| Published Application/Species/Dilution | Reference |
|---|
- western blot (knockout validation); mouse
| Nitta R, Smith C, Kennedy B. Evidence that proteasome-dependent degradation of the retinoblastoma protein in cells lacking A-type lamins occurs independently of gankyrin and MDM2. PLoS ONE. 2007;2:e963 pubmed |
- western blot (knockdown validation); human; fig 3
| Zhang G, Chan B, Samarina N, Abere B, Weidner-Glunde M, Buch A, et al. Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS. Proc Natl Acad Sci U S A. 2016;113:E1034-43 pubmed publisher |
- western blot; mouse; fig 1
| Lagarrigue S, López-Mejía I, Denechaud P, Escote X, Castillo-Armengol J, Jimenez V, et al. CDK4 is an essential insulin effector in adipocytes. J Clin Invest. 2016;126:335-48 pubmed publisher |
- immunocytochemistry; human; tbl 1
| Almeida C, Fernandes S, Ribeiro Junior A, Keith Okamoto O, Vainzof M. Muscle Satellite Cells: Exploring the Basic Biology to Rule Them. Stem Cells Int. 2016;2016:1078686 pubmed publisher |
- western blot; human; fig s5
| Starokadomskyy P, Gemelli T, Rios J, Xing C, Wang R, Li H, et al. DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis. Nat Immunol. 2016;17:495-504 pubmed publisher |
- western blot; mouse; 1:1000; fig 6
| Cannavo A, Liccardo D, Eguchi A, Elliott K, Traynham C, Ibetti J, et al. Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases. Nat Commun. 2016;7:10877 pubmed publisher |
- western blot; human; fig 2
| Chen N, Chyau C, Lee Y, Tseng H, Chou F. Promotion of mitotic catastrophe via activation of PTEN by paclitaxel with supplement of mulberry water extract in bladder cancer cells. Sci Rep. 2016;6:20417 pubmed publisher |
- western blot; human; 1:1000; fig 1a
| Zhang J, Tripathi D, Jing J, Alexander A, Kim J, Powell R, et al. ATM functions at the peroxisome to induce pexophagy in response to ROS. Nat Cell Biol. 2015;17:1259-69 pubmed publisher |
- western blot; human; fig 1f
| Liu X, Yao J, Tripathi D, Ding Z, Xu Y, Sun M, et al. Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis. Oncogene. 2015;34:2450-60 pubmed publisher |
- western blot; mouse; 1:1000; fig 6
| Nemazanyy I, Montagnac G, Russell R, Morzyglod L, Burnol A, Guan K, et al. Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nat Commun. 2015;6:8283 pubmed publisher |
- western blot; human; fig 2c
| Perera R, Stoykova S, Nicolay B, Ross K, Fitamant J, Boukhali M, et al. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 2015;524:361-5 pubmed publisher |
- western blot; human; fig 3
| Kren B, Unger G, Abedin M, Vogel R, Henzler C, Ahmed K, et al. Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy. Breast Cancer Res. 2015;17:524 pubmed publisher |
- western blot; human; 1:1000; fig 1
| Moiseeva O, Lessard F, Acevedo-Aquino M, Vernier M, Tsantrizos Y, Ferbeyre G. Mutant lamin A links prophase to a p53 independent senescence program. Cell Cycle. 2015;14:2408-21 pubmed publisher |
| Kren B, Unger G, Abedin M, Vogel R, Henzler C, Ahmed K, et al. Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy. Breast Cancer Res. 2015;17:19 pubmed publisher |
- western blot; mouse; fig 5
| Tan S, Shui G, Zhou J, Shi Y, Huang J, Xia D, et al. Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway. Autophagy. 2014;10:226-42 pubmed publisher |
| Ucher A, Ranjit S, Kadungure T, Linehan E, Khair L, Xie E, et al. Mismatch repair proteins and AID activity are required for the dominant negative function of C-terminally deleted AID in class switching. J Immunol. 2014;193:1440-50 pubmed publisher |
- western blot; human; 1:2000
| Galvis A, Fisher H, Nitta T, Fan H, Camerini D. Impairment of HIV-1 cDNA synthesis by DBR1 knockdown. J Virol. 2014;88:7054-69 pubmed publisher |
- western blot; mouse; fig 4
| Liang N, Zhang C, Dill P, Panasyuk G, Pion D, Koka V, et al. Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. J Exp Med. 2014;211:2249-63 pubmed publisher |
- western blot; human; 1:1000
| Jorgensen E, Stinson A, Shan L, Yang J, Gietl D, Albino A. Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells. BMC Cancer. 2008;8:229 pubmed publisher |
| Moiseeva O, Lopes-Paciencia S, Huot G, Lessard F, Ferbeyre G. Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at serine 22 during interphase. Aging (Albany NY). 2016;8:366-81 pubmed |
| Wang L, Xu W, Cao L, Tian T, Yang M, Li Z, et al. Differential Expression of Proteins Associated with the Hair Follicle Cycle - Proteomics and Bioinformatics Analyses. PLoS ONE. 2016;11:e0146791 pubmed publisher |
| Maine E, Westcott J, Prechtl A, Dang T, Whitehurst A, Pearson G. The cancer-testis antigens SPANX-A/C/D and CTAG2 promote breast cancer invasion. Oncotarget. 2016;7:14708-26 pubmed publisher |
| Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, et al. HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity. Nat Commun. 2016;7:11635 pubmed publisher |
| Stanford E, Wang Z, Novikov O, Mulas F, Landesman-Bollag E, Monti S, et al. The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells. BMC Biol. 2016;14:20 pubmed publisher |
| Nelson D, Jaber-Hijazi F, Cole J, Robertson N, Pawlikowski J, Norris K, et al. Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability. Genome Biol. 2016;17:158 pubmed publisher |
| Delmas E, Jah N, Pirou C, Bouleau S, Le Floch N, Vayssiere J, et al. FGF1 C-terminal domain and phosphorylation regulate intracrine FGF1 signaling for its neurotrophic and anti-apoptotic activities. Cell Death Dis. 2016;7:e2079 pubmed publisher |
| Wu C, Chen J, Chen C, Wang W, Wen L, Gao K, et al. Wnt/β-catenin coupled with HIF-1α/VEGF signaling pathways involved in galangin neurovascular unit protection from focal cerebral ischemia. Sci Rep. 2015;5:16151 pubmed publisher |
| Shimizu M, Li J, Inoue J, Sato R. Quercetin represses apolipoprotein B expression by inhibiting the transcriptional activity of C/EBPβ. PLoS ONE. 2015;10:e0121784 pubmed publisher |
| Calegari-Silva T, Vivarini Á, Miqueline M, Dos Santos G, Teixeira K, Saliba A, et al. The human parasite Leishmania amazonensis downregulates iNOS expression via NF-κB p50/p50 homodimer: role of the PI3K/Akt pathway. Open Biol. 2015;5:150118 pubmed publisher |
| Tata M, Ruhrberg C, Fantin A. Vascularisation of the central nervous system. Mech Dev. 2015;138:26-36 pubmed publisher |
| Kadungure T, Ucher A, Linehan E, Schrader C, Stavnezer J. Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination. PLoS ONE. 2015;10:e0134397 pubmed publisher |
| Jiang S, Katz T, Garee J, DeMayo F, Lee A, Oesterreich S. Scaffold attachment factor B2 (SAFB2)-null mice reveal non-redundant functions of SAFB2 compared with its paralog, SAFB1. Dis Model Mech. 2015;8:1121-7 pubmed publisher |
| Lefevre L, Omeiri H, Drougat L, Hantel C, Giraud M, Val P, et al. Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of β-catenin in adrenocortical carcinoma. Oncogenesis. 2015;4:e161 pubmed publisher |
| Koo H, Sohn E, Pyo S, Woo H, Park D, Ham Y, et al. An ethanol root extract of Cynanchum wilfordii containing acetophenones suppresses the expression of VCAM-1 and ICAM-1 in TNF-α-stimulated human aortic smooth muscle cells through the NF-κB pathway. Int J Mol Med. 2015;35:915-24 pubmed publisher |
| Nguyen L, Cavadas M, Kholodenko B, Frank T, Cheong A. Species differential regulation of COX2 can be described by an NFκB-dependent logic AND gate. Cell Mol Life Sci. 2015;72:2431-43 pubmed publisher |
| Lee Y, Jang A, Francey L, Sehgal A, Hogenesch J. KPNB1 mediates PER/CRY nuclear translocation and circadian clock function. elife. 2015;4: pubmed publisher |
| Ni H, Bhakta A, Wang S, Li Z, Manley S, Huang H, et al. Role of hypoxia inducing factor-1β in alcohol-induced autophagy, steatosis and liver injury in mice. PLoS ONE. 2014;9:e115849 pubmed publisher |
| Bisio A, Zámborszky J, Zaccara S, Lion M, Tebaldi T, Sharma V, et al. Cooperative interactions between p53 and NFκB enhance cell plasticity. Oncotarget. 2014;5:12111-25 pubmed |
| Manley S, Ni H, Williams J, Kong B, DiTacchio L, Guo G, et al. Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity. Redox Biol. 2014;2:991-1002 pubmed publisher |
| Shevlin E, Miggin S. The TIR-domain containing adaptor TRAM is required for TLR7 mediated RANTES production. PLoS ONE. 2014;9:e107141 pubmed publisher |
| Sarkar S, Raymick J, Schmued L. The use of recently developed histochemical markers for localizing neurotoxicant induced regional brain pathologies. Toxins (Basel). 2014;6:1453-70 pubmed publisher |
| Kines K, Sokolowski M, deHaro D, Christian C, Belancio V. Potential for genomic instability associated with retrotranspositionally-incompetent L1 loci. Nucleic Acids Res. 2014;42:10488-502 pubmed publisher |
| King H, Cobbold L, Pichon X, Pöyry T, Wilson L, Booden H, et al. Remodelling of a polypyrimidine tract-binding protein complex during apoptosis activates cellular IRESs. Cell Death Differ. 2014;21:161-71 pubmed publisher |
| Flück D, Beaudin A, Steinback C, Kumarpillai G, Shobha N, McCreary C, et al. Effects of aging on the association between cerebrovascular responses to visual stimulation, hypercapnia and arterial stiffness. Front Physiol. 2014;5:49 pubmed publisher |
| Brown A, Hunt S, Stephens D. Opposing microtubule motors control motility, morphology and cargo segregation during ER-to-Golgi transport. Biol Open. 2014;3:307-13 pubmed publisher |
| Wang G, Zhao X, Meng Z, Kern M, Dietrich A, Chen Z, et al. The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis. Nat Med. 2014;20:1436-43 pubmed publisher |
| Asante D, Stevenson N, Stephens D. Subunit composition of the human cytoplasmic dynein-2 complex. J Cell Sci. 2014;127:4774-87 pubmed publisher |
| Jor'dan A, Manor B, Novak V. Slow gait speed - an indicator of lower cerebral vasoreactivity in type 2 diabetes mellitus. Front Aging Neurosci. 2014;6:135 pubmed publisher |
| Starke S, Meinke P, Camozzi D, Mattioli E, Pfaeffle R, Siekmeyer M, et al. Progeroid laminopathy with restrictive dermopathy-like features caused by an isodisomic LMNA mutation p.R435C. Aging (Albany NY). 2013;5:445-59 pubmed |
| Hunt S, Townley A, Danson C, Cullen P, Stephens D. Microtubule motors mediate endosomal sorting by maintaining functional domain organization. J Cell Sci. 2013;126:2493-501 pubmed publisher |
| Sokolowski M, Deharo D, Christian C, Kines K, Belancio V. Characterization of L1 ORF1p self-interaction and cellular localization using a mammalian two-hybrid system. PLoS ONE. 2013;8:e82021 pubmed publisher |
| Takahashi C, Muramatsu R, Fujimura H, Mochizuki H, Yamashita T. Prostacyclin promotes oligodendrocyte precursor recruitment and remyelination after spinal cord demyelination. Cell Death Dis. 2013;4:e795 pubmed publisher |
| Ruhrberg C, Bautch V. Neurovascular development and links to disease. Cell Mol Life Sci. 2013;70:1675-84 pubmed publisher |
| Ding J, Guo J, Yuan Q, Yuan F, Chen H, Tian H. Inhibition of phosphatase and tensin homolog deleted on chromosome 10 decreases rat cortical neuron injury and blood-brain barrier permeability, and improves neurological functional recovery in traumatic brain injury model. PLoS ONE. 2013;8:e80429 pubmed publisher |
| Contreras A, Mebratu Y, Delgado M, Montaño G, Hu C, Ryter S, et al. Deacetylation of p53 induces autophagy by suppressing Bmf expression. J Cell Biol. 2013;201:427-37 pubmed publisher |
| Hashizume C, Kobayashi A, Wong R. Down-modulation of nucleoporin RanBP2/Nup358 impaired chromosomal alignment and induced mitotic catastrophe. Cell Death Dis. 2013;4:e854 pubmed publisher |
| Olarerin-George A, Anton L, Hwang Y, Elovitz M, Hogenesch J. A functional genomics screen for microRNA regulators of NF-kappaB signaling. BMC Biol. 2013;11:19 pubmed publisher |
| Mintzer R, Ramaswamy S, Shah K, Hannoush R, Pozniak C, Cohen F, et al. A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C. PLoS ONE. 2012;7:e30376 pubmed publisher |
| Frevert U, Movila A, Nikolskaia O, Raper J, Mackey Z, Abdulla M, et al. Early invasion of brain parenchyma by African trypanosomes. PLoS ONE. 2012;7:e43913 pubmed publisher |
| Reuter K, Loitsch S, Dignass A, Steinhilber D, Stein J. Selective non-steroidal glucocorticoid receptor agonists attenuate inflammation but do not impair intestinal epithelial cell restitution in vitro. PLoS ONE. 2012;7:e29756 pubmed publisher |
| Boucher J, Mori M, Lee K, Smyth G, Liew C, Macotela Y, et al. Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling. Nat Commun. 2012;3:902 pubmed publisher |
| Mizisin A, Weerasuriya A. Homeostatic regulation of the endoneurial microenvironment during development, aging and in response to trauma, disease and toxic insult. Acta Neuropathol. 2011;121:291-312 pubmed publisher |
| Sariyer I, Saribas A, White M, Safak M. Infection by agnoprotein-negative mutants of polyomavirus JC and SV40 results in the release of virions that are mostly deficient in DNA content. Virol J. 2011;8:255 pubmed publisher |
| Urich E, Lazic S, Molnos J, Wells I, Freskgård P. Transcriptional profiling of human brain endothelial cells reveals key properties crucial for predictive in vitro blood-brain barrier models. PLoS ONE. 2012;7:e38149 pubmed publisher |
| Mace K, Restivo T, Rinn J, Paquet A, Chang H, Young D, et al. HOXA3 modulates injury-induced mobilization and recruitment of bone marrow-derived cells. Stem Cells. 2009;27:1654-65 pubmed publisher |
| Deracinois B, Duban-Deweer S, Pottiez G, Cecchelli R, Karamanos Y, Flahaut C. TNAP and EHD1 are over-expressed in bovine brain capillary endothelial cells after the re-induction of blood-brain barrier properties. PLoS ONE. 2012;7:e48428 pubmed publisher |
| Pierce A, Williamson A, Jaworska E, Griffiths J, Taylor S, Walker M, et al. Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation. PLoS ONE. 2012;7:e38928 pubmed publisher |
| Gostner J, Fong D, Wrulich O, Lehne F, Zitt M, Hermann M, et al. Effects of EpCAM overexpression on human breast cancer cell lines. BMC Cancer. 2011;11:45 pubmed publisher |
| Cao P, Deng Z, Wan M, Huang W, Cramer S, Xu J, et al. MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1alpha/HIF-1beta. Mol Cancer. 2010;9:108 pubmed publisher |
| Al-Salihi M, Herhaus L, MacArtney T, Sapkota G. USP11 augments TGFβ signalling by deubiquitylating ALK5. Open Biol. 2012;2:120063 pubmed publisher |
| Yen H, Ooka T, Iguchi A, Hayashi T, Sugimoto N, Tobe T. NleC, a type III secretion protease, compromises NF-κB activation by targeting p65/RelA. PLoS Pathog. 2010;6:e1001231 pubmed publisher |
| Grammas P. Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease. J Neuroinflammation. 2011;8:26 pubmed publisher |
| Yokoyama N, Pate K, Sprowl S, Waterman M. A role for YY1 in repression of dominant negative LEF-1 expression in colon cancer. Nucleic Acids Res. 2010;38:6375-88 pubmed publisher |
| Shao L, Feng W, Lee K, Chen B, Zhou D. A sensitive and quantitative polymerase chain reaction-based cell free in vitro non-homologous end joining assay for hematopoietic stem cells. PLoS ONE. 2012;7:e33499 pubmed publisher |
| Bonnet A, Randrianarison-Huetz V, Nzounza P, Nedelec M, Chazal M, Waast L, et al. Low nuclear body formation and tax SUMOylation do not prevent NF-kappaB promoter activation. Retrovirology. 2012;9:77 pubmed publisher |
| Wang Z, Fessler E, Chuang D. Beneficial effects of mood stabilizers lithium, valproate and lamotrigine in experimental stroke models. Acta Pharmacol Sin. 2011;32:1433-45 pubmed publisher |
| Nicolas C, Peineau S, Amici M, Csaba Z, Fafouri A, Javalet C, et al. The Jak/STAT pathway is involved in synaptic plasticity. Neuron. 2012;73:374-90 pubmed publisher |
| Pendergrass W, Zitnik G, Tsai R, Wolf N. X-ray induced cataract is preceded by LEC loss, and coincident with accumulation of cortical DNA, and ROS; similarities with age-related cataracts. Mol Vis. 2010;16:1496-513 pubmed |
| Pellegrin S, Heesom K, Satchwell T, Hawley B, Daniels G, van den Akker E, et al. Differential proteomic analysis of human erythroblasts undergoing apoptosis induced by epo-withdrawal. PLoS ONE. 2012;7:e38356 pubmed publisher |
| Gómez-Benito M, Conchillo A, Garcia M, Vazquez I, Maicas M, Vicente C, et al. EVI1 controls proliferation in acute myeloid leukaemia through modulation of miR-1-2. Br J Cancer. 2010;103:1292-6 pubmed publisher |
| Hanif M, Rosengardten Y, Sagelius H, Rozell B, Eriksson M. Differential expression of A-type and B-type lamins during hair cycling. PLoS ONE. 2009;4:e4114 pubmed publisher |
