product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
SirT1 Antibody (Mouse Specific)
catalog :
2028
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
citations: 18
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 3b
Yuan X, Qi H, Li X, Wu F, Fang J, Bober E, et al. Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice. J Clin Invest. 2017;127:2235-2248 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2e
Zou T, Chen D, Yang Q, Wang B, Zhu M, Nathanielsz P, et al. Resveratrol supplementation of high-fat diet-fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring. J Physiol. 2017;595:1547-1562 pubmed publisher
  • immunohistochemistry; mouse; 1:250; loading ...; fig 1d
Jablonska B, Gierdalski M, Chew L, Hawley T, Catron M, Lichauco A, et al. Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury. Nat Commun. 2016;7:13866 pubmed publisher
  • western blot; mouse; loading ...; fig 6a
Kong Q, Zhang H, Zhao T, Zhang W, Yan M, Dong X, et al. Tangshen formula attenuates hepatic steatosis by inhibiting hepatic lipogenesis and augmenting fatty acid oxidation in db/db mice. Int J Mol Med. 2016;38:1715-1726 pubmed publisher
  • flow cytometry; mouse; 1:100; fig 7a
Fabbiano S, Suárez Zamorano N, Rigo D, Veyrat Durebex C, Stevanovic Dokic A, Colin D, et al. Caloric Restriction Leads to Browning of White Adipose Tissue through Type 2 Immune Signaling. Cell Metab. 2016;24:434-446 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Wang Y, Cui R, Zhang X, Qiao Y, Liu X, Chang Y, et al. SIRT1 increases YAP- and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma. Oncotarget. 2016;7:11284-98 pubmed publisher
  • western blot; mouse; loading ...; fig 3e
Zhou Y, Zhou Z, Zhang W, Hu X, Wei H, Peng J, et al. SIRT1 inhibits adipogenesis and promotes myogenic differentiation in C3H10T1/2 pluripotent cells by regulating Wnt signaling. Cell Biosci. 2015;5:61 pubmed publisher
  • western blot; mouse; fig 2
Kim S, Sim C, Tang H, Han W, Zhang K, Xu F. Acetylome Analysis Identifies SIRT1 Targets in mRNA-Processing and Chromatin-Remodeling in Mouse Liver. PLoS ONE. 2015;10:e0140619 pubmed publisher
  • western blot; mouse
Brown D, LASSEGUE B, Lee M, Zafari R, Long J, Saavedra H, et al. Poldip2 knockout results in perinatal lethality, reduced cellular growth and increased autophagy of mouse embryonic fibroblasts. PLoS ONE. 2014;9:e96657 pubmed publisher
  • western blot; mouse
Le T, Urasaki Y, Pizzorno G. Uridine prevents fenofibrate-induced fatty liver. PLoS ONE. 2014;9:e87179 pubmed publisher
  • western blot; human; fig 4
  • western blot; mouse; fig 4
Calliari A, Bobba N, Escande C, Chini E. Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner. Exp Neurol. 2014;251:91-100 pubmed publisher
  • western blot; human; 1:1000
Chen M, Yi L, Jin X, Liang X, Zhou Y, Zhang T, et al. Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway. Autophagy. 2013;9:2033-45 pubmed publisher
  • western blot; mouse
Ni H, Du K, You M, Ding W. Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity. Am J Pathol. 2013;183:1815-1825 pubmed publisher
  • western blot; human
Arampatzi P, Gialitakis M, Makatounakis T, Papamatheakis J. Gene-specific factors determine mitotic expression and bookmarking via alternate regulatory elements. Nucleic Acids Res. 2013;41:2202-15 pubmed publisher
Zhou Y, Song T, Peng J, Zhou Z, Wei H, Zhou R, et al. SIRT1 suppresses adipogenesis by activating Wnt/β-catenin signaling in vivo and in vitro. Oncotarget. 2016;7:77707-77720 pubmed publisher
Hong S, Moreno Navarrete J, Wei X, Kikukawa Y, Tzameli I, Prasad D, et al. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nat Med. 2015;21:887-94 pubmed publisher
Traboulsi H, Davoli S, Catez P, Egly J, Compe E. Dynamic partnership between TFIIH, PGC-1α and SIRT1 is impaired in trichothiodystrophy. PLoS Genet. 2014;10:e1004732 pubmed publisher
Jeong H, Cohen D, Cui L, Supinski A, Savas J, Mazzulli J, et al. Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Nat Med. 2011;18:159-65 pubmed publisher
product information
SKU :
2028S
Product-Name :
SirT1 Antibody (Mouse Specific)
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
M
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Chromatin Regulation / Nuclear Function
Shipping-Temp :
COLD
Storage-Temp :
-20°C
Product-Type :
Polyclonal Antibody
MW :
120
Host :
Rabbit
Target :
SirT1 mouse
Primary-Protein :
SIRT1
Alt-Names :
AA673258,MGC150273,NAD-dependent deacetylase sirtuin-1,SIR2-like protein 1,SIR2alpha,Sir2,Sir2a,Sir2l1,Sirt1,mSIR2a,sir2-like 1,sirtuin 1 ((silent mating type information regulation 2, homolog) 1,sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.