product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
eIF4E (C46H6) Rabbit mAb
catalog :
2067
clonality :
monoclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
C46H6
reactivity :
human, mouse, rat, chicken, pig, common platanna
application :
western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 24
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 2d, s1c
Avolio R, Järvelin A, Mohammed S, Agliarulo I, Condelli V, Zoppoli P, et al. Protein Syndesmos is a novel RNA-binding protein that regulates primary cilia formation. Nucleic Acids Res. 2018;46:12067-12086 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4d
Wang J, Ye Q, Cao Y, Guo Y, Huang X, Mi W, et al. Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1. Nat Commun. 2017;8:2207 pubmed publisher
  • western blot; human; loading ...; fig s5p
Schafer S, Viswanathan S, Widjaja A, Lim W, Moreno Moral A, Delaughter D, et al. IL-11 is a crucial determinant of cardiovascular fibrosis. Nature. 2017;552:110-115 pubmed publisher
  • western blot; mouse; loading ...; fig 3f
Hsu J, Hubbell Engler B, Adelmant G, Huang J, Joyce C, Vazquez F, et al. PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer. Cancer Res. 2017;77:4613-4625 pubmed publisher
  • western blot; human; 1:10; loading ...; fig 3c
Sinkala E, Sollier Christen E, Renier C, Rosàs Canyelles E, Che J, Heirich K, et al. Profiling protein expression in circulating tumour cells using microfluidic western blotting. Nat Commun. 2017;8:14622 pubmed publisher
  • western blot; human; 1:1000; fig st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  • western blot; mouse; loading ...; fig s3d
Tsai S, Rodriguez A, Dastidar S, Del Greco E, Carr K, Sitzmann J, et al. Increased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice. Cell Rep. 2016;16:1903-14 pubmed publisher
  • western blot; human; loading ...; fig 2d
Lin S, Choe J, Du P, Triboulet R, Gregory R. The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. Mol Cell. 2016;62:335-345 pubmed publisher
  • western blot; human; fig 4
Lyabin D, Ovchinnikov L. Selective regulation of YB-1 mRNA translation by the mTOR signaling pathway is not mediated by 4E-binding protein. Sci Rep. 2016;6:22502 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:800; fig 1a
  • western blot; human; 1:1000; loading ...; fig 4a
Xu T, Zong Y, Peng L, Kong S, Zhou M, Zou J, et al. Overexpression of eIF4E in colorectal cancer patients is associated with liver metastasis. Onco Targets Ther. 2016;9:815-22 pubmed publisher
  • western blot; human; fig 1
Agarwal S, Bell C, Taylor S, Moran R. p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb. Mol Cancer Res. 2016;14:66-77 pubmed publisher
  • western blot; human; 1:1000; fig 4
Gebhardt A, Habjan M, Benda C, Meiler A, Haas D, Hein M, et al. mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3. Nat Commun. 2015;6:8192 pubmed publisher
  • western blot; common platanna; 1:1000; loading ...; fig 2B
Waghray S, Williams C, Coon J, Wickens M. Xenopus CAF1 requires NOT1-mediated interaction with 4E-T to repress translation in vivo. RNA. 2015;21:1335-45 pubmed publisher
  • western blot; human; fig 1
Van Rechem C, Black J, Boukhali M, Aryee M, Gräslund S, Haas W, et al. Lysine demethylase KDM4A associates with translation machinery and regulates protein synthesis. Cancer Discov. 2015;5:255-63 pubmed publisher
  • western blot; chicken; 1:500; fig 3
Tahiri Alaoui A, Zhao Y, Sadigh Y, Popplestone J, Kgosana L, Smith L, et al. Poly(A) binding protein 1 enhances cap-independent translation initiation of neurovirulence factor from avian herpesvirus. PLoS ONE. 2014;9:e114466 pubmed publisher
  • western blot; human; 1:1000
Ekmay R, Gatrell S, Lum K, Kim J, Lei X. Nutritional and metabolic impacts of a defatted green marine microalgal (Desmodesmus sp.) biomass in diets for weanling pigs and broiler chickens. J Agric Food Chem. 2014;62:9783-91 pubmed publisher
  • western blot; pig; 1:500
Zhang S, Ren M, Zeng X, He P, Ma X, Qiao S. Leucine stimulates ASCT2 amino acid transporter expression in porcine jejunal epithelial cell line (IPEC-J2) through PI3K/Akt/mTOR and ERK signaling pathways. Amino Acids. 2014;46:2633-42 pubmed publisher
  • western blot; mouse; 1:1000
Sidhu H, Dansie L, Hickmott P, Ethell D, Ethell I. Genetic removal of matrix metalloproteinase 9 rescues the symptoms of fragile X syndrome in a mouse model. J Neurosci. 2014;34:9867-79 pubmed publisher
  • western blot; mouse
Bian Z, Liao H, Zhang Y, Wu Q, Zhou H, Yang Z, et al. Never in mitosis gene A related kinase-6 attenuates pressure overload-induced activation of the protein kinase B pathway and cardiac hypertrophy. PLoS ONE. 2014;9:e96095 pubmed publisher
  • western blot; human
Zhu J, Lin F, Brown D, Clark R. A fibronectin peptide redirects PDGF-BB/PDGFR complexes to macropinocytosis-like internalization and augments PDGF-BB survival signals. J Invest Dermatol. 2014;134:921-929 pubmed publisher
  • western blot; human
Woessner D, Lim C. Disrupting BCR-ABL in combination with secondary leukemia-specific pathways in CML cells leads to enhanced apoptosis and decreased proliferation. Mol Pharm. 2013;10:270-7 pubmed publisher
Broeckel R, Sarkar S, May N, Totonchy J, Kreklywich C, Smith P, et al. Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs. Antimicrob Agents Chemother. 2019;63: pubmed publisher
Wang N, Feng Y, Tan H, Cheung F, Hong M, Lao L, et al. Inhibition of eukaryotic elongation factor-2 confers to tumor suppression by a herbal formulation Huanglian-Jiedu decoction in human hepatocellular carcinoma. J Ethnopharmacol. 2015;164:309-18 pubmed publisher
Wu M, Liu H, Fannin J, Katta A, Wang Y, Arvapalli R, et al. Acetaminophen improves protein translational signaling in aged skeletal muscle. Rejuvenation Res. 2010;13:571-9 pubmed publisher
product information
SKU :
2067S
Product-Name :
eIF4E (C46H6) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunohistochemistry (Paraffin)
Product-Category :
Translational Control
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
25
Host :
Rabbit
Target :
eIF4E
Primary-Protein :
eIF4E
Alt-Names :
CBP,EIF4E,EIF4E1,EIF4EL1,EIF4F,Eukaryotic translation initiation factor 4E,IF4E,MGC111573,eIF-4E,eIF-4F 25 kDa subunit,eukaryotic translation initiation factor 4E-like 1,mRNA cap-binding protein
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.