product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
XIAP (3B6) Rabbit mAb
catalog :
2045
clonality :
monoclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
3B6
reactivity :
human
application :
western blot
citations: 28
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 2b
Sahu U, Choudhury A, Parvez S, Biswas S, Kar S. Induction of intestinal stemness and tumorigenicity by aberrant internalization of commensal non-pathogenic E. coli. Cell Death Dis. 2017;8:e2667 pubmed publisher
  • western blot; human; 1:1000; fig 3
Greene L, Nathwani S, Zisterer D. Inhibition of ?-secretase activity synergistically enhances tumour necrosis factor-related apoptosis-inducing ligand induced apoptosis in T-cell acute lymphoblastic leukemia cells via upregulation of death receptor 5. Oncol Lett. 2016;12:2900-2905 pubmed
  • western blot; human; loading ...; fig 4.d,e,f
Klingbeil O, Lesche R, Gelato K, Haendler B, Lejeune P. Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated NSCLC to pro-apoptotic agents. Cell Death Dis. 2016;7:e2365 pubmed publisher
  • western blot; human; loading ...; fig 1d
Jinesh G, Molina J, Huang L, Laing N, Mills G, Bar Eli M, et al. Mitochondrial oligomers boost glycolysis in cancer stem cells to facilitate blebbishield-mediated transformation after apoptosis. Cell Death Discov. 2016;2:16003 pubmed publisher
  • western blot; human; fig 2
Tagscherer K, Fassl A, Sinkovic T, Richter J, Schecher S, Macher Goeppinger S, et al. MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen. Cancer Cell Int. 2016;16:42 pubmed publisher
  • western blot; human
Monian P, Jiang X. The Cellular Apoptosis Susceptibility Protein (CAS) Promotes Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis and Cell Proliferation. J Biol Chem. 2016;291:2379-88 pubmed publisher
  • western blot; human
Qiu J, Zhang Y, Li Y, Zhao J, Zhang W, Jiang Q, et al. Trametinib modulates cancer multidrug resistance by targeting ABCB1 transporter. Oncotarget. 2015;6:15494-509 pubmed
  • western blot; human; fig 5
Brouxhon S, Kyrkanides S, Teng X, O Banion M, Clarke R, Byers S, et al. Soluble-E-cadherin activates HER and IAP family members in HER2+ and TNBC human breast cancers. Mol Carcinog. 2014;53:893-906 pubmed publisher
Marins F, Iddings J, Fontes M, Filosa J. Evidence that remodeling of insular cortex neurovascular unit contributes to hypertension-related sympathoexcitation. Physiol Rep. 2017;5: pubmed publisher
Kim S, Park S, Shim S, Park S, Kim K, Jeong S, et al. Bay 61-3606 Sensitizes TRAIL-Induced Apoptosis by Downregulating Mcl-1 in Breast Cancer Cells. PLoS ONE. 2015;10:e0146073 pubmed publisher
Wu C, Chen J, Chen C, Wang W, Wen L, Gao K, et al. Wnt/β-catenin coupled with HIF-1α/VEGF signaling pathways involved in galangin neurovascular unit protection from focal cerebral ischemia. Sci Rep. 2015;5:16151 pubmed publisher
Chen X, Xie F, Zhu X, Lin F, Pan S, Gong L, et al. Cyclin-dependent kinase inhibitor dinaciclib potently synergizes with cisplatin in preclinical models of ovarian cancer. Oncotarget. 2015;6:14926-39 pubmed
Yi Y, You K, Bae E, Kwak S, Seong Y, Bae I. Dual inhibition of EGFR and MET induces synthetic lethality in triple-negative breast cancer cells through downregulation of ribosomal protein S6. Int J Oncol. 2015;47:122-32 pubmed publisher
Jor dan A, Manor B, Novak V. Slow gait speed - an indicator of lower cerebral vasoreactivity in type 2 diabetes mellitus. Front Aging Neurosci. 2014;6:135 pubmed publisher
Pang Y, Mao H, Shen L, Zhao Z, Liu R, Liu P. MiR-519d represses ovarian cancer cell proliferation and enhances cisplatin-mediated cytotoxicity in vitro by targeting XIAP. Onco Targets Ther. 2014;7:587-97 pubmed publisher
Flück D, Beaudin A, Steinback C, Kumarpillai G, Shobha N, McCreary C, et al. Effects of aging on the association between cerebrovascular responses to visual stimulation, hypercapnia and arterial stiffness. Front Physiol. 2014;5:49 pubmed publisher
Ding J, Guo J, Yuan Q, Yuan F, Chen H, Tian H. Inhibition of phosphatase and tensin homolog deleted on chromosome 10 decreases rat cortical neuron injury and blood-brain barrier permeability, and improves neurological functional recovery in traumatic brain injury model. PLoS ONE. 2013;8:e80429 pubmed publisher
Kumar D, Shankar S, Srivastava R. Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway. Cancer Lett. 2014;343:179-89 pubmed publisher
Takahashi C, Muramatsu R, Fujimura H, Mochizuki H, Yamashita T. Prostacyclin promotes oligodendrocyte precursor recruitment and remyelination after spinal cord demyelination. Cell Death Dis. 2013;4:e795 pubmed publisher
Yang Y, Igumenova T. The C-terminal V5 domain of Protein Kinase C? is intrinsically disordered, with propensity to associate with a membrane mimetic. PLoS ONE. 2013;8:e65699 pubmed publisher
Gillissen B, Richter A, Overkamp T, Essmann F, Hemmati P, Preissner R, et al. Targeted therapy of the XIAP/proteasome pathway overcomes TRAIL-resistance in carcinoma by switching apoptosis signaling to a Bax/Bak-independent 'type I' mode. Cell Death Dis. 2013;4:e643 pubmed publisher
Yi Y, Hong W, Kang H, Kim H, Zhao W, Wang A, et al. Inhibition of the PI3K/AKT pathway potentiates cytotoxicity of EGFR kinase inhibitors in triple-negative breast cancer cells. J Cell Mol Med. 2013;17:648-56 pubmed publisher
Deracinois B, Duban Deweer S, Pottiez G, Cecchelli R, Karamanos Y, Flahaut C. TNAP and EHD1 are over-expressed in bovine brain capillary endothelial cells after the re-induction of blood-brain barrier properties. PLoS ONE. 2012;7:e48428 pubmed publisher
Frevert U, Movila A, Nikolskaia O, Raper J, Mackey Z, Abdulla M, et al. Early invasion of brain parenchyma by African trypanosomes. PLoS ONE. 2012;7:e43913 pubmed publisher
Urich E, Lazic S, Molnos J, Wells I, Freskgård P. Transcriptional profiling of human brain endothelial cells reveals key properties crucial for predictive in vitro blood-brain barrier models. PLoS ONE. 2012;7:e38149 pubmed publisher
Jinesh G G, Chunduru S, Kamat A. Smac mimetic enables the anticancer action of BCG-stimulated neutrophils through TNF-? but not through TRAIL and FasL. J Leukoc Biol. 2012;92:233-44 pubmed publisher
Kim K, Singh R, Strongin R, Moore R, Brard L, Lange T. Organometallic iron(III)-salophene exerts cytotoxic properties in neuroblastoma cells via MAPK activation and ROS generation. PLoS ONE. 2011;6:e19049 pubmed publisher
Schilling S, Hjelmeland A, Radiloff D, Liu I, Wakeman T, Fielhauer J, et al. NDRG4 is required for cell cycle progression and survival in glioblastoma cells. J Biol Chem. 2009;284:25160-9 pubmed publisher
product information
SKU :
2045P
Product-Name :
XIAP (3B6) Rabbit mAb
Size :
40 ul
Price-(USD) :
123 USD
Species-x-Reactivity :
H, Mk
Applications :
Western blot
Product-Category :
Apoptosis
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
53
Host :
Rabbit
Target :
XIAP
Primary-Protein :
XIAP
Alt-Names :
API3,BIRC4,Baculoviral IAP repeat-containing protein 4,E3 ubiquitin-protein ligase XIAP,IAP-3,IAP-like protein,IAP3,ILP,ILP1,Inhibitor of apoptosis protein 3,MIHA,X-linked IAP,X-linked inhibitor of apoptosis,X-linked inhibitor of apoptosis protein,XIAP,XLP2,apoptosis inhibitor 3,baculoviral IAP repeat-containing 4,hIAP-3,hIAP3,hILP
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.