| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; loading ...; fig 2s1b
| Lim J, Park H, Heisler J, Maculins T, Roose Girma M, Xu M, et al. Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins. elife. 2019;8: pubmed publisher |
- western blot knockout validation; mouse; loading ...; fig 2b
| Lin L, Xu L, Lv W, Han L, Xiang Y, Fu L, et al. An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS). PLoS Pathog. 2019;15:e1007795 pubmed publisher |
- western blot knockout validation; mouse; 1:1000; loading ...; fig s7j
| Benmerzoug S, Rose S, Bounab B, Gosset D, Duneau L, Chenuet P, et al. STING-dependent sensing of self-DNA drives silica-induced lung inflammation. Nat Commun. 2018;9:5226 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 7a
| Ding R, Li H, Liu Y, Ou W, Zhang X, Chai H, et al. Activating cGAS-STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosis. J Neuroinflammation. 2022;19:137 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 6a
| Chen K, Hu Q, Xie Z, Yang G. Monocyte NLRP3-IL-1β Hyperactivation Mediates Neuronal and Synaptic Dysfunction in Perioperative Neurocognitive Disorder. Adv Sci (Weinh). 2022;9:e2104106 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 2i
- western blot; mouse; 1:1000; loading ...; fig 2f, 7b
| Wan L, Bai X, Zhou Q, Chen C, Wang H, Liu T, et al. The advanced glycation end-products (AGEs)/ROS/NLRP3 inflammasome axis contributes to delayed diabetic corneal wound healing and nerve regeneration. Int J Biol Sci. 2022;18:809-825 pubmed publisher |
- western blot; mouse; loading ...; fig 1b
| Opoku E, TRAUGHBER C, Zhang D, Iacano A, Khan M, Han J, et al. Gasdermin D Mediates Inflammation-Induced Defects in Reverse Cholesterol Transport and Promotes Atherosclerosis. Front Cell Dev Biol. 2021;9:715211 pubmed publisher |
- western blot; mouse; loading ...; fig 2f, 5d
| Chen J, Yang F, Shi S, Liu X, Qin F, Wei X, et al. The Severity of CVB3-Induced Myocarditis Can Be Improved by Blocking the Orchestration of NLRP3 and Th17 in Balb/c Mice. Mediators Inflamm. 2021;2021:5551578 pubmed publisher |
- western blot; human; loading ...; fig 6b
| Lee S, Kim J, Choi Y, Gong J, Park S, Douangdeuane B, et al. Therapeutic Effects of Dipterocarpus tuberculatus with High Antioxidative Activity Against UV-Induced Photoaging of NHDF Cells and Nude Mice. Antioxidants (Basel). 2021;10: pubmed publisher |
- western blot; mouse; 1:750; loading ...; fig 7b
| Frenis K, Helmstädter J, Ruan Y, Schramm E, Kalinovic S, Kröller Schön S, et al. Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects. Basic Res Cardiol. 2021;116:31 pubmed publisher |
- western blot; mouse; 1:2500; loading ...; fig 6b
| Kucsera D, T xf3 th V, Gerg x151 D, V xf6 r xf6 s I, On xf3 di Z, G xf6 rbe A, et al. Characterization of the CDAA Diet-Induced Non-alcoholic Steatohepatitis Model: Sex-Specific Differences in Inflammation, Fibrosis, and Cholesterol Metabolism in Middle-Aged Mice. Front Physiol. 2021;12:609465 pubmed publisher |
- western blot; mouse; 1:2000; loading ...; fig 1c
| Gao Y, Xu G, Ma L, Shi W, Wang Z, Zhan X, et al. Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Cell Commun Signal. 2021;19:13 pubmed publisher |
- immunoprecipitation; mouse; loading ...; fig 5b
- western blot; mouse; 1:2000; loading ...; fig 5b
| Zhang W, Tao S, Wang T, Zhang J, Liu X, Li Y, et al. ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2. FEBS Lett. 2021;595:169-182 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4g
| Jin X, Morro B, Tørresen O, Moiche V, Solbakken M, Jakobsen K, et al. Innovation in Nucleotide-Binding Oligomerization-Like Receptor and Toll-Like Receptor Sensing Drives the Major Histocompatibility Complex-II Free Atlantic Cod Immune System. Front Immunol. 2020;11:609456 pubmed publisher |
- western blot; human; loading ...; fig 4b
| Sünderhauf A, Raschdorf A, Hicken M, Schlichting H, Fetzer F, Brethack A, et al. GC1qR Cleavage by Caspase-1 Drives Aerobic Glycolysis in Tumor Cells. Front Oncol. 2020;10:575854 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 7a, 7b
| Hu J, Wang H, Li X, Liu Y, Mi Y, Kong H, et al. Fibrinogen-like protein 2 aggravates nonalcoholic steatohepatitis via interaction with TLR4, eliciting inflammation in macrophages and inducing hepatic lipid metabolism disorder. Theranostics. 2020;10:9702-9720 pubmed publisher |
- western blot; mouse; loading ...; fig s7a
| Theivanthiran B, Evans K, Devito N, Plebanek M, Sturdivant M, Wachsmuth L, et al. A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy. J Clin Invest. 2020;130:2570-2586 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; fig 1c
- western blot; human; loading ...; fig 1b
| Teng J, Mei Q, Zhou X, Tang Y, Xiong R, Qiu W, et al. Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer. Cancers (Basel). 2020;12: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3b, 4f, s7b
| Quach C, Song Y, Guo H, Li S, Maazi H, Fung M, et al. A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. Nat Commun. 2019;10:5681 pubmed publisher |
- western blot; rat; loading ...; fig 6b
| Qin W, Wu X, Jia Y, Tong X, Guo C, Chen D, et al. Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma. Biomed Pharmacother. 2019;118:109188 pubmed publisher |
- western blot; mouse; loading ...; fig 4d, 4e
| Kurundkar D, Kurundkar A, Bone N, Becker E, Liu W, Chacko B, et al. SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury. JCI Insight. 2019;4: pubmed publisher |
- western blot; mouse; 1:800; loading ...; fig 2c
| Qiu T, Pei P, Yao X, Jiang L, Wei S, Wang Z, et al. Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway. Cell Death Dis. 2018;9:946 pubmed publisher |
- western blot; human; loading ...; fig 5a
| Kosmidou C, Efstathiou N, Hoang M, Notomi S, Konstantinou E, Hirano M, et al. Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration. Sci Rep. 2018;8:461 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 6g
| Xiao N, Yang L, Yang Y, Liu L, Li J, Liu B, et al. Ginsenoside Rg5 Inhibits Succinate-Associated Lipolysis in Adipose Tissue and Prevents Muscle Insulin Resistance. Front Pharmacol. 2017;8:43 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 9c
| Luan L, Patil N, Guo Y, Hernandez A, Bohannon J, Fensterheim B, et al. Comparative Transcriptome Profiles of Human Blood in Response to the Toll-like Receptor 4 Ligands Lipopolysaccharide and Monophosphoryl Lipid A. Sci Rep. 2017;7:40050 pubmed publisher |
- immunocytochemistry; human; 1:50; fig 6
- western blot; human; 1:1000; fig s1
| Tseng H, Vong C, Kwan Y, Lee S, Hoi M. TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells. Sci Rep. 2016;6:35016 pubmed publisher |
| Zhao J, Ma W, Chen W, Gao J, Li C, Tong Y, et al. AEG-1 aggravates inflammation via promoting NALP3 inflammasome formation in murine endometriosis lesions. Anim Cells Syst (Seoul). 2019;23:407-413 pubmed publisher |
| Hughes M, Hooftman A, Angiari S, Tummala P, Zaslona Z, Runtsch M, et al. Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation. Cell Rep. 2019;29:151-161.e5 pubmed publisher |
| Labzin L, Bottermann M, Rodriguez Silvestre P, Foss S, Andersen J, Vaysburd M, et al. Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection. EMBO J. 2019;38:e101365 pubmed publisher |
| Lang T, Lee J, Elgass K, Pinar A, Tate M, Aitken E, et al. Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation. Nat Commun. 2018;9:2223 pubmed publisher |
| Wakamatsu T, Yamamoto S, Ito T, Sato Y, Matsuo K, Takahashi Y, et al. Indoxyl Sulfate Promotes Macrophage IL-1β Production by Activating Aryl Hydrocarbon Receptor/NF-κ/MAPK Cascades, but the NLRP3 inflammasome Was Not Activated. Toxins (Basel). 2018;10: pubmed publisher |
| Camilli G, Eren E, Williams D, Aimanianda V, Meunier E, Quintin J. Impaired phagocytosis directs human monocyte activation in response to fungal derived β-glucan particles. Eur J Immunol. 2018;48:757-770 pubmed publisher |
| Wang W, Shi Q, Dou S, Li G, Shi X, Jiang X, et al. Negative regulation of Nod-like receptor protein 3 inflammasome activation by T cell Ig mucin-3 protects against peritonitis. Immunology. 2018;153:71-83 pubmed publisher |
| Neudecker V, Haneklaus M, Jensen O, Khailova L, Masterson J, Tye H, et al. Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome. J Exp Med. 2017;214:1737-1752 pubmed publisher |
