product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
GAPDH (14C10) Rabbit mAb
catalog :
2118
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
14C10
reactivity :
southern flounder, hamsters, human, mouse, rat, bovine, zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, western blot knockout validation
citations: 903
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:1500; loading ...; fig 2d
Wang X, Xie W, Yao Y, Zhu Y, Zhou J, Cui Y, et al. The heat shock protein family gene Hspa1l in male mice is dispensable for fertility. Peerj. 2020;8:e8702 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig 1a
  • immunohistochemistry - paraffin section; rat; 1:500; loading ...; fig 1c
Sohn J, Kwak H, Rhim J, Yeo E. AMP-activated protein kinase-dependent nuclear localization of glyceraldehyde 3-phosphate dehydrogenase in senescent human diploid fibroblasts. Aging (Albany NY). 2022;14:4-27 pubmed publisher
  • western blot; mouse; loading ...; fig s7d
Nickl B, Qadri F, Bader M. Anti-inflammatory role of Gpnmb in adipose tissue of mice. Sci Rep. 2021;11:19614 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 9a, 4a
Li K, Wu R, Zhou M, Tong H, Luo K. Desmosomal proteins of DSC2 and PKP1 promote cancer cells survival and metastasis by increasing cluster formation in circulatory system. Sci Adv. 2021;7:eabg7265 pubmed publisher
  • western blot; mouse; loading ...; fig 3f
Ren J, Xu Y, Lu X, Wang L, Ide S, Hall G, et al. Twist1 in podocytes ameliorates podocyte injury and proteinuria by limiting CCL2-dependent macrophage infiltration. JCI Insight. 2021;6: pubmed publisher
  • western blot; mouse; 1:10,000; fig 6c
Coudert L, Osseni A, Gangloff Y, Schaeffer L, Leblanc P. The ESCRT-0 subcomplex component Hrs/Hgs is a master regulator of myogenesis via modulation of signaling and degradation pathways. BMC Biol. 2021;19:153 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 1d
Chen F, Sheng L, Xu C, Li J, Ali I, Li H, et al. Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation. Front Cell Dev Biol. 2021;9:676789 pubmed publisher
  • western blot; mouse; loading ...; fig 1c
Errico A, Stocco A, Riccardi V, Gambalunga A, Bassetto F, Grigatti M, et al. Neurofibromin Deficiency and Extracellular Matrix Cooperate to Increase Transforming Potential through FAK-Dependent Signaling. Cancers (Basel). 2021;13: pubmed publisher
  • western blot; mouse; fig 1a
Lim Y, Kim S, Kim E. Palmitate reduces starvation-induced ER stress by inhibiting ER-phagy in hypothalamic cells. Mol Brain. 2021;14:65 pubmed publisher
  • western blot; human; loading ...; fig 3b
Liss F, Frech M, Wang Y, Giel G, Fischer S, Simon C, et al. IRF8 Is an AML-Specific Susceptibility Factor That Regulates Signaling Pathways and Proliferation of AML Cells. Cancers (Basel). 2021;13: pubmed publisher
  • western blot; human; loading ...; fig 2f
Liu Y, Li X, Zhang H, Zhang M, Wei Y. HuR up-regulates cell surface PD-L1 via stabilizing CMTM6 transcript in cancer. Oncogene. 2021;40:2230-2242 pubmed publisher
  • immunoprecipitation; mouse; loading ...; fig 6c
Yagi M, Toshima T, Amamoto R, Do Y, Hirai H, Setoyama D, et al. Mitochondrial translation deficiency impairs NAD+ -mediated lysosomal acidification. EMBO J. 2021;40:e105268 pubmed publisher
  • western blot; human; loading ...; fig 3b
Chen A, Santana A, Doudican N, Roudiani N, Laursen K, Therrien J, et al. MAGE-A3 is a prognostic biomarker for poor clinical outcome in cutaneous squamous cell carcinoma with perineural invasion via modulation of cell proliferation. PLoS ONE. 2020;15:e0241551 pubmed publisher
  • western blot; human; loading ...; fig 2d
Bao Y, Oguz G, Lee W, Lee P, Ghosh K, Li J, et al. EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy. Nat Commun. 2020;11:5878 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig s7-2a
Fomicheva M, Macara I. Genome-wide CRISPR screen identifies noncanonical NF-κB signaling as a regulator of density-dependent proliferation. elife. 2020;9: pubmed publisher
  • western blot; mouse; loading ...; fig 2a
Wang C, Chen C, Lin M, Su H, Ho M, Yeh J, et al. TLR9 Binding to Beclin 1 and Mitochondrial SIRT3 by a Sodium-Glucose Co-Transporter 2 Inhibitor Protects the Heart from Doxorubicin Toxicity. Biology (Basel). 2020;9: pubmed publisher
  • western blot; mouse; loading ...; fig 6
Kim Y, Oh S, Ahn J, Yook J, Kim C, Park S, et al. The Crucial Role of Xanthine Oxidase in CKD Progression Associated with Hypercholesterolemia. Int J Mol Sci. 2020;21: pubmed publisher
  • immunoprecipitation; mouse; 1:2000; loading ...; fig 2i
Yan J, Bengtson C, Buchthal B, Hagenston A, Bading H. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science. 2020;370: pubmed publisher
  • western blot; mouse; loading ...; fig s1b
Li N, Kang Y, Wang L, Huff S, Tang R, Hui H, et al. ALKBH5 regulates anti-PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment. Proc Natl Acad Sci U S A. 2020;117:20159-20170 pubmed publisher
  • immunocytochemistry; mouse; 1:2000; loading ...
Manzano Nieves G, Bravo M, Baskoylu S, Bath K. Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell development. elife. 2020;9: pubmed publisher
  • western blot; mouse; loading ...; fig s4c
Chu S, Chabon J, Matovina C, Minehart J, Chen B, Zhang J, et al. Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development. iScience. 2020;23:100941 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2b
Zhong X, Harris G, Smirnova L, Zufferey V, Sá R, Baldino Russo F, et al. Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model. Front Cell Neurosci. 2020;14:25 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 4a
Zhang M, Du W, Acklin S, Jin S, Xia F. SIRT2 protects peripheral neurons from cisplatin-induced injury by enhancing nucleotide excision repair. J Clin Invest. 2020;130:2953-2965 pubmed publisher
  • western blot; human; loading ...; fig 5a
Chen Y, Li Y, Chou C, Chiew M, Huang H, Ho J, et al. Control of matrix stiffness promotes endodermal lineage specification by regulating SMAD2/3 via lncRNA LINC00458. Sci Adv. 2020;6:eaay0264 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Rinastiti P, Ikeda K, Rahardini E, Miyagawa K, Tamada N, Kuribayashi Y, et al. Loss of family with sequence similarity 13, member A exacerbates pulmonary hypertension through accelerating endothelial-to-mesenchymal transition. PLoS ONE. 2020;15:e0226049 pubmed publisher
  • western blot; human; 1:10,000; loading ...; fig 6a
Ricker C, Berlow N, Crawford K, Georgopapadakos T, Huelskamp A, Woods A, et al. Undifferentiated small round cell sarcoma in a young male: a case report. Cold Spring Harb Mol Case Stud. 2020;6: pubmed publisher
  • western blot; human; 1:10,000; loading ...; fig 3e
Skoda J, Neradil J, Staniczkova Zambo I, Nunukova A, Macsek P, Borankova K, et al. Serial Xenotransplantation in NSG Mice Promotes a Hybrid Epithelial/Mesenchymal Gene Expression Signature and Stemness in Rhabdomyosarcoma Cells. Cancers (Basel). 2020;12: pubmed publisher
  • western blot; human; loading ...; fig 2c
Singh V, Khalil M, De Benedetti A. The TLK1/Nek1 axis contributes to mitochondrial integrity and apoptosis prevention via phosphorylation of VDAC1. Cell Cycle. 2020;19:363-375 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2b
Hiepen C, Jatzlau J, Hildebrandt S, Kampfrath B, Goktas M, Murgai A, et al. BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics. PLoS Biol. 2019;17:e3000557 pubmed publisher
  • western blot; mouse; 1:80,000; loading ...; fig 2c
Welk V, Meul T, Lukas C, Kammerl I, Mulay S, Schamberger A, et al. Proteasome activator PA200 regulates myofibroblast differentiation. Sci Rep. 2019;9:15224 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3b
Liu D, Wu L, Wu Y, Wei X, Wang W, Zhang S, et al. Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart. Aging (Albany NY). 2019;11:8982-8997 pubmed publisher
  • western blot; human; 1:5000; loading ...; fig 1b
Shemorry A, Harnoss J, Guttman O, Marsters S, Komuves L, Lawrence D, et al. Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress. elife. 2019;8: pubmed publisher
  • western blot; human; loading ...; fig 13b
V gtle T, Sharma S, Mori J, Nagy Z, Semeniak D, Scandola C, et al. Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B. elife. 2019;8: pubmed publisher
  • western blot; human; loading ...; fig 5g
Niu Q, Liu Z, Alamer E, Fan X, Chen H, Endsley J, et al. Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV. J Clin Invest. 2019;129:3361-3373 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 7s1
Moissoglu K, Yasuda K, Wang T, Chrisafis G, Mili S. Translational regulation of protrusion-localized RNAs involves silencing and clustering after transport. elife. 2019;8: pubmed publisher
  • western blot; mouse; loading ...; fig 3d
Liu F, Fan D, Yang Z, Tang N, Guo Z, Ma S, et al. TLR9 is essential for HMGB1-mediated post-myocardial infarction tissue repair through affecting apoptosis, cardiac healing, and angiogenesis. Cell Death Dis. 2019;10:480 pubmed publisher
  • western blot; bovine; loading ...; fig 1a
Iring A, Jin Y, Albarrán Juárez J, Siragusa M, Wang S, Dancs P, et al. Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure. J Clin Invest. 2019;129:2775-2791 pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 1e
James N, Beffa L, Oliver M, Borgstadt A, Emerson J, Chichester C, et al. Inhibition of DUSP6 sensitizes ovarian cancer cells to chemotherapeutic agents via regulation of ERK signaling response genes. Oncotarget. 2019;10:3315-3327 pubmed
  • western blot; human; loading ...; fig 4c
Wang R, Geng J, Sheng W, Liu X, Jiang M, Zhen Y. The ionophore antibiotic gramicidin A inhibits pancreatic cancer stem cells associated with CD47 down-regulation. Cancer Cell Int. 2019;19:145 pubmed publisher
  • western blot; human; 1:5000; loading ...; fig s1a
  • western blot; mouse; 1:5000; loading ...; fig s1a
Wienert B, Wyman S, Richardson C, Yeh C, Akçakaya P, Porritt M, et al. Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq. Science. 2019;364:286-289 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1a
Shen T, Li H, Song Y, Li L, Lin J, Wei G, et al. Alternative polyadenylation dependent function of splicing factor SRSF3 contributes to cellular senescence. Aging (Albany NY). 2019;11:1356-1388 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6d
Geng Y, Liu X, Liang J, Habiel D, Kulur V, Coelho A, et al. PD-L1 on invasive fibroblasts drives fibrosis in a humanized model of idiopathic pulmonary fibrosis. JCI Insight. 2019;4: pubmed publisher
  • western blot; human; 1:10,000; loading ...; fig 1g
Mao D, Lin G, Tepe B, Zuo Z, Tan K, Senturk M, et al. VAMP associated proteins are required for autophagic and lysosomal degradation by promoting a PtdIns4P-mediated endosomal pathway. Autophagy. 2019;15:1214-1233 pubmed publisher
  • western blot; human; loading ...; fig 1e
Chen H, Poran A, Unni A, Huang S, Elemento O, Snoeck H, et al. Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells. J Exp Med. 2019;216:674-687 pubmed publisher
  • western blot; mouse; loading ...; fig 6b
Huang X, Feng Z, Jiang Y, Li J, Xiang Q, Guo S, et al. VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages. Sci Adv. 2019;5:eaau7426 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3f
Keklikoglou I, Cianciaruso C, Güç E, Squadrito M, Spring L, Tazzyman S, et al. Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models. Nat Cell Biol. 2019;21:190-202 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 8e
Düsedau H, Kleveman J, Figueiredo C, Biswas A, Steffen J, Kliche S, et al. p75NTR regulates brain mononuclear cell function and neuronal structure in Toxoplasma infection-induced neuroinflammation. Glia. 2019;67:193-211 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4j
Wang J, Xu S, Duan J, Yi L, Guo Y, Shi Y, et al. Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1-SOX2 positive-feedback loop. Nat Neurosci. 2019;22:91-105 pubmed publisher
  • western blot; human; loading ...; fig 1c
Turowec J, Lau E, Wang X, Brown K, Fellouse F, Jawanda K, et al. Functional genomic characterization of a synthetic anti-HER3 antibody reveals a role for ubiquitination by RNF41 in the anti-proliferative response. J Biol Chem. 2019;294:1396-1409 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s3b
Wang F, Meng M, Mo B, Yang Y, Ji Y, Huang P, et al. Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function. Nat Commun. 2018;9:4874 pubmed publisher
  • western blot; human; loading ...; fig 2e
Sievers Q, Petzold G, Bunker R, Renneville A, Słabicki M, Liddicoat B, et al. Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN. Science. 2018;362: pubmed publisher
  • western blot; human; loading ...; fig 1b
Mena E, Kjolby R, Saxton R, Werner A, Lew B, Boyle J, et al. Dimerization quality control ensures neuronal development and survival. Science. 2018;362: pubmed publisher
  • western blot; human; 1:2000; loading ...; fig 3b
Persi E, Duran Frigola M, Damaghi M, Roush W, Aloy P, Cleveland J, et al. Systems analysis of intracellular pH vulnerabilities for cancer therapy. Nat Commun. 2018;9:2997 pubmed publisher
  • western blot; mouse; loading ...; fig s1d
Poffenberger M, Metcalfe Roach A, Aguilar E, Chen J, Hsu B, Wong A, et al. LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis. Science. 2018;361:406-411 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Shang X, Shen C, Liu J, Tang L, Zhang H, Wang Y, et al. Serine protease PRSS55 is crucial for male mouse fertility via affecting sperm migration and sperm-egg binding. Cell Mol Life Sci. 2018;75:4371-4384 pubmed publisher
  • western blot; human; 1:5000; loading ...; fig 1b
Voelkl J, Luong T, Tuffaha R, Musculus K, Auer T, Lian X, et al. SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling. J Clin Invest. 2018;128:3024-3040 pubmed publisher
  • western blot; human; loading ...; fig 1d
Wu Z, Zhao X, Banaszak L, Gutierrez Rodrigues F, Keyvanfar K, Gao S, et al. CRISPR/Cas9-mediated ASXL1 mutations in U937 cells disrupt myeloid differentiation. Int J Oncol. 2018;52:1209-1223 pubmed publisher
  • western blot; human; loading ...; fig 8b
Yin R, Guo L, Gu J, Li C, Zhang W. Over expressing miR-19b-1 suppress breast cancer growth by inhibiting tumor microenvironment induced angiogenesis. Int J Biochem Cell Biol. 2018;97:43-51 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 2d
Zhang R, Wu Y, Xie F, Zhong Y, Wang Y, Xu M, et al. RGMa mediates reactive astrogliosis and glial scar formation through TGF?1/Smad2/3 signaling after stroke. Cell Death Differ. 2018;25:1503-1516 pubmed publisher
  • immunocytochemistry; mouse; 1:400; loading ...; fig 5c
  • western blot; mouse; 1:1000; loading ...; fig 5b
Takanezawa Y, Nakamura R, Harada R, Sone Y, Uraguchi S, Kiyono M. Sequestosome1/p62 protects mouse embryonic fibroblasts against low-dose methylercury-induced cytotoxicity and is involved in clearance of ubiquitinated proteins. Sci Rep. 2017;7:16735 pubmed publisher
  • western blot; human; loading ...; fig 1a
Zhang F, Virshup D, Cheong J. Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis. Oncogene. 2018;37:363-376 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 12
Nagahara Y, Shimazawa M, Ohuchi K, Ito J, Takahashi H, Tsuruma K, et al. GPNMB ameliorates mutant TDP-43-induced motor neuron cell death. J Neurosci Res. 2017;95:1647-1665 pubmed publisher
  • western blot; mouse; fig 6
Hwang M, Go Y, Park J, Shin S, Song S, Oh B, et al. Epac2a-null mice exhibit obesity-prone nature more susceptible to leptin resistance. Int J Obes (Lond). 2017;41:279-288 pubmed publisher
  • western blot; human; 1:4000; fig s3
Tseng H, Vong C, Kwan Y, Lee S, Hoi M. TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells. Sci Rep. 2016;6:35016 pubmed publisher
  • western blot; human; 1:1000; fig 1
  • western blot; mouse; 1:1000; fig s1
Chen P, Qin L, Li G, Tellides G, Simons M. Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGF?)-dependent smooth muscle cell phenotype modulation. Sci Rep. 2016;6:33407 pubmed publisher
  • western blot; human; 1:5000; fig 5
Bourgonje A, Verrijp K, Schepens J, Navis A, Piepers J, Palmen C, et al. Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma. Acta Neuropathol Commun. 2016;4:96 pubmed publisher
  • western blot; human; 1:1000; fig s4
Coscia F, Watters K, Curtis M, Eckert M, Chiang C, Tyanova S, et al. Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status. Nat Commun. 2016;7:12645 pubmed publisher
  • western blot; human; fig 7
Ayres Pereira M, Mandel Clausen T, Pehrson C, Mao Y, Resende M, Daugaard M, et al. Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1. PLoS Pathog. 2016;12:e1005831 pubmed publisher
  • western blot; human; 1:1000; fig s3
Wilkie A, Lawler J, Coen D. A Role for Nuclear F-Actin Induction in Human Cytomegalovirus Nuclear Egress. MBio. 2016;7: pubmed publisher
  • western blot; human; 1:1000; fig s3
  • western blot; mouse; 1:1000; fig s3
Durand S, Franks T, Lykke Andersen J. Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay. Nat Commun. 2016;7:12434 pubmed publisher
  • western blot; human; 1:2500; fig 2B
Kang M, Park K, Yang J, Lee C, Oh S, Yun J, et al. miR-6734 Up-Regulates p21 Gene Expression and Induces Cell Cycle Arrest and Apoptosis in Colon Cancer Cells. PLoS ONE. 2016;11:e0160961 pubmed publisher
  • western blot; mouse; 1:2000; fig 5
Inoue Y, Inoue T. Brain enhancer activities at the gene-poor 5p14.1 autism-associated locus. Sci Rep. 2016;6:31227 pubmed publisher
  • western blot; human; 1:3000; fig 1
Deskin B, Lasky J, Zhuang Y, Shan B. Requirement of HDAC6 for activation of Notch1 by TGF-?1. Sci Rep. 2016;6:31086 pubmed publisher
  • western blot; human; 1:10,000; fig 1
Kweon H, Kim D, Bae Y, Park J, Suh B. Acid-Sensing Ion Channel 2a (ASIC2a) Promotes Surface Trafficking of ASIC2b via Heteromeric Assembly. Sci Rep. 2016;6:30684 pubmed publisher
  • western blot; human; fig 2
Wang C, Ma Y, Hu Q, Xie T, Wu J, Zeng F, et al. Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors. BMC Cancer. 2016;16:545 pubmed publisher
  • western blot; human; 1:1000; fig 3
Liu M, Feng L, Sun P, Liu W, Wu W, Jiang B, et al. A Novel Bufalin Derivative Exhibited Stronger Apoptosis-Inducing Effect than Bufalin in A549 Lung Cancer Cells and Lower Acute Toxicity in Mice. PLoS ONE. 2016;11:e0159789 pubmed publisher
  • western blot; human; fig 6
Nelson D, Jaber Hijazi F, Cole J, Robertson N, Pawlikowski J, Norris K, et al. Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability. Genome Biol. 2016;17:158 pubmed publisher
  • western blot; human; 1:1000; fig 3
Meitinger F, Anzola J, Kaulich M, Richardson A, Stender J, Benner C, et al. 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. J Cell Biol. 2016;214:155-66 pubmed publisher
  • western blot; zebrafish ; 1:1000; fig s9
  • western blot; rat; 1:1000; fig s18
Wang M, Sips P, Khin E, Rotival M, Sun X, Ahmed R, et al. Wars2 is a determinant of angiogenesis. Nat Commun. 2016;7:12061 pubmed publisher
  • western blot; rat; 1:2000; fig 2
Bai H, Wang M, Foster T, Hu H, He H, Hashimoto T, et al. Pericardial patch venoplasty heals via attraction of venous progenitor cells. Physiol Rep. 2016;4: pubmed publisher
  • western blot; mouse
Shinohara S, Gu Y, Yang Y, Furuta Y, Tanaka M, Yue X, et al. Ethanol extracts of chickpeas alter the total lipid content and expression levels of genes related to fatty acid metabolism in mouse 3T3-L1 adipocytes. Int J Mol Med. 2016;38:574-84 pubmed publisher
  • western blot; human; fig 3
Dejesus R, Moretti F, McAllister G, Wang Z, Bergman P, Liu S, et al. Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62. elife. 2016;5: pubmed publisher
  • western blot; human; 1:5000; fig 3B
Lin X, Yang Z, Zhang P, Liu Y, Shao G. miR-154 inhibits migration and invasion of human non-small cell lung cancer by targeting ZEB2. Oncol Lett. 2016;12:301-306 pubmed
  • western blot; human; fig 2
Kim D, Pauer S, Yong H, An S, Liggett S. ?2-Adrenergic Receptors Chaperone Trapped Bitter Taste Receptor 14 to the Cell Surface as a Heterodimer and Exert Unidirectional Desensitization of Taste Receptor Function. J Biol Chem. 2016;291:17616-28 pubmed publisher
  • western blot; human; 1:5000; fig 1
Meinhardt G, Saleh L, Otti G, Haider S, Velicky P, Fiala C, et al. Wingless ligand 5a is a critical regulator of placental growth and survival. Sci Rep. 2016;6:28127 pubmed publisher
  • western blot; human; fig 4g
Guo Y, Wang L, Li B, Xu H, Yang J, Zheng L, et al. Wnt/?-catenin pathway transactivates microRNA-150 that promotes EMT of colorectal cancer cells by suppressing CREB signaling. Oncotarget. 2016;7:42513-42526 pubmed publisher
  • western blot; rat; 1:1000; fig 1
Nagai Okatani C, Minamino N. Aberrant Glycosylation in the Left Ventricle and Plasma of Rats with Cardiac Hypertrophy and Heart Failure. PLoS ONE. 2016;11:e0150210 pubmed publisher
  • western blot; mouse; fig 6
Tejada T, Tan L, Torres R, Calvert J, Lambert J, Zaidi M, et al. IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction. Proc Natl Acad Sci U S A. 2016;113:6949-54 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Zhang H, Kang E, Wang Y, Yang C, Yu H, Wang Q, et al. Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice. Nat Commun. 2016;7: pubmed publisher
  • western blot; mouse; fig 2
Yu H. Sphingosine-1-Phosphate Receptor 2 Regulates Proinflammatory Cytokine Production and Osteoclastogenesis. PLoS ONE. 2016;11:e0156303 pubmed publisher
  • western blot; mouse; 1:2000; fig 1
Miao H, Ou J, Peng Y, Zhang X, Chen Y, Hao L, et al. Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM. Nat Commun. 2016;7:11716 pubmed publisher
  • western blot; human; 1:1000; fig 1
Chen P, Qin L, Li G, Tellides G, Simons M. Smooth muscle FGF/TGFβ cross talk regulates atherosclerosis progression. EMBO Mol Med. 2016;8:712-28 pubmed publisher
  • western blot; human; 1:2000; fig 1
Ribeiro J, Schorl C, Yano N, Romano N, Kim K, Singh R, et al. HE4 promotes collateral resistance to cisplatin and paclitaxel in ovarian cancer cells. J Ovarian Res. 2016;9:28 pubmed publisher
  • western blot; human; fig 2
Lock R, Ingraham R, Maertens O, Miller A, Weledji N, Legius E, et al. Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers. J Clin Invest. 2016;126:2181-90 pubmed publisher
  • western blot; mouse; fig 1
Nakagawa A, Naito A, Sumida T, Nomura S, Shibamoto M, Higo T, et al. Activation of endothelial β-catenin signaling induces heart failure. Sci Rep. 2016;6:25009 pubmed publisher
  • western blot; human; fig 4
Emmerich C, Bakshi S, Kelsall I, Ortiz Guerrero J, Shpiro N, Cohen P. Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling. Biochem Biophys Res Commun. 2016;474:452-461 pubmed publisher
  • western blot; human; 1:5000; fig 8
Bronnimann M, Calton C, Chiquette S, Li S, Lu M, Chapman J, et al. Furin Cleavage of L2 during Papillomavirus Infection: Minimal Dependence on Cyclophilins. J Virol. 2016;90:6224-6234 pubmed publisher
  • western blot; mouse; fig 4
Ramanathan A, Gusarova V, Stahl N, Gurnett Bander A, Kyratsous C. Alirocumab, a Therapeutic Human Antibody to PCSK9, Does Not Affect CD81 Levels or Hepatitis C Virus Entry and Replication into Hepatocytes. PLoS ONE. 2016;11:e0154498 pubmed publisher
  • western blot; human; fig 5
Xue Y, Qian H, Hu J, Zhou B, Zhou Y, Hu X, et al. Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells. Nat Neurosci. 2016;19:807-15 pubmed publisher
  • western blot; human; 1:1000; fig 2
Lu X, Parvathaneni S, Li X, Lal A, Sharma S. Transcriptome guided identification of novel functions of RECQ1 helicase. Methods. 2016;108:111-7 pubmed publisher
  • western blot; mouse; fig 2
Kim B, Silverman S, Liu Y, Wordinger R, Pang I, Clark A. In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells. Mol Neurodegener. 2016;11:30 pubmed publisher
  • western blot; mouse; 1:5000; fig s4
Laklai H, Miroshnikova Y, Pickup M, Collisson E, Kim G, Barrett A, et al. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2016;22:497-505 pubmed publisher
  • western blot; mouse; 1:5000; fig 1
  • western blot; human; 1:5000; fig 3
Almad A, Doreswamy A, Gross S, Richard J, Huo Y, Haughey N, et al. Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis. Glia. 2016;64:1154-69 pubmed publisher
  • western blot; mouse; 1:1000; fig 7
Waisbourd Zinman O, Koh H, Tsai S, Lavrut P, Dang C, Zhao X, et al. The toxin biliatresone causes mouse extrahepatic cholangiocyte damage and fibrosis through decreased glutathione and SOX17. Hepatology. 2016;64:880-93 pubmed publisher
  • western blot; human; 1:1000; fig 2
Wei T, Zhang H, Cetin N, Miller E, Moak T, Suen J, et al. Elevated Expression of Matrix Metalloproteinase-9 not Matrix Metalloproteinase-2 Contributes to Progression of Extracranial Arteriovenous Malformation. Sci Rep. 2016;6:24378 pubmed publisher
  • western blot; mouse; 1:2000; fig 3a
Shi C, Iura A, Terajima M, Liu F, Lyons K, Pan H, et al. Deletion of BMP receptor type IB decreased bone mass in association with compromised osteoblastic differentiation of bone marrow mesenchymal progenitors. Sci Rep. 2016;6:24256 pubmed publisher
  • western blot; mouse; loading ...; fig s2a
Seneviratne U, Nott A, Bhat V, Ravindra K, Wishnok J, Tsai L, et al. S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration. Proc Natl Acad Sci U S A. 2016;113:4152-7 pubmed publisher
  • western blot; mouse; 1:5000; fig 1
Zhou Z, Tang A, Wong W, Bamezai S, Goddard L, Shenkar R, et al. Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling. Nature. 2016;532:122-6 pubmed publisher
  • western blot; rat; 1:1000; fig 7B
Domínguez Calderón A, Ávila Flores A, Ponce A, López Bayghen E, Calderón Salinas J, Luis Reyes J, et al. ZO-2 silencing induces renal hypertrophy through a cell cycle mechanism and the activation of YAP and the mTOR pathway. Mol Biol Cell. 2016;27:1581-95 pubmed publisher
  • western blot; mouse; fig 7
Yang Y, Xu J, Chen H, Fei X, Tang Y, Yan Y, et al. MiR-128-2 inhibits common lymphoid progenitors from developing into progenitor B cells. Oncotarget. 2016;7:17520-31 pubmed publisher
  • western blot; human; fig 1
Bretin A, Carrière J, Dalmasso G, Bergougnoux A, B chir W, Maurin A, et al. Activation of the EIF2AK4-EIF2A/eIF2?-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasive Escherichia coli infection. Autophagy. 2016;12:770-83 pubmed publisher
  • western blot; mouse; 1:5000; fig 2b
Bowman T, O Keeffe K, D Aquila T, Yan Q, Griffin J, Killion E, et al. Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption. Mol Metab. 2016;5:210-220 pubmed publisher
  • western blot; mouse; 1:1000; fig 4
Zhao Y, Xu L, Qiao Z, Gao L, Ding S, Ying X, et al. YiXin-Shu, a ShengMai-San-based traditional Chinese medicine formula, attenuates myocardial ischemia/reperfusion injury by suppressing mitochondrial mediated apoptosis and upregulating liver-X-receptor α. Sci Rep. 2016;6:23025 pubmed publisher
  • western blot; human; 1:2000; fig 4
Zhang S, Liu B, Fan Z, Wang D, Liu Y, Li J, et al. Targeted inhibition of survivin with YM155 promotes apoptosis of hypoxic human pulmonary arterial smooth muscle cells via the upregulation of voltage-dependent K⁺ channels. Mol Med Rep. 2016;13:3415-22 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Klepac K, Kilić A, Gnad T, Brown L, Herrmann B, Wilderman A, et al. The Gq signalling pathway inhibits brown and beige adipose tissue. Nat Commun. 2016;7:10895 pubmed publisher
  • western blot; human; fig s1a
Shukla S, Schmidt J, Goldfarb K, Cech T, Parker R. Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects. Nat Struct Mol Biol. 2016;23:286-92 pubmed publisher
  • western blot; mouse; fig 1
Shin J, Nunomiya A, Kitajima Y, Dan T, Miyata T, Nagatomi R. Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway. Skelet Muscle. 2016;6:5 pubmed publisher
  • western blot; human; fig s5
Remenyi J, Bajan S, Fuller Pace F, Arthur J, Hutvagner G. The loop structure and the RNA helicase p72/DDX17 influence the processing efficiency of the mice miR-132. Sci Rep. 2016;6:22848 pubmed publisher
  • western blot; mouse; 1:8000; fig 7
Sugar T, Wassenhove McCarthy D, Orr A, Green J, van Kuppevelt T, McCarthy K. N-sulfation of heparan sulfate is critical for syndecan-4-mediated podocyte cell-matrix interactions. Am J Physiol Renal Physiol. 2016;310:F1123-35 pubmed publisher
  • western blot; mouse; 1:5000; tbl 1
Guillot F, Kemppainen S, Lavasseur G, Miettinen P, Laroche S, Tanila H, et al. Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2016;51:1157-73 pubmed publisher
  • western blot; human; 1:3000; fig 1
Krisko J, Begum N, Baker C, Foster J, Garcia J. APOBEC3G and APOBEC3F Act in Concert To Extinguish HIV-1 Replication. J Virol. 2016;90:4681-4695 pubmed publisher
  • western blot; mouse; 1:2000; fig 3
  • western blot; human; 1:2000; fig 3
Keuss M, Thomas Y, Mcarthur R, Wood N, Knebel A, Kurz T. Characterization of the mammalian family of DCN-type NEDD8 E3 ligases. J Cell Sci. 2016;129:1441-54 pubmed publisher
  • western blot; hamsters; 1:1000; fig 1
Prabhu A, Luu W, Sharpe L, Brown A. Cholesterol-mediated Degradation of 7-Dehydrocholesterol Reductase Switches the Balance from Cholesterol to Vitamin D Synthesis. J Biol Chem. 2016;291:8363-73 pubmed publisher
  • western blot; human; fig 1
Morales Hernández A, González Rico F, Román A, Rico Leo E, Alvarez Barrientos A, Sánchez L, et al. Alu retrotransposons promote differentiation of human carcinoma cells through the aryl hydrocarbon receptor. Nucleic Acids Res. 2016;44:4665-83 pubmed publisher
  • western blot; mouse; 1:1000; fig 6
  • western blot; human; 1:1000; fig 1
Wang P, Zhang X, Luo P, Jiang X, Zhang P, Guo J, et al. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun. 2016;7:10592 pubmed publisher
  • western blot; human; 1:2000; fig 5
Passerini V, Ozeri Galai E, de Pagter M, Donnelly N, Schmalbrock S, Kloosterman W, et al. The presence of extra chromosomes leads to genomic instability. Nat Commun. 2016;7:10754 pubmed publisher
  • western blot; mouse; 1:2000; fig 4f
Nakazawa M, Eisinger Mathason T, Sadri N, Ochocki J, Gade T, Amin R, et al. Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth. Nat Commun. 2016;7:10539 pubmed publisher
  • western blot; human; fig 2
Kourtidis A, Anastasiadis P. PLEKHA7 defines an apical junctional complex with cytoskeletal associations and miRNA-mediated growth implications. Cell Cycle. 2016;15:498-505 pubmed publisher
  • western blot; human; 1:1000; fig 6
Crawley S, Weck M, Grega Larson N, Shifrin D, Tyska M. ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation. Dev Cell. 2016;36:190-200 pubmed publisher
  • western blot; mouse; fig 5
Chung S, Moon H, Ju H, Kim D, Cho K, Ribback S, et al. Comparison of liver oncogenic potential among human RAS isoforms. Oncotarget. 2016;7:7354-66 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Liu D, Liu X, Wu Y, Wang W, Ma X, Liu H. Cloning and Transcriptional Activity of the Mouse Omi/HtrA2 Gene Promoter. Int J Mol Sci. 2016;17: pubmed publisher
  • western blot; mouse; fig 4
Jacobsen A, Lowes K, Tanzer M, Lucet I, Hildebrand J, Petrie E, et al. HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death. Cell Death Dis. 2016;7:e2051 pubmed publisher
  • western blot; mouse; fig 3
Cherepkova M, Sineva G, Pospelov V. Leukemia inhibitory factor (LIF) withdrawal activates mTOR signaling pathway in mouse embryonic stem cells through the MEK/ERK/TSC2 pathway. Cell Death Dis. 2016;7:e2050 pubmed publisher
  • western blot; human; fig 1
Terranova Barberio M, Roca M, Zotti A, Leone A, Bruzzese F, Vitagliano C, et al. Valproic acid potentiates the anticancer activity of capecitabine in vitro and in vivo in breast cancer models via induction of thymidine phosphorylase expression. Oncotarget. 2016;7:7715-31 pubmed publisher
  • western blot; rat; 1:2000; fig 3
Zhang T, Zhang Y, Cui M, Jin L, Wang Y, Lv F, et al. CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis. Nat Med. 2016;22:175-82 pubmed publisher
  • western blot; mouse; fig 5
Ge W, Yuan M, Ceylan A, Wang X, Ren J. Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism. Biochim Biophys Acta. 2016;1862:622-634 pubmed publisher
  • western blot; human; 1:1000; fig 3e
O Connor A, Maffini S, Rainey M, Kaczmarczyk A, Gaboriau D, Musacchio A, et al. Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint. Biol Open. 2015;5:11-9 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Zhang Y, Fan J, Ho J, Hu T, Kneeland S, Fan X, et al. Crim1 regulates integrin signaling in murine lens development. Development. 2016;143:356-66 pubmed publisher
  • western blot; human; fig 2c
Choe C, Shin Y, Kim C, Choi S, Lee J, Kim S, et al. Crosstalk with cancer-associated fibroblasts induces resistance of non-small cell lung cancer cells to epidermal growth factor receptor tyrosine kinase inhibition. Onco Targets Ther. 2015;8:3665-78 pubmed publisher
  • western blot; human; 1:5000; fig 2
Qian J, Beullens M, Huang J, De Munter S, Lesage B, Bollen M. Cdk1 orders mitotic events through coordination of a chromosome-associated phosphatase switch. Nat Commun. 2015;6:10215 pubmed publisher
  • western blot; mouse; 1:2000; fig 1
Ogura Y, Hindi S, Sato S, Xiong G, Akira S, Kumar A. TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair. Nat Commun. 2015;6:10123 pubmed publisher
  • western blot; human; loading ...; fig 10e
Bowser J, Blackburn M, Shipley G, Molina J, Dunner K, Broaddus R. Loss of CD73-mediated actin polymerization promotes endometrial tumor progression. J Clin Invest. 2016;126:220-38 pubmed publisher
  • western blot; mouse; 1:5000; fig 1d
Yan Y, Ollila S, Wong I, Vallenius T, Palvimo J, Vaahtomeri K, et al. SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signalling. Nat Commun. 2015;6:8979 pubmed publisher
  • western blot; human; fig 2
de Jong O, van Balkom B, Gremmels H, Verhaar M. Exosomes from hypoxic endothelial cells have increased collagen crosslinking activity through up-regulation of lysyl oxidase-like 2. J Cell Mol Med. 2016;20:342-50 pubmed publisher
  • western blot; human; 1:2000; fig 9
E L, Swerdlow R. Lactate's effect on human neuroblastoma cell bioenergetic fluxes. Biochem Pharmacol. 2016;99:88-100 pubmed publisher
  • western blot; mouse; fig 4
  • western blot; human; fig 1
Ponti D, Bastianelli D, Rosa P, Pacini L, Ibrahim M, Rendina E, et al. The expression of B23 and EGR1 proteins is functionally linked in tumor cells under stress conditions. BMC Cell Biol. 2015;16:27 pubmed publisher
  • western blot; rat; 1:3000; fig 2
  • western blot; mouse; 1:3000; fig 4
Lesmana R, Sinha R, Singh B, Zhou J, Ohba K, Wu Y, et al. Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle. Endocrinology. 2016;157:23-38 pubmed publisher
  • western blot; human; 1:1000; fig 2
Rabinovich S, Adler L, Yizhak K, Sarver A, Silberman A, Agron S, et al. Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis. Nature. 2015;527:379-383 pubmed publisher
  • western blot; human; fig 1
Cerqueira C, Pang Y, Day P, Thompson C, Buck C, Lowy D, et al. A Cell-Free Assembly System for Generating Infectious Human Papillomavirus 16 Capsids Implicates a Size Discrimination Mechanism for Preferential Viral Genome Packaging. J Virol. 2016;90:1096-107 pubmed publisher
  • western blot; human; 1:100; fig s7
Hoshino A, Costa Silva B, Shen T, Rodrigues G, Hashimoto A, Tesic Mark M, et al. Tumour exosome integrins determine organotropic metastasis. Nature. 2015;527:329-35 pubmed publisher
  • immunocytochemistry; human
  • western blot; human; fig s4
Choi J, Lee S, Mallard W, Clement K, Tagliazucchi G, Lim H, et al. A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs. Nat Biotechnol. 2015;33:1173-81 pubmed publisher
  • western blot; human; fig 3
Tonsing Carter E, Bailey B, Saadatzadeh M, Ding J, Wang H, Sinn A, et al. Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model. Mol Cancer Ther. 2015;14:2850-63 pubmed publisher
  • western blot; human; fig 4b
Seashore Ludlow B, Rees M, Cheah J, Cokol M, Price E, Coletti M, et al. Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset. Cancer Discov. 2015;5:1210-23 pubmed publisher
  • western blot; mouse; 1:5000; fig 3
Sochalska M, Ottina E, Tuzlak S, Herzog S, Herold M, Villunger A. Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival. Cell Death Differ. 2016;23:628-39 pubmed publisher
  • western blot; mouse; fig 7
  • western blot; rat; fig 3
  • western blot; human; fig 3
Yu D, Makkar G, Strickland D, Blanpied T, Stumpo D, Blackshear P, et al. Myristoylated Alanine-Rich Protein Kinase Substrate (MARCKS) Regulates Small GTPase Rac1 and Cdc42 Activity and Is a Critical Mediator of Vascular Smooth Muscle Cell Migration in Intimal Hyperplasia Formation. J Am Heart Assoc. 2015;4:e002255 pubmed publisher
  • western blot; mouse; fig 5b
Norlin S, Parekh V, Naredi P, Edlund H. Asna1/TRC40 Controls β-Cell Function and Endoplasmic Reticulum Homeostasis by Ensuring Retrograde Transport. Diabetes. 2016;65:110-9 pubmed publisher
  • western blot; human; fig s6
Zetsche B, Gootenberg J, Abudayyeh O, Slaymaker I, Makarova K, Essletzbichler P, et al. Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system. Cell. 2015;163:759-71 pubmed publisher
  • western blot; human; 1:3000; fig 7
Leve F, Peres Moreira R, Binato R, Abdelhay E, Morgado Díaz J. LPA Induces Colon Cancer Cell Proliferation through a Cooperation between the ROCK and STAT-3 Pathways. PLoS ONE. 2015;10:e0139094 pubmed publisher
  • western blot; mouse; 1:5000; fig s2
Marchi S, Corricelli M, Trapani E, Bravi L, Pittaro A, Delle Monache S, et al. Defective autophagy is a key feature of cerebral cavernous malformations. EMBO Mol Med. 2015;7:1403-17 pubmed publisher
  • western blot; mouse; 1:1000; fig 1
Geng J, Sun X, Wang P, Zhang S, Wang X, Wu H, et al. Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. Nat Immunol. 2015;16:1142-52 pubmed publisher
  • western blot; human; fig s5
Moody P, Sayers E, Magnusson J, Alexander C, Borri P, Watson P, et al. Receptor Crosslinking: A General Method to Trigger Internalization and Lysosomal Targeting of Therapeutic Receptor:Ligand Complexes. Mol Ther. 2015;23:1888-98 pubmed publisher
  • western blot; mouse; 1:5000; fig 1f
Hainer S, Fazzio T. Regulation of Nucleosome Architecture and Factor Binding Revealed by Nuclease Footprinting of the ESC Genome. Cell Rep. 2015;13:61-69 pubmed publisher
  • western blot; rat; 1:2000; fig s2
Radhika N, Govindaraj V, Sarangi S, Rao A. Neonatal exposure to 17β-estradiol down-regulates the expression of synaptogenesis related genes in selected brain regions of adult female rats. Life Sci. 2015;141:1-7 pubmed publisher
  • western blot; human; 1:10,000; fig 3
Werner A, Iwasaki S, McGourty C, Medina Ruiz S, Teerikorpi N, Fedrigo I, et al. Cell-fate determination by ubiquitin-dependent regulation of translation. Nature. 2015;525:523-7 pubmed publisher
  • western blot; human; 1:1000; fig 2b
Vandersmissen I, Craps S, Depypere M, Coppiello G, van Gastel N, Maes F, et al. Endothelial Msx1 transduces hemodynamic changes into an arteriogenic remodeling response. J Cell Biol. 2015;210:1239-56 pubmed publisher
  • western blot; human; fig 7a
Yokdang N, Hatakeyama J, Wald J, Simion C, Tellez J, Chang D, et al. LRIG1 opposes epithelial-to-mesenchymal transition and inhibits invasion of basal-like breast cancer cells. Oncogene. 2016;35:2932-47 pubmed publisher
  • western blot; mouse; 1:5000; fig s3
Liu R, Yang Y, Shen J, Chen H, Zhang Q, Ba R, et al. Fstl1 is involved in the regulation of radial glial scaffold development. Mol Brain. 2015;8:53 pubmed publisher
  • western blot; human
Qiao Y, Lin S, Chen Y, Voon D, Zhu F, Chuang L, et al. RUNX3 is a novel negative regulator of oncogenic TEAD-YAP complex in gastric cancer. Oncogene. 2016;35:2664-74 pubmed publisher
  • western blot; human; 1:1000; fig 9
Okolicsanyi R, Camilleri E, Oikari L, Yu C, Cool S, Van Wijnen A, et al. Human Mesenchymal Stem Cells Retain Multilineage Differentiation Capacity Including Neural Marker Expression after Extended In Vitro Expansion. PLoS ONE. 2015;10:e0137255 pubmed publisher
  • western blot; human
Black J, Lopez S, Cocco E, Bellone S, Altwerger G, Schwab C, et al. PIK3CA oncogenic mutations represent a major mechanism of resistance to trastuzumab in HER2/neu overexpressing uterine serous carcinomas. Br J Cancer. 2015;113:1020-6 pubmed publisher
  • western blot; rat; 1:1000; fig 3
Nishimoto S, Tanaka H, Okamoto M, Okada K, Murase T, Yoshikawa H. Methylcobalamin promotes the differentiation of Schwann cells and remyelination in lysophosphatidylcholine-induced demyelination of the rat sciatic nerve. Front Cell Neurosci. 2015;9:298 pubmed publisher
  • western blot; mouse; fig 1
  • western blot; human; fig 2
Lee S, Litan A, Li Z, Graves B, Lindsey S, Barwe S, et al. Na,K-ATPase β1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity. Mol Cancer. 2015;14:159 pubmed publisher
  • western blot; mouse; fig s3
Hartlerode A, Morgan M, Wu Y, Buis J, Ferguson D. Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors. Nat Struct Mol Biol. 2015;22:736-43 pubmed publisher
  • western blot; human
Sivaraj K, Li R, Albarrán Juárez J, Wang S, Tischner D, Grimm M, et al. Endothelial Gαq/11 is required for VEGF-induced vascular permeability and angiogenesis. Cardiovasc Res. 2015;108:171-80 pubmed publisher
  • western blot; mouse; 1:2000
Sun D, Buttitta L. Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila. Development. 2015;142:3033-45 pubmed publisher
  • western blot; mouse
Chi W, Chen H, Li F, Zhu Y, Yin W, Zhuo Y. HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma. J Neuroinflammation. 2015;12:137 pubmed publisher
  • western blot; mouse; 1:1000; fig 3d
Papke C, Tsunezumi J, Ringuette L, Nagaoka H, Terajima M, Yamashiro Y, et al. Loss of fibulin-4 disrupts collagen synthesis and maturation: implications for pathology resulting from EFEMP2 mutations. Hum Mol Genet. 2015;24:5867-79 pubmed publisher
  • western blot; mouse; 1:2000
Chugh D, Ali I, Bakochi A, Bahonjic E, Etholm L, Ekdahl C. Alterations in Brain Inflammation, Synaptic Proteins, and Adult Hippocampal Neurogenesis during Epileptogenesis in Mice Lacking Synapsin2. PLoS ONE. 2015;10:e0132366 pubmed publisher
  • western blot; hamsters; fig 1
  • western blot; rat; fig 6
Yang Z, Zhang Q, Lu Q, Jia Z, Chen P, Ma K, et al. ISL-1 promotes pancreatic islet cell proliferation by forming an ISL-1/Set7/9/PDX-1 complex. Cell Cycle. 2015;14:3820-9 pubmed publisher
  • western blot; rat; 1:50,000
Hryhorczuk C, Florea M, Rodaros D, Poirier I, Daneault C, Des Rosiers C, et al. Dampened Mesolimbic Dopamine Function and Signaling by Saturated but not Monounsaturated Dietary Lipids. Neuropsychopharmacology. 2016;41:811-21 pubmed publisher
  • western blot; human; fig 4,5,6
Wu Y, Chen H, Lu J, Zhang M, Zhang R, Duan T, et al. Acetylation-dependent function of human single-stranded DNA binding protein 1. Nucleic Acids Res. 2015;43:7878-87 pubmed publisher
  • western blot; human; fig 1
Patergnani S, Giorgi C, Maniero S, Missiroli S, Maniscalco P, Bononi I, et al. The endoplasmic reticulum mitochondrial calcium cross talk is downregulated in malignant pleural mesothelioma cells and plays a critical role in apoptosis inhibition. Oncotarget. 2015;6:23427-44 pubmed
  • western blot; human; fig 3
  • western blot; mouse; fig 1
Jung E, Sim Y, Jeong H, Kim S, Yun Y, Song J, et al. Jmjd2C increases MyoD transcriptional activity through inhibiting G9a-dependent MyoD degradation. Biochim Biophys Acta. 2015;1849:1081-94 pubmed publisher
  • western blot; human; fig 1
Seo G, Ho M, Bui N, Kim Y, Koh D, Lim Y, et al. Novel naphthochalcone derivative accelerate dermal wound healing through induction of epithelial-mesenchymal transition of keratinocyte. J Biomed Sci. 2015;22:47 pubmed publisher
  • western blot; mouse; fig 2.b
Schachtrup C, Ryu J, Mammadzada K, Khan A, Carlton P, Perez A, et al. Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions. Nat Neurosci. 2015;18:1077-80 pubmed publisher
  • western blot; human; fig 1
Hensel J, Duex J, Owens C, Dancik G, Edwards M, Frierson H, et al. Patient Mutation Directed shRNA Screen Uncovers Novel Bladder Tumor Growth Suppressors. Mol Cancer Res. 2015;13:1306-15 pubmed publisher
  • western blot; human; 1:1000; fig s6
Taylor S, Dantas T, Durán I, Wu S, Lachman R, Nelson S, et al. Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome. Nat Commun. 2015;6:7092 pubmed publisher
  • western blot; mouse; 1:5000; fig 5
Shi S, Lu S, Sivasubramaniyam T, Revelo X, Cai E, Luk C, et al. DJ-1 links muscle ROS production with metabolic reprogramming and systemic energy homeostasis in mice. Nat Commun. 2015;6:7415 pubmed publisher
  • western blot; human; fig 1
Bock F, Tanzer M, Haschka M, Krumschnabel G, Sohm B, Goetsch K, et al. The p53 binding protein PDCD5 is not rate-limiting in DNA damage induced cell death. Sci Rep. 2015;5:11268 pubmed publisher
  • western blot; human; fig 3
Unni A, Lockwood W, Zejnullahu K, Lee Lin S, Varmus H. Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma. elife. 2015;4:e06907 pubmed publisher
  • western blot; human; fig s1b
Belian E, Noseda M, Abreu Paiva M, Leja T, Sampson R, Schneider M. Forward Programming of Cardiac Stem Cells by Homogeneous Transduction with MYOCD plus TBX5. PLoS ONE. 2015;10:e0125384 pubmed publisher
  • western blot; mouse; 1:20,000; fig 1
Regha K, Assi S, Tsoulaki O, Gilmour J, Lacaud G, Bonifer C. Developmental-stage-dependent transcriptional response to leukaemic oncogene expression. Nat Commun. 2015;6:7203 pubmed publisher
  • western blot; human; fig s7
Dorr C, Janik C, Weg M, Been R, Bader J, Kang R, et al. Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor. Mol Cancer Res. 2015;13:1238-47 pubmed publisher
  • western blot; mouse; 1:2000; fig 5
Iglesias Bartolomé R, Torres D, Marone R, Feng X, Martin D, Simaan M, et al. Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nat Cell Biol. 2015;17:793-803 pubmed publisher
  • western blot; human; 1:1000; fig s7
Shao H, Chung J, Lee K, Balaj L, Min C, Carter B, et al. Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma. Nat Commun. 2015;6:6999 pubmed publisher
  • western blot; mouse; 1:1000; fig 6a
Qi S, Wang Z, Huang L, Liang L, Xian Y, Ouyang Y, et al. Casein kinase 1 (α, δ and ε) localize at the spindle poles, but may not be essential for mammalian oocyte meiotic progression. Cell Cycle. 2015;14:1675-85 pubmed publisher
  • western blot; human; 1:1000; fig 8
Park J, Zhao L, Willingham M, Cheng S. Oncogenic mutations of thyroid hormone receptor β. Oncotarget. 2015;6:8115-31 pubmed
  • western blot; human; 1:5000; fig 2
Haschka M, Soratroi C, Kirschnek S, Hacker G, Hilbe R, Geley S, et al. The NOXA-MCL1-BIM axis defines lifespan on extended mitotic arrest. Nat Commun. 2015;6:6891 pubmed publisher
  • western blot; human; fig 1
Rojas Fernandez A, Herhaus L, MacArtney T, Lachaud C, Hay R, Sapkota G. Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9. Sci Rep. 2015;5:9811 pubmed publisher
  • western blot; mouse; fig 2
Shikama Y, Kudo Y, Ishimaru N, Funaki M. Possible Involvement of Palmitate in Pathogenesis of Periodontitis. J Cell Physiol. 2015;230:2981-9 pubmed publisher
  • western blot; human
Willy J, Young S, Stevens J, Masuoka H, Wek R. CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis. Mol Biol Cell. 2015;26:2190-204 pubmed publisher
  • western blot; rat; loading ...; fig 7a
Koenig S, Moreau C, Dupont G, Scoumanne A, Erneux C. Regulation of NGF-driven neurite outgrowth by Ins(1,4,5)P3 kinase is specifically associated with the two isoenzymes Itpka and Itpkb in a model of PC12 cells. FEBS J. 2015;282:2553-69 pubmed publisher
  • western blot; mouse; fig 1
Malik N, Vollmer S, Nanda S, López Pelaéz M, Prescott A, Gray N, et al. Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members. Biochem J. 2015;468:363-72 pubmed publisher
  • western blot; human; fig 1e
Barfeld S, Fazli L, Persson M, Marjavaara L, Urbanucci A, Kaukoniemi K, et al. Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer. Oncotarget. 2015;6:12587-602 pubmed
  • western blot; rat; 1:2000
Trakhtenberg E, Morkin M, Patel K, Fernandez S, Sang A, Shaw P, et al. The N-terminal Set-β Protein Isoform Induces Neuronal Death. J Biol Chem. 2015;290:13417-26 pubmed publisher
  • western blot; human; fig 4
Berard A, Coombs K, Severini A. Quantification of the host response proteome after herpes simplex virus type 1 infection. J Proteome Res. 2015;14:2121-42 pubmed publisher
  • western blot; human; 1:10,000
Prosser S, Morrison C. Centrin2 regulates CP110 removal in primary cilium formation. J Cell Biol. 2015;208:693-701 pubmed publisher
  • western blot; human; fig 4
Xie Q, Wu Q, Horbinski C, Flavahan W, Yang K, Zhou W, et al. Mitochondrial control by DRP1 in brain tumor initiating cells. Nat Neurosci. 2015;18:501-10 pubmed publisher
  • western blot; human; 1:4000; fig 2
Bauckman K, Haller E, Taran N, Rockfield S, Ruiz Rivera A, Nanjundan M. Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells. Biochem J. 2015;466:401-13 pubmed publisher
  • western blot; human; 1:5000; fig 5D
Ousterout D, Kabadi A, Thakore P, Majoros W, Reddy T, Gersbach C. Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy. Nat Commun. 2015;6:6244 pubmed publisher
  • western blot; rat; 1:1000
Hirunsai M, Srikuea R, Yimlamai T. Heat stress promotes extracellular matrix remodelling via TGF-β1 and MMP-2/TIMP-2 modulation in tenotomised soleus and plantaris muscles. Int J Hyperthermia. 2015;31:336-48 pubmed publisher
  • western blot; human; 1:1000; fig 2
Plessl K, Haider S, Fiala C, Pollheimer J, Knöfler M. Expression pattern and function of Notch2 in different subtypes of first trimester cytotrophoblast. Placenta. 2015;36:365-71 pubmed publisher
  • western blot; human; 1:5000; fig 1
Sun S, Ling S, Qiu J, Albuquerque C, Zhou Y, Tokunaga S, et al. ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. Nat Commun. 2015;6:6171 pubmed publisher
  • western blot; mouse
Chavan H, Li F, Tessman R, Mickey K, Dorko K, Schmitt T, et al. Functional coupling of ATP-binding cassette transporter Abcb6 to cytochrome P450 expression and activity in liver. J Biol Chem. 2015;290:7871-86 pubmed publisher
  • western blot; human
Seeßle J, Liebisch G, Schmitz G, Stremmel W, Chamulitrat W. Palmitate activation by fatty acid transport protein 4 as a model system for hepatocellular apoptosis and steatosis. Biochim Biophys Acta. 2015;1851:549-65 pubmed publisher
  • western blot; mouse
Golob M, Tian L, Wang Z, Zimmerman T, Caneba C, Hacker T, et al. Mitochondria DNA mutations cause sex-dependent development of hypertension and alterations in cardiovascular function. J Biomech. 2015;48:405-12 pubmed publisher
  • western blot; human; fig 5
Hirakawa H, Fujisawa H, Masaoka A, Noguchi M, Hirayama R, Takahashi M, et al. The combination of Hsp90 inhibitor 17AAG and heavy-ion irradiation provides effective tumor control in human lung cancer cells. Cancer Med. 2015;4:426-36 pubmed publisher
  • western blot; rat; fig 1f
Mir S, George N, Zahoor L, Harms R, Guinn Z, SARVETNICK N. Inhibition of autophagic turnover in β-cells by fatty acids and glucose leads to apoptotic cell death. J Biol Chem. 2015;290:6071-85 pubmed publisher
  • western blot; mouse; fig 4
Hill R, Kuijper S, Lindsey J, Petrie K, Schwalbe E, Barker K, et al. Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease. Cancer Cell. 2015;27:72-84 pubmed publisher
  • western blot; southern flounder; 1:2000
Wilson W, Baumgarner B, Watanabe W, Alam M, Kinsey S. Effects of resveratrol on growth and skeletal muscle physiology of juvenile southern flounder. Comp Biochem Physiol A Mol Integr Physiol. 2015;183:27-35 pubmed publisher
  • western blot; human; fig 5
Ye S, Lowther S, Stambas J. Inhibition of reactive oxygen species production ameliorates inflammation induced by influenza A viruses via upregulation of SOCS1 and SOCS3. J Virol. 2015;89:2672-83 pubmed publisher
  • western blot; human; 1:2000
Durán I, Nevarez L, Sarukhanov A, Wu S, Lee K, Krejci P, et al. HSP47 and FKBP65 cooperate in the synthesis of type I procollagen. Hum Mol Genet. 2015;24:1918-28 pubmed publisher
  • western blot; human; 1:5000; fig 2
Kabadi A, Thakore P, Vockley C, Ousterout D, Gibson T, Guilak F, et al. Enhanced MyoD-induced transdifferentiation to a myogenic lineage by fusion to a potent transactivation domain. ACS Synth Biol. 2015;4:689-99 pubmed publisher
  • western blot; human
Sekimoto T, Oda T, Kurashima K, Hanaoka F, Yamashita T. Both high-fidelity replicative and low-fidelity Y-family polymerases are involved in DNA rereplication. Mol Cell Biol. 2015;35:699-715 pubmed publisher
  • western blot; mouse; 1:1000
Crane J, Palanivel R, Mottillo E, Bujak A, Wang H, Ford R, et al. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nat Med. 2015;21:166-72 pubmed publisher
  • western blot; human; fig s2
Lew Q, Chu K, Chia Y, Soo B, Ho J, Ng C, et al. GCN5 inhibits XBP-1S-mediated transcription by antagonizing PCAF action. Oncotarget. 2015;6:271-87 pubmed
  • western blot; mouse; 1:1000
Nashine S, Liu Y, Kim B, Clark A, Pang I. Role of C/EBP homologous protein in retinal ganglion cell death after ischemia/reperfusion injury. Invest Ophthalmol Vis Sci. 2014;56:221-31 pubmed publisher
  • western blot; mouse; fig 1
Kim T, Jo S, Choi H, Park J, Kim M, Nojima H, et al. Identification of Creb3l4 as an essential negative regulator of adipogenesis. Cell Death Dis. 2014;5:e1527 pubmed publisher
  • western blot; mouse
Beccano Kelly D, Kuhlmann N, Tatarnikov I, Volta M, Munsie L, Chou P, et al. Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice. Front Cell Neurosci. 2014;8:301 pubmed publisher
  • western blot; human; fig 5
Gabaev I, Elbasani E, Ameres S, Steinbrück L, Stanton R, Döring M, et al. Expression of the human cytomegalovirus UL11 glycoprotein in viral infection and evaluation of its effect on virus-specific CD8 T cells. J Virol. 2014;88:14326-39 pubmed publisher
  • western blot; human
Brandau S, Jakob M, Bruderek K, Bootz F, Giebel B, Radtke S, et al. Mesenchymal stem cells augment the anti-bacterial activity of neutrophil granulocytes. PLoS ONE. 2014;9:e106903 pubmed publisher
  • western blot; human; fig 1
Tang J, Shen L, Yang Q, Zhang C. Overexpression of metadherin mediates metastasis of osteosarcoma by regulating epithelial-mesenchymal transition. Cell Prolif. 2014;47:427-34 pubmed publisher
  • western blot; human; fig 2
Tripathi B, Lowy D, Zelenka P. The Cdk5 activator P39 specifically links muskelin to myosin II and regulates stress fiber formation and actin organization in lens. Exp Cell Res. 2015;330:186-98 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Kienzl Wagner K, Moschen A, Geiger S, Bichler A, Aigner F, Brandacher G, et al. The role of lipocalin-2 in liver regeneration. Liver Int. 2015;35:1195-202 pubmed publisher
  • western blot; mouse; 1:2000
E L, Burns J, Swerdlow R. Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation. Neurobiol Aging. 2014;35:2574-2583 pubmed publisher
  • western blot; human; 1:1000
Yoda S, Soejima K, Hamamoto J, Yasuda H, Nakayama S, Satomi R, et al. Claudin-1 is a novel target of miR-375 in non-small-cell lung cancer. Lung Cancer. 2014;85:366-72 pubmed publisher
  • western blot; mouse; fig 2
Cowling R, Yeo S, Kim I, Park J, Gu Y, Dalton N, et al. Discoidin domain receptor 2 germline gene deletion leads to altered heart structure and function in the mouse. Am J Physiol Heart Circ Physiol. 2014;307:H773-81 pubmed publisher
  • western blot; mouse; 1:1000; fig 7
Stewart M, Plante I, Bechberger J, Naus C, Laird D. Mammary gland specific knockdown of the physiological surge in Cx26 during lactation retains normal mammary gland development and function. PLoS ONE. 2014;9:e101546 pubmed publisher
  • western blot; human; fig 1
  • western blot; mouse; fig 1
Lau H, Ramanujulu P, Guo D, Yang T, Wirawan M, Casey P, et al. An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo. Cancer Biol Ther. 2014;15:1280-91 pubmed publisher
  • western blot; mouse; 1:10,000; tbl 4
Menalled L, Kudwa A, Oakeshott S, Farrar A, Paterson N, Filippov I, et al. Genetic deletion of transglutaminase 2 does not rescue the phenotypic deficits observed in R6/2 and zQ175 mouse models of Huntington's disease. PLoS ONE. 2014;9:e99520 pubmed publisher
  • western blot; rat; 1:2000
Yang N, Liu Y, Pan C, Sun K, Wei X, Mao X, et al. Pretreatment with andrographolide pills(®) attenuates lipopolysaccharide-induced pulmonary microcirculatory disturbance and acute lung injury in rats. Microcirculation. 2014;21:703-16 pubmed publisher
  • western blot; human; fig 1c
Baron Y, Pedrioli P, Tyagi K, Johnson C, Wood N, Fountaine D, et al. VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase. BMC Biol. 2014;12:39 pubmed publisher
  • western blot; mouse; fig 6
Costes S, Gurlo T, Rivera J, Butler P. UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy. Autophagy. 2014;10:1004-14 pubmed publisher
  • western blot; rat; 1:2000
Trakhtenberg E, Wang Y, Morkin M, Fernandez S, Mlacker G, Shechter J, et al. Regulating Set-?'s Subcellular Localization Toggles Its Function between Inhibiting and Promoting Axon Growth and Regeneration. J Neurosci. 2014;34:7361-74 pubmed publisher
  • western blot; rat
Yi X, Li X, Zhou Y, Ren S, Wan W, Feng G, et al. Hepatocyte growth factor regulates the TGF-?1-induced proliferation, differentiation and secretory function of cardiac fibroblasts. Int J Mol Med. 2014;34:381-90 pubmed publisher
  • western blot; mouse; 1:500 to 1:1000
Guibinga G, Barron N, Pandori W. Striatal neurodevelopment is dysregulated in purine metabolism deficiency and impacts DARPP-32, BDNF/TrkB expression and signaling: new insights on the molecular and cellular basis of Lesch-Nyhan Syndrome. PLoS ONE. 2014;9:e96575 pubmed publisher
  • western blot; human
Bao Y, Cao X, Luo D, Sun R, Peng L, Wang L, et al. Urokinase-type plasminogen activator receptor signaling is critical in nasopharyngeal carcinoma cell growth and metastasis. Cell Cycle. 2014;13:1958-69 pubmed publisher
  • western blot; human
Garimella S, Gehlhaus K, Dine J, Pitt J, Grandin M, Chakka S, et al. Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening. Breast Cancer Res. 2014;16:R41 pubmed publisher
  • western blot; human; 1:500; fig 2
Zhang J, Zhou S, Zhang Q, Feng S, Chen Y, Zheng H, et al. Proteomic Analysis of RBP4/Vitamin A in Children with Cleft Lip and/or Palate. J Dent Res. 2014;93:547-52 pubmed publisher
  • western blot; human; 1:1000
Biadasiewicz K, Fock V, Dekan S, Proestling K, Velicky P, Haider S, et al. Extravillous trophoblast-associated ADAM12 exerts pro-invasive properties, including induction of integrin beta 1-mediated cellular spreading. Biol Reprod. 2014;90:101 pubmed publisher
  • western blot; human
  • western blot; mouse
Luo J, Hosoki K, Bacsi A, Radak Z, Hegde M, Sur S, et al. 8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization. Free Radic Biol Med. 2014;73:430-8 pubmed publisher
  • western blot; human; 1:1000
Sun S, Han Y, Liu J, Fang Y, Tian Y, Zhou J, et al. Trichostatin A targets the mitochondrial respiratory chain, increasing mitochondrial reactive oxygen species production to trigger apoptosis in human breast cancer cells. PLoS ONE. 2014;9:e91610 pubmed publisher
  • western blot; mouse; 1:2000; fig 2
Zhang L, Chen X, Sharma P, Moon M, Sheftel A, Dawood F, et al. HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress. Nat Commun. 2014;5:3430 pubmed publisher
  • western blot; human; 1:1000; fig 4
Linke R, Pries R, Könnecke M, Bruchhage K, Böscke R, Gebhard M, et al. The MEK1/2-ERK1/2 pathway is activated in chronic rhinosinusitis with nasal polyps. Arch Immunol Ther Exp (Warsz). 2014;62:217-29 pubmed publisher
  • western blot; mouse; 1:10,000; fig 4
  • western blot; human; 1:10,000; fig 4
Rutledge C, Lau H, Mangan H, Hardy L, Sunnotel O, Guo F, et al. Efficient translation of Dnmt1 requires cytoplasmic polyadenylation and Musashi binding elements. PLoS ONE. 2014;9:e88385 pubmed publisher
  • western blot; mouse; 1:3000; fig s6
Shao D, Zhai P, Del Re D, Sciarretta S, Yabuta N, Nojima H, et al. A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response. Nat Commun. 2014;5:3315 pubmed publisher
  • western blot; mouse; fig 3
Furuya N, Ikeda S, Sato S, Soma S, Ezaki J, Oliva Trejo J, et al. PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation. Autophagy. 2014;10:631-41 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Liu J, Rong C, Li Y, Liu X, Wang W, Li N. Vasectomy induces oxidative stress and up-regulates the expression of peroxiredoxins in mouse testis in short and early periods after surgery. J Urol. 2014;191:1920-6 pubmed publisher
  • western blot; human; fig 4
Hart M, Nolte E, Wach S, Szczyrba J, Taubert H, Rau T, et al. Comparative microRNA profiling of prostate carcinomas with increasing tumor stage by deep sequencing. Mol Cancer Res. 2014;12:250-63 pubmed publisher
  • western blot; mouse; fig 5
Tan S, Shui G, Zhou J, Shi Y, Huang J, Xia D, et al. Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway. Autophagy. 2014;10:226-42 pubmed publisher
  • western blot; human; 1:1000
Ogunkolade B, Jones T, Aarum J, Szary J, Owen N, Ottaviani D, et al. BORIS/CTCFL is an RNA-binding protein that associates with polysomes. BMC Cell Biol. 2013;14:52 pubmed publisher
  • western blot; human; 1:1000
Shishido S, Delahaye A, Beck A, Nguyen T. The anticancer effect of PQ1 in the MMTV-PyVT mouse model. Int J Cancer. 2014;134:1474-83 pubmed publisher
  • western blot; mouse; 1:1000
Sha L, Wu X, Yao Y, Wen B, Feng J, Sha Z, et al. Notch signaling activation promotes seizure activity in temporal lobe epilepsy. Mol Neurobiol. 2014;49:633-44 pubmed publisher
  • immunocytochemistry; human; 1.5:1000
Copeland A, Altamura L, Van Deusen N, Schmaljohn C. Nuclear relocalization of polyadenylate binding protein during rift valley fever virus infection involves expression of the NSs gene. J Virol. 2013;87:11659-69 pubmed publisher
  • western blot; rat; 1:5000
García Pérez D, López Bellido R, Hidalgo J, Rodriguez R, Laorden M, Nunez C, et al. Morphine regulates Argonaute 2 and TH expression and activity but not miR-133b in midbrain dopaminergic neurons. Addict Biol. 2015;20:104-19 pubmed publisher
  • western blot; human; 1:1000
Devine D, Rostas J, Metge B, Das S, Mulekar M, Tucker J, et al. Loss of N-Myc interactor promotes epithelial-mesenchymal transition by activation of TGF-?/SMAD signaling. Oncogene. 2014;33:2620-8 pubmed publisher
  • western blot; human
Thu K, Radulovich N, Becker Santos D, Pikor L, Pusic A, Lockwood W, et al. SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/?-catenin signaling. Oncogene. 2014;33:279-88 pubmed publisher
  • western blot; mouse
Qi W, Spier C, Liu X, Agarwal A, Cooke L, Persky D, et al. Alisertib (MLN8237) an investigational agent suppresses Aurora A and B activity, inhibits proliferation, promotes endo-reduplication and induces apoptosis in T-NHL cell lines supporting its importance in PTCL treatment. Leuk Res. 2013;37:434-9 pubmed publisher
  • western blot; mouse
Rahman A, Ekman M, Shakirova Y, Andersson K, Morgelin M, Erjefalt J, et al. Late onset vascular dysfunction in the R6/1 model of Huntington's disease. Eur J Pharmacol. 2013;698:345-53 pubmed publisher
  • western blot; mouse; 1:5000; fig 1
Henke N, Albrecht P, Pfeiffer A, Toutzaris D, Zanger K, Methner A. Stromal interaction molecule 1 (STIM1) is involved in the regulation of mitochondrial shape and bioenergetics and plays a role in oxidative stress. J Biol Chem. 2012;287:42042-52 pubmed publisher
  • western blot; mouse; 1:2000
Koch S, Scifo E, Rokka A, Trippner P, Lindfors M, Korhonen R, et al. Cathepsin D deficiency induces cytoskeletal changes and affects cell migration pathways in the brain. Neurobiol Dis. 2013;50:107-19 pubmed publisher
  • western blot; mouse; 1:1000; fig 6
Wodarczyk C, Rowe I, Chiaravalli M, Pema M, Qian F, Boletta A. A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus. PLoS ONE. 2009;4:e7137 pubmed publisher
Greer S, Chen J, Ogmundsdóttir M, Ayala C, Lau B, Delacruz R, et al. Germline variants of ATG7 in familial cholangiocarcinoma alter autophagy and p62. Sci Rep. 2022;12:10333 pubmed publisher
Duclaux Loras R, Lebreton C, Berthelet J, Charbit Henrion F, Nicolle O, Revenu de Courtils C, et al. UNC45A deficiency causes microvillus inclusion disease-like phenotype by impairing myosin VB-dependent apical trafficking. J Clin Invest. 2022;132: pubmed publisher
Suh J, Kim K, Conner M, Moore D, Preidis G. Hepatic PPARα Is Destabilized by SIRT1 Deacetylase in Undernourished Male Mice. Front Nutr. 2022;9:831879 pubmed publisher
Jiang H, Chiang C, Chen Z, Nathan S, D Agostino G, Paulo J, et al. Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates. J Biol Chem. 2022;298:101854 pubmed publisher
Ricci E, Fava M, Rizza P, Pellegrino M, Bonofiglio D, Casaburi I, et al. FoxO3a Inhibits Tamoxifen-Resistant Breast Cancer Progression by Inducing Integrin α5 Expression. Cancers (Basel). 2022;14: pubmed publisher
Talluri S, Samur M, Buon L, Kumar S, Potluri L, Shi J, et al. Dysregulated APOBEC3G causes DNA damage and promotes genomic instability in multiple myeloma. Blood Cancer J. 2021;11:166 pubmed publisher
Akasu M, Shimada S, Kabashima A, Akiyama Y, Shimokawa M, Akahoshi K, et al. Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in hepatocellular carcinoma. Sci Rep. 2021;11:16732 pubmed publisher
Kremer D, Nelson B, Lin L, Yarosz E, Halbrook C, Kerk S, et al. GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis. Nat Commun. 2021;12:4860 pubmed publisher
Adams G, López M, Cartagena Rivera A, Waterman C. Survey of cancer cell anatomy in non-adhesive confinement reveals a role for filamin-A and fascin-1 in leader bleb-based migration. Mol Biol Cell. 2021;:mbcE21040174 pubmed publisher
Chernyakov D, Groß A, Fischer A, Bornkessel N, Schultheiss C, Gerloff D, et al. Loss of RANBP3L leads to transformation of renal epithelial cells towards a renal clear cell carcinoma like phenotype. J Exp Clin Cancer Res. 2021;40:226 pubmed publisher
Conley J, Sun H, Ayers K, Zhu H, Chen R, Shen M, et al. Human GPR17 missense variants identified in metabolic disease patients have distinct downstream signaling profiles. J Biol Chem. 2021;297:100881 pubmed publisher
Arcones A, Vila Bedmar R, Mirasierra M, Cruces Sande M, Vallejo M, Jones B, et al. GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo. BMC Biol. 2021;19:40 pubmed publisher
Kennedy A, Myers K, Bowman J, Gibson C, Camarda N, Furutani E, et al. Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome. Nat Commun. 2021;12:1334 pubmed publisher
Masalmeh R, Taglini F, Rubio Ramon C, Musialik K, Higham J, Davidson Smith H, et al. De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands. Nat Commun. 2021;12:694 pubmed publisher
Robert Hollingsworth L, David L, Li Y, Griswold A, Ruan J, Sharif H, et al. Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nat Commun. 2021;12:189 pubmed publisher
Shirasaki R, Matthews G, Gandolfi S, de Matos Simoes R, Buckley D, Raja Vora J, et al. Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins. Cell Rep. 2021;34:108532 pubmed publisher
Parsels L, Engelke C, Parsels J, Flanagan S, Zhang Q, Tanska D, et al. Combinatorial Efficacy of Olaparib with Radiation and ATR Inhibitor Requires PARP1 Protein in Homologous Recombination-Proficient Pancreatic Cancer. Mol Cancer Ther. 2021;20:263-273 pubmed publisher
Wang Q, Zhao Y, Zheng H, Wang Q, Wang W, Liu B, et al. CCDC170 affects breast cancer apoptosis through IRE1 pathway. Aging (Albany NY). 2020;13:1332-1356 pubmed publisher
García Keller C, Scofield M, Neuhofer D, Varanasi S, Reeves M, Hughes B, et al. Relapse-Associated Transient Synaptic Potentiation Requires Integrin-Mediated Activation of Focal Adhesion Kinase and Cofilin in D1-Expressing Neurons. J Neurosci. 2020;40:8463-8477 pubmed publisher
Puhach O, Ostermann E, Krisp C, Frascaroli G, Schluter H, Brinkmann M, et al. Murine cytomegaloviruses m139 targets DDX3 to curtail interferon production and promote viral replication. PLoS Pathog. 2020;16:e1008546 pubmed publisher
Golubicki M, Bonjoch L, Acuña Ochoa J, Díaz Gay M, Muñoz J, Cuatrecasas M, et al. Germline biallelic Mcm8 variants are associated with early-onset Lynch-like syndrome. JCI Insight. 2020;5: pubmed publisher
Chu N, Viennet T, Bae H, Salguero A, Boeszoermenyi A, Arthanari H, et al. The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling. elife. 2020;9: pubmed publisher
Galeone A, Adams J, Matsuda S, Presa M, Pandey A, Han S, et al. Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation. elife. 2020;9: pubmed publisher
Elmallah M, Cogo S, Constantinescu A, Elifio Esposito S, Abdelfattah M, Micheau O. Marine Actinomycetes-Derived Secondary Metabolites Overcome TRAIL-Resistance via the Intrinsic Pathway through Downregulation of Survivin and XIAP. Cells. 2020;9: pubmed publisher
Desai P, Stuck M, Lv B, Pazour G. Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling. J Cell Biol. 2020;219: pubmed publisher
Akpa C, Kleo K, Oker E, Tomaszewski N, Messerschmidt C, Lopez C, et al. Acquired resistance to DZNep-mediated apoptosis is associated with copy number gains of AHCY in a B-cell lymphoma model. BMC Cancer. 2020;20:427 pubmed publisher
Trembinski D, Bink D, Theodorou K, Sommer J, Fischer A, van Bergen A, et al. Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. Nat Commun. 2020;11:2039 pubmed publisher
Guo Y, Pei Y, Li K, Cui W, Zhang D. DNA N6-methyladenine modification in hypertension. Aging (Albany NY). 2020;12:6276-6291 pubmed publisher
Khan E, Sankaran S, Llontop L, del Campo A. Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro. BMC Mol Cell Biol. 2020;21:22 pubmed publisher
Loe T, Li J, Zhang Y, Azeroglu B, BODDY M, Denchi E. Telomere length heterogeneity in ALT cells is maintained by PML-dependent localization of the BTR complex to telomeres. Genes Dev. 2020;34:650-662 pubmed publisher
González Rico F, Vicente Garcia C, Fernandez A, Muñoz Santos D, Montoliu L, Morales Hernández A, et al. Alu retrotransposons modulate Nanog expression through dynamic changes in regional chromatin conformation via aryl hydrocarbon receptor. Epigenetics Chromatin. 2020;13:15 pubmed publisher
Legut M, Daniloski Z, Xue X, McKenzie D, Guo X, Wessels H, et al. High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation. Cell Rep. 2020;30:2859-2868.e5 pubmed publisher
Martin E, Pacholewska A, Patel H, Dashora H, Sung M. Integrative analysis suggests cell type-specific decoding of NF-κB dynamics. Sci Signal. 2020;13: pubmed publisher
Ehexige E, Bao M, Bazarjav P, Yu X, Xiao H, Han S, et al. Silencing of STAT3 via Peptidomimetic LNP-Mediated Systemic Delivery of RNAi Downregulates PD-L1 and Inhibits Melanoma Growth. Biomolecules. 2020;10: pubmed publisher
Grey M, Cloots E, Simpson M, Leduc N, Serebrenik Y, De Luca H, et al. IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress. J Cell Biol. 2020;219: pubmed publisher
Tessier S, Doolittle A, Sao K, Rotty J, Bear J, Ulici V, et al. Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation. JCI Insight. 2020;5: pubmed publisher
Vassilieva I, Kosheverova V, Vitte M, Kamentseva R, Shatrova A, Tsupkina N, et al. Paracrine senescence of human endometrial mesenchymal stem cells: a role for the insulin-like growth factor binding protein 3. Aging (Albany NY). 2020;12:1987-2004 pubmed publisher
Hart P, Kenny H, Grassl N, Watters K, Litchfield L, Coscia F, et al. Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk. Cell Rep. 2019;29:4086-4098.e6 pubmed publisher
Frisbie C, Lushnikov A, Krasnoslobodtsev A, Riethoven J, Clarke J, Stepchenkova E, et al. Post-ER Stress Biogenesis of Golgi Is Governed by Giantin. Cells. 2019;8: pubmed publisher
Kouloulia S, Hallin E, Simbriger K, Amorim I, Lach G, Amvrosiadis T, et al. Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity. Cell Rep. 2019;29:3620-3635.e7 pubmed publisher
Werner A, Pieh D, Echchannaoui H, Rupp J, Rajalingam K, Theobald M, et al. Cationic Amino Acid Transporter-1-Mediated Arginine Uptake Is Essential for Chronic Lymphocytic Leukemia Cell Proliferation and Viability. Front Oncol. 2019;9:1268 pubmed publisher
Krivtsov A, Evans K, Gadrey J, Eschle B, Hatton C, Uckelmann H, et al. A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia. Cancer Cell. 2019;36:660-673.e11 pubmed publisher
Martin E, Chakraborty S, Presman D, Tomassoni Ardori F, Oh K, Kaileh M, et al. Assaying Homodimers of NF-κB in Live Single Cells. Front Immunol. 2019;10:2609 pubmed publisher
De Snoo M, Friesen E, Zhang Y, Earnshaw R, Dorval G, Kapadia M, et al. Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death. Cell Death Dis. 2019;10:907 pubmed publisher
Tang M, Pan H, Zheng Z, Guo Y, Peng J, Yang J, et al. Prostaglandin E1 protects cardiomyocytes against hypoxia-reperfusion induced injury via the miR-21-5p/FASLG axis. Biosci Rep. 2019;39: pubmed publisher
Ruiz M, Bodhicharla R, Ståhlman M, Svensk E, Busayavalasa K, Palmgren H, et al. Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity. elife. 2019;8: pubmed publisher
Sullivan N, Dampier W, Chung C, Allen A, Atkins A, Pirrone V, et al. Novel gRNA design pipeline to develop broad-spectrum CRISPR/Cas9 gRNAs for safe targeting of the HIV-1 quasispecies in patients. Sci Rep. 2019;9:17088 pubmed publisher
De la Cuesta F, Passalacqua I, Rodor J, Bhushan R, Denby L, Baker A. Extracellular vesicle cross-talk between pulmonary artery smooth muscle cells and endothelium during excessive TGF-β signalling: implications for PAH vascular remodelling. Cell Commun Signal. 2019;17:143 pubmed publisher
Abildgaard A, Stein A, Nielsen S, Schultz Knudsen K, Papaleo E, Shrikhande A, et al. Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome. elife. 2019;8: pubmed publisher
Hadrevi J, Barbe M, Ørtenblad N, Frandsen U, Boyle E, Lazar S, et al. Calcium Fluxes in Work-Related Muscle Disorder: Implications from a Rat Model. Biomed Res Int. 2019;2019:5040818 pubmed publisher
LeRoy G, Oksuz O, Descostes N, Aoi Y, Ganai R, Kara H, et al. LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells. Sci Adv. 2019;5:eaay3068 pubmed publisher
Faust J, Millis B, Tyska M. Profilin-Mediated Actin Allocation Regulates the Growth of Epithelial Microvilli. Curr Biol. 2019;29:3457-3465.e3 pubmed publisher
Puleo J, Parker S, Roman M, Watson A, Eliato K, Peng L, et al. Mechanosensing during directed cell migration requires dynamic actin polymerization at focal adhesions. J Cell Biol. 2019;218:4215-4235 pubmed publisher
Zhao X, Nedvetsky P, Stanchi F, Vion A, Popp O, Zühlke K, et al. Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1. elife. 2019;8: pubmed publisher
Gao L, Liu H, Yin N, Zuo S, Jin G, Hu Y, et al. BNIPL‑2 expression is correlated with the prognosis and regulates the proliferation of colorectal cancer through CD44. Mol Med Rep. 2019;20:4073-4080 pubmed publisher
Forero A, Ozarkar S, Li H, Lee C, Hemann E, Nadjsombati M, et al. Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons. Immunity. 2019;51:451-464.e6 pubmed publisher
Ekman F, Ojala D, Adil M, Lopez P, Schaffer D, Gaj T. CRISPR-Cas9-Mediated Genome Editing Increases Lifespan and Improves Motor Deficits in a Huntington's Disease Mouse Model. Mol Ther Nucleic Acids. 2019;17:829-839 pubmed publisher
Chitirala P, Ravichandran K, Galgano D, Sleiman M, Krause E, Bryceson Y, et al. Cytotoxic Granule Exocytosis From Human Cytotoxic T Lymphocytes Is Mediated by VAMP7. Front Immunol. 2019;10:1855 pubmed publisher
Frikstad K, Molinari E, Thoresen M, Ramsbottom S, Hughes F, Letteboer S, et al. A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling. Cell Rep. 2019;28:1907-1922.e6 pubmed publisher
Sharma N, Majerciak V, Kruhlak M, Yu L, Kang J, Yang A, et al. KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182. Nucleic Acids Res. 2019;47:9368-9385 pubmed publisher
Kabir S, Cidado J, Andersen C, Dick C, Lin P, Mitros T, et al. The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells. elife. 2019;8: pubmed publisher
Gamache J, Benzow K, Forster C, Kemper L, Hlynialuk C, Furrow E, et al. Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice. Nat Commun. 2019;10:2479 pubmed publisher
Kornyeyev D, Ramakrishnan D, Voitenleitner C, Livingston C, Xing W, Hung M, et al. Spatiotemporal Analysis of Hepatitis B Virus X Protein in Primary Human Hepatocytes. J Virol. 2019;: pubmed publisher
Ramakrishnan D, Xing W, Beran R, Chemuru S, Rohrs H, Niedziela Majka A, et al. Hepatitis B Virus X Protein Function Requires Zinc Binding. J Virol. 2019;: pubmed publisher
Mokuda S, Nakamichi R, Matsuzaki T, Ito Y, Sato T, Miyata K, et al. Wwp2 maintains cartilage homeostasis through regulation of Adamts5. Nat Commun. 2019;10:2429 pubmed publisher
Hammerschmidt P, Ostkotte D, Nolte H, Gerl M, Jais A, Brunner H, et al. CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity. Cell. 2019;177:1536-1552.e23 pubmed publisher
Das R, Schwintzer L, Vinopal S, Roca E, Sylvester M, Oprişoreanu A, et al. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. J Cell Sci. 2019;: pubmed publisher
Ungefroren H, Otterbein H, Fiedler C, Mihara K, Hollenberg M, Gieseler F, et al. RAC1B Suppresses TGF-β1-Dependent Cell Migration in Pancreatic Carcinoma Cells through Inhibition of the TGF-β Type I Receptor ALK5. Cancers (Basel). 2019;11: pubmed publisher
Lorenz Guertin J, Bambino M, Das S, Weintraub S, Jacob T. Diazepam Accelerates GABAAR Synaptic Exchange and Alters Intracellular Trafficking. Front Cell Neurosci. 2019;13:163 pubmed publisher
Ruiz Gutierrez M, Bölükbaşı Ö, Alexe G, Kotini A, Ballotti K, Joyce C, et al. Therapeutic discovery for marrow failure with MDS predisposition using pluripotent stem cells. JCI Insight. 2019;5: pubmed publisher
Griswold A, Cifani P, Rao S, Axelrod A, Miele M, Hendrickson R, et al. A Chemical Strategy for Protease Substrate Profiling. Cell Chem Biol. 2019;26:901-907.e6 pubmed publisher
Brown A, Winter J, Gapinske M, Tague N, Woods W, Perez Pinera P. Multiplexed and tunable transcriptional activation by promoter insertion using nuclease-assisted vector integration. Nucleic Acids Res. 2019;47:e67 pubmed publisher
Drews K, Calgi M, Harrison W, Drews C, Costa Pinheiro P, Shaw J, et al. Glucosylceramidase Maintains Influenza Virus Infection by Regulating Endocytosis. J Virol. 2019;93: pubmed publisher
Broeckel R, Sarkar S, May N, Totonchy J, Kreklywich C, Smith P, et al. Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs. Antimicrob Agents Chemother. 2019;63: pubmed publisher
Wu C, Koay T, Ho Y, Lovat P, Lunec J. TP53 mutant cell lines selected for resistance to MDM2 inhibitors retain growth inhibition by MAPK pathway inhibitors but a reduced apoptotic response. Cancer Cell Int. 2019;19:53 pubmed publisher
Cao Y, Trillo Tinoco J, Sierra R, Anadon C, Dai W, Mohamed E, et al. ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression. Nat Commun. 2019;10:1280 pubmed publisher
Ruiz M, Ståhlman M, Boren J, Pilon M. AdipoR1 and AdipoR2 maintain membrane fluidity in most human cell types and independently of adiponectin. J Lipid Res. 2019;60:995-1004 pubmed publisher
Hong A, Tseng Y, Wala J, Kim W, Kynnap B, Doshi M, et al. Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition. elife. 2019;8: pubmed publisher
Zhu H, Bhatt B, Sivaprakasam S, Cai Y, Liu S, Kodeboyina S, et al. Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR. Nat Commun. 2019;10:1084 pubmed publisher
Ly P, Brunner S, Shoshani O, Kim D, Lan W, Pyntikova T, et al. Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements. Nat Genet. 2019;51:705-715 pubmed publisher
Dong J, Du X, Wang H, Wang J, Lu C, Chen X, et al. Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2. Nat Commun. 2019;10:829 pubmed publisher
Feng X, Arang N, Rigiracciolo D, Lee J, Yeerna H, Wang Z, et al. A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK. Cancer Cell. 2019;35:457-472.e5 pubmed publisher
Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson F, et al. p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors. Cancer Cell. 2019;35:204-220.e9 pubmed publisher
Tobita T, Kiyozumi D, Muto M, Noda T, Ikawa M. Lvrn expression is not critical for mouse placentation. J Reprod Dev. 2019;65:239-244 pubmed publisher
Nakamura M, Liu T, Husain S, Zhai P, Warren J, Hsu C, et al. Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy. Cell Metab. 2019;29:1119-1134.e12 pubmed publisher
Igotti M, Svetlikova S, Pospelov V. Overexpression of Adenoviral E1A Sensitizes E1A+Ras-Transformed Cells to the Action of Histone Deacetylase Inhibitors. Acta Naturae. 2018;10:70-78 pubmed
Wheeler M, Jaronen M, Covacu R, Zandee S, Scalisi G, Rothhammer V, et al. Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation. Cell. 2019;176:581-596.e18 pubmed publisher
Alam M, Yang D, Trivett A, Meyer T, Oppenheim J. HMGN1 and R848 Synergistically Activate Dendritic Cells Using Multiple Signaling Pathways. Front Immunol. 2018;9:2982 pubmed publisher
Griukova A, Deryabin P, Sirotkina M, Shatrova A, Nikolsky N, Borodkina A. P38 MAPK inhibition prevents polybrene-induced senescence of human mesenchymal stem cells during viral transduction. PLoS ONE. 2018;13:e0209606 pubmed publisher
Martínez Fábregas J, Prescott A, van Kasteren S, Pedrioli D, McLean I, Moles A, et al. Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis. Nat Commun. 2018;9:5343 pubmed publisher
Parlato M, Charbit Henrion F, Nader E, Begue B, Guegan N, Bruneau J, et al. Efficacy of Ruxolitinib Therapy in a Patient with Severe Enterocolitis Associated with a STAT3 Gain of Function Mutation. Gastroenterology. 2018;: pubmed publisher
Ostermann E, Loroch S, Qian Z, Sickmann A, Wiebusch L, Brune W. Activation of E2F-dependent transcription by the mouse cytomegalovirus M117 protein affects the viral host range. PLoS Pathog. 2018;14:e1007481 pubmed publisher
Yi Q, Chen Q, Yan H, Zhang M, Liang C, Xiang X, et al. Aurora B kinase activity-dependent and -independent functions of the chromosomal passenger complex in regulating sister chromatid cohesion. J Biol Chem. 2019;294:2021-2035 pubmed publisher
Ohui K, Afanasenko E, Bacher F, Ting R, Zafar A, Blanco Cabra N, et al. New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action. J Med Chem. 2018;: pubmed publisher
Liang C, Zhang Z, Chen Q, Yan H, Zhang M, Xiang X, et al. A positive feedback mechanism ensures proper assembly of the functional inner centromere during mitosis in human cells. J Biol Chem. 2019;294:1437-1450 pubmed publisher
Santofimia Castaño P, Lan W, Bintz J, Gayet O, Carrier A, Lomberk G, et al. Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis. Sci Rep. 2018;8:16999 pubmed publisher
Ayoubian H, Ludwig N, Fehlmann T, Menegatti J, Gröger L, Anastasiadou E, et al. Epstein-Barr Virus Infection of Cell Lines Derived from Diffuse Large B-Cell Lymphomas Alters MicroRNA Loading of the Ago2 Complex. J Virol. 2019;93: pubmed publisher
Assi S, Imperato M, Coleman D, Pickin A, Potluri S, Ptasinska A, et al. Subtype-specific regulatory network rewiring in acute myeloid leukemia. Nat Genet. 2019;51:151-162 pubmed publisher
Jones G, Rooney C, Griffin N, Roudier M, Young L, Garcia Trinidad A, et al. pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry. Br J Cancer. 2018;119:1233-1243 pubmed publisher
Nanda S, Nagamori T, Windheim M, Amu S, Aviello G, Patterson Kane J, et al. ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism. J Immunol. 2018;201:3373-3382 pubmed publisher
Wen L, Feil S, Wolters M, Thunemann M, Regler F, Schmidt K, et al. A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis. Nat Commun. 2018;9:4301 pubmed publisher
Sadleir K, Popovic J, Vassar R. ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease. J Biol Chem. 2018;293:18434-18443 pubmed publisher
Valcarcel Jimenez L, Macchia A, Martin Martin N, Cortazar A, Schaub Clerigué A, Pujana Vaquerizo M, et al. Integrative analysis of transcriptomics and clinical data uncovers the tumor-suppressive activity of MITF in prostate cancer. Cell Death Dis. 2018;9:1041 pubmed publisher
Munoz I, Morgan M, Peltier J, Weiland F, Gregorczyk M, Brown F, et al. Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase. EMBO J. 2018;37: pubmed publisher
Mödinger Y, Rapp A, Pázmándi J, Vikman A, Holzmann K, Haffner Luntzer M, et al. C5aR1 interacts with TLR2 in osteoblasts and stimulates the osteoclast-inducing chemokine CXCL10. J Cell Mol Med. 2018;22:6002-6014 pubmed publisher
Nguyen T, Su C, Singh M. Let-7i inhibition enhances progesterone-induced functional recovery in a mouse model of ischemia. Proc Natl Acad Sci U S A. 2018;115:E9668-E9677 pubmed publisher
Abdullah N, Kelly J, Graham S, Birch J, Gonçalves Carneiro D, Mitchell T, et al. Structure-Guided Identification of a Nonhuman Morbillivirus with Zoonotic Potential. J Virol. 2018;92: pubmed publisher
Wei J, Yuan Y, Chen L, Xu Y, Zhang Y, Wang Y, et al. ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes. Nat Commun. 2018;9:3659 pubmed publisher
Albarrán Juárez J, Iring A, Wang S, Joseph S, Grimm M, Strilic B, et al. Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation. J Exp Med. 2018;215:2655-2672 pubmed publisher
He Y, Yuan X, Li Y, Zhong C, Liu Y, Qian H, et al. Loss of Gαq impairs regulatory B-cell function. Arthritis Res Ther. 2018;20:186 pubmed publisher
Duggimpudi S, Kloetgen A, Maney S, Münch P, Hezaveh K, Shaykhalishahi H, et al. Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2's RNA-binding activity on IL-6 signaling. J Biol Chem. 2018;293:15359-15369 pubmed publisher
Avanzino B, Jue H, Miller C, Cheung E, Fuchs G, Fraser C. Molecular mechanism of poliovirus Sabin vaccine strain attenuation. J Biol Chem. 2018;293:15471-15482 pubmed publisher
Lee J, Adler L, Karathia H, Carmel N, Rabinovich S, Auslander N, et al. Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures. Cell. 2018;174:1559-1570.e22 pubmed publisher
Konovalova S, Liu X, Manjunath P, Baral S, Neupane N, Hilander T, et al. Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone. Redox Biol. 2018;19:37-45 pubmed publisher
Attig J, Agostini F, Gooding C, Chakrabarti A, Singh A, Haberman N, et al. Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing. Cell. 2018;174:1067-1081.e17 pubmed publisher
Siddiquey M, Zhang H, Nguyen C, Domma A, Kamil J. The Human Cytomegalovirus Endoplasmic Reticulum-Resident Glycoprotein UL148 Activates the Unfolded Protein Response. J Virol. 2018;92: pubmed publisher
Wen J, Garg N. Manganese superoxide dismutase deficiency exacerbates the mitochondrial ROS production and oxidative damage in Chagas disease. PLoS Negl Trop Dis. 2018;12:e0006687 pubmed publisher
Wienert B, Shin J, Zelin E, Pestal K, Corn J. In vitro-transcribed guide RNAs trigger an innate immune response via the RIG-I pathway. PLoS Biol. 2018;16:e2005840 pubmed publisher
Loureiro M, Zorzetto Fernandes A, Radoshitzky S, Chi X, Dallari S, Marooki N, et al. DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection. PLoS Pathog. 2018;14:e1007125 pubmed publisher
Quartey M, Nyarko J, Pennington P, Heistad R, Klassen P, Baker G, et al. Alzheimer Disease and Selected Risk Factors Disrupt a Co-regulation of Monoamine Oxidase-A/B in the Hippocampus, but Not in the Cortex. Front Neurosci. 2018;12:419 pubmed publisher
Geng J, Zaitouna A, Raghavan M. Selected HLA-B allotypes are resistant to inhibition or deficiency of the transporter associated with antigen processing (TAP). PLoS Pathog. 2018;14:e1007171 pubmed publisher
Johnson D, Taabazuing C, Okondo M, Chui A, Rao S, Brown F, et al. DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia. Nat Med. 2018;24:1151-1156 pubmed publisher
Silva Aguiar R, Bezerra N, Lucena M, Sirtoli G, Sudo R, Zapata Sudo G, et al. O-GlcNAcylation reduces proximal tubule protein reabsorption and promotes proteinuria in spontaneously hypertensive rats. J Biol Chem. 2018;293:12749-12758 pubmed publisher
Kouskou M, Thomson D, Brett R, Wheeler L, Tate R, Pratt J, et al. Disruption of the Zdhhc9 intellectual disability gene leads to behavioural abnormalities in a mouse model. Exp Neurol. 2018;308:35-46 pubmed publisher
Hojo N, Huisken A, Wang H, Chirshev E, Kim N, Nguyen S, et al. Snail knockdown reverses stemness and inhibits tumour growth in ovarian cancer. Sci Rep. 2018;8:8704 pubmed publisher
Nakazeki F, Nishiga M, Horie T, Nishi H, Nakashima Y, Baba O, et al. Loss of periostin ameliorates adipose tissue inflammation and fibrosis in vivo. Sci Rep. 2018;8:8553 pubmed publisher
Millership S, Da Silva Xavier G, Choudhury A, Bertazzo S, Chabosseau P, Pedroni S, et al. Neuronatin regulates pancreatic β cell insulin content and secretion. J Clin Invest. 2018;128:3369-3381 pubmed publisher
Franqui Machin R, Hao M, Bai H, Gu Z, Zhan X, Habelhah H, et al. Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma. J Clin Invest. 2018;: pubmed publisher
Chatterjee M, Del Campo M, Morrema T, de Waal M, van der Flier W, Hoozemans J, et al. Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer's disease. Alzheimers Res Ther. 2018;10:52 pubmed publisher
Li Z, Liu B, Jin W, Wu X, Zhou M, Liu V, et al. hDNA2 nuclease/helicase promotes centromeric DNA replication and genome stability. EMBO J. 2018;37: pubmed publisher
Rothhammer V, Borucki D, Tjon E, Takenaka M, Chao C, Ardura Fabregat A, et al. Microglial control of astrocytes in response to microbial metabolites. Nature. 2018;557:724-728 pubmed publisher
Feng L, Vujicic S, Dietrich M, Litbarg N, Setty S, Antoni A, et al. Repeated exposure of epithelial cells to apoptotic cells induces the specific selection of an adaptive phenotype: Implications for tumorigenesis. J Biol Chem. 2018;293:10245-10263 pubmed publisher
Sheng P, Fields C, Aadland K, Wei T, Kolaczkowski O, Gu T, et al. Dicer cleaves 5'-extended microRNA precursors originating from RNA polymerase II transcription start sites. Nucleic Acids Res. 2018;46:5737-5752 pubmed publisher
Lopes C, Mesquita M, Cunha A, Cardoso J, Carapeta S, Laranjeira C, et al. Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis. J Cell Biol. 2018;217:2353-2363 pubmed publisher
Vila Cuenca M, Keuning E, Talhout W, Paauw N, van Ittersum F, ter Wee P, et al. Differences in peritoneal response after exposure to low-GDP bicarbonate/lactate-buffered dialysis solution compared to conventional dialysis solution in a uremic mouse model. Int Urol Nephrol. 2018;50:1151-1161 pubmed publisher
Pinarbasi E, Cagatay T, Fung H, Li Y, Chook Y, Thomas P. Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization. Sci Rep. 2018;8:7083 pubmed publisher
Thakore P, Kwon J, Nelson C, Rouse D, Gemberling M, Oliver M, et al. RNA-guided transcriptional silencing in vivo with S. aureus CRISPR-Cas9 repressors. Nat Commun. 2018;9:1674 pubmed publisher
Tan K, Haelterman N, Kwartler C, Regalado E, Lee P, Nagarkar Jaiswal S, et al. Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms. Dev Cell. 2018;45:226-244.e8 pubmed publisher
Oh R, Haak A, Smith K, Ligresti G, Choi K, Xie T, et al. RNAi screening identifies a mechanosensitive ROCK-JAK2-STAT3 network central to myofibroblast activation. J Cell Sci. 2018;131: pubmed publisher
Zhao Y, Liu N, Miao G, Chen Y, Zhao H, Zhang H. The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis. Curr Biol. 2018;28:1234-1245.e4 pubmed publisher
Coleman J, Mouat M, Wu J, Jancovski N, Bassi J, Chan A, et al. Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control. Biol Sex Differ. 2018;9:14 pubmed publisher
Ghosh R, Roy S, Franco S. PARP1 depletion induces RIG-I-dependent signaling in human cancer cells. PLoS ONE. 2018;13:e0194611 pubmed publisher
Augustin H, McGourty K, Allen M, Adcott J, Wong C, Boucrot E, et al. Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster. Neurobiol Aging. 2018;66:149-157 pubmed publisher
Fan J, Zhao R, Parro C, Zhao W, Chou H, Robert J, et al. Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway. J Lipid Res. 2018;59:830-842 pubmed publisher
Stabell A, Meyerson N, Gullberg R, Gilchrist A, Webb K, Old W, et al. Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir. elife. 2018;7: pubmed publisher
Cheng X, Kim S, Okamoto H, Xin Y, Yancopoulos G, Murphy A, et al. Glucagon contributes to liver zonation. Proc Natl Acad Sci U S A. 2018;115:E4111-E4119 pubmed publisher
Toompuu M, Tuomela T, Laine P, Paulin L, Dufour E, Jacobs H. Polyadenylation and degradation of structurally abnormal mitochondrial tRNAs in human cells. Nucleic Acids Res. 2018;46:5209-5226 pubmed publisher
Tsuchiya M, Ogawa H, Koujin T, Mori C, Osakada H, Kobayashi S, et al. p62/SQSTM1 promotes rapid ubiquitin conjugation to target proteins after endosome rupture during xenophagy. FEBS Open Bio. 2018;8:470-480 pubmed publisher
Hayes M, McCarthy K, Jin A, Oliveira M, Iyer S, Garcia S, et al. Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma. Cell Stem Cell. 2018;22:414-427.e6 pubmed publisher
Sonowal H, Pal P, Shukla K, Saxena A, Srivastava S, Ramana K. Aldose reductase inhibitor, fidarestat prevents doxorubicin-induced endothelial cell death and dysfunction. Biochem Pharmacol. 2018;150:181-190 pubmed publisher
Kuzuya K, Ichihara S, Suzuki Y, Inoue C, Ichihara G, Kurimoto S, et al. Proteomics analysis identified peroxiredoxin 2 involved in early-phase left ventricular impairment in hamsters with cardiomyopathy. PLoS ONE. 2018;13:e0192624 pubmed publisher
Zhang J, Wang L, Zhang Y. Downregulation of NIMA-related kinase-7 inhibits cell proliferation by inducing cell cycle arrest in human retinoblastoma cells. Exp Ther Med. 2018;15:1360-1366 pubmed publisher
Ladanyi A, Mukherjee A, Kenny H, Johnson A, Mitra A, Sundaresan S, et al. Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis. Oncogene. 2018;37:2285-2301 pubmed publisher
Wu X, Zhi F, Lun W, Deng Q, Zhang W. Baicalin inhibits PDGF-BB-induced hepatic stellate cell proliferation, apoptosis, invasion, migration and activation via the miR-3595/ACSL4 axis. Int J Mol Med. 2018;41:1992-2002 pubmed publisher
Ortíz Rentería M, Juárez Contreras R, González Ramírez R, Islas L, Sierra Ramírez F, Llorente I, et al. TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain. Proc Natl Acad Sci U S A. 2018;115:E1657-E1666 pubmed publisher
Reinhardt S, Stoye N, Luderer M, Kiefer F, Schmitt U, Lieb K, et al. Identification of disulfiram as a secretase-modulating compound with beneficial effects on Alzheimer's disease hallmarks. Sci Rep. 2018;8:1329 pubmed publisher
Du X, Zadoorian A, Lukmantara I, Qi Y, Brown A, Yang H. Oxysterol-binding protein-related protein 5 (ORP5) promotes cell proliferation by activation of mTORC1 signaling. J Biol Chem. 2018;293:3806-3818 pubmed publisher
Korczeniewska J, Barnes B. Corrected and Republished from: The COP9 Signalosome Interacts with and Regulates Interferon Regulatory Factor 5 Protein Stability. Mol Cell Biol. 2018;38: pubmed publisher
Hale M, Richardson J, Day R, McConnell O, Arboleda J, Wang E, et al. An engineered RNA binding protein with improved splicing regulation. Nucleic Acids Res. 2018;46:3152-3168 pubmed publisher
Sun X, Gupta K, Wu B, Zhang D, Yuan B, Zhang X, et al. Tumor-extrinsic discoidin domain receptor 1 promotes mammary tumor growth by regulating adipose stromal interleukin 6 production in mice. J Biol Chem. 2018;293:2841-2849 pubmed publisher
Norppa A, Kauppala T, Heikkinen H, Verma B, Iwai H, Frilander M. Mutations in the U11/U12-65K protein associated with isolated growth hormone deficiency lead to structural destabilization and impaired binding of U12 snRNA. RNA. 2018;24:396-409 pubmed publisher
Wu C, Esfandiari A, Ho Y, Wang N, Mahdi A, Aptullahoglu E, et al. Targeting negative regulation of p53 by MDM2 and WIP1 as a therapeutic strategy in cutaneous melanoma. Br J Cancer. 2018;118:495-508 pubmed publisher
Bu Y, Yoshida A, Chitnis N, Altman B, Tameire F, Oran A, et al. A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival. Nat Cell Biol. 2018;20:104-115 pubmed publisher
Hilander T, Zhou X, Konovalova S, Zhang F, Euro L, Chilov D, et al. Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria. Nucleic Acids Res. 2018;46:849-860 pubmed publisher
Sorrentino V, Romani M, Mouchiroud L, Beck J, Zhang H, D Amico D, et al. Enhancing mitochondrial proteostasis reduces amyloid-? proteotoxicity. Nature. 2017;552:187-193 pubmed publisher
Cox N, Unlu G, Bisnett B, Meister T, Condon B, Luo P, et al. Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking Pathway. Biochemistry. 2018;57:91-107 pubmed publisher
Schafer S, Viswanathan S, Widjaja A, Lim W, Moreno Moral A, Delaughter D, et al. IL-11 is a crucial determinant of cardiovascular fibrosis. Nature. 2017;552:110-115 pubmed publisher
Liang C, Chen Q, Yi Q, Zhang M, Yan H, Zhang B, et al. A kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion. EMBO Rep. 2018;19:43-56 pubmed publisher
Suh J, Lai L, Nam D, Kim J, Jo J, Taffet G, et al. Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis. J Biol Chem. 2017;292:21643-21652 pubmed publisher
Sreekumar A, Toneff M, Toh E, Roarty K, Creighton C, Belka G, et al. WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis. Dev Cell. 2017;43:436-448.e6 pubmed publisher
Kopp Y, Lang W, Schuster T, Martínez Limón A, Hofbauer H, Ernst R, et al. CHIP as a membrane-shuttling proteostasis sensor. elife. 2017;6: pubmed publisher
Zhan Y, Guo J, Yang W, Goncalves C, Rzymski T, Dreas A, et al. MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma. J Clin Invest. 2017;127:4179-4192 pubmed publisher
Idica A, Sevrioukov E, Zisoulis D, Hamdorf M, Daugaard I, Kadandale P, et al. MicroRNA miR-128 represses LINE-1 (L1) retrotransposition by down-regulating the nuclear import factor TNPO1. J Biol Chem. 2017;292:20494-20508 pubmed publisher
Chua N, Howe V, Jatana N, Thukral L, Brown A. A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis. J Biol Chem. 2017;292:19959-19973 pubmed publisher
Younan P, Iampietro M, Nishida A, Ramanathan P, Santos R, Dutta M, et al. Ebola Virus Binding to Tim-1 on T Lymphocytes Induces a Cytokine Storm. MBio. 2017;8: pubmed publisher
Diaz J, Morgan C, Minogue C, Hebert A, Coon J, Wells J. A Split-Abl Kinase for Direct Activation in Cells. Cell Chem Biol. 2017;24:1250-1258.e4 pubmed publisher
Chen P, Li D, Chen Y, Sun J, Fu K, Guan L, et al. p53-mediated regulation of bile acid disposition attenuates cholic acid-induced cholestasis in mice. Br J Pharmacol. 2017;174:4345-4361 pubmed publisher
Comiskey D, Jacob A, Sanford B, Montes M, Goodwin A, Steiner H, et al. A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo. Oncogene. 2018;37:95-106 pubmed publisher
Pinniger G, Terrill J, Assan E, Grounds M, Arthur P. Pre-clinical evaluation of N-acetylcysteine reveals side effects in the mdx mouse model of Duchenne muscular dystrophy. J Physiol. 2017;595:7093-7107 pubmed publisher
Bellmaine S, Ovchinnikov D, Manallack D, Cuddy C, Elefanty A, Stanley E, et al. Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells. elife. 2017;6: pubmed publisher
di Pietro F, Valon L, Li Y, Goïame R, Genovesio A, Morin X. An RNAi Screen in a Novel Model of Oriented Divisions Identifies the Actin-Capping Protein Z ? as an Essential Regulator of Spindle Orientation. Curr Biol. 2017;27:2452-2464.e8 pubmed publisher
Li D, Ren Z. Cordyceps sinensis promotes immune regulation and enhances bacteriostatic activity of PA-824 via IL-10 in Mycobacterium tuberculosis disease. Braz J Med Biol Res. 2017;50:e6188 pubmed publisher
Venkat S, Linstedt A. Manganese-induced trafficking and turnover of GPP130 is mediated by sortilin. Mol Biol Cell. 2017;28:2569-2578 pubmed publisher
Tsherniak A, Vazquez F, Montgomery P, Weir B, Kryukov G, Cowley G, et al. Defining a Cancer Dependency Map. Cell. 2017;170:564-576.e16 pubmed publisher
Wurm A, Zjablovskaja P, Kardosova M, Gerloff D, Bräuer Hartmann D, Katzerke C, et al. Disruption of the C/EBP?-miR-182 balance impairs granulocytic differentiation. Nat Commun. 2017;8:46 pubmed publisher
Hsu J, Hubbell Engler B, Adelmant G, Huang J, Joyce C, Vazquez F, et al. PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer. Cancer Res. 2017;77:4613-4625 pubmed publisher
Kaur G, Gras S, Mobbs J, Vivian J, Cortes A, Barber T, et al. Structural and regulatory diversity shape HLA-C protein expression levels. Nat Commun. 2017;8:15924 pubmed publisher
Kim S, Kim H, Park M, Cho S, Goughnour P, Han D, et al. Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells. J Cell Biol. 2017;216:2201-2216 pubmed publisher
Ünlü B, Bogdanov V, Versteeg H. Interplay between alternatively spliced Tissue Factor and full length Tissue Factor in modulating coagulant activity of endothelial cells. Thromb Res. 2017;156:1-7 pubmed publisher
Liang J, Zheng S, Xiao X, Wei J, Zhang Z, Ernberg I, et al. Epstein-Barr virus-encoded LMP2A stimulates migration of nasopharyngeal carcinoma cells via the EGFR/Ca2+/calpain/ITG?4 axis. Biol Open. 2017;6:914-922 pubmed publisher
Mei X, Wang H, Li J, Liu X, Lu X, Li Y, et al. Dusuqing granules (DSQ) suppress inflammation in Klebsiella pneumonia rat via NF-?B/MAPK signaling. BMC Complement Altern Med. 2017;17:216 pubmed publisher
Liu H, Xiong Y, Zhu X, Gao H, Yin S, Wang J, et al. Icariin improves osteoporosis, inhibits the expression of PPAR?, C/EBP?, FABP4 mRNA, N1ICD and jagged1 proteins, and increases Notch2 mRNA in ovariectomized rats. Exp Ther Med. 2017;13:1360-1368 pubmed publisher
Huhn S, Liu J, Ye C, Lu H, Jiang X, Feng X, et al. Regulation of spindle integrity and mitotic fidelity by BCCIP. Oncogene. 2017;36:4750-4766 pubmed publisher
Iwawaki T, Akai R, Toyoshima T, Takeda N, Ishikawa T, Yamamura K. Transgenic mouse model for imaging of ATF4 translational activation-related cellular stress responses in vivo. Sci Rep. 2017;7:46230 pubmed publisher
Besse W, Dong K, Choi J, Punia S, Fedeles S, Choi M, et al. Isolated polycystic liver disease genes define effectors of polycystin-1 function. J Clin Invest. 2017;127:1772-1785 pubmed publisher
Lechuga S, Naydenov N, Feygin A, Jiménez A, Ivanov A. A vesicle trafficking protein αSNAP regulates Paneth cell differentiation in vivo. Biochem Biophys Res Commun. 2017;486:951-957 pubmed publisher
Neuber S, Wagner K, Goldner T, Lischka P, Steinbrueck L, Messerle M, et al. Mutual Interplay between the Human Cytomegalovirus Terminase Subunits pUL51, pUL56, and pUL89 Promotes Terminase Complex Formation. J Virol. 2017;91: pubmed publisher
Lei L, Chen C, Zhao J, Wang H, Guo M, Zhou Y, et al. Targeted Expression of miR-7 Operated by TTF-1 Promoter Inhibited the Growth of Human Lung Cancer through the NDUFA4 Pathway. Mol Ther Nucleic Acids. 2017;6:183-197 pubmed publisher
Romani B, Kavyanifard A, Allahbakhshi E. Functional conservation and coherence of HIV-1 subtype A Vpu alleles. Sci Rep. 2017;7:44894 pubmed publisher
Chung E, Joiner H, Skelton T, Looten K, Manczak M, Reddy P. Maternal exercise upregulates mitochondrial gene expression and increases enzyme activity of fetal mouse hearts. Physiol Rep. 2017;5: pubmed publisher
De Cicco P, Panza E, Armogida C, Ercolano G, Taglialatela Scafati O, Shokoohinia Y, et al. The Hydrogen Sulfide Releasing Molecule Acetyl Deacylasadisulfide Inhibits Metastatic Melanoma. Front Pharmacol. 2017;8:65 pubmed publisher
Guix F, Sannerud R, Berditchevski F, Arranz A, Horré K, Snellinx A, et al. Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments. Mol Neurodegener. 2017;12:25 pubmed publisher
Mosialou I, Shikhel S, Liu J, Maurizi A, Luo N, He Z, et al. MC4R-dependent suppression of appetite by bone-derived lipocalin 2. Nature. 2017;543:385-390 pubmed publisher
Zhang X, Li J, Qin J, Cheng W, Zhu X, Gong F, et al. Oncostatin M receptor β deficiency attenuates atherogenesis by inhibiting JAK2/STAT3 signaling in macrophages. J Lipid Res. 2017;58:895-906 pubmed publisher
Day P, Thompson C, Lowy D, Schiller J. Interferon Gamma Prevents Infectious Entry of Human Papillomavirus 16 via an L2-Dependent Mechanism. J Virol. 2017;91: pubmed publisher
Hägglund A, Jones I, Carlsson L. A novel mouse model of anterior segment dysgenesis (ASD): conditional deletion of Tsc1 disrupts ciliary body and iris development. Dis Model Mech. 2017;10:245-257 pubmed publisher
Nechemia Arbely Y, Fachinetti D, Miga K, Sekulic N, Soni G, Kim D, et al. Human centromeric CENP-A chromatin is a homotypic, octameric nucleosome at all cell cycle points. J Cell Biol. 2017;216:607-621 pubmed publisher
Moran C, Seto S, Krishna S, Sharma S, Jose R, Biros E, et al. Parenteral administration of factor Xa/IIa inhibitors limits experimental aortic aneurysm and atherosclerosis. Sci Rep. 2017;7:43079 pubmed publisher
Yang Y, Hu S, Liu J, Cui Y, Fan Y, Lv T, et al. CD8+ T cells promote proliferation of benign prostatic hyperplasia epithelial cells under low androgen level via modulation of CCL5/STAT5/CCND1 signaling pathway. Sci Rep. 2017;7:42893 pubmed publisher
Chowdhury A, Hasselbach L, Echtermeyer F, Jyotsana N, Theilmeier G, Herzog C. Fibulin-6 regulates pro-fibrotic TGF-β responses in neonatal mouse ventricular cardiac fibroblasts. Sci Rep. 2017;7:42725 pubmed publisher
Zieba J, Zhang W, Chong J, Forlenza K, Martin J, Heard K, et al. A postnatal role for embryonic myosin revealed by MYH3 mutations that alter TGFβ signaling and cause autosomal dominant spondylocarpotarsal synostosis. Sci Rep. 2017;7:41803 pubmed publisher
Dingjan I, Linders P, van den Bekerom L, Baranov M, Halder P, ter Beest M, et al. Oxidized phagosomal NOX2 complex is replenished from lysosomes. J Cell Sci. 2017;130:1285-1298 pubmed publisher
Fremont R, Tewari A, Angueyra C, Khodakhah K. A role for cerebellum in the hereditary dystonia DYT1. elife. 2017;6: pubmed publisher
Gemmink A, Bakker L, Guigas B, Kornips E, Schaart G, Meinders A, et al. Lipid droplet dynamics and insulin sensitivity upon a 5-day high-fat diet in Caucasians and South Asians. Sci Rep. 2017;7:42393 pubmed publisher
Lau H, Tang J, Casey P, Wang M. Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms. Oncogene. 2017;36:3934-3942 pubmed publisher
Rothhammer V, Kenison J, Tjon E, Takenaka M, de Lima K, Borucki D, et al. Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation. Proc Natl Acad Sci U S A. 2017;114:2012-2017 pubmed publisher
Luk C, Shi S, Cai E, Sivasubramaniyam T, Krishnamurthy M, Brunt J, et al. FAK signalling controls insulin sensitivity through regulation of adipocyte survival. Nat Commun. 2017;8:14360 pubmed publisher
Chavan H, Christudoss P, Mickey K, Tessman R, Ni H, Swerdlow R, et al. Arsenite Effects on Mitochondrial Bioenergetics in Human and Mouse Primary Hepatocytes Follow a Nonlinear Dose Response. Oxid Med Cell Longev. 2017;2017:9251303 pubmed publisher
Bakshi S, Taylor J, Strickson S, McCartney T, Cohen P. Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon ?. Biochem J. 2017;474:1163-1174 pubmed publisher
Nie Y, Chen H, Guo C, Yuan Z, Zhou X, Zhang Y, et al. Palmdelphin promotes myoblast differentiation and muscle regeneration. Sci Rep. 2017;7:41608 pubmed publisher
Zeng H, Jiang Y, Chen P, Fan X, Li D, Liu A, et al. Schisandrol B protects against cholestatic liver injury through pregnane X receptors. Br J Pharmacol. 2017;174:672-688 pubmed publisher
Qin M, Zhang J, Xu C, Peng P, Tan L, Liu S, et al. Knockdown of NIK and IKK?-Binding Protein (NIBP) Reduces Colorectal Cancer Metastasis through Down-Regulation of the Canonical NF-?? Signaling Pathway and Suppression of MAPK Signaling Mediated through ERK and JNK. PLoS ONE. 2017;12:e0170595 pubmed publisher
Stayte S, Rentsch P, Tröscher A, Bamberger M, Li K, Vissel B. Activin A Inhibits MPTP and LPS-Induced Increases in Inflammatory Cell Populations and Loss of Dopamine Neurons in the Mouse Midbrain In Vivo. PLoS ONE. 2017;12:e0167211 pubmed publisher
Jahny E, Yang H, Liu B, Jahnke B, Lademann F, Knösel T, et al. The G Protein-Coupled Receptor RAI3 Is an Independent Prognostic Factor for Pancreatic Cancer Survival and Regulates Proliferation via STAT3 Phosphorylation. PLoS ONE. 2017;12:e0170390 pubmed publisher
Das S, Jackson W, Prasain J, Hanna A, Bailey S, Tucker J, et al. Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling. Sci Rep. 2017;7:40773 pubmed publisher
Kanuri B, Kanshana J, Rebello S, Pathak P, Gupta A, Gayen J, et al. Altered glucose and lipid homeostasis in liver and adipose tissue pre-dispose inducible NOS knockout mice to insulin resistance. Sci Rep. 2017;7:41009 pubmed publisher
Tse B, Volpert M, Ratther E, Stylianou N, Nouri M, McGowan K, et al. Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality. Oncogene. 2017;36:3417-3427 pubmed publisher
Tschurtschenthaler M, Adolph T, Ashcroft J, Niederreiter L, Bharti R, Saveljeva S, et al. Defective ATG16L1-mediated removal of IRE1? drives Crohn's disease-like ileitis. J Exp Med. 2017;214:401-422 pubmed publisher
Sendoel A, Dunn J, Rodriguez E, Naik S, Gomez N, Hurwitz B, et al. Translation from unconventional 5' start sites drives tumour initiation. Nature. 2017;541:494-499 pubmed publisher
Shen X, Jia Z, D Alonzo D, Wang X, Bruder E, Emch F, et al. HECTD1 controls the protein level of IQGAP1 to regulate the dynamics of adhesive structures. Cell Commun Signal. 2017;15:2 pubmed publisher
Gallo A, Lampe M, Gunther T, Brune W. The Viral Bcl-2 Homologs of Kaposi's Sarcoma-Associated Herpesvirus and Rhesus Rhadinovirus Share an Essential Role for Viral Replication. J Virol. 2017;91: pubmed publisher
Hu F, Sun B, Xu P, Zhu Y, Meng X, Teng G, et al. MiR-218 Induces Neuronal Differentiation of ASCs in a Temporally Sequential Manner with Fibroblast Growth Factor by Regulation of the Wnt Signaling Pathway. Sci Rep. 2017;7:39427 pubmed publisher
Thakar K, May C, Rogers A, Carroll C. Opposing roles for distinct LINC complexes in regulation of the small GTPase RhoA. Mol Biol Cell. 2017;28:182-191 pubmed publisher
Stabell A, Hawkins J, Li M, Gao X, David M, Press W, et al. Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins. PLoS Pathog. 2016;12:e1006066 pubmed publisher
Pomeroy E, Lee L, Lee R, Schirm D, Temiz N, Ma J, et al. Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia. Oncogene. 2017;36:3263-3273 pubmed publisher
Chung H, Ryu D, Kim K, Chang J, Kim Y, Yi H, et al. Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. J Cell Biol. 2017;216:149-165 pubmed publisher
Wang H, Wu S, Huang S, Yin S, Zou G, Huang K, et al. Follistatin-like protein 1 contributes to dendritic cell and T-lymphocyte activation in nasopharyngeal carcinoma patients by altering nuclear factor κb and Jun N-terminal kinase expression. Cell Biochem Funct. 2016;34:554-562 pubmed publisher
Ellinger J, Gromes A, Poss M, Brüggemann M, Schmidt D, Ellinger N, et al. Systematic expression analysis of the mitochondrial complex III subunits identifies UQCRC1 as biomarker in clear cell renal cell carcinoma. Oncotarget. 2016;7:86490-86499 pubmed publisher
Shen X, Wang M, Bi X, Zhang J, Wen S, Fu G, et al. Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR??/HO?1 pathways. Mol Med Rep. 2016;14:5528-5534 pubmed publisher
Rodríguez Martínez E, Nava Ruíz C, Escamilla Chimal E, Borgonio Perez G, Rivas Arancibia S. The Effect of Chronic Ozone Exposure on the Activation of Endoplasmic Reticulum Stress and Apoptosis in Rat Hippocampus. Front Aging Neurosci. 2016;8:245 pubmed
Baron L, Paatero A, Morel J, Impens F, Guenin Macé L, Saint Auret S, et al. Mycolactone subverts immunity by selectively blocking the Sec61 translocon. J Exp Med. 2016;213:2885-2896 pubmed
Tada H, Miyazaki T, Takemoto K, Takase K, Jitsuki S, Nakajima W, et al. Neonatal isolation augments social dominance by altering actin dynamics in the medial prefrontal cortex. Proc Natl Acad Sci U S A. 2016;113:E7097-E7105 pubmed publisher
Fulcher L, MacArtney T, Bozatzi P, Hornberger A, Rojas Fernandez A, Sapkota G. An affinity-directed protein missile system for targeted proteolysis. Open Biol. 2016;6: pubmed
Andrade A, Hope J, Allen A, Yorgan V, Lipscombe D, Pan J. A rare schizophrenia risk variant of CACNA1I disrupts CaV3.3 channel activity. Sci Rep. 2016;6:34233 pubmed publisher
Xie Y, Tao W, Yang T, Qiao J. Anticancer effect of cucurbitacin B on MKN-45 cells via inhibition of the JAK2/STAT3 signaling pathway. Exp Ther Med. 2016;12:2709-2715 pubmed
Wang P, Liu X, Xu P, Lu J, Wang R, Mu W. Decorin reduces hypertrophic scarring through inhibition of the TGF-?1/Smad signaling pathway in a rat osteomyelitis model. Exp Ther Med. 2016;12:2102-2108 pubmed
Adams S, Yang H, Savariar E, Aguilera J, Crisp J, Jones K, et al. Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize. Nat Commun. 2016;7:13019 pubmed publisher
Uo T, Dvinge H, Sprenger C, Bradley R, Nelson P, Plymate S. Systematic and functional characterization of novel androgen receptor variants arising from alternative splicing in the ligand-binding domain. Oncogene. 2017;36:1440-1450 pubmed publisher
Rahman N, Ramos Espiritu L, Milner T, Buck J, Levin L. Soluble adenylyl cyclase is essential for proper lysosomal acidification. J Gen Physiol. 2016;148:325-39 pubmed publisher
Chen B, Zeng X, He Y, Wang X, Liang Z, Liu J, et al. STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways. Oncotarget. 2016;7:71400-71416 pubmed publisher
Kojima K, Maeda A, Yoshimura M, Nishida Y, Kimura S. The pathophysiological significance of PPM1D and therapeutic targeting of PPM1D-mediated signaling by GSK2830371 in mantle cell lymphoma. Oncotarget. 2016;7:69625-69637 pubmed publisher
Marques F, Tenney J, Durán I, Martin J, Nevarez L, Pogue R, et al. Altered mRNA Splicing, Chondrocyte Gene Expression and Abnormal Skeletal Development due to SF3B4 Mutations in Rodriguez Acrofacial Dysostosis. PLoS Genet. 2016;12:e1006307 pubmed publisher
Halevy T, Biancotti J, Yanuka O, Golan Lev T, Benvenisty N. Molecular Characterization of Down Syndrome Embryonic Stem Cells Reveals a Role for RUNX1 in Neural Differentiation. Stem Cell Reports. 2016;7:777-786 pubmed publisher
Katsyv I, Wang M, Song W, Zhou X, Zhao Y, Park S, et al. EPRS is a critical regulator of cell proliferation and estrogen signaling in ER+ breast cancer. Oncotarget. 2016;7:69592-69605 pubmed publisher
Feng D, Yan K, Zhou Y, Liang H, Liang J, Zhao W, et al. Piwil2 is reactivated by HPV oncoproteins and initiates cell reprogramming via epigenetic regulation during cervical cancer tumorigenesis. Oncotarget. 2016;7:64575-64588 pubmed publisher
Eckfeldt C, Pomeroy E, Lee R, Hazen K, Lee L, Moriarity B, et al. RALB provides critical survival signals downstream of Ras in acute myeloid leukemia. Oncotarget. 2016;7:65147-65156 pubmed publisher
Romani B, Kamali Jamil R, Hamidi Fard M, Rahimi P, Momen S, Aghasadeghi M, et al. HIV-1 Vpr reactivates latent HIV-1 provirus by inducing depletion of class I HDACs on chromatin. Sci Rep. 2016;6:31924 pubmed publisher
Tjomsland V, Sandnes D, Pomianowska E, Cizmovic S, Aasrum M, Brusevold I, et al. The TGFβ-SMAD3 pathway inhibits IL-1α induced interactions between human pancreatic stellate cells and pancreatic carcinoma cells and restricts cancer cell migration. J Exp Clin Cancer Res. 2016;35:122 pubmed publisher
Zhao W, Xu H. High expression of TRPM8 predicts poor prognosis in patients with osteosarcoma. Oncol Lett. 2016;12:1373-1379 pubmed
Han R, Huang S, Bao Y, Liu X, Peng X, Chen Z, et al. Upregulation of SOX4 antagonizes cellular senescence in esophageal squamous cell carcinoma. Oncol Lett. 2016;12:1367-1372 pubmed
Zhang Y, Xue Y, Liu Y, Song G, Lv G, Wang Y, et al. MicroRNA-146a expression inhibits the proliferation and promotes the apoptosis of bronchial smooth muscle cells in asthma by directly targeting the epidermal growth factor receptor. Exp Ther Med. 2016;12:854-858 pubmed
Rodríguez Nieves J, Patalano S, Almanza D, Gharaee Kermani M, Macoska J. CXCL12/CXCR4 Axis Activation Mediates Prostate Myofibroblast Phenoconversion through Non-Canonical EGFR/MEK/ERK Signaling. PLoS ONE. 2016;11:e0159490 pubmed publisher
Watson A, Hopkins G, Hitchin S, Begum H, Jones S, Jordan A, et al. Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade. F1000Res. 2016;5:1005 pubmed publisher
Steven A, Leisz S, Sychra K, Hiebl B, Wickenhauser C, Mougiakakos D, et al. Hypoxia-mediated alterations and their role in the HER-2/neuregulated CREB status and localization. Oncotarget. 2016;7:52061-52084 pubmed publisher
Sommer A, Hermawan A, Mickler F, Ljepoja B, Knyazev P, Bräuchle C, et al. Salinomycin co-treatment enhances tamoxifen cytotoxicity in luminal A breast tumor cells by facilitating lysosomal degradation of receptor tyrosine kinases. Oncotarget. 2016;7:50461-50476 pubmed publisher
Laurens C, Badin P, Louche K, Mairal A, Tavernier G, Marette A, et al. G0/G1 Switch Gene 2 controls adipose triglyceride lipase activity and lipid metabolism in skeletal muscle. Mol Metab. 2016;5:527-537 pubmed publisher
Klatte Schulz F, Giese G, Differ C, Minkwitz S, Ruschke K, Puts R, et al. An investigation of BMP-7 mediated alterations to BMP signalling components in human tenocyte-like cells. Sci Rep. 2016;6:29703 pubmed publisher
Dai J, Sun C, Yao Z, Chen W, Yu L, Long M. Exposure to concentrated ambient fine particulate matter disrupts vascular endothelial cell barrier function via the IL-6/HIF-1? signaling pathway. FEBS Open Bio. 2016;6:720-8 pubmed publisher
Hatem R, El Botty R, Chateau Joubert S, Servely J, Labiod D, de Plater L, et al. Targeting mTOR pathway inhibits tumor growth in different molecular subtypes of triple-negative breast cancers. Oncotarget. 2016;7:48206-48219 pubmed publisher
Cocco E, Lopez S, Black J, Bellone S, Bonazzoli E, Predolini F, et al. Dual CCNE1/PIK3CA targeting is synergistic in CCNE1-amplified/PIK3CA-mutated uterine serous carcinomas in vitro and in vivo. Br J Cancer. 2016;115:303-11 pubmed publisher
Xia L, Wu Y, Ma J, Yang J, Zhang F. The antibacterial peptide from Bombyx mori cecropinXJ induced growth arrest and apoptosis in human hepatocellular carcinoma cells. Oncol Lett. 2016;12:57-62 pubmed
Zhang Q, Ma S, Liu B, Liu J, Zhu R, Li M. Chrysin induces cell apoptosis via activation of the p53/Bcl-2/caspase-9 pathway in hepatocellular carcinoma cells. Exp Ther Med. 2016;12:469-474 pubmed
Zhou Y, Huang R, Lin J, Xu Y, He X, He Y. Bushen-Qiangdu-Zhilv decoction inhibits osteogenic differentiation of rat fibroblasts by regulating connexin 43. Exp Ther Med. 2016;12:347-353 pubmed
Chen G, Wang C, Wang J, Yin S, Gao H, Xiang L, et al. Antiosteoporotic effect of icariin in ovariectomized rats is mediated via the Wnt/?-catenin pathway. Exp Ther Med. 2016;12:279-287 pubmed
Zhang H, Li L, Wang Y, Dong F, Chen X, Liu F, et al. NF-?B signaling maintains the survival of cadmium-exposed human renal glomerular endothelial cells. Int J Mol Med. 2016;38:417-22 pubmed publisher
Chan W, Ismail H, Mayaki D, Sanchez V, Tiedemann K, Davis E, et al. Fibulin-5 Regulates Angiopoietin-1/Tie-2 Receptor Signaling in Endothelial Cells. PLoS ONE. 2016;11:e0156994 pubmed publisher
Zhao Y, Wang W, Guo S, Wang Y, Miao L, Xiong Y, et al. PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery. Nat Commun. 2016;7:11822 pubmed publisher
Eriksson O, Thulin A, Asplund A, Hegde G, Navani S, Siegbahn A. Cross-talk between the Tissue Factor/coagulation factor VIIa complex and the tyrosine kinase receptor EphA2 in cancer. BMC Cancer. 2016;16:341 pubmed publisher
Habener A, Chowdhury A, Echtermeyer F, Lichtinghagen R, Theilmeier G, Herzog C. MitoNEET Protects HL-1 Cardiomyocytes from Oxidative Stress Mediated Apoptosis in an In Vitro Model of Hypoxia and Reoxygenation. PLoS ONE. 2016;11:e0156054 pubmed publisher
Torrano V, Valcarcel Jimenez L, Cortazar A, Liu X, Urosevic J, Castillo Martin M, et al. The metabolic co-regulator PGC1α suppresses prostate cancer metastasis. Nat Cell Biol. 2016;18:645-656 pubmed publisher
Schmidt K, Joyce C, Buquicchio F, Brown A, Ritz J, Distel R, et al. The lncRNA SLNCR1 Mediates Melanoma Invasion through a Conserved SRA1-like Region. Cell Rep. 2016;15:2025-37 pubmed publisher
Chen C, Dienhart J, Bolton E. Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells. PLoS ONE. 2016;11:e0156145 pubmed publisher
Knudsen J, Joensen E, Bertholdt L, Jessen H, van Hauen L, Hidalgo J, et al. Skeletal muscle IL-6 and regulation of liver metabolism during high-fat diet and exercise training. Physiol Rep. 2016;4: pubmed publisher
Shi Q, Wang W, Jia Z, Chen P, Ma K, Zhou C. ISL1, a novel regulator of CCNB1, CCNB2 and c-MYC genes, promotes gastric cancer cell proliferation and tumor growth. Oncotarget. 2016;7:36489-36500 pubmed publisher
Gao J, Fu S, Zeng Z, Li F, Niu Q, Jing D, et al. Cyclic stretch promotes osteogenesis-related gene expression in osteoblast-like cells through a cofilin-associated mechanism. Mol Med Rep. 2016;14:218-24 pubmed publisher
Liu B, Shi Y, Peng W, Zhang Q, Liu J, Chen N, et al. Diosmetin induces apoptosis by upregulating p53 via the TGF-? signal pathway in HepG2 hepatoma cells. Mol Med Rep. 2016;14:159-64 pubmed publisher
Langlands H, Blain P, Jowsey P. Fe65 Is Phosphorylated on Ser289 after UV-Induced DNA Damage. PLoS ONE. 2016;11:e0155056 pubmed publisher
Guo L, Rolfe A, Wang X, Tai W, Cheng Z, Cao K, et al. Rescuing macrophage normal function in spinal cord injury with embryonic stem cell conditioned media. Mol Brain. 2016;9:48 pubmed publisher
Zhang C, Weng Y, Shi F, Jin W. The Engrailed-1 Gene Stimulates Brown Adipogenesis. Stem Cells Int. 2016;2016:7369491 pubmed publisher
Holler M, Grottke A, Mueck K, Manes J, Jücker M, Rodemann H, et al. Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells. PLoS ONE. 2016;11:e0154745 pubmed publisher
Wei M, Xie Q, Zhu J, Wang T, Zhang F, Cheng Y, et al. MicroRNA-33 suppresses CCL2 expression in chondrocytes. Biosci Rep. 2016;36: pubmed publisher
Pei Y, Tao R, Li J, Su L, Yu B, Wu X, et al. TET1 inhibits gastric cancer growth and metastasis by PTEN demethylation and re-expression. Oncotarget. 2016;7:31322-35 pubmed publisher
Barquissau V, Beuzelin D, Pisani D, Beranger G, Mairal A, Montagner A, et al. White-to-brite conversion in human adipocytes promotes metabolic reprogramming towards fatty acid anabolic and catabolic pathways. Mol Metab. 2016;5:352-365 pubmed publisher
Feng F, Zhang Y, Kothari V, Evans J, Jackson W, Chen W, et al. MDM2 Inhibition Sensitizes Prostate Cancer Cells to Androgen Ablation and Radiotherapy in a p53-Dependent Manner. Neoplasia. 2016;18:213-22 pubmed publisher
Li N, Liu S, Zhang H, Deng Z, Zhao H, Zhao Q, et al. Exogenous R-Spondin1 Induces Precocious Telogen-to-Anagen Transition in Mouse Hair Follicles. Int J Mol Sci. 2016;17: pubmed publisher
Shi Y, Li Y, Huang C, Ying L, Xue J, Wu H, et al. Resveratrol enhances HBV replication through activating Sirt1-PGC-1?-PPAR? pathway. Sci Rep. 2016;6:24744 pubmed publisher
Huang J, Chen L, Yao Y, Tang C, Ding J, Fu C, et al. Pivotal Role of Regulator of G-protein Signaling 12 in Pathological Cardiac Hypertrophy. Hypertension. 2016;67:1228-36 pubmed publisher
Liang H, Zhang Q, Lu J, Yang G, Tian N, Wang X, et al. MSX2 Induces Trophoblast Invasion in Human Placenta. PLoS ONE. 2016;11:e0153656 pubmed publisher
Papangeli I, Kim J, Maier I, Park S, Lee A, Kang Y, et al. MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation. Nat Commun. 2016;7:11268 pubmed publisher
Ronpirin C, Pattarachotanant N, Tencomnao T. Protective Effect of Mangifera indica Linn., Cocos nucifera Linn., and Averrhoa carambola Linn. Extracts against Ultraviolet B-Induced Damage in Human Keratinocytes. Evid Based Complement Alternat Med. 2016;2016:1684794 pubmed publisher
Xia X, Che Y, Gao Y, Zhao S, Ao C, Yang H, et al. Arginine Supplementation Recovered the IFN-?-Mediated Decrease in Milk Protein and Fat Synthesis by Inhibiting the GCN2/eIF2? Pathway, Which Induces Autophagy in Primary Bovine Mammary Epithelial Cells. Mol Cells. 2016;39:410-7 pubmed publisher
Zieba J, Forlenza K, Khatra J, Sarukhanov A, Durán I, Rigueur D, et al. TGF? and BMP Dependent Cell Fate Changes Due to Loss of Filamin B Produces Disc Degeneration and Progressive Vertebral Fusions. PLoS Genet. 2016;12:e1005936 pubmed publisher
Connell J, Allison R, Reid E. Quantitative Gait Analysis Using a Motorized Treadmill System Sensitively Detects Motor Abnormalities in Mice Expressing ATPase Defective Spastin. PLoS ONE. 2016;11:e0152413 pubmed publisher
Jacques C, Lamoureux F, Baud huin M, Rodriguez Calleja L, Quillard T, Amiaud J, et al. Targeting the epigenetic readers in Ewing sarcoma inhibits the oncogenic transcription factor EWS/Fli1. Oncotarget. 2016;7:24125-40 pubmed publisher
Tuand K, Stijnen P, Volders K, Declercq J, Nuytens K, Meulemans S, et al. Nuclear Localization of the Autism Candidate Gene Neurobeachin and Functional Interaction with the NOTCH1 Intracellular Domain Indicate a Role in Regulating Transcription. PLoS ONE. 2016;11:e0151954 pubmed publisher
Mediavilla Varela M, Boateng K, Noyes D, Antonia S. The anti-fibrotic agent pirfenidone synergizes with cisplatin in killing tumor cells and cancer-associated fibroblasts. BMC Cancer. 2016;16:176 pubmed publisher
Kim M, Kogan N, Slack F. Cis-acting elements in its 3' UTR mediate post-transcriptional regulation of KRAS. Oncotarget. 2016;7:11770-84 pubmed publisher
Zhu X, Li D, Yu F, Jia C, Xie J, Ma Y, et al. miR-194 inhibits the proliferation, invasion, migration, and enhances the chemosensitivity of non-small cell lung cancer cells by targeting forkhead box A1 protein. Oncotarget. 2016;7:13139-52 pubmed publisher
Jing X, Ou C, Chen H, Wang T, Xu B, Lu S, et al. Electroacupuncture Reduces Weight Gain Induced by Rosiglitazone through PPARγ and Leptin Receptor in CNS. Evid Based Complement Alternat Med. 2016;2016:8098561 pubmed publisher
Harris D, Chandrasekharan U, Bandyopadhyay S, Willard B, DiCorleto P. PRMT5-Mediated Methylation of NF-κB p65 at Arg174 Is Required for Endothelial CXCL11 Gene Induction in Response to TNF-α and IFN-γ Costimulation. PLoS ONE. 2016;11:e0148905 pubmed publisher
Wei Z, Liang C, Feng D, Cheng Y, Wang W, Yang D, et al. Low tristetraprolin expression promotes cell proliferation and predicts poor patients outcome in pancreatic cancer. Oncotarget. 2016;7:17737-50 pubmed publisher
D Amato Brito C, Cipriano D, Colin D, Germain S, Seimbille Y, Robert J, et al. Role of MIF/CD74 signaling pathway in the development of pleural mesothelioma. Oncotarget. 2016;7:11512-25 pubmed publisher
Schrödter S, Braun M, Syring I, Klümper N, Deng M, Schmidt D, et al. Identification of the dopamine transporter SLC6A3 as a biomarker for patients with renal cell carcinoma. Mol Cancer. 2016;15:10 pubmed publisher
Chung S, Moon H, Kim D, Cho K, Ju H, Kim D, et al. Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background. BMC Gastroenterol. 2016;16:13 pubmed publisher
Lu X, Zhou C, Li R, Liang Z, Zhai W, Zhao L, et al. Critical role for the long non-coding RNA AFAP1-AS1 in the proliferation and metastasis of hepatocellular carcinoma. Tumour Biol. 2016;37:9699-707 pubmed publisher
Huang T, Kang W, Zhang B, Wu F, Dong Y, Tong J, et al. miR-508-3p concordantly silences NFKB1 and RELA to inactivate canonical NF-κB signaling in gastric carcinogenesis. Mol Cancer. 2016;15:9 pubmed publisher
Albert V, Svensson K, Shimobayashi M, Colombi M, Munoz S, Jimenez V, et al. mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue. EMBO Mol Med. 2016;8:232-46 pubmed publisher
Lu F, Chen H, Kossenkov A, DeWispeleare K, Won K, Lieberman P. EBNA2 Drives Formation of New Chromosome Binding Sites and Target Genes for B-Cell Master Regulatory Transcription Factors RBP-jκ and EBF1. PLoS Pathog. 2016;12:e1005339 pubmed publisher
de Matos Neto E, Lima J, de Pereira W, Figuerêdo R, Riccardi D, Radloff K, et al. Systemic Inflammation in Cachexia - Is Tumor Cytokine Expression Profile the Culprit?. Front Immunol. 2015;6:629 pubmed publisher
Lee K, Hsieh Y, Yang Y, Chan C, Huang Y, Lin H. Aliskiren Reduces Hepatic steatosis and Epididymal Fat Mass and Increases Skeletal Muscle Insulin Sensitivity in High-Fat Diet-Fed Mice. Sci Rep. 2016;6:18899 pubmed publisher
Romagnolo D, Papoutsis A, LAUKAITIS C, Selmin O. Constitutive expression of AhR and BRCA-1 promoter CpG hypermethylation as biomarkers of ERα-negative breast tumorigenesis. BMC Cancer. 2015;15:1026 pubmed publisher
Cheng C, Cheng Y, Chang I, Chen H, Wu C, Hsieh C. Dodecyl gallate induces apoptosis by upregulating the caspase-dependent apoptotic pathway and inhibiting the expression of anti-apoptotic Bcl-2 family proteins in human osteosarcoma cells. Mol Med Rep. 2016;13:1495-500 pubmed publisher
Zheng R, You Z, Jia J, Lin S, Han S, Liu A, et al. Curcumin enhances the antitumor effect of ABT-737 via activation of the ROS-ASK1-JNK pathway in hepatocellular carcinoma cells. Mol Med Rep. 2016;13:1570-6 pubmed publisher
Zhang P, Li G, Deng Z, Liu L, Chen L, Tang J, et al. Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents. Nucleic Acids Res. 2016;44:3629-42 pubmed publisher
Han S, Bui N, Ho M, Kim Y, Cho M, Shin D. Dexamethasone Inhibits TGF-β1-Induced Cell Migration by Regulating the ERK and AKT Pathways in Human Colon Cancer Cells Via CYR61. Cancer Res Treat. 2016;48:1141-53 pubmed publisher
Drummond R, Collar A, Swamydas M, Rodriguez C, Lim J, Mendez L, et al. CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System. PLoS Pathog. 2015;11:e1005293 pubmed publisher
Vural A, Al Khodor S, Cheung G, Shi C, Srinivasan L, McQuiston T, et al. Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection. J Immunol. 2016;196:846-56 pubmed publisher
Zeng Z, Yin X, Zhang X, Jing D, Feng X. Cyclic stretch enhances bone morphogenetic protein-2-induced osteoblastic differentiation through the inhibition of Hey1. Int J Mol Med. 2015;36:1273-81 pubmed publisher
Borodkina A, Shatrova A, Deryabin P, Grukova A, Nikolsky N, Burova E. Tetraploidization or autophagy: The ultimate fate of senescent human endometrial stem cells under ATM or p53 inhibition. Cell Cycle. 2016;15:117-27 pubmed publisher
Tirosh O, Cohen Y, Shitrit A, Shani O, Le Trilling V, Trilling M, et al. The Transcription and Translation Landscapes during Human Cytomegalovirus Infection Reveal Novel Host-Pathogen Interactions. PLoS Pathog. 2015;11:e1005288 pubmed publisher
Salinas E, Byrum S, Moreland L, Mackintosh S, Tackett A, Forrest J. Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication. J Virol. 2016;90:1397-413 pubmed publisher
Lowin T, Apitz M, Anders S, Straub R. Anti-inflammatory effects of N-acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX-2 dependent manner. Arthritis Res Ther. 2015;17:321 pubmed publisher
Chen R, Zhang G, Garfield S, Shi Y, Chen K, Robey P, et al. Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States. PLoS ONE. 2015;10:e0142554 pubmed publisher
Ren H, Zhang P, Tang Y, Wu M, Zhang W. Forkhead box protein A1 is a prognostic predictor and promotes tumor growth of gastric cancer. Onco Targets Ther. 2015;8:3029-39 pubmed publisher
Friedman A, Amzallag A, Pruteanu Malinici I, Baniya S, Cooper Z, Piris A, et al. Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment. PLoS ONE. 2015;10:e0140310 pubmed publisher
Lakshmanan A, Scarberry D, Green J, Zhang X, Selmi Ruby S, Jhiang S. Modulation of thyroidal radioiodide uptake by oncological pipeline inhibitors and Apigenin. Oncotarget. 2015;6:31792-804 pubmed publisher
Martin E, Buzza M, Driesbaugh K, Liu S, Fortenberry Y, Leppla S, et al. Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden. Oncotarget. 2015;6:33534-53 pubmed publisher
Sun H, Damez Werno D, Scobie K, Shao N, Dias C, Rabkin J, et al. ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior. Nat Med. 2015;21:1146-53 pubmed publisher
Kim Y, Chen C, Bolton E. Androgen Receptor-Mediated Growth Suppression of HPr-1AR and PC3-Lenti-AR Prostate Epithelial Cells. PLoS ONE. 2015;10:e0138286 pubmed publisher
Brusgard J, Choe M, Chumsri S, Renoud K, MacKerell A, Sudol M, et al. RUNX2 and TAZ-dependent signaling pathways regulate soluble E-Cadherin levels and tumorsphere formation in breast cancer cells. Oncotarget. 2015;6:28132-50 pubmed publisher
Miao H, Chen L, Hao L, Zhang X, Chen Y, Ruan Z, et al. Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes. Sci Rep. 2015;5:13092 pubmed publisher
Newton P, Vuppalapati K, Bouderlique T, Chagin A. Pharmacological inhibition of lysosomes activates the MTORC1 signaling pathway in chondrocytes in an autophagy-independent manner. Autophagy. 2015;11:1594-607 pubmed publisher
Mulcahy M, Blattman S, Barrantes F, Lukas R, Hawrot E. Resistance to Inhibitors of Cholinesterase 3 (Ric-3) Expression Promotes Selective Protein Associations with the Human α7-Nicotinic Acetylcholine Receptor Interactome. PLoS ONE. 2015;10:e0134409 pubmed publisher
Zeng Z, Jing D, Zhang X, Duan Y, Xue F. Cyclic mechanical stretch promotes energy metabolism in osteoblast-like cells through an mTOR signaling-associated mechanism. Int J Mol Med. 2015;36:947-56 pubmed publisher
Wang K, Li N, Yeung C, Cooper T, Liu X, Liu J, et al. Comparison of gene expression of the oncogenic Wnt/β-catenin signaling pathway components in the mouse and human epididymis. Asian J Androl. 2015;17:1006-11 pubmed publisher
Song M, Ryoo I, Choi H, Choi B, Kim S, Heo T, et al. NRF2 Signaling Negatively Regulates Phorbol-12-Myristate-13-Acetate (PMA)-Induced Differentiation of Human Monocytic U937 Cells into Pro-Inflammatory Macrophages. PLoS ONE. 2015;10:e0134235 pubmed publisher
Shao Z, Bao Q, Jiang F, Qian H, Fang Q, Hu X. VS-5584, a Novel PI3K-mTOR Dual Inhibitor, Inhibits Melanoma Cell Growth In Vitro and In Vivo. PLoS ONE. 2015;10:e0132655 pubmed publisher
Kamata S, Akahoshi N, Ishii I. 2D DIGE proteomic analysis highlights delayed postnatal repression of α-fetoprotein expression in homocystinuria model mice. FEBS Open Bio. 2015;5:535-41 pubmed publisher
Pencik J, Schlederer M, Gruber W, Unger C, Walker S, Chalaris A, et al. STAT3 regulated ARF expression suppresses prostate cancer metastasis. Nat Commun. 2015;6:7736 pubmed publisher
Grosser C, Wagner N, Grothaus K, Horsthemke B. Altering TET dioxygenase levels within physiological range affects DNA methylation dynamics of HEK293 cells. Epigenetics. 2015;10:819-33 pubmed publisher
Greene N, Lee D, Brown J, Rosa M, Brown L, Perry R, et al. Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice. Physiol Rep. 2015;3: pubmed publisher
García Pérez D, Laorden M, Milanés M. Regulation of Pleiotrophin, Midkine, Receptor Protein Tyrosine Phosphatase β/ζ, and Their Intracellular Signaling Cascades in the Nucleus Accumbens During Opiate Administration. Int J Neuropsychopharmacol. 2015;19: pubmed publisher
Metge B, Mitra A, Chen D, Shevde L, Samant R. N-Myc and STAT Interactor regulates autophagy and chemosensitivity in breast cancer cells. Sci Rep. 2015;5:11995 pubmed publisher
Tada H, Koide M, Ara W, Shibata Y, Funabashi T, Suyama K, et al. Estrous Cycle-Dependent Phasic Changes in the Stoichiometry of Hippocampal Synaptic AMPA Receptors in Rats. PLoS ONE. 2015;10:e0131359 pubmed publisher
Yang H, Peng Y, Ni H, Li Y, Shi Y, Ding W, et al. Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth. PLoS ONE. 2015;10:e0130953 pubmed publisher
Randle S, Nelson D, Patel S, Laman H. Defective erythropoiesis in a mouse model of reduced Fbxo7 expression due to decreased p27 expression. J Pathol. 2015;237:263-72 pubmed publisher
Chen L, Yan X, Yan Q, Fan J, Huang H, Shi X, et al. The Modified JiuWei QiangHuo Decoction Alleviated Severe Lung Injury Induced by H1N1 Influenza Virus by Regulating the NF- κ B Pathway in Mice. Evid Based Complement Alternat Med. 2015;2015:790739 pubmed publisher
Steneberg P, Sykaras A, Backlund F, Straseviçiene J, Söderström I, Edlund H. Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance. J Biol Chem. 2015;290:19034-43 pubmed publisher
Burdine L, Burdine M, Moreland L, Fogel B, Orr L, James J, et al. Proteomic Identification of DNA-PK Involvement within the RET Signaling Pathway. PLoS ONE. 2015;10:e0127943 pubmed publisher
Zhang Y, Zhang Z, Yan H. Simvastatin inhibits ischemia/reperfusion injury-induced apoptosis of retinal cells via downregulation of the tumor necrosis factor-α/nuclear factor-κB pathway. Int J Mol Med. 2015;36:399-405 pubmed publisher
Wang F, Yang L, Shi L, Li Q, Zhang G, Wu J, et al. Nuclear translocation of fibroblast growth factor-2 (FGF2) is regulated by Karyopherin-β2 and Ran GTPase in human glioblastoma cells. Oncotarget. 2015;6:21468-78 pubmed
Zhou L, Wang Z, Zhou H, Liu T, Lu F, Wang S, et al. Neonatal exposure to sevoflurane may not cause learning and memory deficits and behavioral abnormality in the childhood of Cynomolgus monkeys. Sci Rep. 2015;5:11145 pubmed publisher
Percival S, Thomas H, Amsterdam A, Carroll A, Lees J, Yost H, et al. Variations in dysfunction of sister chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndrome. Dis Model Mech. 2015;8:941-55 pubmed publisher
Kc K, Rothenberg M, Sherrill J. In vitro model for studying esophageal epithelial differentiation and allergic inflammatory responses identifies keratin involvement in eosinophilic esophagitis. PLoS ONE. 2015;10:e0127755 pubmed publisher
Chen Z, Yuan Y, Wang Y, Liu Z, Chan H, Chen S. Down-regulation of programmed cell death 4 (PDCD4) is associated with aromatase inhibitor resistance and a poor prognosis in estrogen receptor-positive breast cancer. Breast Cancer Res Treat. 2015;152:29-39 pubmed publisher
Liu Y, Jiao R, Ma Z, Liu W, Wu Q, Yang Z, et al. Sanguinarine inhibits angiotensin II-induced apoptosis in H9c2 cardiac cells via restoring reactive oxygen species-mediated decreases in the mitochondrial membrane potential. Mol Med Rep. 2015;12:3400-3408 pubmed publisher
Yamamoto J, Kamata S, Miura A, Nagata T, Kainuma R, Ishii I. Differential adaptive responses to 1- or 2-day fasting in various mouse tissues revealed by quantitative PCR analysis. FEBS Open Bio. 2015;5:357-68 pubmed publisher
Patil K, Mohapatra P, Patel H, Goyal S, Ojha S, Kundu C, et al. Pentacyclic Triterpenoids Inhibit IKKβ Mediated Activation of NF-κB Pathway: In Silico and In Vitro Evidences. PLoS ONE. 2015;10:e0125709 pubmed publisher
Atkinson J, Rank K, Zeng Y, Capen A, Yadav V, Manro J, et al. Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma--Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3. PLoS ONE. 2015;10:e0125028 pubmed publisher
Huang B, Lee R, Akbar M, Kim H. Threonine 34 phosphorylation by phosphoinositide-dependent protein kinase 1 facilitates dissociation of Akt from the plasma membrane. Int J Biochem Cell Biol. 2015;64:195-201 pubmed publisher
Ezzati P, Komher K, Severini G, Coombs K. Comparative proteomic analyses demonstrate enhanced interferon and STAT-1 activation in reovirus T3D-infected HeLa cells. Front Cell Infect Microbiol. 2015;5:30 pubmed publisher
Brodarac A, Šarić T, Oberwallner B, Mahmoodzadeh S, Neef K, Albrecht J, et al. Susceptibility of murine induced pluripotent stem cell-derived cardiomyocytes to hypoxia and nutrient deprivation. Stem Cell Res Ther. 2015;6:83 pubmed publisher
Dong C, Mi R, Jin G, Zhou Y, Zhang J, Liu F. Identification of the proliferative effect of Smad2 and 3 in the TGF β2/Smad signaling pathway using RNA interference in a glioma cell line. Mol Med Rep. 2015;12:1824-8 pubmed publisher
Zehavi L, Schayek H, Jacob Hirsch J, Sidi Y, Leibowitz Amit R, Avni D. MiR-377 targets E2F3 and alters the NF-kB signaling pathway through MAP3K7 in malignant melanoma. Mol Cancer. 2015;14:68 pubmed publisher
Li X, Lao Y, Zhang H, Wang X, Tan H, Lin Z, et al. The natural compound Guttiferone F sensitizes prostate cancer to starvation induced apoptosis via calcium and JNK elevation. BMC Cancer. 2015;15:254 pubmed publisher
Ohno T, Shimizu M, Shirakami Y, Baba A, Kochi T, Kubota M, et al. Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice. PLoS ONE. 2015;10:e0124081 pubmed publisher
Cui T, Srivastava A, Han C, Yang L, Zhao R, Zou N, et al. XPC inhibits NSCLC cell proliferation and migration by enhancing E-Cadherin expression. Oncotarget. 2015;6:10060-72 pubmed
Jang K, Mano H, Aoki K, Hayashi T, Muto A, Nambu Y, et al. Mitochondrial function provides instructive signals for activation-induced B-cell fates. Nat Commun. 2015;6:6750 pubmed publisher
Reddy N, Shoja M, Jayashree B, Nayak P, Kumar N, Prasad V, et al. In vitro and in vivo evaluation of novel cinnamyl sulfonamide hydroxamate derivative against colon adenocarcinoma. Chem Biol Interact. 2015;233:81-94 pubmed publisher
Klein W, Westendorf C, Schmidt A, Conill Cortés M, Rutz C, Blohs M, et al. Defining a conformational consensus motif in cotransin-sensitive signal sequences: a proteomic and site-directed mutagenesis study. PLoS ONE. 2015;10:e0120886 pubmed publisher
Ahmad Z, Jasnos L, Gil V, Howell L, Hallsworth A, Petrie K, et al. Molecular and in vivo characterization of cancer-propagating cells derived from MYCN-dependent medulloblastoma. PLoS ONE. 2015;10:e0119834 pubmed publisher
Morad S, Tan S, Feith D, Kester M, Claxton D, Loughran T, et al. Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia--Impact on enzyme activity and response to cytotoxics. Biochim Biophys Acta. 2015;1851:919-28 pubmed publisher
Way S, Podojil J, Clayton B, Zaremba A, Collins T, Kunjamma R, et al. Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic. Nat Commun. 2015;6:6532 pubmed publisher
Zanardelli M, Micheli L, Nicolai R, Failli P, Ghelardini C, Di Cesare Mannelli L. Different apoptotic pathways activated by oxaliplatin in primary astrocytes vs. colo-rectal cancer cells. Int J Mol Sci. 2015;16:5386-99 pubmed publisher
Salah Z, Arafeh R, Maximov V, Galasso M, Khawaled S, Abou Sharieha S, et al. miR-27a and miR-27a* contribute to metastatic properties of osteosarcoma cells. Oncotarget. 2015;6:4920-35 pubmed
Wei W, Li L, Wang X, Yan L, Cao W, Zhan Z, et al. Overexpression of caudal type homeobox transcription factor 2 inhibits the growth of the MGC-803 human gastric cancer cell line in vivo. Mol Med Rep. 2015;12:905-12 pubmed publisher
Christoffolete M, Silva W, Ramos G, Bento M, Costa M, Ribeiro M, et al. Muscle IGF-1-induced skeletal muscle hypertrophy evokes higher insulin sensitivity and carbohydrate use as preferential energy substrate. Biomed Res Int. 2015;2015:282984 pubmed publisher
Dennis K, Valentine W. Ziram and sodium N,N-dimethyldithiocarbamate inhibit ubiquitin activation through intracellular metal transport and increased oxidative stress in HEK293 cells. Chem Res Toxicol. 2015;28:682-90 pubmed publisher
Safaee M, Fakurnejad S, Bloch O, Clark A, Ivan M, Sun M, et al. Proportional upregulation of CD97 isoforms in glioblastoma and glioblastoma-derived brain tumor initiating cells. PLoS ONE. 2015;10:e0111532 pubmed publisher
Wu H, Wei L, Fan F, Ji S, Zhang S, Geng J, et al. Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis. Nat Commun. 2015;6:6239 pubmed publisher
Polstein L, Gersbach C. A light-inducible CRISPR-Cas9 system for control of endogenous gene activation. Nat Chem Biol. 2015;11:198-200 pubmed publisher
Ito S, Tanaka Y, Oshino R, Aiba K, Thanasegaran S, Nishio N, et al. GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy. Sci Rep. 2015;5:8327 pubmed publisher
Howat W, Miller J, Gounaris I. Application of ARID1A to murine formalin-fixed paraffin embedded tissue using immunohistochemistry. F1000Res. 2014;3:244 pubmed publisher
Dilwali S, Kao S, Fujita T, Landegger L, Stankovic K. Nonsteroidal anti-inflammatory medications are cytostatic against human vestibular schwannomas. Transl Res. 2015;166:1-11 pubmed publisher
Okabe N, Ezaki J, Yamaura T, Muto S, Osugi J, Tamura H, et al. FAM83B is a novel biomarker for diagnosis and prognosis of lung squamous cell carcinoma. Int J Oncol. 2015;46:999-1006 pubmed publisher
Maier A, Peille A, Vuaroqueaux V, Lahn M. Anti-tumor activity of the TGF-β receptor kinase inhibitor galunisertib (LY2157299 monohydrate) in patient-derived tumor xenografts. Cell Oncol (Dordr). 2015;38:131-44 pubmed publisher
Brand S, Amann K, Mandel P, Zimnol A, Schupp N. Oxidative DNA damage in kidneys and heart of hypertensive mice is prevented by blocking angiotensin II and aldosterone receptors. PLoS ONE. 2014;9:e115715 pubmed publisher
Park H, Bolton E. Glial cell line-derived neurotrophic factor induces cell proliferation in the mouse urogenital sinus. Mol Endocrinol. 2015;29:289-306 pubmed publisher
Yuan L, Zhang Y, Xia J, Liu B, Zhang Q, Liu J, et al. Resveratrol induces cell cycle arrest via a p53-independent pathway in A549 cells. Mol Med Rep. 2015;11:2459-64 pubmed publisher
Shen W, Wang Y, Lu S, Hong H, Fu S, He S, et al. Acupuncture promotes white adipose tissue browning by inducing UCP1 expression on DIO mice. BMC Complement Altern Med. 2014;14:501 pubmed publisher
Ousterout D, Kabadi A, Thakore P, Perez Pinera P, Brown M, Majoros W, et al. Correction of dystrophin expression in cells from Duchenne muscular dystrophy patients through genomic excision of exon 51 by zinc finger nucleases. Mol Ther. 2015;23:523-32 pubmed publisher
Blum D, Labarge S. Registered report: Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. elife. 2014;3: pubmed publisher
Meier J, Haendler B, Seidel H, Groth P, Adams R, Ziegelbauer K, et al. Knockdown of platinum-induced growth differentiation factor 15 abrogates p27-mediated tumor growth delay in the chemoresistant ovarian cancer model A2780cis. Cancer Med. 2015;4:253-67 pubmed publisher
Yang R, Chen Y, Tang C, Li H, Wang B, Yan Q, et al. MicroRNA-144 suppresses cholangiocarcinoma cell proliferation and invasion through targeting platelet activating factor acetylhydrolase isoform 1b. BMC Cancer. 2014;14:917 pubmed publisher
Manley S, Ni H, Williams J, Kong B, DiTacchio L, Guo G, et al. Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity. Redox Biol. 2014;2:991-1002 pubmed publisher
Zhao Y, Ma X, Wang J, Zhu Y, Li R, Wang J, et al. Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway. Fitoterapia. 2014;99:318-27 pubmed publisher
Tripathi B, Qian X, Mertins P, Wang D, Papageorge A, Carr S, et al. CDK5 is a major regulator of the tumor suppressor DLC1. J Cell Biol. 2014;207:627-42 pubmed publisher
Hari A, Zhang Y, Tu Z, Detampel P, Stenner M, Ganguly A, et al. Activation of NLRP3 inflammasome by crystalline structures via cell surface contact. Sci Rep. 2014;4:7281 pubmed publisher
Gong Y, Liu Y, Li J, Su L, Yu S, Zhu X, et al. Hypermethylation of Cox5a promoter is associated with mitochondrial dysfunction in skeletal muscle of high fat diet-induced insulin resistant rats. PLoS ONE. 2014;9:e113784 pubmed publisher
Ryland K, Svoboda L, Vesely E, McIntyre J, Zhang L, Martens J, et al. Polycomb-dependent repression of the potassium channel-encoding gene KCNA5 promotes cancer cell survival under conditions of stress. Oncogene. 2015;34:4591-600 pubmed publisher
Yang W, Hu B, Wu W, Batra S, Blackburn M, Alcorn J, et al. Alveolar type II epithelial cell dysfunction in rat experimental hepatopulmonary syndrome (HPS). PLoS ONE. 2014;9:e113451 pubmed publisher
He Q, Pu J, Yuan A, Yao T, Ying X, Zhao Y, et al. Liver X receptor agonist treatment attenuates cardiac dysfunction in type 2 diabetic db/db mice. Cardiovasc Diabetol. 2014;13:149 pubmed publisher
Besser J, Malan D, Wystub K, Bachmann A, Wietelmann A, Sasse P, et al. MiRNA-1/133a clusters regulate adrenergic control of cardiac repolarization. PLoS ONE. 2014;9:e113449 pubmed publisher
Horsch M, Beckers J, Fuchs H, Gailus Durner V, HrabÄ› de Angelis M, Rathkolb B, et al. Uromodulin retention in thick ascending limb of Henle's loop affects SCD1 in neighboring proximal tubule: renal transcriptome studies in mouse models of uromodulin-associated kidney disease. PLoS ONE. 2014;9:e113125 pubmed publisher
Lawhorn I, Ferreira J, Wang C. Evaluation of sgRNA target sites for CRISPR-mediated repression of TP53. PLoS ONE. 2014;9:e113232 pubmed publisher
Otti G, Saleh L, Velicky P, Fiala C, Pollheimer J, Knöfler M. Notch2 controls prolactin and insulin-like growth factor binding protein-1 expression in decidualizing human stromal cells of early pregnancy. PLoS ONE. 2014;9:e112723 pubmed publisher
Fang P, Xu W, Li D, Zhao X, Dai J, Wang Z, et al. A novel acrosomal protein, IQCF1, involved in sperm capacitation and the acrosome reaction. Andrology. 2015;3:332-44 pubmed publisher
Recktenwald C, Lichtenfels R, Wulfaenger J, Müller A, Dressler S, Seliger B. Impact of the mitogen-activated protein kinase pathway on the subproteome of detergent-resistant microdomains of colon carcinoma cells. Proteomics. 2015;15:77-88 pubmed publisher
Choi J, Chandrasekaran K, Demarest T, Kristian T, Xu S, Vijaykumar K, et al. Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity. Ann Clin Transl Neurol. 2014;1:589-604 pubmed publisher
Pan W, Cheng Y, Zhang H, Liu B, Mo X, Li T, et al. CSBF/C10orf99, a novel potential cytokine, inhibits colon cancer cell growth through inducing G1 arrest. Sci Rep. 2014;4:6812 pubmed publisher
Suh S, Yoo J, Cui R, Kaur B, Huebner K, Lee T, et al. FHIT suppresses epithelial-mesenchymal transition (EMT) and metastasis in lung cancer through modulation of microRNAs. PLoS Genet. 2014;10:e1004652 pubmed publisher
Souza R, Piedade W, Soares L, Souza P, Aguiar A, Vechetti Júnior I, et al. Aerobic exercise training prevents heart failure-induced skeletal muscle atrophy by anti-catabolic, but not anabolic actions. PLoS ONE. 2014;9:e110020 pubmed publisher
Eurlings I, Reynaert N, van den Beucken T, Gosker H, de Theije C, Verhamme F, et al. Cigarette smoke extract induces a phenotypic shift in epithelial cells; involvement of HIF1α in mesenchymal transition. PLoS ONE. 2014;9:e107757 pubmed publisher
Chapiro J, Sur S, Savic L, Ganapathy Kanniappan S, Reyes J, Duran R, et al. Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer. Clin Cancer Res. 2014;20:6406-17 pubmed publisher
Kenicer J, Spears M, Lyttle N, Taylor K, Liao L, Cunningham C, et al. Molecular characterisation of isogenic taxane resistant cell lines identify novel drivers of drug resistance. BMC Cancer. 2014;14:762 pubmed publisher
Schuck R, Zha W, Edin M, Gruzdev A, Vendrov K, Miller T, et al. The cytochrome P450 epoxygenase pathway regulates the hepatic inflammatory response in fatty liver disease. PLoS ONE. 2014;9:e110162 pubmed publisher
Wilson T, Omelchenko I, Foster S, Zhang Y, Shi X, Nuttall A. JAK2/STAT3 inhibition attenuates noise-induced hearing loss. PLoS ONE. 2014;9:e108276 pubmed publisher
Park J, Zhao L, Webb P, Cheng S. Src-dependent phosphorylation at Y406 on the thyroid hormone receptor β confers the tumor suppressor activity. Oncotarget. 2014;5:10002-16 pubmed
Kononenko A, Bansal R, Lee N, Grimes B, Masumoto H, Earnshaw W, et al. A portable BRCA1-HAC (human artificial chromosome) module for analysis of BRCA1 tumor suppressor function. Nucleic Acids Res. 2014;42: pubmed publisher
Moore N, Azarova A, Bhatnagar N, Ross K, Drake L, Frumm S, et al. Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma. Oncotarget. 2014;5:8737-49 pubmed
Moak S, Dougan G, MarElia C, Danse W, Fernandez A, Kuehl M, et al. Enhanced glucose tolerance in pancreatic-derived factor (PANDER) knockout C57BL/6 mice. Dis Model Mech. 2014;7:1307-15 pubmed publisher
Masiello M, Cucina A, Proietti S, Palombo A, Coluccia P, D Anselmi F, et al. Phenotypic switch induced by simulated microgravity on MDA-MB-231 breast cancer cells. Biomed Res Int. 2014;2014:652434 pubmed publisher
Liu L, Nishio N, Ito S, Tanaka Y, Isobe K. Negative regulation of GADD34 on myofibroblasts during cutaneous wound healing. Biomed Res Int. 2014;2014:137049 pubmed publisher
Altamirano F, Perez C, Liu M, Widrick J, Barton E, Allen P, et al. Whole body periodic acceleration is an effective therapy to ameliorate muscular dystrophy in mdx mice. PLoS ONE. 2014;9:e106590 pubmed publisher
Gangalum R, Jing Z, Bhat A, Lee J, Nagaoka Y, Deng S, et al. Expression of the HSF4 DNA binding domain-EGFP hybrid gene recreates early childhood lamellar cataract in transgenic mice. Invest Ophthalmol Vis Sci. 2014;55:7227-40 pubmed publisher
Melotti A, Mas C, Kuciak M, Lorente Trigos A, Borges I, Ruiz i Altaba A. The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer. EMBO Mol Med. 2014;6:1263-78 pubmed publisher
Niu H, Nie L, Liu M, Chi Y, Zhang T, Li Y. Benazepril affects integrin-linked kinase and smooth muscle α-actin expression in diabetic rat glomerulus and cultured mesangial cells. BMC Nephrol. 2014;15:135 pubmed publisher
Xu R, Hu Q, Ma Q, Liu C, Wang G. The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway. Cell Death Dis. 2014;5:e1373 pubmed publisher
Tian D, Kreeger P. Analysis of the quantitative balance between insulin-like growth factor (IGF)-1 ligand, receptor, and binding protein levels to predict cell sensitivity and therapeutic efficacy. BMC Syst Biol. 2014;8:98 pubmed publisher
Jacob A, Singh R, Comiskey D, Rouhier M, Mohammad F, Bebee T, et al. Stress-induced alternative splice forms of MDM2 and MDMX modulate the p53-pathway in distinct ways. PLoS ONE. 2014;9:e104444 pubmed publisher
Gama J, Ohlmeier S, Martins T, Fraga A, Sampaio Marques B, Carvalho M, et al. Proteomic analysis of the action of the Mycobacterium ulcerans toxin mycolactone: targeting host cells cytoskeleton and collagen. PLoS Negl Trop Dis. 2014;8:e3066 pubmed publisher
Okinami T, Imamura M, Nishikawa N, Negoro H, Sugino Y, Yoshimura K, et al. Altered detrusor gap junction communications induce storage symptoms in bladder inflammation: a mouse cyclophosphamide-induced model of cystitis. PLoS ONE. 2014;9:e104216 pubmed publisher
Lei B, Mace B, Dawson H, Warner D, Laskowitz D, James M. Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia. PLoS ONE. 2014;9:e103969 pubmed publisher
Jacobshagen M, Niquille M, Chaumont Dubel S, Marin P, Dayer A. The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism. Development. 2014;141:3370-7 pubmed publisher
Cavaretta J, Sherer K, Lee K, Kim E, Issema R, Chung H. Polarized axonal surface expression of neuronal KCNQ potassium channels is regulated by calmodulin interaction with KCNQ2 subunit. PLoS ONE. 2014;9:e103655 pubmed publisher
Chen T, Wang X, Guo L, Wu M, Duan Z, Lv J, et al. Embryonic Stem Cells Promoting Macrophage Survival and Function are Crucial for Teratoma Development. Front Immunol. 2014;5:275 pubmed publisher
Vlková V, Stepanek I, Hruskova V, Senigl F, Mayerova V, Srámek M, et al. Epigenetic regulations in the IFN? signalling pathway: IFN?-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes. Oncotarget. 2014;5:6923-35 pubmed
Zhang Q, Yang Z, Jia Z, Liu C, Guo C, Lu H, et al. ISL-1 is overexpressed in non-Hodgkin lymphoma and promotes lymphoma cell proliferation by forming a p-STAT3/p-c-Jun/ISL-1 complex. Mol Cancer. 2014;13:181 pubmed publisher
Ho M, Kang H, Huh J, Kim Y, Lim Y, Cho M. Effects of the novel compound DK223 ([1E,2E-1,2-Bis(6-methoxy-2H-chromen-3-yl)methylene]hydrazine) on migration and proliferation of human keratinocytes and primary dermal fibroblasts. Int J Mol Sci. 2014;15:13091-110 pubmed publisher
Hirai S, Endo S, Saito R, Hirose M, Ueno T, Suzuki H, et al. Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation. PLoS ONE. 2014;9:e102831 pubmed publisher
Liang Y, Chen M, Hua Y, Chen S, Zheng L, Cao X, et al. Downregulation of Ras association domain family member 6 (RASSF6) underlies the treatment resistance of highly metastatic nasopharyngeal carcinoma cells. PLoS ONE. 2014;9:e100843 pubmed publisher
Pavese J, Ogden I, Voll E, Huang X, Xu L, Jovanovic B, et al. Mitogen-activated protein kinase kinase 4 (MAP2K4) promotes human prostate cancer metastasis. PLoS ONE. 2014;9:e102289 pubmed publisher
Luo C, Shibata K, Suzuki S, Kajiyama H, Senga T, Koya Y, et al. GPC3 expression in mouse ovarian cancer induces GPC3?specific T cell-mediated immune response through M1 macrophages and suppresses tumor growth. Oncol Rep. 2014;32:913-21 pubmed publisher
Ambrosio F, Brown E, Stolz D, Ferrari R, Goodpaster B, Deasy B, et al. Arsenic induces sustained impairment of skeletal muscle and muscle progenitor cell ultrastructure and bioenergetics. Free Radic Biol Med. 2014;74:64-73 pubmed publisher
Stengel C, Newman S, Day J, Chander S, Jourdan F, Leese M, et al. In vivo and in vitro properties of STX2484: a novel non-steroidal anti-cancer compound active in taxane-resistant breast cancer. Br J Cancer. 2014;111:300-8 pubmed publisher
Shanmugam V, Ramanathan R, Lavender N, Sinari S, Chadha M, Liang W, et al. Whole genome sequencing reveals potential targets for therapy in patients with refractory KRAS mutated metastatic colorectal cancer. BMC Med Genomics. 2014;7:36 pubmed publisher
Obri A, Makinistoglu M, Zhang H, Karsenty G. HDAC4 integrates PTH and sympathetic signaling in osteoblasts. J Cell Biol. 2014;205:771-80 pubmed publisher
Brouwer Visser J, Lee J, McCullagh K, Cossio M, Wang Y, Huang G. Insulin-like growth factor 2 silencing restores taxol sensitivity in drug resistant ovarian cancer. PLoS ONE. 2014;9:e100165 pubmed publisher
Vallur R, Kalbacher H, Feil R. Catalytic activity of cGMP-dependent protein kinase type I in intact cells is independent of N-terminal autophosphorylation. PLoS ONE. 2014;9:e98946 pubmed publisher
Wang J, Jenkins S, Lamartiniere C. Cell proliferation and apoptosis in rat mammary glands following combinational exposure to bisphenol A and genistein. BMC Cancer. 2014;14:379 pubmed publisher
Lou L, Wu A, Zhang D, Wu S, Gao Y, Nie B, et al. Yiqi Huoxue Recipe Improves Heart Function through Inhibiting Apoptosis Related to Endoplasmic Reticulum Stress in Myocardial Infarction Model of Rats. Evid Based Complement Alternat Med. 2014;2014:745919 pubmed publisher
Yanagawa Y, Hiraide S, Matsumoto M, Shimamura K, Togashi H. Enhanced transglutaminase 2 expression in response to stress-related catecholamines in macrophages. Immunobiology. 2014;219:680-6 pubmed publisher
Li R, Tan J, Chen L, Feng J, Liang W, Guo X, et al. Iqcg is essential for sperm flagellum formation in mice. PLoS ONE. 2014;9:e98053 pubmed publisher
Chen Y, Chen J, Yu J, Yang G, Temple E, Harbinski F, et al. Identification of mixed lineage leukemia 1(MLL1) protein as a coactivator of heat shock factor 1(HSF1) protein in response to heat shock protein 90 (HSP90) inhibition. J Biol Chem. 2014;289:18914-27 pubmed publisher
Davidson B, Rosenfeld Y, Holth A, Hellesylt E, Trope C, Reich R, et al. VICKZ2 protein expression in ovarian serous carcinoma effusions is associated with poor survival. Hum Pathol. 2014;45:1520-8 pubmed publisher
Riddle E, Campbell M, Lang B, Bierer R, Wang Y, Bagley H, et al. Intrauterine growth restriction increases TNF ? and activates the unfolded protein response in male rat pups. J Obes. 2014;2014:829862 pubmed publisher
Hall D, Wu Y, Domann F, Spitz D, Anderson M. Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival. PLoS ONE. 2014;9:e96866 pubmed publisher
Yoon S, Han E, Choi Y, Kee H, Jeong Y, Yoon J, et al. Inhibition of cell proliferation and migration by miR-509-3p that targets CDK2, Rac1, and PIK3C2A. Mol Cells. 2014;37:314-21 pubmed publisher
Voll E, Ogden I, Pavese J, Huang X, Xu L, Jovanovic B, et al. Heat shock protein 27 regulates human prostate cancer cell motility and metastatic progression. Oncotarget. 2014;5:2648-63 pubmed
Loubeau G, Boudra R, Maquaire S, Lours Calet C, Beaudoin C, Verrelle P, et al. NPM1 silencing reduces tumour growth and MAPK signalling in prostate cancer cells. PLoS ONE. 2014;9:e96293 pubmed publisher
Badshah I, Baines D, Dockrell M. Erk5 is a mediator to TGF?1-induced loss of phenotype and function in human podocytes. Front Pharmacol. 2014;5:71 pubmed publisher
Pei J, Liu C, Lai W. Distinct phenotypes of new transmembrane-domain neuregulin 1 mutant mice and the rescue effects of valproate on the observed schizophrenia-related cognitive deficits. Front Behav Neurosci. 2014;8:126 pubmed publisher
Bian Z, Liao H, Zhang Y, Wu Q, Zhou H, Yang Z, et al. Never in mitosis gene A related kinase-6 attenuates pressure overload-induced activation of the protein kinase B pathway and cardiac hypertrophy. PLoS ONE. 2014;9:e96095 pubmed publisher
Zhou D, Li Y, Zhou L, Tan R, Xiao L, Liang M, et al. Sonic hedgehog is a novel tubule-derived growth factor for interstitial fibroblasts after kidney injury. J Am Soc Nephrol. 2014;25:2187-200 pubmed publisher
Juan W, Roca X, Ong S. Identification of cis-acting elements and splicing factors involved in the regulation of BIM Pre-mRNA splicing. PLoS ONE. 2014;9:e95210 pubmed publisher
Ponichtera H, Shainheit M, Liu B, Raychowdhury R, Larkin B, Russo J, et al. CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis. J Immunol. 2014;192:4655-65 pubmed publisher
Müller N, Schulte D, Hillebrand S, Türk K, Hampe J, Schafmayer C, et al. B Lymphocyte Stimulator (BLyS) is expressed in human adipocytes in vivo and is related to obesity but not to insulin resistance. PLoS ONE. 2014;9:e94282 pubmed publisher
Guo Y, Riley K, Iwasaki A, Steitz J. Alternative capture of noncoding RNAs or protein-coding genes by herpesviruses to alter host T cell function. Mol Cell. 2014;54:67-79 pubmed publisher
Hanin G, Shenhar Tsarfaty S, Yayon N, Yau Y, Hoe Y, Bennett E, et al. Competing targets of microRNA-608 affect anxiety and hypertension. Hum Mol Genet. 2014;23:4569-80 pubmed publisher
Schworer S, Smirnova I, Kurbatova I, Bagina U, Churova M, Fowler T, et al. Toll-like receptor-mediated down-regulation of the deubiquitinase cylindromatosis (CYLD) protects macrophages from necroptosis in wild-derived mice. J Biol Chem. 2014;289:14422-33 pubmed publisher
Peters D, Szabo R, Friis S, Shylo N, Uzzun Sales K, Holmbeck K, et al. The membrane-anchored serine protease prostasin (CAP1/PRSS8) supports epidermal development and postnatal homeostasis independent of its enzymatic activity. J Biol Chem. 2014;289:14740-9 pubmed publisher
Gaulke C, Porter M, Han Y, Sankaran Walters S, Grishina I, George M, et al. Intestinal epithelial barrier disruption through altered mucosal microRNA expression in human immunodeficiency virus and simian immunodeficiency virus infections. J Virol. 2014;88:6268-80 pubmed publisher
Watanabe M, Nakatsuka A, Murakami K, Inoue K, Terami T, Higuchi C, et al. Pemt deficiency ameliorates endoplasmic reticulum stress in diabetic nephropathy. PLoS ONE. 2014;9:e92647 pubmed publisher
Jing Y, Cui D, Guo W, Jiang J, Jiang B, Lu Y, et al. Activated androgen receptor promotes bladder cancer metastasis via Slug mediated epithelial-mesenchymal transition. Cancer Lett. 2014;348:135-45 pubmed publisher
Taha M, Nouri K, Milroy L, Moll J, Herrmann C, Brunsveld L, et al. Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin. PLoS ONE. 2014;9:e91465 pubmed publisher
Glenthøj A, Dahl S, Larsen M, Cowland J, Borregaard N. Human ?-defensin expression is not dependent on CCAAT/enhancer binding protein-? in a murine model. PLoS ONE. 2014;9:e92471 pubmed publisher
Singel S, Batten K, Cornelius C, Jia G, Fasciani G, Barron S, et al. Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways. Breast Cancer Res. 2014;16:R28 pubmed publisher
Tu Q, Zheng R, Li J, Hu L, Chang Y, Li L, et al. Palmitic acid induces autophagy in hepatocytes via JNK2 activation. Acta Pharmacol Sin. 2014;35:504-12 pubmed publisher
Arroyo J, Gallichotte E, Tewari M. Systematic design and functional analysis of artificial microRNAs. Nucleic Acids Res. 2014;42:6064-77 pubmed publisher
Slot I, van den Borst B, Hellwig V, Barreiro E, Schols A, Gosker H. The muscle oxidative regulatory response to acute exercise is not impaired in less advanced COPD despite a decreased oxidative phenotype. PLoS ONE. 2014;9:e90150 pubmed publisher
Ciceri P, Müller S, O Mahony A, Fedorov O, Filippakopoulos P, Hunt J, et al. Dual kinase-bromodomain inhibitors for rationally designed polypharmacology. Nat Chem Biol. 2014;10:305-12 pubmed publisher
Queisser N, Oteiza P, Link S, Hey V, Stopper H, Schupp N. Aldosterone activates transcription factor Nrf2 in kidney cells both in vitro and in vivo. Antioxid Redox Signal. 2014;21:2126-42 pubmed publisher
Li A, Morton J, Ma Y, Karim S, Zhou Y, Faller W, et al. Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes. Gastroenterology. 2014;146:1386-96.e1-17 pubmed publisher
Coffey E, Beckel J, Laties A, Mitchell C. Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer's disease-linked presenilin 1 A246E mutation can be reversed with cAMP. Neuroscience. 2014;263:111-24 pubmed publisher
Lygizos M, Yang Y, Altmann C, Okamura K, Hernando A, Perez M, et al. Heparanase mediates renal dysfunction during early sepsis in mice. Physiol Rep. 2013;1:e00153 pubmed publisher
Seervi M, Sobhan P, Joseph J, Ann Mathew K, Santhoshkumar T. ERO1?-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1). Cell Death Dis. 2013;4:e968 pubmed publisher
Hu Y, Li S, Yang M, Yan C, Fan D, Zhou Y, et al. Sorcin silencing inhibits epithelial-to-mesenchymal transition and suppresses breast cancer metastasis in vivo. Breast Cancer Res Treat. 2014;143:287-99 pubmed publisher
Xu X, Bucala R, Ren J. Macrophage migration inhibitory factor deficiency augments doxorubicin-induced cardiomyopathy. J Am Heart Assoc. 2013;2:e000439 pubmed publisher
Tarafdar A, Dobbin E, Corrigan P, Freeburn R, Wheadon H. Canonical Wnt signaling promotes early hematopoietic progenitor formation and erythroid specification during embryonic stem cell differentiation. PLoS ONE. 2013;8:e81030 pubmed publisher
Chen J, Chung F, Yang G, Pu M, Gao H, Jiang W, et al. Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth. Oncotarget. 2013;4:2502-11 pubmed
Wong C, Martincorena I, Rust A, Rashid M, Alifrangis C, Alexandrov L, et al. Inactivating CUX1 mutations promote tumorigenesis. Nat Genet. 2014;46:33-8 pubmed publisher
Basford J, Koch S, Anjak A, Singh V, Krause E, Robbins N, et al. Smooth muscle LDL receptor-related protein-1 deletion induces aortic insufficiency and promotes vascular cardiomyopathy in mice. PLoS ONE. 2013;8:e82026 pubmed publisher
Zhu J, Lin F, Brown D, Clark R. A fibronectin peptide redirects PDGF-BB/PDGFR complexes to macropinocytosis-like internalization and augments PDGF-BB survival signals. J Invest Dermatol. 2014;134:921-929 pubmed publisher
Zarrinpashneh E, Poggioli T, Sarathchandra P, Lexow J, Monassier L, Terracciano C, et al. Ablation of SGK1 impairs endothelial cell migration and tube formation leading to decreased neo-angiogenesis following myocardial infarction. PLoS ONE. 2013;8:e80268 pubmed publisher
Arens J, Duong T, Dehmelt L. A morphometric screen identifies specific roles for microtubule-regulating genes in neuronal development of P19 stem cells. PLoS ONE. 2013;8:e79796 pubmed publisher
Haas D, Bala K, Büsche G, Weidner Glunde M, Santag S, Kati S, et al. The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells. PLoS Pathog. 2013;9:e1003737 pubmed publisher
Biensø R, Knudsen J, Brandt N, Pedersen P, Pilegaard H. Effects of IL-6 on pyruvate dehydrogenase regulation in mouse skeletal muscle. Pflugers Arch. 2014;466:1647-57 pubmed publisher
Di Carli M, Tanno B, Capodicasa C, Villani M, Salzano A, Scaloni A, et al. Proteome changes induced by c-myb silencing in human chronic myeloid leukemia cells suggest molecular mechanisms and putative biomarkers of hematopoietic malignancies. J Proteomics. 2014;96:200-22 pubmed publisher
Herrmann M, Lennerz J, Bullinger L, Bartholomae S, Holzmann K, Westhoff M, et al. Transitory dasatinib-resistant states in KIT(mut) t(8;21) acute myeloid leukemia cells correlate with altered KIT expression. Exp Hematol. 2014;42:90-100 pubmed publisher
Verhees K, Pansters N, Baarsma H, Remels A, Haegens A, de Theije C, et al. Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: II. Effects on skeletal muscle atrophy. Respir Res. 2013;14:117 pubmed publisher
Chang K, Yan M, Yao C, Lin P, Lai G. Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells. Oncol Lett. 2013;6:1435-1438 pubmed
Seo J, Kim K, Chang D, Kang H, Shin E, Kwon J, et al. Genome-wide reorganization of histone H2AX toward particular fragile sites on cell activation. Nucleic Acids Res. 2014;42:1016-25 pubmed publisher
Deng S, Wang M, Yan Z, Tian Z, Chen H, Yang X, et al. Autophagy in retinal ganglion cells in a rhesus monkey chronic hypertensive glaucoma model. PLoS ONE. 2013;8:e77100 pubmed publisher
King H, Cobbold L, Pichon X, Pöyry T, Wilson L, Booden H, et al. Remodelling of a polypyrimidine tract-binding protein complex during apoptosis activates cellular IRESs. Cell Death Differ. 2014;21:161-71 pubmed publisher
Ferranti F, D Anselmi F, Caruso M, Lei V, Dinicola S, Pasqualato A, et al. TCam-2 seminoma cells exposed to egg-derived microenvironment modify their shape, adhesive pattern and migratory behaviour: a molecular and morphometric analysis. PLoS ONE. 2013;8:e76192 pubmed publisher
Jiang Y, Rumble J, Gleixner A, Unnithan A, Pulugulla S, Posimo J, et al. N-Acetyl cysteine blunts proteotoxicity in a heat shock protein-dependent manner. Neuroscience. 2013;255:19-32 pubmed publisher
Jo S, Lee H, Kim S, Lee C, Chung H. Korean red ginseng extract induces proliferation to differentiation transition of human acute promyelocytic leukemia cells via MYC-SKP2-CDKN1B axis. J Ethnopharmacol. 2013;150:700-7 pubmed publisher
Eichhorn J, Sakurikar N, Alford S, Chu R, Chambers T. Critical role of anti-apoptotic Bcl-2 protein phosphorylation in mitotic death. Cell Death Dis. 2013;4:e834 pubmed publisher
Adolph T, Tomczak M, Niederreiter L, Ko H, Böck J, Martínez Naves E, et al. Paneth cells as a site of origin for intestinal inflammation. Nature. 2013;503:272-6 pubmed publisher
Li J, Davies B, Han S, Zhou M, Bai Y, Zhang J, et al. The AKT inhibitor AZD5363 is selectively active in PI3KCA mutant gastric cancer, and sensitizes a patient-derived gastric cancer xenograft model with PTEN loss to Taxotere. J Transl Med. 2013;11:241 pubmed publisher
Turcan S, Fabius A, Borodovsky A, Pedraza A, Brennan C, Huse J, et al. Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine. Oncotarget. 2013;4:1729-36 pubmed
Herhaus L, Al Salihi M, MacArtney T, Weidlich S, Sapkota G. OTUB1 enhances TGF? signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3. Nat Commun. 2013;4:2519 pubmed publisher
Vrzal R, Frauenstein K, Proksch P, Abel J, Dvorak Z, Haarmann Stemmann T. Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cells. PLoS ONE. 2013;8:e74917 pubmed publisher
Burova E, Borodkina A, Shatrova A, Nikolsky N. Sublethal oxidative stress induces the premature senescence of human mesenchymal stem cells derived from endometrium. Oxid Med Cell Longev. 2013;2013:474931 pubmed publisher
Gebhard A, Jain P, Nair R, Emmons M, Argilagos R, Koomen J, et al. MTI-101 (cyclized HYD1) binds a CD44 containing complex and induces necrotic cell death in multiple myeloma. Mol Cancer Ther. 2013;12:2446-58 pubmed publisher
Reddy P, Deguchi M, Cheng Y, Hsueh A. Actin cytoskeleton regulates Hippo signaling. PLoS ONE. 2013;8:e73763 pubmed publisher
Wang J, Lu K, Liang F, Li X, Wang L, Yang C, et al. Decreased autophagy contributes to myocardial dysfunction in rats subjected to nonlethal mechanical trauma. PLoS ONE. 2013;8:e71400 pubmed publisher
Coe B, Thu K, Aviel Ronen S, Vucic E, Gazdar A, Lam S, et al. Genomic deregulation of the E2F/Rb pathway leads to activation of the oncogene EZH2 in small cell lung cancer. PLoS ONE. 2013;8:e71670 pubmed publisher
Brand T, Iida M, Luthar N, Wleklinski M, Starr M, Wheeler D. Mapping C-terminal transactivation domains of the nuclear HER family receptor tyrosine kinase HER3. PLoS ONE. 2013;8:e71518 pubmed publisher
Ouellet D, Vigneault Edwards J, Létourneau K, Gobeil L, Plante I, Burnett J, et al. Regulation of host gene expression by HIV-1 TAR microRNAs. Retrovirology. 2013;10:86 pubmed publisher
Okemoto K, Wagner B, Meisen H, Haseley A, Kaur B, Chiocca E. STAT3 activation promotes oncolytic HSV1 replication in glioma cells. PLoS ONE. 2013;8:e71932 pubmed publisher
Ma T, Trinh M, Wexler A, Bourbon C, Gatti E, Pierre P, et al. Suppression of eIF2? kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci. 2013;16:1299-305 pubmed publisher
Suh J, Sieglaff D, Zhang A, Xia X, Cvoro A, Winnier G, et al. SIRT1 is a direct coactivator of thyroid hormone receptor ?1 with gene-specific actions. PLoS ONE. 2013;8:e70097 pubmed publisher
Zhu Y, Yao Z, Wu Z, Mei Y, Wu M. Role of tumor necrosis factor alpha-induced protein 1 in paclitaxel resistance. Oncogene. 2014;33:3246-55 pubmed publisher
Ito S, Satoh J, Matsubara T, Shah Y, Ahn S, Anderson C, et al. Cholestasis induces reversible accumulation of periplakin in mouse liver. BMC Gastroenterol. 2013;13:116 pubmed publisher
Bottermann K, Reinartz M, Barsoum M, Kötter S, Gödecke A. Systematic Analysis Reveals Elongation Factor 2 and ?-Enolase as Novel Interaction Partners of AKT2. PLoS ONE. 2013;8:e66045 pubmed publisher
Coombs K. HeLa cell response proteome alterations induced by mammalian reovirus T3D infection. Virol J. 2013;10:202 pubmed publisher
Obitsu S, Sakata K, Teshima R, Kondo K. Eleostearic acid induces RIP1-mediated atypical apoptosis in a kinase-independent manner via ERK phosphorylation, ROS generation and mitochondrial dysfunction. Cell Death Dis. 2013;4:e674 pubmed publisher
Shishido S, Prasain K, Beck A, Nguyen T, Hua D, Nguyen T. Bioavailability and efficacy of a gap junction enhancer (PQ7) in a mouse mammary tumor model. PLoS ONE. 2013;8:e67174 pubmed publisher
Nishimura T, Zhao X, Gan H, Koyasu S, Remold H. The prostaglandin E2 receptor EP4 is integral to a positive feedback loop for prostaglandin E2 production in human macrophages infected with Mycobacterium tuberculosis. FASEB J. 2013;27:3827-36 pubmed publisher
Osawa Y, Hoshi M, Yasuda I, Saibara T, Moriwaki H, Kozawa O. Tumor necrosis factor-? promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells. PLoS ONE. 2013;8:e65251 pubmed publisher
Stubbendorff M, Deuse T, Hua X, Phan T, Bieback K, Atkinson K, et al. Immunological properties of extraembryonic human mesenchymal stromal cells derived from gestational tissue. Stem Cells Dev. 2013;22:2619-29 pubmed publisher
Osaki L, Gama P. MAPKs and signal transduction in the control of gastrointestinal epithelial cell proliferation and differentiation. Int J Mol Sci. 2013;14:10143-61 pubmed publisher
Yi T, Papadopoulos E, Hagner P, Wagner G. Hypoxia-inducible factor-1? (HIF-1?) promotes cap-dependent translation of selective mRNAs through up-regulating initiation factor eIF4E1 in breast cancer cells under hypoxia conditions. J Biol Chem. 2013;288:18732-42 pubmed publisher
Safaee M, Clark A, Oh M, Ivan M, Bloch O, Kaur G, et al. Overexpression of CD97 confers an invasive phenotype in glioblastoma cells and is associated with decreased survival of glioblastoma patients. PLoS ONE. 2013;8:e62765 pubmed publisher
Chen Y, Chen J, Loo A, Jaeger S, Bagdasarian L, Yu J, et al. Targeting HSF1 sensitizes cancer cells to HSP90 inhibition. Oncotarget. 2013;4:816-29 pubmed
Xu J, Yao Q, Hou Y, Xu M, Liu S, Yang L, et al. MiR-223/Ect2/p21 signaling regulates osteosarcoma cell cycle progression and proliferation. Biomed Pharmacother. 2013;67:381-6 pubmed publisher
Lu X, Parvathaneni S, Hara T, Lal A, Sharma S. Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D. Mol Cancer. 2013;12:29 pubmed publisher
Andres D, Keyser B, Petrali J, Benton B, Hubbard K, McNutt P, et al. Morphological and functional differentiation in BE(2)-M17 human neuroblastoma cells by treatment with Trans-retinoic acid. BMC Neurosci. 2013;14:49 pubmed publisher
Oaks A, Frankfurt M, Finkelstein D, Sidhu A. Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function. PLoS ONE. 2013;8:e60378 pubmed publisher
Krisko J, Martinez Torres F, Foster J, Garcia J. HIV restriction by APOBEC3 in humanized mice. PLoS Pathog. 2013;9:e1003242 pubmed publisher
Dufour J, Pommier A, Alves G, de Boussac H, Lours Calet C, Volle D, et al. Lack of liver X receptors leads to cell proliferation in a model of mouse dorsal prostate epithelial cell. PLoS ONE. 2013;8:e58876 pubmed publisher
Posimo J, Titler A, Choi H, Unnithan A, Leak R. Neocortex and allocortex respond differentially to cellular stress in vitro and aging in vivo. PLoS ONE. 2013;8:e58596 pubmed publisher
Barthwal M, Anzinger J, Xu Q, Bohnacker T, Wymann M, Kruth H. Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation. PLoS ONE. 2013;8:e58054 pubmed publisher
Carnevale J, Ross L, Puissant A, Banerji V, Stone R, DeAngelo D, et al. SYK regulates mTOR signaling in AML. Leukemia. 2013;27:2118-28 pubmed publisher
Dearth C, Goh Q, Marino J, Cicinelli P, Torres Palsa M, Pierre P, et al. Skeletal muscle cells express ICAM-1 after muscle overload and ICAM-1 contributes to the ensuing hypertrophic response. PLoS ONE. 2013;8:e58486 pubmed publisher
Aksenova V, Turoverova L, Khotin M, Magnusson K, Tulchinsky E, Melino G, et al. Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB. Oncotarget. 2013;4:362-72 pubmed
Naughton C, Avlonitis N, Corless S, Prendergast J, Mati I, Eijk P, et al. Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures. Nat Struct Mol Biol. 2013;20:387-95 pubmed publisher
Wang R, Zhang Q, Pan Y, Guo Q. Etanercept decreases HMGB1 expression in dorsal root ganglion neuron cells in a rat chronic constriction injury model. Exp Ther Med. 2013;5:581-585 pubmed
Perez Pinera P, Ousterout D, Brunger J, Farin A, Glass K, Guilak F, et al. Synergistic and tunable human gene activation by combinations of synthetic transcription factors. Nat Methods. 2013;10:239-42 pubmed publisher
Zarnack K, König J, Tajnik M, Martincorena I, Eustermann S, Stévant I, et al. Direct competition between hnRNP C and U2AF65 protects the transcriptome from the exonization of Alu elements. Cell. 2013;152:453-66 pubmed publisher
Linke R, Pries R, Könnecke M, Bruchhage K, Böscke R, Gebhard M, et al. Glycogen synthase kinase 3 in chronic rhinosinusitis: two faces of a single enzyme in one disease. Ann Allergy Asthma Immunol. 2013;110:101-6 pubmed publisher
Henke N, Albrecht P, Bouchachia I, Ryazantseva M, Knoll K, Lewerenz J, et al. The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress. Cell Death Dis. 2013;4:e470 pubmed publisher
Gu C, Banasavadi Siddegowda Y, Joshi K, Nakamura Y, Kurt H, Gupta S, et al. Tumor-specific activation of the C-JUN/MELK pathway regulates glioma stem cell growth in a p53-dependent manner. Stem Cells. 2013;31:870-81 pubmed publisher
Cui X, Witalison E, Chumanevich A, Chumanevich A, Poudyal D, Subramanian V, et al. The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest. PLoS ONE. 2013;8:e53791 pubmed publisher
Xie P, Zhang W, Yuan S, Chen Z, Yang Q, Yuan D, et al. Suppression of experimental choroidal neovascularization by curcumin in mice. PLoS ONE. 2012;7:e53329 pubmed publisher
Baltazar G, Guha S, Lu W, Lim J, Boesze Battaglia K, Laties A, et al. Acidic nanoparticles are trafficked to lysosomes and restore an acidic lysosomal pH and degradative function to compromised ARPE-19 cells. PLoS ONE. 2012;7:e49635 pubmed publisher
Kim J, Kang Y, Kojima Y, Lighthouse J, Hu X, Aldred M, et al. An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension. Nat Med. 2013;19:74-82 pubmed publisher
Berard A, Cortens J, Krokhin O, Wilkins J, Severini A, Coombs K. Quantification of the host response proteome after mammalian reovirus T1L infection. PLoS ONE. 2012;7:e51939 pubmed publisher
Shea F, ROWELL J, Li Y, Chang T, Alvarez C. Mammalian ? arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with ? arrestins. PLoS ONE. 2012;7:e50557 pubmed publisher
Qiu R, Cai A, Dong Y, Zhou Y, Yu D, Huang Y, et al. SDF-1? upregulation by atorvastatin in rats with acute myocardial infarction via nitric oxide production confers anti-inflammatory and anti-apoptotic effects. J Biomed Sci. 2012;19:99 pubmed publisher
Shiota A, Shimabukuro M, Fukuda D, Soeki T, Sato H, Uematsu E, et al. Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice. Cardiovasc Diabetol. 2012;11:139 pubmed publisher
Ren D, Wang X, Ha T, Liu L, Kalbfleisch J, Gao X, et al. SR-A deficiency reduces myocardial ischemia/reperfusion injury; involvement of increased microRNA-125b expression in macrophages. Biochim Biophys Acta. 2013;1832:336-46 pubmed publisher
Kaur J, Reinhardt D. Immobilized metal affinity chromatography co-purifies TGF-?1 with histidine-tagged recombinant extracellular proteins. PLoS ONE. 2012;7:e48629 pubmed publisher
Dhurandhar E, Krishnapuram R, Hegde V, Dubuisson O, Tao R, Dong X, et al. E4orf1 improves lipid and glucose metabolism in hepatocytes: a template to improve steatosis & hyperglycemia. PLoS ONE. 2012;7:e47813 pubmed publisher
Rice D, Hansen G, Liu F, Crist M, Newhouse M, Potter D, et al. Keratinocyte migration in the developing eyelid requires LIMK2. PLoS ONE. 2012;7:e47168 pubmed publisher
Jiang J, Opanubi K, Coombs K. Non-Biased Enrichment Does Not Improve Quantitative Proteomic Delineation of Reovirus T3D-Infected HeLa Cell Protein Alterations. Front Microbiol. 2012;3:310 pubmed
Li M, Kao E, Gao X, Sandig H, Limmer K, PAVON ETERNOD M, et al. Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Nature. 2012;491:125-8 pubmed publisher
Mate S, van der Meulen J, Arya P, Bhattacharyya S, Band H, Hoffman E. Eps homology domain endosomal transport proteins differentially localize to the neuromuscular junction. Skelet Muscle. 2012;2:19 pubmed publisher
Abcejo A, Sathish V, Smelter D, Aravamudan B, Thompson M, Hartman W, et al. Brain-derived neurotrophic factor enhances calcium regulatory mechanisms in human airway smooth muscle. PLoS ONE. 2012;7:e44343 pubmed publisher
Abdalla H, Srinivasan L, Shah S, Mayer Barber K, Sher A, Sutterwala F, et al. Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1? and IL-18 secretion but not to pyroptosis. PLoS ONE. 2012;7:e40722 pubmed publisher
Bhowmick R, Halder U, Chattopadhyay S, Chanda S, Nandi S, Bagchi P, et al. Rotaviral enterotoxin nonstructural protein 4 targets mitochondria for activation of apoptosis during infection. J Biol Chem. 2012;287:35004-20 pubmed publisher
Ou Y, Ma L, Dong L, Ma L, Zhao Z, Ma L, et al. Migfilin protein promotes migration and invasion in human glioma through epidermal growth factor receptor-mediated phospholipase C-? and STAT3 protein signaling pathways. J Biol Chem. 2012;287:32394-405 pubmed
Bachstetter A, Norris C, Sompol P, Wilcock D, Goulding D, Neltner J, et al. Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology. J Neurosci. 2012;32:10201-10 pubmed publisher
Al Salihi M, Herhaus L, MacArtney T, Sapkota G. USP11 augments TGFβ signalling by deubiquitylating ALK5. Open Biol. 2012;2:120063 pubmed publisher
Yang S, Wang C. The intraflagellar transport protein IFT80 is required for cilia formation and osteogenesis. Bone. 2012;51:407-17 pubmed publisher
Straussman R, Morikawa T, Shee K, Barzily Rokni M, Qian Z, Du J, et al. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature. 2012;487:500-4 pubmed publisher
Ghosh A, Klocke B, Ballestas M, Roth K. CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PLoS ONE. 2012;7:e39586 pubmed publisher
Sharmin S, Guan H, Williams A, Yang K. Caffeine reduces 11β-hydroxysteroid dehydrogenase type 2 expression in human trophoblast cells through the adenosine A(2B) receptor. PLoS ONE. 2012;7:e38082 pubmed publisher
Okamoto M. Immunoreactivity of the amino-terminal portion of the amyloid-beta precursor protein in the nucleolus. Neurosci Lett. 2012;521:82-7 pubmed publisher
Ye Y, Gao J, Tian H, Yearsley K, Lange A, Robertson F, et al. Early to intermediate steps of tumor embolic formation involve specific proteolytic processing of E-cadherin regulated by Rab7. Mol Cancer Res. 2012;10:713-26 pubmed publisher
Sun Y, Kathawala R, Singh S, Zheng K, Talele T, Jiang W, et al. Zafirlukast antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance. Anticancer Drugs. 2012;23:865-73 pubmed publisher
Yin X, Chen J, Mao W, Wang Y, Chen M. A selective aryl hydrocarbon receptor modulator 3,3'-Diindolylmethane inhibits gastric cancer cell growth. J Exp Clin Cancer Res. 2012;31:46 pubmed publisher
Kopf J, Petersen A, Duda G, Knaus P. BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway. BMC Biol. 2012;10:37 pubmed publisher
Cui D, Wang L, Qi A, Zhou Q, Zhang X, Jiang W. Propofol prevents autophagic cell death following oxygen and glucose deprivation in PC12 cells and cerebral ischemia-reperfusion injury in rats. PLoS ONE. 2012;7:e35324 pubmed publisher
de Lartigue G, Barbier de la Serre C, Espero E, Lee J, Raybould H. Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats. PLoS ONE. 2012;7:e32967 pubmed publisher
Cantrup R, Dixit R, Palmesino E, Bonfield S, Shaker T, Tachibana N, et al. Cell-type specific roles for PTEN in establishing a functional retinal architecture. PLoS ONE. 2012;7:e32795 pubmed publisher
Van de Wouwer M, Couzinié C, Serrano Palero M, Gonzalez Fernandez O, Galmés Varela C, Menéndez Antolí P, et al. Activation of the BRCA1/Chk1/p53/p21(Cip1/Waf1) pathway by nitric oxide and cell cycle arrest in human neuroblastoma NB69 cells. Nitric Oxide. 2012;26:182-91 pubmed publisher
Fung C, Ke X, Brown A, Yu X, McKnight R, Lane R. Uteroplacental insufficiency alters rat hippocampal cellular phenotype in conjunction with ErbB receptor expression. Pediatr Res. 2012;72:2-9 pubmed publisher
Wang X, Wang J, Huang V, Place R, Li L. Induction of NANOG expression by targeting promoter sequence with small activating RNA antagonizes retinoic acid-induced differentiation. Biochem J. 2012;443:821-8 pubmed publisher
Nicolas C, Peineau S, Amici M, Csaba Z, Fafouri A, Javalet C, et al. The Jak/STAT pathway is involved in synaptic plasticity. Neuron. 2012;73:374-90 pubmed publisher
Miao H, Zhang Y, Lu Z, Liu Q, Gan L. FOXO1 involvement in insulin resistance-related pro-inflammatory cytokine production in hepatocytes. Inflamm Res. 2012;61:349-58 pubmed publisher
Xie P, Kamei M, Suzuki M, Matsumura N, Nishida K, Sakimoto S, et al. Suppression and regression of choroidal neovascularization in mice by a novel CCR2 antagonist, INCB3344. PLoS ONE. 2011;6:e28933 pubmed publisher
Li H, Panina S, Kaur A, Ruano M, Sánchez González P, la Cour J, et al. Regulation of the ligand-dependent activation of the epidermal growth factor receptor by calmodulin. J Biol Chem. 2012;287:3273-81 pubmed publisher
Carlin L, Evans R, Milewicz H, Fernandes L, Matthews D, Perani M, et al. A targeted siRNA screen identifies regulators of Cdc42 activity at the natural killer cell immunological synapse. Sci Signal. 2011;4:ra81 pubmed publisher
Zhou H, Shen D, Bian Z, Zong J, Deng W, Zhang Y, et al. Activating transcription factor 3 deficiency promotes cardiac hypertrophy, dysfunction, and fibrosis induced by pressure overload. PLoS ONE. 2011;6:e26744 pubmed publisher
Janas M, Khaled M, Schubert S, Bernstein J, Golan D, Veguilla R, et al. Feed-forward microprocessing and splicing activities at a microRNA-containing intron. PLoS Genet. 2011;7:e1002330 pubmed publisher
Heining E, Bhushan R, Paarmann P, Henis Y, Knaus P. Spatial segregation of BMP/Smad signaling affects osteoblast differentiation in C2C12 cells. PLoS ONE. 2011;6:e25163 pubmed publisher
Bjorklund N, Sadagoparamanujam V, Taglialatela G. Selective, quantitative measurement of releasable synaptic zinc in human autopsy hippocampal brain tissue from Alzheimer's disease patients. J Neurosci Methods. 2012;203:146-51 pubmed publisher
Osawa Y, Kanamori H, Seki E, Hoshi M, Ohtaki H, Yasuda Y, et al. L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin. J Biol Chem. 2011;286:34800-8 pubmed publisher
Bonetto A, Aydogdu T, Kunzevitzky N, Guttridge D, Khuri S, Koniaris L, et al. STAT3 activation in skeletal muscle links muscle wasting and the acute phase response in cancer cachexia. PLoS ONE. 2011;6:e22538 pubmed publisher
Qi W, Liu X, Cooke L, Persky D, Miller T, Squires M, et al. AT9283, a novel aurora kinase inhibitor, suppresses tumor growth in aggressive B-cell lymphomas. Int J Cancer. 2012;130:2997-3005 pubmed publisher
Bartoli K, Jakovljevic J, Woolford J, Saunders W. Kinesin molecular motor Eg5 functions during polypeptide synthesis. Mol Biol Cell. 2011;22:3420-30 pubmed publisher
Biermann J, Lagrèze W, Schallner N, Schwer C, Goebel U. Inhalative preconditioning with hydrogen sulfide attenuated apoptosis after retinal ischemia/reperfusion injury. Mol Vis. 2011;17:1275-86 pubmed
Lazaridis I, Charalampopoulos I, Alexaki V, Avlonitis N, Pediaditakis I, Efstathopoulos P, et al. Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. PLoS Biol. 2011;9:e1001051 pubmed publisher
Saji M, Narahara K, McCarty S, Vasko V, La Perle K, Porter K, et al. Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer. Oncogene. 2011;30:4307-15 pubmed publisher
Ball S, Li C, Li P, Lin J. The small molecule, LLL12, inhibits STAT3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells. PLoS ONE. 2011;6:e18820 pubmed publisher
Siemens N, Patenge N, Otto J, Fiedler T, Kreikemeyer B. Streptococcus pyogenes M49 plasminogen/plasmin binding facilitates keratinocyte invasion via integrin-integrin-linked kinase (ILK) pathways and protects from macrophage killing. J Biol Chem. 2011;286:21612-22 pubmed publisher
Kim H, Kim K, Roh T, Park J, Jung K, Lee J, et al. Gene silencing in HIV-1 latency by polycomb repressive group. Virol J. 2011;8:179 pubmed publisher
Lutz S, Hennige A, Feil S, Peter A, Gerling A, Machann J, et al. Genetic ablation of cGMP-dependent protein kinase type I causes liver inflammation and fasting hyperglycemia. Diabetes. 2011;60:1566-76 pubmed publisher
Wei M, Wang Z, Yao H, Yang Z, Zhang Q, Liu B, et al. P27(Kip1), regulated by glycogen synthase kinase-3?, results in HMBA-induced differentiation of human gastric cancer cells. BMC Cancer. 2011;11:109 pubmed publisher
Gromova P, Rubin B, Thys A, Cullus P, Erneux C, Vanderwinden J. ENDOGLIN/CD105 is expressed in KIT positive cells in the gut and in gastrointestinal stromal tumours. J Cell Mol Med. 2012;16:306-17 pubmed publisher
Matheny R, Nindl B. Loss of IGF-IEa or IGF-IEb impairs myogenic differentiation. Endocrinology. 2011;152:1923-34 pubmed publisher
Lee C, Dykema K, Hawkins D, Cherba D, Webb C, Furge K, et al. MEK2 is sufficient but not necessary for proliferation and anchorage-independent growth of SK-MEL-28 melanoma cells. PLoS ONE. 2011;6:e17165 pubmed publisher
Mazzio E, Close F, Soliman K. The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. Int J Mol Sci. 2011;12:506-69 pubmed publisher
Wu M, Liu H, Fannin J, Katta A, Wang Y, Arvapalli R, et al. Acetaminophen improves protein translational signaling in aged skeletal muscle. Rejuvenation Res. 2010;13:571-9 pubmed publisher
Frietze K, Campos S, Kajon A. Open reading frame E3-10.9K of subspecies B1 human adenoviruses encodes a family of late orthologous proteins that vary in their predicted structural features and subcellular localization. J Virol. 2010;84:11310-22 pubmed publisher
Pansters N, van der Velden J, Kelders M, Laeremans H, Schols A, Langen R. Segregation of myoblast fusion and muscle-specific gene expression by distinct ligand-dependent inactivation of GSK-3?. Cell Mol Life Sci. 2011;68:523-35 pubmed publisher
Zaman M, Chen Y, Deng G, Shahryari V, Suh S, Saini S, et al. The functional significance of microRNA-145 in prostate cancer. Br J Cancer. 2010;103:256-64 pubmed publisher
Chuykin I, Lapidus I, Popova E, Vilianovich L, Mosienko V, Alenina N, et al. Characterization of trophoblast and extraembryonic endoderm cell lineages derived from rat preimplantation embryos. PLoS ONE. 2010;5:e9794 pubmed publisher
Yang M, Adla S, Temburni M, Patel V, Lagow E, Brady O, et al. Stimulation of glioma cell motility by expression, proteolysis, and release of the L1 neural cell recognition molecule. Cancer Cell Int. 2009;9:27 pubmed publisher
product information
SKU :
2118L
Product-Name :
GAPDH (14C10) Rabbit mAb
Size :
300 ul
Price-(USD) :
574 USD
Species-x-Reactivity :
H, M, R, Mk, (Pg)
Applications :
Flow cytometry
Product-Category :
Metabolism
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
37
Host :
Rabbit
Target :
GAPDH
Primary-Protein :
GAPDH
Alt-Names :
G3P,G3PD,GAPD,GAPDH,Glyceraldehyde-3-phosphate dehydrogenase,MGC88685,aging-associated gene 9 protein,glyceraldehyde 3-phosphate dehydrogenase
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.