| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; loading ...; fig 2a
- western blot knockout validation; mouse; loading ...; fig 6a
| Koh H, Kim Y, Kim J, Yun J, Jang K, Yang C. Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKCα. PLoS Pathog. 2017;13:e1006126 pubmed publisher |
- western blot; human; loading ...; fig 6b
| Nakanishi M, Mitchell R, Benoit Y, Orlando L, Reid J, Shimada K, et al. Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells. Cell. 2019;177:910-924.e22 pubmed publisher |
- western blot; human; loading ...; fig 3e
| Son S, Park S, Lee H, Siddiqi F, Lee J, Menzies F, et al. Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A. Cell Metab. 2019;29:192-201.e7 pubmed publisher |
- other; human; loading ...; fig 4c
| Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3b
| Jung Y, Cackowski F, Yumoto K, Decker A, Wang J, Kim J, et al. CXCL12γ Promotes Metastatic Castration-Resistant Prostate Cancer by Inducing Cancer Stem Cell and Neuroendocrine Phenotypes. Cancer Res. 2018;78:2026-2039 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3
| Lu F, Shao G, Wang Y, Guan S, Burlingame A, Liu X, et al. Hypoxia-ischemia modifies postsynaptic GluN2B-containing NMDA receptor complexes in the neonatal mouse brain. Exp Neurol. 2018;299:65-74 pubmed publisher |
- western blot; human; loading ...; fig 1b
| Chen X, Wu Q, Depeille P, Chen P, Thornton S, Kalirai H, et al. RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma. Cancer Cell. 2017;31:685-696.e6 pubmed publisher |
- western blot; human; loading ...
| Zhai S, Liu C, Zhang L, Zhu J, Guo J, Zhang J, et al. PLCE1 Promotes Esophageal Cancer Cell Progression by Maintaining the Transcriptional Activity of Snail. Neoplasia. 2017;19:154-164 pubmed publisher |
- western blot; human; loading ...; fig 2b
| Sakre N, Wildey G, Behtaj M, Kresak A, Yang M, Fu P, et al. RICTOR amplification identifies a subgroup in small cell lung cancer and predicts response to drugs targeting mTOR. Oncotarget. 2017;8:5992-6002 pubmed publisher |
- western blot; human; 1:500; fig s3
| Tseng H, Vong C, Kwan Y, Lee S, Hoi M. TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells. Sci Rep. 2016;6:35016 pubmed publisher |
- western blot; human; 1:1000; fig 3
| Lee E, Wang J, Yumoto K, Jung Y, Cackowski F, Decker A, et al. DNMT1 Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cells, Which Promotes Prostate Cancer Metastasis. Neoplasia. 2016;18:553-66 pubmed publisher |
- western blot; mouse; loading ...; fig 7a
| Wu Y, Ren D, Chen G. Siglec-E Negatively Regulates the Activation of TLR4 by Controlling Its Endocytosis. J Immunol. 2016;197:3336-3347 pubmed |
- western blot; mouse; fig 5e
| Girola N, Matsuo A, Figueiredo C, Massaoka M, Farias C, Arruda D, et al. The Ig VH complementarity-determining region 3-containing Rb9 peptide, inhibits melanoma cells migration and invasion by interactions with Hsp90 and an adhesion G-protein coupled receptor. Peptides. 2016;85:1-15 pubmed publisher |
- western blot; mouse; 1:1000; fig st2
| Gharib M, Tao H, Fungwe T, Hajri T. Cluster Differentiating 36 (CD36) Deficiency Attenuates Obesity-Associated Oxidative Stress in the Heart. PLoS ONE. 2016;11:e0155611 pubmed publisher |
- western blot; mouse; 1:1000; fig 5
| Najibi M, Labed S, Visvikis O, IRAZOQUI J. An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense. Cell Rep. 2016;15:1728-42 pubmed publisher |
- western blot; human; fig s15
| Weigel C, Veldwijk M, Oakes C, Seibold P, Slynko A, Liesenfeld D, et al. Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis. Nat Commun. 2016;7:10893 pubmed publisher |
- immunocytochemistry; mouse; 1:50; fig 6
| Sugar T, Wassenhove McCarthy D, Orr A, Green J, van Kuppevelt T, McCarthy K. N-sulfation of heparan sulfate is critical for syndecan-4-mediated podocyte cell-matrix interactions. Am J Physiol Renal Physiol. 2016;310:F1123-35 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 6e
| Albert V, Svensson K, Shimobayashi M, Colombi M, Munoz S, Jimenez V, et al. mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue. EMBO Mol Med. 2016;8:232-46 pubmed publisher |
- western blot; human; fig 5
| Yasuda K, Takahashi M, Mori N. Mdm20 Modulates Actin Remodeling through the mTORC2 Pathway via Its Effect on Rictor Expression. PLoS ONE. 2015;10:e0142943 pubmed publisher |
- western blot; mouse; 1:1000; fig 6c
| Dong H, Chen Z, Wang C, Xiong Z, Zhao W, Jia C, et al. Rictor Regulates Spermatogenesis by Controlling Sertoli Cell Cytoskeletal Organization and Cell Polarity in the Mouse Testis. Endocrinology. 2015;156:4244-56 pubmed publisher |
- immunocytochemistry; mouse
| Balzamino B, Esposito G, Marino R, Keller F, Micera A. NGF Expression in Reelin-Deprived Retinal Cells: A Potential Neuroprotective Effect. Neuromolecular Med. 2015;17:314-25 pubmed publisher |
- western blot; mouse; fig 4
| Li J, Ren J, Liu X, Jiang L, He W, Yuan W, et al. Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis. Kidney Int. 2015;88:515-27 pubmed publisher |
| Corbel C, Zhang B, Le Parc A, Baratte B, Colas P, Couturier C, et al. Tamoxifen inhibits CDK5 kinase activity by interacting with p35/p25 and modulates the pattern of tau phosphorylation. Chem Biol. 2015;22:472-482 pubmed publisher |
- western blot; mouse; 1:1000; fig s1e
| Mignogna M, Giannandrea M, Gurgone A, Fanelli F, Raimondi F, Mapelli L, et al. The intellectual disability protein RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition. Nat Commun. 2015;6:6504 pubmed publisher |
- western blot; mouse; fig 2
- western blot; human; fig 9
| Wang S, Amato K, Song W, Youngblood V, Lee K, Boothby M, et al. Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways. Mol Cell Biol. 2015;35:1299-313 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 3l
| Zou M, Luo H, Xiang M. Selective neuronal lineages derived from Dll4-expressing progenitors/precursors in the retina and spinal cord. Dev Dyn. 2015;244:86-97 pubmed publisher |
| Lu G, Zhang Q, Huang Y, Song J, Tomaino R, Ehrenberger T, et al. Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor. Cancer Cell. 2014;26:222-34 pubmed publisher |
| Shimobayashi M, Albert V, Woelnerhanssen B, Frei I, Weissenberger D, Meyer Gerspach A, et al. Insulin resistance causes inflammation in adipose tissue. J Clin Invest. 2018;128:1538-1550 pubmed publisher |
| Meng M, Wang H, Cui Y, Wu Z, Shi Y, Zaorsky N, et al. Necroptosis in tumorigenesis, activation of anti-tumor immunity, and cancer therapy. Oncotarget. 2016;7:57391-57413 pubmed publisher |
| Termini C, Lidke K, Gillette J. Tetraspanin CD82 Regulates the Spatiotemporal Dynamics of PKCα in Acute Myeloid Leukemia. Sci Rep. 2016;6:29859 pubmed publisher |
| Lange S, Gehmlich K, Lun A, Blondelle J, Hooper C, Dalton N, et al. MLP and CARP are linked to chronic PKC? signalling in dilated cardiomyopathy. Nat Commun. 2016;7:12120 pubmed publisher |
| Reinhard N, van Helden S, Anthony E, Yin T, Wu Y, Goedhart J, et al. Spatiotemporal analysis of RhoA/B/C activation in primary human endothelial cells. Sci Rep. 2016;6:25502 pubmed publisher |
| Dondelinger Y, Darding M, Bertrand M, Walczak H. Poly-ubiquitination in TNFR1-mediated necroptosis. Cell Mol Life Sci. 2016;73:2165-76 pubmed publisher |
| Vanden Berghe T, Hassannia B, Vandenabeele P. An outline of necrosome triggers. Cell Mol Life Sci. 2016;73:2137-52 pubmed publisher |
| Tian F, Yao J, Yan M, Sun X, Wang W, Gao W, et al. 5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Inhibits RIPK1/RIPK3-Dependent Necroptosis in THP-1-Derived Foam Cells. Sci Rep. 2016;6:21992 pubmed publisher |
| Murphy J, Vince J. Post-translational control of RIPK3 and MLKL mediated necroptotic cell death. F1000Res. 2015;4: pubmed publisher |
| Giampietro C, Disanza A, Bravi L, Barrios Rodiles M, Corada M, Frittoli E, et al. The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling. J Cell Biol. 2015;211:1177-92 pubmed publisher |
| Geng J, Sun X, Wang P, Zhang S, Wang X, Wu H, et al. Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. Nat Immunol. 2015;16:1142-52 pubmed publisher |
| Li S, Payne S, Wang F, Claus P, Su Z, Groth J, et al. Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance. Breast Cancer Res. 2015;17:91 pubmed publisher |
| Kang S, Fernandes Alnemri T, Rogers C, Mayes L, Wang Y, Dillon C, et al. Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3. Nat Commun. 2015;6:7515 pubmed publisher |
| Lee J, Yeganeh B, Ermini L, Post M. Sphingolipids as cell fate regulators in lung development and disease. Apoptosis. 2015;20:740-57 pubmed publisher |
| Liu T, Bao Y, Wang Y, Jiang J. The role of necroptosis in neurosurgical diseases. Braz J Med Biol Res. 2015;48:292-8 pubmed publisher |
| Moriwaki K, Bertin J, Gough P, Orlowski G, Chan F. Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death. Cell Death Dis. 2015;6:e1636 pubmed publisher |
| Calandria J, Asatryan A, Balaszczuk V, Knott E, Jun B, Mukherjee P, et al. NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival. Cell Death Differ. 2015;22:1363-77 pubmed publisher |
| Bolger G, Dunlop A, Meng D, Day J, Klussmann E, Baillie G, et al. Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains. Cell Signal. 2015;27:756-69 pubmed publisher |
| Gavard J. Endothelial permeability and VE-cadherin: a wacky comradeship. Cell Adh Migr. 2014;8:158-64 pubmed |
| Boyle G, D Souza M, Pierce C, Adams R, Cantor A, Johns J, et al. Intra-lesional injection of the novel PKC activator EBC-46 rapidly ablates tumors in mouse models. PLoS ONE. 2014;9:e108887 pubmed publisher |
| Nugues A, El Bouazzati H, Hétuin D, Berthon C, Loyens A, Bertrand E, et al. RIP3 is downregulated in human myeloid leukemia cells and modulates apoptosis and caspase-mediated p65/RelA cleavage. Cell Death Dis. 2014;5:e1384 pubmed publisher |
| Banerjee R, Russo N, Liu M, Basrur V, Bellile E, Palanisamy N, et al. TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer. Nat Commun. 2014;5:4527 pubmed publisher |
| Lu C, Zhou L, Xu H, Chen X, Tong Z, Liu X, et al. RIP3 overexpression sensitizes human breast cancer cells to parthenolide in vitro via intracellular ROS accumulation. Acta Pharmacol Sin. 2014;35:929-36 pubmed publisher |
| Consonni S, Brouwer P, van Slobbe E, Bos J. The PDZ domain of the guanine nucleotide exchange factor PDZGEF directs binding to phosphatidic acid during brush border formation. PLoS ONE. 2014;9:e98253 pubmed publisher |
| Pannekoek W, Post A, Bos J. Rap1 signaling in endothelial barrier control. Cell Adh Migr. 2014;8:100-7 pubmed |
| Jo Watanabe A, Ohse T, Nishimatsu H, Takahashi M, Ikeda Y, Wada T, et al. Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation. Aging Cell. 2014;13:519-28 pubmed publisher |
| Montano R, Thompson R, Chung I, Hou H, Khan N, Eastman A. Sensitization of human cancer cells to gemcitabine by the Chk1 inhibitor MK-8776: cell cycle perturbation and impact of administration schedule in vitro and in vivo. BMC Cancer. 2013;13:604 pubmed publisher |
| Moquin D, McQuade T, Chan F. CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis. PLoS ONE. 2013;8:e76841 pubmed publisher |
| Ando K, Fukuhara S, Moriya T, Obara Y, Nakahata N, Mochizuki N. Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization. J Cell Biol. 2013;202:901-16 pubmed publisher |
| Monteiro A, Sumagin R, Rankin C, Leoni G, Mina M, Reiter D, et al. JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function. Mol Biol Cell. 2013;24:2849-60 pubmed publisher |
| Wu J, Huang Z, Ren J, Zhang Z, He P, Li Y, et al. Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Cell Res. 2013;23:994-1006 pubmed publisher |
| Wang K, Liu F, Zhou L, Ding S, Long B, Liu C, et al. miR-874 regulates myocardial necrosis by targeting caspase-8. Cell Death Dis. 2013;4:e709 pubmed publisher |
| Lu Q, Ivanova E, Ganjawala T, Pan Z. Cre-mediated recombination efficiency and transgene expression patterns of three retinal bipolar cell-expressing Cre transgenic mouse lines. Mol Vis. 2013;19:1310-20 pubmed |
| Pannekoek W, Linnemann J, Brouwer P, Bos J, Rehmann H. Rap1 and Rap2 antagonistically control endothelial barrier resistance. PLoS ONE. 2013;8:e57903 pubmed publisher |
| Ito Y, Ito T, Karasawa S, Enomoto T, Nashimoto A, Hase Y, et al. Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of bisphenol A. PLoS ONE. 2012;7:e50481 pubmed publisher |
| Zhao Q, Niu Y, Matsumoto K, Tsuneyama K, Tanaka K, Miyata T, et al. Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain. BMC Complement Altern Med. 2012;12:188 pubmed publisher |
| Madrigal A, Barth K, Papadopoulos G, Genco C. Pathogen-mediated proteolysis of the cell death regulator RIPK1 and the host defense modulator RIPK2 in human aortic endothelial cells. PLoS Pathog. 2012;8:e1002723 pubmed publisher |
| Vanlangenakker N, Bertrand M, Bogaert P, Vandenabeele P, Vanden Berghe T. TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members. Cell Death Dis. 2011;2:e230 pubmed publisher |
| Kye M, Neveu P, Lee Y, Zhou M, Steen J, Sahin M, et al. NMDA mediated contextual conditioning changes miRNA expression. PLoS ONE. 2011;6:e24682 pubmed publisher |
| Chen Y, Yu G, Yu D, Zhu M. PKCalpha-induced drug resistance in pancreatic cancer cells is associated with transforming growth factor-beta1. J Exp Clin Cancer Res. 2010;29:104 pubmed publisher |
| Holmes K, Chapman E, See V, Cross M. VEGF stimulates RCAN1.4 expression in endothelial cells via a pathway requiring Ca2+/calcineurin and protein kinase C-delta. PLoS ONE. 2010;5:e11435 pubmed publisher |
