| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; human; 1:1000; loading ...; fig 2a
| Zeng H, Castillo Cabrera J, Manser M, Lu B, Yang Z, Strande V, et al. Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC. elife. 2019;8: pubmed publisher |
- western blot knockout validation; human; 1:1000; loading ...; fig 1e
| Yao F, Zhou Z, Kim J, Hang Q, Xiao Z, Ton B, et al. SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity. Nat Commun. 2018;9:2269 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 8a
- immunohistochemistry knockout validation; mouse; loading ...; fig s4b
| Kim J, Kim Y, Kim J, Park D, Bae H, Lee D, et al. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest. 2017;127:3441-3461 pubmed publisher |
- western blot knockout validation; mouse; fig 1a
| Moroishi T, Hayashi T, Pan W, Fujita Y, Holt M, Qin J, et al. The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 2016;167:1525-1539.e17 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig s2c
| Mukhtar T, Breda J, Grison A, Karimaddini Z, Grobecker P, Iber D, et al. Tead transcription factors differentially regulate cortical development. Sci Rep. 2020;10:4625 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 1f
| Kegelman C, Coulombe J, Jordan K, Horan D, Qin L, Robling A, et al. YAP and TAZ Mediate Osteocyte Perilacunar/Canalicular Remodeling. J Bone Miner Res. 2020;35:196-210 pubmed publisher |
- immunohistochemistry; mouse; 1:100; loading ...; fig 5b
| Roy A, Murphy R, Deng M, MacDonald J, Bammler T, Aldinger K, et al. PI3K-Yap activity drives cortical gyrification and hydrocephalus in mice. elife. 2019;8: pubmed publisher |
- immunoprecipitation; human; loading ...; fig 1d
- immunocytochemistry; human; loading ...; fig 1b
- western blot; human; loading ...; fig 1a
| Jia Y, Li H, Wang J, Wang Y, Zhang P, Ma N, et al. Phosphorylation of 14-3-3ζ links YAP transcriptional activation to hypoxic glycolysis for tumorigenesis. Oncogenesis. 2019;8:31 pubmed publisher |
- immunohistochemistry; mouse; 1:200; loading ...; fig 4g
| Serra D, Mayr U, Boni A, Lukonin I, Rempfler M, Challet Meylan L, et al. Self-organization and symmetry breaking in intestinal organoid development. Nature. 2019;569:66-72 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:400; loading ...; fig 2a
- western blot; human; loading ...; fig 6h
| Li Y, Hu Q, Li C, Liang K, Xiang Y, Hsiao H, et al. PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease. J Clin Invest. 2019;129:1129-1151 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 9e
- western blot; mouse; 1:250; loading ...; fig 2e
| Mason D, Collins J, Dawahare J, Nguyen T, Lin Y, Voytik Harbin S, et al. YAP and TAZ limit cytoskeletal and focal adhesion maturation to enable persistent cell motility. J Cell Biol. 2019;218:1369-1389 pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 6e
- western blot; mouse; loading ...; fig 2b
| Pan W, Moroishi T, Koo J, Guan K. Cell type-dependent function of LATS1/2 in cancer cell growth. Oncogene. 2019;38:2595-2610 pubmed publisher |
- immunocytochemistry; mouse; loading ...; fig 4s
| Schell C, Sabass B, Helmstaedter M, Geist F, Abed A, Yasuda Yamahara M, et al. ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier. Dev Cell. 2018;47:741-757.e8 pubmed publisher |
- western blot; human; 1:5000; loading ...; fig 3a
| Greenhough A, Bagley C, Heesom K, Gurevich D, Gay D, Bond M, et al. Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis. EMBO Mol Med. 2018;10: pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:200
- immunohistochemistry - paraffin section; mouse; 1:200
| Rickelt S, Hynes R. Antibodies and methods for immunohistochemistry of extracellular matrix proteins. Matrix Biol. 2018;71-72:10-27 pubmed publisher |
- immunohistochemistry; mouse; 1:500; loading ...; fig 6b
| Hoefert J, Bjerke G, Wang D, Yi R. The microRNA-200 family coordinately regulates cell adhesion and proliferation in hair morphogenesis. J Cell Biol. 2018;217:2185-2204 pubmed publisher |
- immunohistochemistry - paraffin section; rat; 1:100; loading ...; fig 1b
| Chen B, Liu G. WWC3 inhibits intimal proliferation following vascular injury via the Hippo signaling pathway. Mol Med Rep. 2018;17:5175-5183 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 7b
- immunocytochemistry; human; loading ...; fig 6c
| Mello S, Valente L, Raj N, Seoane J, Flowers B, McClendon J, et al. A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer. Cancer Cell. 2017;32:460-473.e6 pubmed publisher |
- western blot; human; loading ...; fig s5b
| Chen X, Wu Q, Depeille P, Chen P, Thornton S, Kalirai H, et al. RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma. Cancer Cell. 2017;31:685-696.e6 pubmed publisher |
- western blot; mouse; 1:1000; fig 6d
| Mindos T, Dun X, North K, Doddrell R, Schulz A, Edwards P, et al. Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity. J Cell Biol. 2017;216:495-510 pubmed publisher |
- western blot; mouse; 1:1000; fig s7a
| Kechele D, Blue R, Zwarycz B, Espenschied S, Mah A, Siegel M, et al. Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation. J Clin Invest. 2017;127:593-607 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4a
| Xu S, Yang Z, Fan Y, Guan B, Jia J, Gao Y, et al. Curcumin enhances temsirolimus-induced apoptosis in human renal carcinoma cells through upregulation of YAP/p53. Oncol Lett. 2016;12:4999-5006 pubmed publisher |
- immunocytochemistry; human; 1:300; loading ...; fig 4d
| Bergert M, Lendenmann T, Zündel M, Ehret A, Panozzo D, Richner P, et al. Confocal reference free traction force microscopy. Nat Commun. 2016;7:12814 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; fig 4h
- immunocytochemistry; human; 1:100; loading ...; fig 4a
| Lee J, Lee W, Seol M, Lee S, Kim D, Kim H, et al. Coupling of LETM1 up-regulation with oxidative phosphorylation and platelet-derived growth factor receptor signaling via YAP1 transactivation. Oncotarget. 2016;7:66728-66739 pubmed publisher |
- immunohistochemistry; mouse; 1:150; fig 5
- western blot; mouse; 1:2000; fig 5
| Reginensi A, Enderle L, Gregorieff A, Johnson R, Wrana J, McNeill H. A critical role for NF2 and the Hippo pathway in branching morphogenesis. Nat Commun. 2016;7:12309 pubmed publisher |
- proximity ligation assay; mouse; 1:100; loading ...; fig 5a
- immunoprecipitation; human; loading ...; fig 1b
- western blot; human; loading ...; fig 1a
| Sayedyahossein S, Li Z, Hedman A, Morgan C, Sacks D. IQGAP1 Binds to Yes-associated Protein (YAP) and Modulates Its Transcriptional Activity. J Biol Chem. 2016;291:19261-73 pubmed publisher |
- western blot; human; loading ...; fig 4a
| Fullenkamp C, Hall S, Jaber O, Pakalniskis B, Savage E, Savage J, et al. TAZ and YAP are frequently activated oncoproteins in sarcomas. Oncotarget. 2016;7:30094-108 pubmed publisher |
- chromatin immunoprecipitation; mouse; loading ...; fig 4a
- immunocytochemistry; mouse; 1:100; loading ...; fig 2a
- western blot; mouse; 1:1000; loading ...; fig 2c
| Jia Q, Zhou W, Yao W, Yang F, Zhang S, Singh R, et al. Downregulation of YAP-dependent Nupr1 promotes tumor-repopulating cell growth in soft matrices. Oncogenesis. 2016;5:e220 pubmed publisher |
- western blot; mouse; fig 5
| Keyvani Chahi A, Martin C, Jones N. Nephrin Suppresses Hippo Signaling through the Adaptor Proteins Nck and WTIP. J Biol Chem. 2016;291:12799-808 pubmed publisher |
- chromatin immunoprecipitation; mouse; loading ...; fig 8e-f
| Wang Y, Cui R, Zhang X, Qiao Y, Liu X, Chang Y, et al. SIRT1 increases YAP- and MKK3-dependent p38 phosphorylation in mouse liver and human hepatocellular carcinoma. Oncotarget. 2016;7:11284-98 pubmed publisher |
- immunocytochemistry; human; 1:100
| Iglesias Bartolomé R, Torres D, Marone R, Feng X, Martin D, Simaan M, et al. Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nat Cell Biol. 2015;17:793-803 pubmed publisher |
| Isfort I, Elges S, Cyra M, Berthold R, Renner M, Mechtersheimer G, et al. Prevalence of the Hippo Effectors YAP1/TAZ in Tumors of Soft Tissue and Bone. Sci Rep. 2019;9:19704 pubmed publisher |
| Yu S, Zhang M, Huang L, Ma Z, Gong X, Liu W, et al. ERK1 indicates good prognosis and inhibits breast cancer progression by suppressing YAP1 signaling. Aging (Albany NY). 2019;11:12295-12314 pubmed publisher |
| Borreguero Muñoz N, Fletcher G, Aguilar Aragon M, Elbediwy A, Vincent Mistiaen Z, Thompson B. The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth. PLoS Biol. 2019;17:e3000509 pubmed publisher |
| Yu M, Cui R, Huang Y, Luo Y, Qin S, Zhong M. Increased proton-sensing receptor GPR4 signalling promotes colorectal cancer progression by activating the hippo pathway. EBioMedicine. 2019;48:264-276 pubmed publisher |
| Wang M, Fer N, Galeas J, Collisson E, Kim S, Sharib J, et al. Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer. Nat Commun. 2019;10:3055 pubmed publisher |
| Pattschull G, Walz S, Gründl M, Schwab M, Rühl E, Baluapuri A, et al. The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes. Cell Rep. 2019;27:3533-3546.e7 pubmed publisher |
| Liu J, Zhao X, Wang K, Zhang X, Yu Y, Lv Y, et al. A novel YAP1/SLC35B4 regulatory axis contributes to proliferation and progression of gastric carcinoma. Cell Death Dis. 2019;10:452 pubmed publisher |
| Wu Y, Shen L, Liang X, Li S, Ma L, Zheng L, et al. Helicobacter pylori-induced YAP1 nuclear translocation promotes gastric carcinogenesis by enhancing IL-1β expression. Cancer Med. 2019;: pubmed publisher |
| Figeac N, Mohamed A, Sun C, Schönfelder M, Matallanas D, Garcia Munoz A, et al. Vgll3 operates via Tead1, Tead3 and Tead4 to influence myogenesis in skeletal muscle. J Cell Sci. 2019;: pubmed publisher |
| Ito T, Nakamura A, Tanaka I, Tsuboi Y, Morikawa T, Nakajima J, et al. CADM1 associates with Hippo pathway core kinases; membranous co-expression of CADM1 and LATS2 in lung tumors predicts good prognosis. Cancer Sci. 2019;110:2284-2295 pubmed publisher |
| Shu Z, Gao Y, Zhang G, Zhou Y, Cao J, Wan D, et al. A functional interaction between Hippo-YAP signalling and SREBPs mediates hepatic steatosis in diabetic mice. J Cell Mol Med. 2019;23:3616-3628 pubmed publisher |
| Tiemann K, Garri C, Lee S, Malihi P, Park M, Alvarez R, et al. Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis. Oncogene. 2019;38:3003-3018 pubmed publisher |
| Yang X, Shen H, Buckley B, Chen Y, Yang N, Mussell A, et al. NTRK1 is a positive regulator of YAP oncogenic function. Oncogene. 2019;38:2778-2787 pubmed publisher |
| Deng L, Qi M, Peng Q, Chen M, Qi Q, Zhang J, et al. Arenobufagin induces MCF-7 cell apoptosis by promoting JNK-mediated multisite phosphorylation of Yes-associated protein. Cancer Cell Int. 2018;18:209 pubmed publisher |
| Komatsu N, Kajiya M, Motoike S, Takewaki M, Horikoshi S, Iwata T, et al. Type I collagen deposition via osteoinduction ameliorates YAP/TAZ activity in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes. Stem Cell Res Ther. 2018;9:342 pubmed publisher |
| Luu A, Schott C, Jones R, Poon A, Golding B, Hamed R, et al. An evaluation of TAZ and YAP crosstalk with TGFβ signalling in canine osteosarcoma suggests involvement of hippo signalling in disease progression. BMC Vet Res. 2018;14:365 pubmed publisher |
| Moreno Vicente R, Pavón D, Martin Padura I, Català Montoro M, Díez Sánchez A, Quílez Álvarez A, et al. Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP. Cell Rep. 2018;25:1622-1635.e6 pubmed publisher |
| Bonse J, Wennmann D, Kremerskothen J, Weide T, Michgehl U, Pavenstadt H, et al. Nuclear YAP localization as a key regulator of podocyte function. Cell Death Dis. 2018;9:850 pubmed publisher |
| Webb Strickland S, Brimer N, Lyons C, Vande Pol S. Human Papillomavirus E6 interaction with cellular PDZ domain proteins modulates YAP nuclear localization. Virology. 2018;516:127-138 pubmed publisher |
| Diamantopoulou Z, White G, Fadlullah M, Dreger M, Pickering K, Maltas J, et al. TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells. Cancer Cell. 2017;31:621-634.e6 pubmed publisher |
| Mori S, Takeuchi T, Ishii Y, Yugawa T, Kiyono T, Nishina H, et al. Human Papillomavirus 16 E6 Upregulates APOBEC3B via the TEAD Transcription Factor. J Virol. 2017;91: pubmed publisher |
