product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Src (32G6) Rabbit mAb
catalog :
2123
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
32G6
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 55
Published Application/Species/Sample/DilutionReference
  • immunoprecipitation; human; loading ...; fig s3c
  • western blot; human; 1:1000; loading ...; fig s3c
Kennedy S, Jarboui M, Srihari S, Raso C, Bryan K, Dernayka L, et al. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. Nat Commun. 2020;11:499 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3c
Harde E, Nicholson L, Furones Cuadrado B, Bissen D, Wigge S, Urban S, et al. EphrinB2 regulates VEGFR2 during dendritogenesis and hippocampal circuitry development. elife. 2019;8: pubmed publisher
  • immunoprecipitation; human; 1:1000; loading ...; fig 6a
Luxan G, Stewen J, Díaz N, Kato K, Maney S, Aravamudhan A, et al. Endothelial EphB4 maintains vascular integrity and transport function in adult heart. elife. 2019;8: pubmed publisher
  • western blot; human; loading ...; fig 7f
Timms R, Zhang Z, Rhee D, Harper J, Koren I, Elledge S. A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation. Science. 2019;365: pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 8a
  • western blot; mouse; 1:2000; loading ...; fig 8b
Zhang S, Liu W, Yang Y, Sun K, Li S, Xu H, et al. Tmem30a Deficiency in endothelial cells impairs cell proliferation and angiogenesis. J Cell Sci. 2019;: pubmed publisher
  • western blot; mouse; loading ...; fig 5c
Chorzalska A, Morgan J, Ahsan N, Treaba D, Olszewski A, Petersen M, et al. Bone marrow-specific loss of ABI1 induces myeloproliferative neoplasm with features resembling human myelofibrosis. Blood. 2018;: pubmed publisher
  • western blot; human; 1:1000; fig 3a
Park G, Kim D. Cigarette smoke-induced EGFR activation promotes epithelial mesenchymal migration of human retinal pigment epithelial cells through regulation of the FAK-mediated Syk/Src pathway. Mol Med Rep. 2018;17:3563-3574 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 6h
  • western blot; human; loading ...; fig 6k
  • immunohistochemistry; mouse; loading ...; fig s7c
  • western blot; mouse; loading ...; fig s7d
Ran H, Kong S, Zhang S, Cheng J, Zhou C, He B, et al. Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase. Proc Natl Acad Sci U S A. 2017;114:4816-4821 pubmed publisher
  • western blot; human; fig 5b
Soni D, Regmi S, Wang D, Debroy A, Zhao Y, Vogel S, et al. Pyk2 phosphorylation of VE-PTP downstream of STIM1-induced Ca2+ entry regulates disassembly of adherens junctions. Am J Physiol Lung Cell Mol Physiol. 2017;312:L1003-L1017 pubmed publisher
  • western blot; human; loading ...; fig 3d
Merhi A, Delree P, Marini A. The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling. Sci Rep. 2017;7:44602 pubmed publisher
  • western blot; human; 1:1000; fig 5b
Hurst L, Dunmore B, Long L, Crosby A, Al Lamki R, Deighton J, et al. TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. Nat Commun. 2017;8:14079 pubmed publisher
  • western blot; human; fig 2
Vallo S, Michaelis M, Gust K, Black P, Rothweiler F, Kvasnicka H, et al. Dasatinib enhances tumor growth in gemcitabine-resistant orthotopic bladder cancer xenografts. BMC Res Notes. 2016;9:454 pubmed
  • western blot; mouse; fig 5e
Girola N, Matsuo A, Figueiredo C, Massaoka M, Farias C, Arruda D, et al. The Ig VH complementarity-determining region 3-containing Rb9 peptide, inhibits melanoma cells migration and invasion by interactions with Hsp90 and an adhesion G-protein coupled receptor. Peptides. 2016;85:1-15 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5a
Kreger B, Dougherty A, Greene K, Cerione R, Antonyak M. Microvesicle Cargo and Function Changes upon Induction of Cellular Transformation. J Biol Chem. 2016;291:19774-85 pubmed publisher
  • western blot; human; loading ...; fig 1c
Monica V, Lo Iacono M, Bracco E, Busso S, di Blasio L, Primo L, et al. Dasatinib modulates sensitivity to pemetrexed in malignant pleural mesothelioma cell lines. Oncotarget. 2016;7:76577-76589 pubmed publisher
  • western blot; human; fig 1
Subramaniam S, Ozdener M, Abdoul Azize S, Saito K, Malik B, Maquart G, et al. ERK1/2 activation in human taste bud cells regulates fatty acid signaling and gustatory perception of fat in mice and humans. FASEB J. 2016;30:3489-3500 pubmed
  • western blot; human; 1:2000; loading ...; fig 5d
Cichon M, Moruzzi M, Shqau T, Miller E, Mehner C, Ethier S, et al. MYC Is a Crucial Mediator of TGF?-Induced Invasion in Basal Breast Cancer. Cancer Res. 2016;76:3520-30 pubmed publisher
  • western blot; human; fig 8
Huang D, Zhao C, Ju R, Kumar A, Tian G, Huang L, et al. VEGF-B inhibits hyperglycemia- and Macugen-induced retinal apoptosis. Sci Rep. 2016;6:26059 pubmed publisher
  • western blot; human; 1:3000; fig 8
Kii I, Sumida Y, Goto T, Sonamoto R, Okuno Y, Yoshida S, et al. Selective inhibition of the kinase DYRK1A by targeting its folding process. Nat Commun. 2016;7:11391 pubmed publisher
  • western blot; human; fig 7
Braley A, Kwak T, Jules J, Harja E, Landgraf R, Hudson B. Regulation of Receptor for Advanced Glycation End Products (RAGE) Ectodomain Shedding and Its Role in Cell Function. J Biol Chem. 2016;291:12057-73 pubmed publisher
  • immunocytochemistry; human; fig 2
  • western blot; human; fig 2
Xiao J, Duan Q, Wang Z, Yan W, Sun H, Xue P, et al. Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon. Oncotarget. 2016;7:24483-94 pubmed publisher
  • western blot; human; fig 4
Kourtidis A, Anastasiadis P. PLEKHA7 defines an apical junctional complex with cytoskeletal associations and miRNA-mediated growth implications. Cell Cycle. 2016;15:498-505 pubmed publisher
  • western blot; mouse; 1:2000; fig 4
Lee H, Kang J, Kim S, Ji S, Park S, Kim M, et al. Gene Silencing and Haploinsufficiency of Csk Increase Blood Pressure. PLoS ONE. 2016;11:e0146841 pubmed publisher
  • western blot; rat; 1:1000; fig 6
Grindheim A, Hollås H, Raddum A, Saraste J, Vedeler A. Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of annexin A2. J Cell Sci. 2016;129:314-28 pubmed publisher
  • western blot; human; 1:1000; fig 6
Kurozumi A, Goto Y, Matsushita R, Fukumoto I, Kato M, Nishikawa R, et al. Tumor-suppressive microRNA-223 inhibits cancer cell migration and invasion by targeting ITGA3/ITGB1 signaling in prostate cancer. Cancer Sci. 2016;107:84-94 pubmed publisher
  • western blot; rat; 1:1000; fig 2
Fiore V, Strane P, Bryksin A, White E, Hagood J, Barker T. Conformational coupling of integrin and Thy-1 regulates Fyn priming and fibroblast mechanotransduction. J Cell Biol. 2015;211:173-90 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 7a
Gu Y, Li H, Zhao L, Zhao S, He W, Rui L, et al. GRP78 confers the resistance to 5-FU by activating the c-Src/LSF/TS axis in hepatocellular carcinoma. Oncotarget. 2015;6:33658-74 pubmed publisher
  • western blot; human; fig 4
Yang L, Li Y, Bhattacharya A, Zhang Y. Inhibition of ERBB2-overexpressing Tumors by Recombinant Human Prolidase and Its Enzymatically Inactive Mutant. EBioMedicine. 2015;2:396-405 pubmed
  • western blot; human; 1:2000; fig 6
Lu H, Clauser K, Tam W, Fröse J, Ye X, Eaton E, et al. A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Nat Cell Biol. 2014;16:1105-17 pubmed publisher
  • western blot; human
Lu G, Zhang Q, Huang Y, Song J, Tomaino R, Ehrenberger T, et al. Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor. Cancer Cell. 2014;26:222-34 pubmed publisher
  • western blot; rat; 1:2000
Yang N, Liu Y, Pan C, Sun K, Wei X, Mao X, et al. Pretreatment with andrographolide pills(®) attenuates lipopolysaccharide-induced pulmonary microcirculatory disturbance and acute lung injury in rats. Microcirculation. 2014;21:703-16 pubmed publisher
  • western blot; human; loading ...; fig 2c
Shaiken T, Opekun A. Dissecting the cell to nucleus, perinucleus and cytosol. Sci Rep. 2014;4:4923 pubmed publisher
Beadnell T, Nassar K, Rose M, Clark E, Danysh B, Hofmann M, et al. Src-mediated regulation of the PI3K pathway in advanced papillary and anaplastic thyroid cancer. Oncogenesis. 2018;7:23 pubmed publisher
Daly C, Castanaro C, Zhang W, Zhang Q, Wei Y, Ni M, et al. FGFR3-TACC3 fusion proteins act as naturally occurring drivers of tumor resistance by functionally substituting for EGFR/ERK signaling. Oncogene. 2017;36:471-481 pubmed publisher
Kim J, Tan Y, Wang X, Cao X, Veeraraghavan J, Liang Y, et al. Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers. Nat Commun. 2016;7:12991 pubmed publisher
Shelby S, Veatch S, Holowka D, Baird B. Functional nanoscale coupling of Lyn kinase with IgE-Fc?RI is restricted by the actin cytoskeleton in early antigen-stimulated signaling. Mol Biol Cell. 2016;27:3645-3658 pubmed
Gnazzo M, Uhlemann E, Villarreal A, Shirayama M, Dominguez E, Skop A. The RNA-binding protein ATX-2 regulates cytokinesis through PAR-5 and ZEN-4. Mol Biol Cell. 2016;27:3052-3064 pubmed
Thinon E, Morales Sanfrutos J, Mann D, Tate E. N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells. ACS Chem Biol. 2016;11:2165-76 pubmed publisher
Chen L, Brar M, Leung F, Hsiao W. Triterpenoid herbal saponins enhance beneficial bacteria, decrease sulfate-reducing bacteria, modulate inflammatory intestinal microenvironment and exert cancer preventive effects in ApcMin/+ mice. Oncotarget. 2016;7:31226-42 pubmed publisher
Peng K, Dai Q, Wei J, Shao G, Sun A, Yang W, et al. Stress-induced endocytosis and degradation of epidermal growth factor receptor are two independent processes. Cancer Cell Int. 2016;16:25 pubmed publisher
Archibald M, Pritchard T, Nehoff H, Rosengren R, Greish K, Taurin S. A combination of sorafenib and nilotinib reduces the growth of castrate-resistant prostate cancer. Int J Nanomedicine. 2016;11:179-200 pubmed publisher
Labedz Maslowska A, Lipert B, Berdecka D, Kedracka Krok S, Jankowska U, Kamycka E, et al. Monocyte Chemoattractant Protein-Induced Protein 1 (MCPIP1) Enhances Angiogenic and Cardiomyogenic Potential of Murine Bone Marrow-Derived Mesenchymal Stem Cells. PLoS ONE. 2015;10:e0133746 pubmed publisher
Liu H, Wu Y, Zhu S, Liang W, Wang Z, Wang Y, et al. PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer. Cancer Lett. 2015;359:218-25 pubmed publisher
Wang G, Liu K, Li Y, Yi W, Yang Y, Zhao D, et al. Endoplasmic reticulum stress mediates the anti-inflammatory effect of ethyl pyruvate in endothelial cells. PLoS ONE. 2014;9:e113983 pubmed publisher
Duan J, Yu Y, Yu Y, Li Y, Huang P, Zhou X, et al. Silica nanoparticles enhance autophagic activity, disturb endothelial cell homeostasis and impair angiogenesis. Part Fibre Toxicol. 2014;11:50 pubmed publisher
Thinon E, Serwa R, Broncel M, Brannigan J, Brassat U, Wright M, et al. Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. Nat Commun. 2014;5:4919 pubmed publisher
Kong Q, Hua H, Cui A, Shao T, Song P, Jiang Y. SP600125 induces Src and type I IGF receptor phosphorylation independent of JNK. Int J Mol Sci. 2014;15:16246-56 pubmed publisher
Sáez P, Villalobos Labra R, Westermeier F, Sobrevia L, Farías Jofré M. Modulation of endothelial cell migration by ER stress and insulin resistance: a role during maternal obesity?. Front Pharmacol. 2014;5:189 pubmed publisher
Sakata A, Ohmori T, Nishimura S, Suzuki H, Madoiwa S, Mimuro J, et al. Paxillin is an intrinsic negative regulator of platelet activation in mice. Thromb J. 2014;12:1 pubmed publisher
Montagner A, Delgado M, Tallichet Blanc C, Chan J, Sng M, Mottaz H, et al. Src is activated by the nuclear receptor peroxisome proliferator-activated receptor ?/? in ultraviolet radiation-induced skin cancer. EMBO Mol Med. 2014;6:80-98 pubmed
Kim H, Abd Elmageed Z, Ju J, Naura A, Abdel Mageed A, Varughese S, et al. PDZK1 is a novel factor in breast cancer that is indirectly regulated by estrogen through IGF-1R and promotes estrogen-mediated growth. Mol Med. 2013;19:253-62 pubmed publisher
Huveldt D, Lewis Tuffin L, Carlson B, Schroeder M, Rodriguez F, Giannini C, et al. Targeting Src family kinases inhibits bevacizumab-induced glioma cell invasion. PLoS ONE. 2013;8:e56505 pubmed publisher
Stabile L, He G, Lui V, Thomas S, Henry C, Gubish C, et al. c-Src activation mediates erlotinib resistance in head and neck cancer by stimulating c-Met. Clin Cancer Res. 2013;19:380-92 pubmed publisher
Kajiya M, Ichimonji I, Min C, Zhu T, Jin J, Yu Q, et al. Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation. Mol Pharmacol. 2012;82:115-24 pubmed publisher
Ferlin A, Perilli L, Gianesello L, Taglialavoro G, Foresta C. Profiling insulin like factor 3 (INSL3) signaling in human osteoblasts. PLoS ONE. 2011;6:e29733 pubmed publisher
product information
SKU :
2123P
Product-Name :
Src (32G6) Rabbit mAb
Size :
40 ul
Price-(USD) :
123 USD
Species-x-Reactivity :
H, M, R, (C)
Applications :
Immunoprecipitation
Product-Category :
MAP Kinase Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
60
Host :
Rabbit
Target :
Src
Primary-Protein :
Src
Alt-Names :
ASV,Proto-oncogene c-Src,Proto-oncogene tyrosine-protein kinase Src,SRC,SRC1,c-SRC,p60-Src,pp60c-src,protooncogene SRC, Rous sarcoma,tyrosine kinase pp60c-src,tyrosine-protein kinase SRC-1,v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.