product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Axin1 (C76H11) Rabbit mAb
catalog :
2087
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
C76H11
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 24
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 3b
Guo C, Ma X, Xing Y, Zheng C, Xu Y, Shan L, et al. Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells. Cell. 2020;181:621-636.e22 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s7d
Quach C, Song Y, Guo H, Li S, Maazi H, Fung M, et al. A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. Nat Commun. 2019;10:5681 pubmed publisher
  • western blot; mouse; 81 ng/ml; loading ...; fig 4c
Choi J, Zhong X, McAlpine W, Liao T, Zhang D, Fang B, et al. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. Science. 2019;364: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a
Vallardi G, Allan L, Crozier L, Saurin A. Division of labour between PP2A-B56 isoforms at the centromere and kinetochore. elife. 2019;8: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4e, 5a, 5b
Ji L, Lu B, Wang Z, Yang Z, Reece Hoyes J, Russ C, et al. Identification of ICAT as an APC Inhibitor, Revealing Wnt-Dependent Inhibition of APC-Axin Interaction. Mol Cell. 2018;72:37-47.e4 pubmed publisher
  • immunoprecipitation; mouse; fig 5f
  • western blot; mouse; 1:1000; fig 5f
Chen X, Wang R, Liu X, Wu Y, Zhou T, Yang Y, et al. A Chemical-Genetic Approach Reveals the Distinct Roles of GSK3? and GSK3? in Regulating Embryonic Stem Cell Fate. Dev Cell. 2017;43:563-576.e4 pubmed publisher
  • western blot; mouse; loading ...; fig 3g
Matsumoto Y, La Rose J, Lim M, Adissu H, Law N, Mao X, et al. Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism. J Clin Invest. 2017;127:2612-2625 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Matsumoto Y, LaRose J, Kent O, Lim M, Changoor A, Zhang L, et al. RANKL coordinates multiple osteoclastogenic pathways by regulating expression of ubiquitin ligase RNF146. J Clin Invest. 2017;127:1303-1315 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4c
Li C, Chang L, Chen Z, Liu Z, Wang Y, Ye Q. The role of lncRNA MALAT1 in the regulation of hepatocyte proliferation during liver regeneration. Int J Mol Med. 2017;39:347-356 pubmed publisher
  • western blot; mouse; fig 2
Fagnocchi L, Cherubini A, Hatsuda H, Fasciani A, Mazzoleni S, Poli V, et al. A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity. Nat Commun. 2016;7:11903 pubmed publisher
  • immunoprecipitation; human; fig 5
  • western blot; human; fig 5
Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, et al. YAP/TAZ incorporation in the ?-catenin destruction complex orchestrates the Wnt response. Cell. 2014;158:157-70 pubmed publisher
  • western blot; human
Knoblich K, Wang H, Sharma C, Fletcher A, Turley S, Hemler M. Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits ?-catenin degradation. Cell Mol Life Sci. 2014;71:1305-14 pubmed publisher
Xu J, Deng X, Wu X, Zhu H, Zhu Y, Liu J, et al. Primary cilia regulate gastric cancer-induced bone loss via cilia/Wnt/β-catenin signaling pathway. Aging (Albany NY). 2021;13:8989-9010 pubmed publisher
Kan W, Enos M, Korkmazhan E, Muennich S, Chen D, Gammons M, et al. Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction. elife. 2020;9: pubmed publisher
Bernkopf D, Jalal K, Brückner M, Knaup K, Gentzel M, Schambony A, et al. Pgam5 released from damaged mitochondria induces mitochondrial biogenesis via Wnt signaling. J Cell Biol. 2018;217:1383-1394 pubmed publisher
Ji L, Jiang B, Jiang X, Charlat O, Chen A, Mickanin C, et al. The SIAH E3 ubiquitin ligases promote Wnt/?-catenin signaling through mediating Wnt-induced Axin degradation. Genes Dev. 2017;31:904-915 pubmed publisher
Mariotti L, Templeton C, Ranes M, Paracuellos P, Cronin N, Beuron F, et al. Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling. Mol Cell. 2016;63:498-513 pubmed publisher
Goto T, Matsuzawa J, Iemura S, Natsume T, Shibuya H. WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway. FEBS Lett. 2016;590:1291-303 pubmed publisher
Atkinson J, Rank K, Zeng Y, Capen A, Yadav V, Manro J, et al. Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma--Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3. PLoS ONE. 2015;10:e0125028 pubmed publisher
Fei C, Li Z, Li C, Chen Y, Chen Z, He X, et al. Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin negatively regulates Wnt/?-catenin signaling. Mol Cell Biol. 2013;33:4095-105 pubmed publisher
Farrell A, Pelz C, Wang X, Daniel C, Wang Z, Su Y, et al. Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis. Mol Cell Biol. 2013;33:2930-49 pubmed publisher
Shao L, Oshima S, Duong B, Advincula R, Barrera J, Malynn B, et al. A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis. PLoS ONE. 2013;8:e62223 pubmed publisher
James R, Davidson K, Bosch K, Biechele T, Robin N, Taylor R, et al. WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling. PLoS ONE. 2012;7:e50457 pubmed publisher
Tanneberger K, Pfister A, Kriz V, Bryja V, Schambony A, Behrens J. Structural and functional characterization of the Wnt inhibitor APC membrane recruitment 1 (Amer1). J Biol Chem. 2011;286:19204-14 pubmed publisher
product information
SKU :
2087S
Product-Name :
Axin1 (C76H11) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M
Applications :
Immunohistochemistry (Paraffin)
Product-Category :
Developmental Biology
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
110
Host :
Rabbit
Target :
Axin1
Primary-Protein :
axin 1
Alt-Names :
AXIN,AXIN1,AXN1,Axin-1,Axis inhibition protein 1,MGC52315,axin 1,axis inhibitor 1,fused, mouse, homolog of,hAxin
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.