| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; human; loading ...; fig 2a
| Li T, Huang T, Du M, Chen X, Du F, Ren J, et al. Phosphorylation and chromatin tethering prevent cGAS activation during mitosis. Science. 2021;371: pubmed publisher |
- western blot knockout validation; human; loading ...; fig 1b
| Lohard S, Bourgeois N, Maillet L, Gautier F, Fétiveau A, Lasla H, et al. STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment. Nat Commun. 2020;11:259 pubmed publisher |
- immunocytochemistry knockout validation; human; loading ...; fig 1d
- western blot; human; loading ...; fig 1a
| Barnett K, Coronas Serna J, Zhou W, Ernandes M, Cao A, Kranzusch P, et al. Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA. Cell. 2019;: pubmed publisher |
- western blot knockout validation; human; fig 3a
| Botto S, Abraham J, Mizuno N, Pryke K, Gall B, Landais I, et al. Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome. MBio. 2019;10: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3a
| Schwertner B, Lindner G, Toledo Stauner C, Klapproth E, Magnus C, Rohrhofer A, et al. Nectin-1 Expression Correlates with the Susceptibility of Malignant Melanoma to Oncolytic Herpes Simplex Virus In Vitro and In Vivo. Cancers (Basel). 2021;13: pubmed publisher |
- western blot; human; loading ...; fig 3b
| Volkman H, Cambier S, Gray E, Stetson D. Tight nuclear tethering of cGAS is essential for preventing autoreactivity. elife. 2019;8: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4c
| Moriyama M, Koshiba T, Ichinohe T. Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses. Nat Commun. 2019;10:4624 pubmed publisher |
- immunocytochemistry; human; 1:200; loading ...; fig 2f
| Reisländer T, Lombardi E, Groelly F, Miar A, Porru M, Di Vito S, et al. BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors. Nat Commun. 2019;10:3143 pubmed publisher |
- western blot; human; loading ...; fig 2a
| Zierhut C, Yamaguchi N, Paredes M, Luo J, Carroll T, Funabiki H. The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death. Cell. 2019;178:302-315.e23 pubmed publisher |
- immunocytochemistry; human; 1:200; loading ...; fig 3a
- western blot; human; loading ...; fig 1c
| Gentili M, Lahaye X, Nadalin F, Nader G, Puig Lombardi E, Hervé S, et al. The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus. Cell Rep. 2019;26:2377-2393.e13 pubmed publisher |
- immunoprecipitation; human; loading ...; fig s3a
- immunocytochemistry; human; loading ...; fig 3d
- western blot; human; loading ...; fig 2f
| Dai J, Huang Y, He X, Zhao M, Wang X, Liu Z, et al. Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity. Cell. 2019;: pubmed publisher |
- immunocytochemistry; human; loading ...; fig 4c
- western blot; human; loading ...; fig 4e
| Nassour J, Radford R, Correia A, Fusté J, Schoell B, Jauch A, et al. Autophagic cell death restricts chromosomal instability during replicative crisis. Nature. 2019;565:659-663 pubmed publisher |
- western blot; human; loading ...; fig 5b
| Suspène R, Mussil B, Laude H, Caval V, Berry N, Bouzidi M, et al. Self-cytoplasmic DNA upregulates the mutator enzyme APOBEC3A leading to chromosomal DNA damage. Nucleic Acids Res. 2017;45:3231-3241 pubmed publisher |
| Fermaintt C, Takahashi Ruiz L, Liang H, Mooberry S, Risinger A. Eribulin Activates the cGAS-STING Pathway via the Cytoplasmic Accumulation of Mitochondrial DNA. Mol Pharmacol. 2021;100:309-318 pubmed publisher |
| Kim C, Wang X, Yu Y. PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response. elife. 2020;9: pubmed publisher |
| Zhao B, Liu P, Fukumoto T, Nacarelli T, Fatkhutdinov N, Wu S, et al. Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence. Nat Commun. 2020;11:908 pubmed publisher |
| Labzin L, Bottermann M, Rodriguez Silvestre P, Foss S, Andersen J, Vaysburd M, et al. Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection. EMBO J. 2019;38:e101365 pubmed publisher |
| Barroso González J, García Expósito L, Hoang S, Lynskey M, Roncaioli J, Ghosh A, et al. RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres. Mol Cell. 2019;76:11-26.e7 pubmed publisher |
| Xia Y, Pfeifer C, Zhu K, Irianto J, Liu D, Pannell K, et al. Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. J Cell Biol. 2019;: pubmed publisher |
| Smith L, Irianto J, Xia Y, Pfeifer C, Discher D. Constricted migration modulates stem cell differentiation. Mol Biol Cell. 2019;:mbcE19020090 pubmed publisher |
| Ritchie C, Cordova A, Hess G, Bassik M, Li L. SLC19A1 Is an Importer of the Immunotransmitter cGAMP. Mol Cell. 2019;: pubmed publisher |
| Lahaye X, Gentili M, Silvin A, Conrad C, Picard L, Jouve M, et al. NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation. Cell. 2018;175:488-501.e22 pubmed publisher |
| Xia Y, Ivanovska I, Zhu K, Smith L, Irianto J, Pfeifer C, et al. Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. J Cell Biol. 2018;217:3796-3808 pubmed publisher |
| Steinhagen F, Zillinger T, Peukert K, Fox M, Thudium M, Barchet W, et al. Suppressive oligodeoxynucleotides containing TTAGGG motifs Inhibit cGAS activation in human monocytes. Eur J Immunol. 2017;: pubmed publisher |
| Costa Franco M, Marim F, Guimarães E, Assis N, Cerqueira D, Alves Silva J, et al. Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation. J Immunol. 2018;200:607-622 pubmed publisher |
| Mackenzie K, Carroll P, Martin C, Murina O, Fluteau A, Simpson D, et al. cGAS surveillance of micronuclei links genome instability to innate immunity. Nature. 2017;548:461-465 pubmed publisher |
