| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; 1:1000; loading ...; fig ev1 a
| Albert V, Svensson K, Shimobayashi M, Colombi M, Munoz S, Jimenez V, et al. mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue. EMBO Mol Med. 2016;8:232-46 pubmed publisher |
- western blot; human; loading ...; fig 7b
| Wang W, Shen T, Dong B, Creighton C, Meng Y, Zhou W, et al. MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling. J Clin Invest. 2019;: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s1b
| Wang F, Meng M, Mo B, Yang Y, Ji Y, Huang P, et al. Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function. Nat Commun. 2018;9:4874 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3b
| NGUYEN J, Ray C, Fox A, Mendonça D, Kim J, Krebsbach P. Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration. Sci Adv. 2018;4:eaao5838 pubmed publisher |
- other; human; loading ...; fig 4c
| Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 7e
| Li N, Xue W, Yuan H, Dong B, Ding Y, Liu Y, et al. AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. J Clin Invest. 2017;127:1284-1302 pubmed publisher |
- western blot; human; loading ...; fig 2b
| Merhi A, Delree P, Marini A. The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling. Sci Rep. 2017;7:44602 pubmed publisher |
- reverse phase protein lysate microarray; human; loading ...; fig st6
| Cherniack A, Shen H, Walter V, Stewart C, Murray B, Bowlby R, et al. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017;31:411-423 pubmed publisher |
- reverse phase protein lysate microarray; human; loading ...; fig 3a
| . Integrated genomic and molecular characterization of cervical cancer. Nature. 2017;543:378-384 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 9e
| Hussain R, Macklin W. Integrin-Linked Kinase (ILK) Deletion Disrupts Oligodendrocyte Development by Altering Cell Cycle. J Neurosci. 2017;37:397-412 pubmed publisher |
- western blot; mouse; loading ...; fig 6b
| Yamauchi T, Nishiyama M, Moroishi T, Kawamura A, Nakayama K. FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells. Mol Cell Biol. 2017;37: pubmed publisher |
- western blot; mouse; loading ...; fig 2e
- western blot; rat; loading ...; fig 2f
| Jin F, Jiang K, Ji S, Wang L, Ni Z, Huang F, et al. Deficient TSC1/TSC2-complex suppression of SOX9-osteopontin-AKT signalling cascade constrains tumour growth in tuberous sclerosis complex. Hum Mol Genet. 2017;26:407-419 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 6a
| Fourneaux B, Chaire V, Lucchesi C, Karanian M, Pineau R, Laroche Clary A, et al. Dual inhibition of the PI3K/AKT/mTOR pathway suppresses the growth of leiomyosarcomas but leads to ERK activation through mTORC2: biological and clinical implications. Oncotarget. 2017;8:7878-7890 pubmed publisher |
- western blot; human; loading ...; fig 2b
| Sakre N, Wildey G, Behtaj M, Kresak A, Yang M, Fu P, et al. RICTOR amplification identifies a subgroup in small cell lung cancer and predicts response to drugs targeting mTOR. Oncotarget. 2017;8:5992-6002 pubmed publisher |
- western blot; human; 1:1000; fig 1
| Carbonneau M, M Gagné L, Lalonde M, Germain M, Motorina A, Guiot M, et al. The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat Commun. 2016;7:12700 pubmed publisher |
- immunoprecipitation; human; loading ...; fig 3b
- western blot; human; loading ...; fig 3b
| Su K, Cao J, Tang Z, Dai S, He Y, Sampson S, et al. HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth. Nat Cell Biol. 2016;18:527-39 pubmed publisher |
- western blot; human; fig 6
| Yasuda K, Takahashi M, Mori N. Mdm20 Modulates Actin Remodeling through the mTORC2 Pathway via Its Effect on Rictor Expression. PLoS ONE. 2015;10:e0142943 pubmed publisher |
- western blot; mouse; loading ...; fig 1d
- immunohistochemistry; human; loading ...; fig 2c
| Zidek L, Ackermann T, Hartleben G, Eichwald S, Kortman G, Kiehntopf M, et al. Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice. EMBO Rep. 2015;16:1022-36 pubmed publisher |
- western blot; mouse; fig 3h
- western blot; human; fig 1
| Kazyken D, Kaz Y, Kiyan V, Zhylkibayev A, Chen C, Agarwal N, et al. The nuclear import of ribosomal proteins is regulated by mTOR. Oncotarget. 2014;5:9577-93 pubmed |
- western blot; mouse; fig 3
| Tan S, Shui G, Zhou J, Shi Y, Huang J, Xia D, et al. Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway. Autophagy. 2014;10:226-42 pubmed publisher |
| Zheng B, Mao J, Li X, Qian L, Zhu H, Gu D, et al. Over-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2? expression and cell proliferation. Sci Rep. 2016;6:29415 pubmed publisher |
| Tandelilin A, Hirase T, Hudoyo A, Cheng J, Toyama K, Morisaki H, et al. AMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle. BMC Endocr Disord. 2015;15:11 pubmed publisher |
| Bernard M, Dieudé M, Yang B, Hamelin K, Underwood K, Hébert M. Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF. Autophagy. 2014;10:2193-207 pubmed publisher |
| Patursky Polischuk I, Kasir J, Miloslavski R, Hayouka Z, Hausner Hanochi M, Stolovich Rain M, et al. Reassessment of the role of TSC, mTORC1 and microRNAs in amino acids-meditated translational control of TOP mRNAs. PLoS ONE. 2014;9:e109410 pubmed publisher |
| Wan G, Xie W, Liu Z, Xu W, Lao Y, Huang N, et al. Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway. Autophagy. 2014;10:70-9 pubmed publisher |
| Paliouras G, Hamilton L, Aumont A, Joppé S, Barnabe Heider F, Fernandes K. Mammalian target of rapamycin signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain. J Neurosci. 2012;32:15012-26 pubmed publisher |
| Koh Y, Shah M, Agarwal K, McCarty S, Koo B, Brendel V, et al. Sorafenib and Mek inhibition is synergistic in medullary thyroid carcinoma in vitro. Endocr Relat Cancer. 2012;19:29-38 pubmed publisher |
| González I, Martin P, Burdsal C, Sloan J, Mager S, Harris T, et al. Leucine and arginine regulate trophoblast motility through mTOR-dependent and independent pathways in the preimplantation mouse embryo. Dev Biol. 2012;361:286-300 pubmed publisher |
| Rosner M, Fuchs C, Siegel N, Valli A, Hengstschlager M. Functional interaction of mammalian target of rapamycin complexes in regulating mammalian cell size and cell cycle. Hum Mol Genet. 2009;18:3298-310 pubmed publisher |
| Guertin D, Stevens D, Saitoh M, Kinkel S, Crosby K, Sheen J, et al. mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell. 2009;15:148-59 pubmed publisher |
