product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
CDK6 (D4S8S) Rabbit mAb
catalog :
13331
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D4S8S
reactivity :
human, rat
application :
western blot
more info or order :
Cell Signaling Technology product webpage
citations: 9
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 2c
Cornell L, Wander S, Visal T, Wagle N, Shapiro G. MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance. Cell Rep. 2019;26:2667-2680.e7 pubmed publisher
  • western blot; human; loading ...; fig 6h
Martinez Soria N, McKenzie L, Draper J, Ptasinska A, Issa H, Potluri S, et al. The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation. Cancer Cell. 2018;34:626-642.e8 pubmed publisher
  • western blot; human; loading ...; fig 5a
Reuther C, Heinzle V, Nölting S, Herterich S, Hahner S, Halilovic E, et al. The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1. Neuroendocrinology. 2018;106:1-19 pubmed publisher
  • western blot; human; loading ...; fig 1c
Liao P, Zeng S, Zhou X, Chen T, Zhou F, Cao B, et al. Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding. Mol Cell. 2017;68:1134-1146.e6 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 7a
Sun J, Zhang X, Sun Y, Tang Z, Guo D. Effects of Hylomecon vernalis ethanol extracts on cell cycle and apoptosis of colon cancer cells. Mol Med Rep. 2017;15:3485-3492 pubmed publisher
  • western blot; rat; loading ...; fig 4a
Yang F, Li H, Du Y, Shi Q, Zhao L. Downregulation of microRNA‑34b is responsible for the elevation of blood pressure in spontaneously hypertensive rats. Mol Med Rep. 2017;15:1031-1036 pubmed publisher
  • western blot; human; loading ...; fig 6a
Reuther C, Heinzle V, Spampatti M, Vlotides G, de Toni E, Spöttl G, et al. Cabozantinib and Tivantinib, but Not INC280, Induce Antiproliferative and Antimigratory Effects in Human Neuroendocrine Tumor Cells in vitro: Evidence for 'Off-Target' Effects Not Mediated by c-Met Inhibition. Neuroendocrinology. 2016;103:383-401 pubmed publisher
Hadjadj D, Kim S, Denecker T, Ben Driss L, Cadoret J, Maric C, et al. A hypothesis-driven approach identifies CDK4 and CDK6 inhibitors as candidate drugs for treatments of adrenocortical carcinomas. Aging (Albany NY). 2017;9:2695-2716 pubmed publisher
Gieseler Halbach S, Meltendorf S, Pierau M, Weinert S, Heidel F, Fischer T, et al. RSK-mediated nuclear accumulation of the cold-shock Y-box protein-1 controls proliferation of T cells and T-ALL blasts. Cell Death Differ. 2017;24:371-383 pubmed publisher
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.