product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
PP2A C Subunit Antibody
catalog :
2038
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
more info or order :
Cell Signaling Technology product webpage
citations: 20
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...
Sangodkar J, Perl A, Tohme R, Kiselar J, Kastrinsky D, Zaware N, et al. Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth. J Clin Invest. 2017;127:2081-2090 pubmed publisher
  • western blot; rat; fig 7
Morgan K, Black L. Investigation into the effects of varying frequency of mechanical stimulation in a cycle-by-cycle manner on engineered cardiac construct function. J Tissue Eng Regen Med. 2017;11:342-353 pubmed publisher
  • immunoprecipitation; human; fig 6
Liu C, Lin S, Hsu H, Yang S, Lin C, Yang M, et al. Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells. Nat Commun. 2016;7:11798 pubmed publisher
  • western blot; human; fig 4
Shu S, Lin C, He H, Witwicki R, Tabassum D, Roberts J, et al. Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer. Nature. 2016;529:413-417 pubmed publisher
  • western blot; human; loading ...; fig 4a
Pokharel Y, Saarela J, Szwajda A, Rupp C, Rokka A, Lal Kumar Karna S, et al. Relevance Rank Platform (RRP) for Functional Filtering of High Content Protein-Protein Interaction Data. Mol Cell Proteomics. 2015;14:3274-83 pubmed publisher
  • western blot; human; fig 3
Xia X, Gholkar A, Senese S, Torres J. A LCMT1-PME-1 methylation equilibrium controls mitotic spindle size. Cell Cycle. 2015;14:1938-47 pubmed publisher
  • western blot; human; 1:1000
Qiu M, Liu L, Chen L, Tan G, Liang Z, Wang K, et al. microRNA-183 plays as oncogenes by increasing cell proliferation, migration and invasion via targeting protein phosphatase 2A in renal cancer cells. Biochem Biophys Res Commun. 2014;452:163-9 pubmed publisher
Wang X, Wang R, Luo M, Li C, Wang H, Huan C, et al. (DEAD)-box RNA helicase 3 modulates NF-κB signal pathway by controlling the phosphorylation of PP2A-C subunit. Oncotarget. 2017;8:33197-33213 pubmed publisher
Park S, Chung T, Kim S, Hwang B, Kim J, Lee H, et al. HSP70-1 is required for interleukin-5-induced angiogenic responses through eNOS pathway. Sci Rep. 2017;7:44687 pubmed publisher
Wei R, De Vivo I, Huang S, Zhu X, Risch H, Moore J, et al. Meta-dimensional data integration identifies critical pathways for susceptibility, tumorigenesis and progression of endometrial cancer. Oncotarget. 2016;7:55249-55263 pubmed publisher
Wang S, Xie W, Wang D, Peng Z, Zheng Y, Liu N, et al. Discovery of a small molecule targeting SET-PP2A interaction to overcome BCR-ABLT315I mutation of chronic myeloid leukemia. Oncotarget. 2015;6:12128-40 pubmed
Grallert A, Boke E, Hagting A, Hodgson B, Connolly Y, Griffiths J, et al. A PP1-PP2A phosphatase relay controls mitotic progression. Nature. 2015;517:94-98 pubmed publisher
Müller I, Beissert S, Kulms D. Anti-apoptotic NF-κB and "gain of function" mutp53 in concert act pro-apoptotic in response to UVB+IL-1 via enhanced TNF production. J Invest Dermatol. 2015;135:851-860 pubmed publisher
Sobral L, Sousa L, Coletta R, Cabral H, Greene L, Tajara E, et al. Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models. Mol Cancer. 2014;13:32 pubmed publisher
Feng Y, Niu L, Wei W, Zhang W, Li X, Cao J, et al. A feedback circuit between miR-133 and the ERK1/2 pathway involving an exquisite mechanism for regulating myoblast proliferation and differentiation. Cell Death Dis. 2013;4:e934 pubmed publisher
Shao J, Diamond M. Protein phosphatase 1 dephosphorylates profilin-1 at Ser-137. PLoS ONE. 2012;7:e32802 pubmed publisher
Wang Y, Steimle P, Ren Y, Ross C, Robinson D, Egelhoff T, et al. Dictyostelium huntingtin controls chemotaxis and cytokinesis through the regulation of myosin II phosphorylation. Mol Biol Cell. 2011;22:2270-81 pubmed publisher
Witt J, Barisic S, Schumann E, Allgöwer F, Sawodny O, Sauter T, et al. Mechanism of PP2A-mediated IKK beta dephosphorylation: a systems biological approach. BMC Syst Biol. 2009;3:71 pubmed publisher
Laurila J, Laatikainen L, Castellone M, Laukkanen M. SOD3 reduces inflammatory cell migration by regulating adhesion molecule and cytokine expression. PLoS ONE. 2009;4:e5786 pubmed publisher
Bredemeyer A, Helmink B, Innes C, Calderon B, McGinnis L, Mahowald G, et al. DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes. Nature. 2008;456:819-23 pubmed publisher
product information
SKU :
2038S
Product-Name :
PP2A C Subunit Antibody
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk, Dm, (C, Pg)
Applications :
Flow cytometry
Product-Category :
Cell Cycle / Checkpoint Control
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
36, 38
Host :
Rabbit
Target :
PP2A C subunit
Primary-Protein :
PPP2CA
Alt-Names :
PP2A-alpha,PP2AA,PP2Ac,PP2CA,PP2Calpha,PPP2CA,RP-C,Replication protein C,Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform,protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform,protein phosphatase 2, catalytic subunit, alpha isoform,protein phosphatase 2, catalytic subunit, alpha isozyme,protein phosphatase 2A catalytic subunit, alpha isoform,serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.