product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
E-Cadherin
catalog :
14472
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4A2
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
Cell Signaling Technology product webpage
citations: 40
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 5a
  • western blot; rat; fig 2a
Shi Y, Hu Y, Wang Y, Ma X, Tang L, Tao M, et al. Blockade of Autophagy Prevents the Development and Progression of Peritoneal Fibrosis. Front Pharmacol. 2021;12:724141 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 1d
Moreira T, Mangani D, Cox L, Leibowitz J, Lobo E, Oliveira M, et al. PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis. Nat Commun. 2021;12:4907 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 3a
Zheng Z, Li C, Shao G, Li J, Xu K, Zhao Z, et al. Hippo-YAP/MCP-1 mediated tubular maladaptive repair promote inflammation in renal failed recovery after ischemic AKI. Cell Death Dis. 2021;12:754 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2g
Mao C, Jiang S, Wang X, Tao S, Jiang B, Mao C, et al. BCAR1 plays critical roles in the formation and immunoevasion of invasive circulating tumor cells in lung adenocarcinoma. Int J Biol Sci. 2021;17:2461-2475 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4c, 4d
Zou J, Zhu X, Xiang D, Zhang Y, Li J, Su Z, et al. LIX1-like protein promotes liver cancer progression via miR-21-3p-mediated inhibition of fructose-1,6-bisphosphatase. Acta Pharm Sin B. 2021;11:1578-1591 pubmed publisher
  • immunohistochemistry; human; fig 4j
  • western blot; human; loading ...; fig 4f 4h
Qin X, Li J, Wang S, Lv J, Luan F, Liu Y, et al. Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer. Theranostics. 2021;11:6950-6965 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 6d
  • western blot; mouse; 1:1000; loading ...; fig 4b
Xu Y, Pan S, Chen H, Qian H, Wang Z, Zhu X. MEX3A suppresses proliferation and EMT via inhibiting Akt signaling pathway in cervical cancer. Am J Cancer Res. 2021;11:1446-1462 pubmed
  • western blot; human; loading ...; fig 3e
Li X, Lin P, Tao Y, Jiang X, Li T, Wang Y, et al. LECT 2 Antagonizes FOXM1 Signaling via Inhibiting MET to Retard PDAC Progression. Front Cell Dev Biol. 2021;9:661122 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 6e
Wang W, Wang H, Xiang L, Ni T, Jin F, Deng J, et al. DJ‑1 is a new prognostic marker and predicts chemotherapy efficacy in colorectal cancer. Oncol Rep. 2020;44:77-90 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 4b
Zhou X, Cai D, Xiao S, Ning M, Zhou R, Zhang S, et al. InvivoPen: A novel plasma source for in vivo cancer treatment. J Cancer. 2020;11:2273-2282 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5c
McGinn O, Ward A, Fettig L, Riley D, Ivie J, Paul K, et al. Cytokeratin 5 alters β-catenin dynamics in breast cancer cells. Oncogene. 2020;39:2478-2492 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 3d
  • western blot; human; loading ...; fig 3c
Liu X, Ma F, Liu C, Zhu K, Li W, Xu Y, et al. UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKα2/mTORC1-MYC positive feedback loop. Cell Death Dis. 2020;11:10 pubmed publisher
  • western blot; human; loading ...; fig 4e
Chen X, Xiong X, Cui D, Yang F, Wei D, Li H, et al. DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals. Oncogene. 2020;39:1557-1571 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 4b
  • western blot; human; loading ...; fig 5d
Zhang K, Yang L, Wang J, Sun T, Guo Y, Nelson R, et al. Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer. Cell Commun Signal. 2019;17:167 pubmed publisher
  • western blot; human; 1:2000; fig 3b
Wu X, Chen S, Lu C. Amyloid precursor protein promotes the migration and invasion of breast cancer cells by regulating the MAPK signaling pathway. Int J Mol Med. 2019;: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2f
Zhang J, Zhang Z, Sun J, Ma Q, Zhao W, Chen X, et al. MiR-942 regulates the function of breast cancer cell by targeting FOXA2. Biosci Rep. 2019;39: pubmed publisher
  • western blot; human; 1:1000; fig 1a
Takeuchi H, Sasaki N, Yamaga S, Kuboniwa M, Matsusaki M, Amano A. Porphyromonas gingivalis induces penetration of lipopolysaccharide and peptidoglycan through the gingival epithelium via degradation of junctional adhesion molecule 1. PLoS Pathog. 2019;15:e1008124 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4f
Tan P, Xu Y, Du Y, Wu L, Guo B, Huang S, et al. SPOP suppresses pancreatic cancer progression by promoting the degradation of NANOG. Cell Death Dis. 2019;10:794 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2c
Diaz Osterman C, Ozmadenci D, Kleinschmidt E, Taylor K, Barrie A, Jiang S, et al. FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. elife. 2019;8: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3c
Wang X, Liu R, Zhu W, Chu H, Yu H, Wei P, et al. UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis. Nature. 2019;571:127-131 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 6b
  • immunocytochemistry; human; loading ...; fig s2
  • western blot; human; 1:1000; loading ...; fig 3b
Wang M, Xiong L, Jiang L, Lu Y, Liu F, Song L, et al. miR-4739 mediates pleural fibrosis by targeting bone morphogenetic protein 7. EBioMedicine. 2019;41:670-682 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3a
Liu Z, Liu J, Dong X, Hu X, Jiang Y, Li L, et al. Tn antigen promotes human colorectal cancer metastasis via H-Ras mediated epithelial-mesenchymal transition activation. J Cell Mol Med. 2019;23:2083-2092 pubmed publisher
  • western blot; human; loading ...; fig 1f
Schwab A, Siddiqui A, Vazakidou M, Napoli F, Böttcher M, Menchicchi B, et al. Polyol Pathway Links Glucose Metabolism to the Aggressiveness of Cancer Cells. Cancer Res. 2018;78:1604-1618 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 9d
  • western blot; human; 1:1000; loading ...; fig 3a
Lu J, Yang Y, Guo G, Liu Y, Zhang Z, Dong S, et al. IKBKE regulates cell proliferation and epithelial-mesenchymal transition of human malignant glioma via the Hippo pathway. Oncotarget. 2017;8:49502-49514 pubmed publisher
  • western blot; mouse; loading ...; fig 7b
Jiang P, Zhang D, Qiu H, Yi X, Zhang Y, Cao Y, et al. Tiron ameliorates high glucose-induced cardiac myocyte apoptosis by PKCδ-dependent inhibition of osteopontin. Clin Exp Pharmacol Physiol. 2017;44:760-770 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 4b
  • western blot; human; loading ...; fig 1c
Siddiqui A, Vazakidou M, Schwab A, Napoli F, Fernandez Molina C, Rapa I, et al. Thymidylate synthase is functionally associated with ZEB1 and contributes to the epithelial-to-mesenchymal transition of cancer cells. J Pathol. 2017;242:221-233 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 2a
  • western blot; mouse; loading ...; fig s3e
Genovese G, Carugo A, TEPPER J, Robinson F, Li L, Svelto M, et al. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature. 2017;542:362-366 pubmed publisher
  • immunohistochemistry; rat; 1:100; fig 3a
  • western blot; rat; 1:1000; fig 4a
Shu D, Wojciechowski M, Lovicu F. Bone Morphogenetic Protein-7 Suppresses TGF?2-Induced Epithelial-Mesenchymal Transition in the Lens: Implications for Cataract Prevention. Invest Ophthalmol Vis Sci. 2017;58:781-796 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 4b
  • western blot; human; 1:1000; loading ...; fig 1i
Liu T, Yu J, Deng M, Yin Y, Zhang H, Luo K, et al. CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1. Nat Commun. 2017;8:13923 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 6a
  • western blot; human; loading ...; fig 5a
Yang S, Ji Q, Chang B, Wang Y, Zhu Y, Li D, et al. STC2 promotes head and neck squamous cell carcinoma metastasis through modulating the PI3K/AKT/Snail signaling. Oncotarget. 2017;8:5976-5991 pubmed publisher
  • western blot; human; loading ...; fig 1b
Giovannini C, Minguzzi M, Genovese F, Baglioni M, Gualandi A, Ravaioli M, et al. Molecular and proteomic insight into Notch1 characterization in hepatocellular carcinoma. Oncotarget. 2016;7:39609-39626 pubmed publisher
  • western blot; human; fig 7
Jadav R, Kumar D, Buwa N, Ganguli S, Thampatty S, Balasubramanian N, et al. Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice. Cell Signal. 2016;28:1124-36 pubmed publisher
  • western blot; human; loading ...; fig 6a
Li Y, Wang X, He B, Cai H, Gao Y. Downregulation and tumor-suppressive role of XPO5 in hepatocellular carcinoma. Mol Cell Biochem. 2016;415:197-205 pubmed publisher
  • immunocytochemistry; mouse; fig 5
  • western blot; mouse; fig 5
Sun H, Chen J, Qian W, Kang J, Wang J, Jiang L, et al. Integrated long non-coding RNA analyses identify novel regulators of epithelial-mesenchymal transition in the mouse model of pulmonary fibrosis. J Cell Mol Med. 2016;20:1234-46 pubmed publisher
  • immunocytochemistry; human; fig 3b
Yokdang N, Hatakeyama J, Wald J, Simion C, Tellez J, Chang D, et al. LRIG1 opposes epithelial-to-mesenchymal transition and inhibits invasion of basal-like breast cancer cells. Oncogene. 2016;35:2932-47 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 2b
  • western blot; human; 1:500; loading ...; fig s4c
Liang S, Marti T, Dorn P, Froment L, Hall S, Berezowska S, et al. Blocking the epithelial-to-mesenchymal transition pathway abrogates resistance to anti-folate chemotherapy in lung cancer. Cell Death Dis. 2015;6:e1824 pubmed publisher
Sun J, Wei S, Zhang Y, Li J. Protective Effects of Astragalus Polysaccharide on Sepsis-Induced Acute Kidney Injury. Anal Cell Pathol (Amst). 2021;2021:7178253 pubmed publisher
Pang K, Zhang Z, Hao L, Shi Z, Chen B, Zang G, et al. The ERH gene regulates migration and invasion in 5637 and T24 bladder cancer cells. BMC Cancer. 2019;19:225 pubmed publisher
Wang L, Shen S, Wang M, Ding F, Xiao H, Li G, et al. Rho GTPase Activating Protein 24 (ARHGAP24) Silencing Promotes Lung Cancer Cell Migration and Invasion by Activating β-Catenin Signaling. Med Sci Monit. 2019;25:21-31 pubmed publisher
Zhang Z, Bu X, Chen H, Wang Q, Sha W. Bmi-1 promotes the invasion and migration of colon cancer stem cells through the downregulation of E-cadherin. Int J Mol Med. 2016;38:1199-207 pubmed publisher
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.