Saichi N, Ueda K, Hirata M, Tanikawa C, et al. Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53. Sci Adv. 2017;3:e1603204 pubmed publisher
Gokulakrishnan G, Chang X, Fleischmann R, Fiorotto M. Precocious glucocorticoid exposure reduces skeletal muscle satellite cells in the fetal rat. J Endocrinol. 2017;232:561-572 pubmed publisher
Szíber Z, Liliom H, Morales C, Ignácz A, Rátkai A, Ellwanger K, et al. Ras and Rab interactor 1 controls neuronal plasticity by coordinating dendritic filopodial motility and AMPA receptor turnover. Mol Biol Cell. 2017;28:285-295 pubmed publisher
Harold C, Cox D, Riley K. Epstein-Barr viral microRNAs target caspase 3. Virol J. 2016;13:145 pubmed publisher
Yan X, Cen Y, Wang Q. Mesenchymal stem cells alleviate experimental rheumatoid arthritis through microRNA-regulated I?B expression. Sci Rep. 2016;6:28915 pubmed publisher
Yamada T, Yoshii T, Yasuda H, Okawa A, Sotome S. Dexamethasone Regulates EphA5, a Potential Inhibitory Factor with Osteogenic Capability of Human Bone Marrow Stromal Cells. Stem Cells Int. 2016;2016:1301608 pubmed publisher
Simões M, Martins C, Ferreira F. Early intranuclear replication of African swine fever virus genome modifies the landscape of the host cell nucleus. Virus Res. 2015;210:1-7 pubmed publisher
Cieply B, Koontz C, Frisch S. CD44S-hyaluronan interactions protect cells resulting from EMT against anoikis. Matrix Biol. 2015;48:55-65 pubmed publisher
Safaee M, Fakurnejad S, Bloch O, Clark A, Ivan M, Sun M, et al. Proportional upregulation of CD97 isoforms in glioblastoma and glioblastoma-derived brain tumor initiating cells. PLoS ONE. 2015;10:e0111532 pubmed publisher
Chen R, Xu M, Nagati J, Hogg R, Das A, Gerard R, et al. The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment. PLoS ONE. 2015;10:e0116515 pubmed publisher
Chia R, Haddock S, Beilina A, Rudenko I, Mamais A, Kaganovich A, et al. Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7. Nat Commun. 2014;5:5827 pubmed publisher
Zhang Q, Zhai S, Li L, Li X, Jiang C, Zhang C, et al. P-glycoprotein-evading anti-tumor activity of a novel tubulin and HSP90 dual inhibitor in a non-small-cell lung cancer model. J Pharmacol Sci. 2014;126:66-76 pubmed
Sekine C, Nanki T, Yagita H. Macrophage-derived delta-like protein 1 enhances interleukin-6 and matrix metalloproteinase 3 production by fibroblast-like synoviocytes in mice with collagen-induced arthritis. Arthritis Rheumatol. 2014;66:2751-61 pubmed publisher
Shibuya H, Yoshitomi H, Murata K, Kobayashi S, Furu M, Ishikawa M, et al. TNF?, PDGF, and TGF? synergistically induce synovial lining hyperplasia via inducible PI3K?. Mod Rheumatol. 2015;25:72-8 pubmed publisher
Zhu J, Sheng J, Dong H, Kang L, Ang J, Xu Z. Phospholipid scramblase 1 functionally interacts with angiogenin and regulates angiogenin-enhanced rRNA transcription. Cell Physiol Biochem. 2013;32:1695-706 pubmed publisher
Szepietowska B, Horvath T, Sherwin R. Role of synaptic plasticity and EphA5-ephrinA5 interaction within the ventromedial hypothalamus in response to recurrent hypoglycemia. Diabetes. 2014;63:1140-7 pubmed publisher
Tan S, Furusato B, Fang X, He F, Mohamed A, Griner N, et al. Evaluation of ERG responsive proteome in prostate cancer. Prostate. 2014;74:70-89 pubmed publisher
Liu B, Stoop J, Huizinga T, Toes R. IL-21 enhances the activity of the TLR-MyD88-STAT3 pathway but not the classical TLR-MyD88-NF-?B pathway in human B cells to boost antibody production. J Immunol. 2013;191:4086-94 pubmed publisher
Yamada T, Yuasa M, Masaoka T, Taniyama T, Maehara H, Torigoe I, et al. After repeated division, bone marrow stromal cells express inhibitory factors with osteogenic capabilities, and EphA5 is a primary candidate. Bone. 2013;57:343-54 pubmed publisher
Zhang Q, Liu X, Li X, Li C, Zhou H, Yan B. Antitumor activity of (2E,5Z)-5-(2-hydroxybenzylidene)-2-((4-phenoxyphenyl)imino) thiazolidin-4-one, a novel microtubule-depolymerizing agent, in U87MG human glioblastoma cells and corresponding mouse xenograft model. J Pharmacol Sci. 2013;122:223-31 pubmed
Li Z, Gong Y, Sun S, Du Y, Lu D, Liu X, et al. Differential regulation of stiffness, topography, and dimension of substrates in rat mesenchymal stem cells. Biomaterials. 2013;34:7616-25 pubmed publisher
Zhang Q, Zhai S, Li L, Li X, Zhou H, Liu A, et al. Anti-tumor selectivity of a novel tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models. Biochem Pharmacol. 2013;86:351-60 pubmed publisher
Safaee M, Clark A, Oh M, Ivan M, Bloch O, Kaur G, et al. Overexpression of CD97 confers an invasive phenotype in glioblastoma cells and is associated with decreased survival of glioblastoma patients. PLoS ONE. 2013;8:e62765 pubmed publisher
Gonzalez D, Rojas A, Herrera M, Conlan R. iNOS activation regulates ?-catenin association with its partners in endothelial cells. PLoS ONE. 2012;7:e52964 pubmed publisher
Szepietowska B, Zhu W, Czyzyk J, Eid T, Sherwin R. EphA5-EphrinA5 interactions within the ventromedial hypothalamus influence counterregulatory hormone release and local glutamine/glutamate balance during hypoglycemia. Diabetes. 2013;62:1282-8 pubmed publisher
Reyes Reyes E, Jin Z, Vaisberg A, Hammond G, Bates P. Physangulidine A, a withanolide from Physalis angulata, perturbs the cell cycle and induces cell death by apoptosis in prostate cancer cells. J Nat Prod. 2013;76:2-7 pubmed publisher
Geletu M, Arulanandam R, Greer S, Trotman Grant A, Tomai E, Raptis L. Stat3 is a positive regulator of gap junctional intercellular communication in cultured, human lung carcinoma cells. BMC Cancer. 2012;12:605 pubmed publisher
Ward S, Kim H, Komurov K, Mendiratta S, Tsai P, Schmolke M, et al. Host modulators of H1N1 cytopathogenicity. PLoS ONE. 2012;7:e39284 pubmed publisher
Wang Q, Na B, Ou J, Pulliam L, Yen T. Hepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to Fas signaling. PLoS ONE. 2012;7:e36818 pubmed publisher
Donigan K, Sun K, Nemec A, MURPHY D, Cong X, Northrup V, et al. Human POLB gene is mutated in high percentage of colorectal tumors. J Biol Chem. 2012;287:23830-9 pubmed publisher
Decaris M, Lee C, Yoder M, Tarantal A, Leach J. Influence of the oxygen microenvironment on the proangiogenic potential of human endothelial colony forming cells. Angiogenesis. 2009;12:303-11 pubmed publisher
product information
SKU :
2125S
Product-Name :
α-Tubulin (11H10) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk, Dm, B, (Dg, Pg)
Applications :
Flow cytometry
Product-Category :
Cytoskeletal Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
52
Host :
Rabbit
Target :
tubulin alpha
Primary-Protein :
TUBA1B
Alt-Names :
Alpha-tubulin ubiquitous,K-ALPHA-1,TBA1B,TUBA1B,Tubulin K-alpha-1,Tubulin alpha-1B chain,Tubulin alpha-ubiquitous chain,alpha tubulin,tubulin, alpha 1b,tubulin, alpha, ubiquitous
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.