| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; human; 1:1000; loading ...; fig 4s2a
| Zeng H, Castillo Cabrera J, Manser M, Lu B, Yang Z, Strande V, et al. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. elife. 2019;8: pubmed publisher |
- western blot; rat; 1:1000; loading ...; fig 1b
| Tan J, Zhang X, Li D, Liu G, Wang Y, Zhang D, et al. scAAV2-Mediated C3 Transferase Gene Therapy in a Rat Model with Retinal Ischemia/Reperfusion Injuries. Mol Ther Methods Clin Dev. 2020;17:894-903 pubmed publisher |
- western blot; mouse; loading ...; fig s1d
| Yang S, Harding A, Sweeney C, Miao D, Swan G, Zhou C, et al. Control of antiviral innate immune response by protein geranylgeranylation. Sci Adv. 2019;5:eaav7999 pubmed publisher |
- western blot; human; loading ...; fig 3f
| Liu Y, Wang X, Deng L, Ping L, Shi Y, Zheng W, et al. ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma. Cancer Cell Int. 2019;19:32 pubmed publisher |
- western blot; human; 1:2000; loading ...; fig 5b
| Mathieu J, Detraux D, Kuppers D, Wang Y, Cavanaugh C, Sidhu S, et al. Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency. Nat Commun. 2019;10:632 pubmed publisher |
- western blot; human; loading ...; fig 3e
| Bouafia A, Lofek S, Bruneau J, Chentout L, Lamrini H, Trinquand A, et al. Loss of ARHGEF1 causes a human primary antibody deficiency. J Clin Invest. 2019;129:1047-1060 pubmed publisher |
- western blot; human; 1:2000; loading ...; fig 3a
| Greenhough A, Bagley C, Heesom K, Gurevich D, Gay D, Bond M, et al. Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis. EMBO Mol Med. 2018;10: pubmed publisher |
- western blot; mouse; fig 3c
| Khalifeh Soltani A, Gupta D, Ha A, Podolsky M, Datta R, Atabai K. The Mfge8-α8β1-PTEN pathway regulates airway smooth muscle contraction in allergic inflammation. FASEB J. 2018;:fj201800109R pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2a
| Escamilla C, Filonova I, Walker A, Xuan Z, Holehonnur R, Espinosa F, et al. Kctd13 deletion reduces synaptic transmission via increased RhoA. Nature. 2017;551:227-231 pubmed publisher |
- western blot; human; loading ...; fig 2b
| Sahu U, Choudhury A, Parvez S, Biswas S, Kar S. Induction of intestinal stemness and tumorigenicity by aberrant internalization of commensal non-pathogenic E. coli. Cell Death Dis. 2017;8:e2667 pubmed publisher |
- western blot; human; 1:400; loading ...; fig s5d
| Sun T, Yang L, Kaur H, Pestel J, Looso M, Nolte H, et al. A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib. J Cell Biol. 2017;216:199-215 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 5b
| Jørgensen L, Jepsen P, Boysen A, Dalgaard L, Hvid L, Ørtenblad N, et al. SPARC Interacts with Actin in Skeletal Muscle in Vitro and in Vivo. Am J Pathol. 2017;187:457-474 pubmed publisher |
- western blot; human; loading ...; fig 6a
| Liu Z, Chu S, Yao S, Li Y, Fan S, Sun X, et al. CD74 interacts with CD44 and enhances tumorigenesis and metastasis via RHOA-mediated cofilin phosphorylation in human breast cancer cells. Oncotarget. 2016;7:68303-68313 pubmed publisher |
- western blot; dogs; 1:500; fig s1d
| Hammers D, Sleeper M, Forbes S, Shima A, Walter G, Sweeney H. Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts. J Am Heart Assoc. 2016;5: pubmed publisher |
- western blot; human; fig 4b
| Hatem R, El Botty R, Chateau Joubert S, Servely J, Labiod D, de Plater L, et al. Targeting mTOR pathway inhibits tumor growth in different molecular subtypes of triple-negative breast cancers. Oncotarget. 2016;7:48206-48219 pubmed publisher |
- western blot; zebrafish ; 1:500; fig 9
| Zhang J, Jiang Z, Liu X, Meng A. Eph/ephrin signaling maintains the boundary of dorsal forerunner cell cluster during morphogenesis of the zebrafish embryonic left-right organizer. Development. 2016;143:2603-15 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3e
| Zuckerwise L, Li J, Lu L, Men Y, Geng T, Buhimschi C, et al. H19 long noncoding RNA alters trophoblast cell migration and invasion by regulating TβR3 in placentae with fetal growth restriction. Oncotarget. 2016;7:38398-38407 pubmed publisher |
- western blot; human; fig 4
| Bianchi Smiraglia A, Bagati A, Fink E, Moparthy S, Wawrzyniak J, Marvin E, et al. Microphthalmia-associated transcription factor suppresses invasion by reducing intracellular GTP pools. Oncogene. 2017;36:84-96 pubmed publisher |
- western blot; rat; loading ...; fig 2a
| Boateng L, Bennin D, de Oliveira S, Huttenlocher A. Mammalian Actin-binding Protein-1/Hip-55 Interacts with FHL2 and Negatively Regulates Cell Invasion. J Biol Chem. 2016;291:13987-98 pubmed publisher |
- western blot; human; 1:1000; fig 4
| Guen V, Gamble C, Perez D, Bourassa S, Zappel H, Gartner J, et al. STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis. Cell Cycle. 2016;15:678-88 pubmed publisher |
- western blot; human; loading ...; fig 2a
| von Mässenhausen A, SANDERS C, Thewes B, Deng M, Queisser A, Vogel W, et al. MERTK as a novel therapeutic target in head and neck cancer. Oncotarget. 2016;7:32678-94 pubmed publisher |
- western blot; human; fig 2
| Scott D, Tolbert C, Burridge K. Tension on JAM-A activates RhoA via GEF-H1 and p115 RhoGEF. Mol Biol Cell. 2016;27:1420-30 pubmed publisher |
- western blot; mouse; fig s4
| Jo D, Bae J, Chae S, Kim J, Han J, Hwang D, et al. Quantitative Proteomics Reveals β2 Integrin-mediated Cytoskeletal Rearrangement in Vascular Endothelial Growth Factor (VEGF)-induced Retinal Vascular Hyperpermeability. Mol Cell Proteomics. 2016;15:1681-91 pubmed publisher |
- western blot; human; fig 5
| Podmirseg S, Jäkel H, Ranches G, Kullmann M, Sohm B, Villunger A, et al. Caspases uncouple p27(Kip1) from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion. Oncogene. 2016;35:4580-90 pubmed publisher |
- western blot; human; 1:1000; fig s1
| Heemskerk N, Schimmel L, Oort C, van Rijssel J, Yin T, Ma B, et al. F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling. Nat Commun. 2016;7:10493 pubmed publisher |
- western blot; human; fig 4
| O Hayre M, Inoue A, Kufareva I, Wang Z, Mikelis C, Drummond R, et al. Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells. Oncogene. 2016;35:3771-80 pubmed publisher |
| Fujimura K, Choi S, Wyse M, Strnadel J, Wright T, Klemke R. Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels. J Biol Chem. 2015;290:29907-19 pubmed publisher |
- western blot; human; 1:250; loading ...; fig 3g
| Leyme A, Marivin A, Perez Gutierrez L, Nguyen L, Garcia Marcos M. Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin. J Cell Biol. 2015;210:1165-84 pubmed publisher |
- western blot; human; fig 1
| Ibeawuchi S, Agbor L, Quelle F, Sigmund C. Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors. J Biol Chem. 2015;290:19208-17 pubmed publisher |
- western blot; human; fig 3a
| Liu X, Yao J, Tripathi D, Ding Z, Xu Y, Sun M, et al. Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis. Oncogene. 2015;34:2450-60 pubmed publisher |
- western blot; mouse
- western blot; guinea pig
| Cheng Y, Cao A, Zheng J, Wang H, Sun Y, Liu C, et al. Airway hyperresponsiveness induced by repeated esophageal infusion of HCl in guinea pigs. Am J Respir Cell Mol Biol. 2014;51:701-8 pubmed publisher |
- western blot; mouse; fig 3
| Arroyo A, Camoletto P, Morando L, Sassoè Pognetto M, Giustetto M, Van Veldhoven P, et al. Pharmacological reversion of sphingomyelin-induced dendritic spine anomalies in a Niemann Pick disease type A mouse model. EMBO Mol Med. 2014;6:398-413 pubmed publisher |
| Nerurkar N, Lee C, Mahadevan L, Tabin C. Molecular control of macroscopic forces drives formation of the vertebrate hindgut. Nature. 2019;565:480-484 pubmed publisher |
| Bussche L, Rauner G, Antonyak M, Syracuse B, McDowell M, Brown A, et al. Microvesicle-mediated Wnt/?-Catenin Signaling Promotes Interspecies Mammary Stem/Progenitor Cell Growth. J Biol Chem. 2016;291:24390-24405 pubmed |
| Takenaka N, Nihata Y, Satoh T. Rac1 Activation Caused by Membrane Translocation of a Guanine Nucleotide Exchange Factor in Akt2-Mediated Insulin Signaling in Mouse Skeletal Muscle. PLoS ONE. 2016;11:e0155292 pubmed publisher |
| Sabbir M, Dillon R, Mowat M. Dlc1 interaction with non-muscle myosin heavy chain II-A (Myh9) and Rac1 activation. Biol Open. 2016;5:452-60 pubmed publisher |
| Bernardo B, Sapra G, Patterson N, Cemerlang N, Kiriazis H, Ueyama T, et al. Long-Term Overexpression of Hsp70 Does Not Protect against Cardiac Dysfunction and Adverse Remodeling in a MURC Transgenic Mouse Model with Chronic Heart Failure and Atrial Fibrillation. PLoS ONE. 2015;10:e0145173 pubmed publisher |
| Basak P, Dillon R, Leslie H, Raouf A, Mowat M. The Deleted in Liver Cancer 1 (Dlc1) tumor suppressor is haploinsufficient for mammary gland development and epithelial cell polarity. BMC Cancer. 2015;15:630 pubmed publisher |
| Pasquier J, Abu Kaoud N, Abdesselem H, Madani A, Hoarau Véchot J, Thawadi H, et al. SDF-1alpha concentration dependent modulation of RhoA and Rac1 modifies breast cancer and stromal cells interaction. BMC Cancer. 2015;15:569 pubmed publisher |
| Zandvakili I, Davis A, Hu G, Zheng Y. Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice. PLoS ONE. 2015;10:e0127923 pubmed publisher |
| Rasheed S, Teo C, Beillard E, Voorhoeve P, Zhou W, Ghosh S, et al. MicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells. Mol Cancer. 2015;14:67 pubmed publisher |
| Mikelis C, Simaan M, Ando K, Fukuhara S, Sakurai A, Amornphimoltham P, et al. RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock. Nat Commun. 2015;6:6725 pubmed publisher |
| Howell M, Brickner H, Delorme Walker V, Choi J, Saffin J, Miller D, et al. WISp39 binds phosphorylated Coronin 1B to regulate Arp2/3 localization and Cofilin-dependent motility. J Cell Biol. 2015;208:961-74 pubmed publisher |
| Ackerman S, Garcia C, Piao X, Gutmann D, Monk K. The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA. Nat Commun. 2015;6:6122 pubmed publisher |
| Jensen T, Sylow L, Rose A, Madsen A, Angin Y, Maarbjerg S, et al. Contraction-stimulated glucose transport in muscle is controlled by AMPK and mechanical stress but not sarcoplasmatic reticulum Ca(2+) release. Mol Metab. 2014;3:742-53 pubmed publisher |
| Thompson D, McArthur S, Hislop J, Flower R, Perretti M. Identification of a novel recycling sequence in the C-tail of FPR2/ALX receptor: association with cell protection from apoptosis. J Biol Chem. 2014;289:36166-78 pubmed publisher |
| Satoh T. Molecular mechanisms for the regulation of insulin-stimulated glucose uptake by small guanosine triphosphatases in skeletal muscle and adipocytes. Int J Mol Sci. 2014;15:18677-92 pubmed publisher |
| Osborne L, Li G, How T, O Brien E, Blobe G, Superfine R, et al. TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion. Mol Biol Cell. 2014;25:3528-40 pubmed publisher |
| Lima V, Lobato N, Filgueira F, Webb R, Tostes R, Giachini F. Vascular O-GlcNAcylation augments reactivity to constrictor stimuli by prolonging phosphorylated levels of the myosin light chain. Braz J Med Biol Res. 2014;47:826-33 pubmed |
| André G, Sandoval J, Retailleau K, Loufrani L, Toumaniantz G, Offermanns S, et al. Smooth muscle specific Rac1 deficiency induces hypertension by preventing p116RIP3-dependent RhoA inhibition. J Am Heart Assoc. 2014;3:e000852 pubmed publisher |
| Kempf A, Tews B, Arzt M, Weinmann O, Obermair F, Pernet V, et al. The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. PLoS Biol. 2014;12:e1001763 pubmed publisher |
| Palomero T, Couronné L, Khiabanian H, Kim M, Ambesi Impiombato A, Perez Garcia A, et al. Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas. Nat Genet. 2014;46:166-70 pubmed publisher |
| Rohani M, PILCHER B, Chen P, Parks W. Cdc42 inhibits ERK-mediated collagenase-1 (MMP-1) expression in collagen-activated human keratinocytes. J Invest Dermatol. 2014;134:1230-1237 pubmed publisher |
| Tang X, Jin R, Qu G, Wang X, Li Z, Yuan Z, et al. GPR116, an adhesion G-protein-coupled receptor, promotes breast cancer metastasis via the G?q-p63RhoGEF-Rho GTPase pathway. Cancer Res. 2013;73:6206-18 pubmed publisher |
| Xue H, Li Y, Everett E, Ryan K, Peng L, Porecha R, et al. Ameloblasts require active RhoA to generate normal dental enamel. Eur J Oral Sci. 2013;121:293-302 pubmed publisher |
| Rudich A, Klip A. Putting Rac1 on the path to glucose uptake. Diabetes. 2013;62:1831-2 pubmed publisher |
| Cattaneo F, Parisi M, Ammendola R. Distinct signaling cascades elicited by different formyl peptide receptor 2 (FPR2) agonists. Int J Mol Sci. 2013;14:7193-230 pubmed publisher |
| Gu H, Yu S, Gutekunst C, Gross R, Wei L. Inhibition of the Rho signaling pathway improves neurite outgrowth and neuronal differentiation of mouse neural stem cells. Int J Physiol Pathophysiol Pharmacol. 2013;5:11-20 pubmed |
| Sylow L, Jensen T, Kleinert M, Højlund K, Kiens B, Wojtaszewski J, et al. Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle. Diabetes. 2013;62:1865-75 pubmed publisher |
| Shin J, Krey J, Hassan A, Metlagel Z, Tauscher A, Pagana J, et al. Molecular architecture of the chick vestibular hair bundle. Nat Neurosci. 2013;16:365-74 pubmed publisher |
| Shikatani E, Trifonova A, Mandel E, Liu S, Roudier E, Krylova A, et al. Inhibition of proliferation, migration and proteolysis contribute to corticosterone-mediated inhibition of angiogenesis. PLoS ONE. 2012;7:e46625 pubmed publisher |
| Ponsaerts R, D hondt C, Hertens F, Parys J, Leybaert L, Vereecke J, et al. RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system. PLoS ONE. 2012;7:e42074 pubmed publisher |
| Bielenberg D, Seth A, Shimizu A, Pelton K, Cristofaro V, Ramachandran A, et al. Increased smooth muscle contractility in mice deficient for neuropilin 2. Am J Pathol. 2012;181:548-59 pubmed publisher |
| Zhang S, Zhou X, Lang R, Guo F. RhoA of the Rho family small GTPases is essential for B lymphocyte development. PLoS ONE. 2012;7:e33773 pubmed publisher |
| Worzfeld T, Swiercz J, Looso M, Straub B, Sivaraj K, Offermanns S. ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis. J Clin Invest. 2012;122:1296-305 pubmed publisher |
| Zaytseva Y, Rychahou P, Gulhati P, Elliott V, Mustain W, O CONNOR K, et al. Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer. Cancer Res. 2012;72:1504-17 pubmed publisher |
| Li L, Ying J, Li H, Zhang Y, Shu X, Fan Y, et al. The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/?-catenin signaling and silenced in common carcinomas. Oncogene. 2012;31:3901-12 pubmed publisher |
| Toullec A, Gerald D, Despouy G, Bourachot B, Cardon M, Lefort S, et al. Oxidative stress promotes myofibroblast differentiation and tumour spreading. EMBO Mol Med. 2010;2:211-30 pubmed publisher |
| Kamanova J, Kofronova O, Masin J, Genth H, Vojtova J, Linhartova I, et al. Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive ruffling. J Immunol. 2008;181:5587-97 pubmed |
| Feral C, Zijlstra A, Tkachenko E, Prager G, Gardel M, Slepak M, et al. CD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling. J Cell Biol. 2007;178:701-11 pubmed |
