product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
PCNA
catalog :
13110
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D3H8P
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 46
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 3c
Li B, Lian M, Li Y, Qian Q, Zhang J, Liu Q, et al. Myeloid-Derived Suppressive Cells Deficient in Liver X Receptor α Protected From Autoimmune Hepatitis. Front Immunol. 2021;12:732102 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 6a
  • western blot; mouse; loading ...; fig 6d
Yan M, Wang Z, Xia T, Jin S, Liu Y, Hu H, et al. Enhancement of TEX264-Mediated ER-Phagy Contributes to the Therapeutic Effect of Glycycoumarin against APA Hepatotoxicity in Mice. Biomedicines. 2021;9: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2k
Dong J, Viswanathan S, Adami E, Schafer S, Kuthubudeen F, Widjaja A, et al. The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling. elife. 2021;10: pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 1e
Lee S, Remark L, Josephson A, Leclerc K, Lopez E, Kirby D, et al. Notch-Wnt signal crosstalk regulates proliferation and differentiation of osteoprogenitor cells during intramembranous bone healing. NPJ Regen Med. 2021;6:29 pubmed publisher
  • immunohistochemistry; human; 1:300; fig 7g
Dai M, Yan G, Wang N, Daliah G, Edick A, Poulet S, et al. In vivo genome-wide CRISPR screen reveals breast cancer vulnerabilities and synergistic mTOR/Hippo targeted combination therapy. Nat Commun. 2021;12:3055 pubmed publisher
  • immunocytochemistry; mouse; fig 9c
Tan S, Liu X, Chen L, Wu X, Tao L, Pan X, et al. Fas/FasL mediates NF-κBp65/PUMA-modulated hepatocytes apoptosis via autophagy to drive liver fibrosis. Cell Death Dis. 2021;12:474 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3m
Zheng T, Liu X, Li X, Wang Q, Zhao Y, Li X, et al. Dickkopf-1 promotes Vascular Smooth Muscle Cell proliferation and migration through upregulating UHRF1 during Cyclic Stretch application. Int J Biol Sci. 2021;17:1234-1249 pubmed publisher
  • western blot; human; 1:1000; fig 2h
Lu M, Qin X, Zhou Y, Li G, Liu Z, Geng X, et al. Long non-coding RNA LINC00665 promotes gemcitabine resistance of Cholangiocarcinoma cells via regulating EMT and stemness properties through miR-424-5p/BCL9L axis. Cell Death Dis. 2021;12:72 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4b
  • western blot; mouse; loading ...; fig 4c
Jiao T, Yao X, Zhao Y, Zhou Y, Gao Y, Fan S, et al. Dexamethasone-Induced Liver Enlargement Is Related to PXR/YAP Activation and Lipid Accumulation but Not Hepatocyte Proliferation. Drug Metab Dispos. 2020;48:830-839 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6i
Lin Z, Lin X, Zhu L, Huang J, Huang Y. TRIM2 directly deubiquitinates and stabilizes Snail1 protein, mediating proliferation and metastasis of lung adenocarcinoma. Cancer Cell Int. 2020;20:228 pubmed publisher
  • immunohistochemistry; rat; 1:2500; loading ...; fig 5a
Luo L, Xiao L, Lian G, Wang H, Xie L. miR-125a-5p inhibits glycolysis by targeting hexokinase-II to improve pulmonary arterial hypertension. Aging (Albany NY). 2020;12:9014-9030 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4d
Bott A, Shen J, Tonelli C, Zhan L, Sivaram N, Jiang Y, et al. Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism. Cell Rep. 2019;29:1287-1298.e6 pubmed publisher
  • western blot; human; loading ...; fig 1g
Yoshida A, Bu Y, Qie S, Wrangle J, Camp E, Hazard E, et al. SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors. Sci Adv. 2019;5:eaax6352 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 2f
Zhong H, Wu H, Bai H, Wang M, Wen J, Gong J, et al. Panax notoginseng saponins promote liver regeneration through activation of the PI3K/AKT/mTOR cell proliferation pathway and upregulation of the AKT/Bad cell survival pathway in mice. BMC Complement Altern Med. 2019;19:122 pubmed publisher
  • western blot; human; loading ...; fig 5a
Wang Z, Feng X, Molinolo A, Martin D, Vitale Cross L, Nohata N, et al. 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer. Cancer Res. 2019;: pubmed publisher
  • western blot; rat; loading ...; fig s1
Hlavac N, VandeVord P. Astrocyte Mechano-Activation by High-Rate Overpressure Involves Alterations in Structural and Junctional Proteins. Front Neurol. 2019;10:99 pubmed publisher
  • western blot; human; loading ...; fig 3a, 3b
Lou C, Lu H, Ma Z, Liu C, Zhang Y. Ginkgolide B enhances gemcitabine sensitivity in pancreatic cancer cell lines via inhibiting PAFR/NF-кB pathway. Biomed Pharmacother. 2019;109:563-572 pubmed publisher
  • immunocytochemistry; human; 1:300; loading ...; fig s4i
Gut G, Herrmann M, Pelkmans L. Multiplexed protein maps link subcellular organization to cellular states. Science. 2018;361: pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 7d
Zhao C, Li Y, Qiu W, He F, Zhang W, Zhao D, et al. C5a induces A549 cell proliferation of non-small cell lung cancer via GDF15 gene activation mediated by GCN5-dependent KLF5 acetylation. Oncogene. 2018;37:4821-4837 pubmed publisher
  • western blot; human; loading ...; fig 5c
Huang G, Jiang H, Lin Y, Wu Y, Cai W, Shi B, et al. lncAKHE enhances cell growth and migration in hepatocellular carcinoma via activation of NOTCH2 signaling. Cell Death Dis. 2018;9:487 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 4f
Zhao Y, Wu X, Li X, Jiang L, Gui X, Liu Y, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 2018;97:1023-1031.e7 pubmed publisher
  • immunohistochemistry; mouse; 1:800; loading ...; fig s3b
Duchamp de Lageneste O, Julien A, Abou Khalil R, Frangi G, Carvalho C, Cagnard N, et al. Periosteum contains skeletal stem cells with high bone regenerative potential controlled by Periostin. Nat Commun. 2018;9:773 pubmed publisher
  • western blot; human; loading ...; fig s4
Yu Y, Shang R, Chen Y, Li J, Liang Z, Hu J, et al. Tumor suppressive ZBTB4 inhibits cell growth by regulating cell cycle progression and apoptosis in Ewing sarcoma. Biomed Pharmacother. 2018;100:108-115 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 6a
El Zowalaty A, Li R, Chen W, Ye X. Seipin deficiency leads to increased endoplasmic reticulum stress and apoptosis in mammary gland alveolar epithelial cells during lactation. Biol Reprod. 2018;98:570-578 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 3f
Akiel M, Guo C, Li X, Rajasekaran D, Mendoza R, Robertson C, et al. IGFBP7 Deletion Promotes Hepatocellular Carcinoma. Cancer Res. 2017;77:4014-4025 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 3a
Choiniere J, Wu J, Wang L. Pyruvate Dehydrogenase Kinase 4 Deficiency Results in Expedited Cellular Proliferation through E2F1-Mediated Increase of Cyclins. Mol Pharmacol. 2017;91:189-196 pubmed publisher
  • immunohistochemistry; mouse; fig 3
Li L, Byrd M, Doh K, Dixon P, Lee H, Tiwari S, et al. Absence of renal enlargement in fructose-fed proximal-tubule-select insulin receptor (IR), insulin-like-growth factor receptor (IGF1R) double knockout mice. Physiol Rep. 2016;4: pubmed
  • immunohistochemistry - paraffin section; mouse; fig 2b
Wang W, Song B, Anbarchian T, Shirazyan A, Sadik J, Lyons K. Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate. PLoS Genet. 2016;12:e1006352 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:800; loading ...; fig 1a
Fan T, Warmoes M, Sun Q, Song H, Turchan Cholewo J, Martin J, et al. Distinctly perturbed metabolic networks underlie differential tumor tissue damages induced by immune modulator ?-glucan in a two-case ex vivo non-small-cell lung cancer study. Cold Spring Harb Mol Case Stud. 2016;2:a000893 pubmed publisher
  • western blot; human; loading ...; fig 6e
Hong S, Eun J, Choi S, Shen Q, Choi W, Han J, et al. Epigenetic reader BRD4 inhibition as a therapeutic strategy to suppress E2F2-cell cycle regulation circuit in liver cancer. Oncotarget. 2016;7:32628-40 pubmed publisher
  • western blot; human; 1:1000; fig 6
Montalbano M, Curcurù G, Shirafkan A, Vento R, Rastellini C, Cicalese L. Modeling of Hepatocytes Proliferation Isolated from Proximal and Distal Zones from Human Hepatocellular Carcinoma Lesion. PLoS ONE. 2016;11:e0153613 pubmed publisher
  • western blot; human; fig 5
Catanzaro G, Besharat Z, Garg N, Ronci M, Pieroni L, Miele E, et al. MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs. Stem Cells Int. 2016;2016:2683042 pubmed publisher
  • western blot; human; 1:1000; fig 3
Wu T, Li Y, Liu B, Zhang S, Wu L, Zhu X, et al. Expression of Ferritin Light Chain (FTL) Is Elevated in Glioblastoma, and FTL Silencing Inhibits Glioblastoma Cell Proliferation via the GADD45/JNK Pathway. PLoS ONE. 2016;11:e0149361 pubmed publisher
  • western blot; human; fig 3
Haim Y, Bluher M, Slutsky N, Goldstein N, Kloting N, Harman Boehm I, et al. Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1. Autophagy. 2015;11:2074-2088 pubmed publisher
He Y, Wang R, Zhang P, Yan J, Gong N, Li Y, et al. Curcumin inhibits the proliferation and migration of vascular smooth muscle cells by targeting the chemerin / CMKLR1 / LCN2 axis. Aging (Albany NY). 2021;13:13859-13875 pubmed publisher
Jo H, Park Y, Kim T, Kim J, Lee J, Kim S, et al. Modulation of SIRT3 expression through CDK4/6 enhances the anti-cancer effect of sorafenib in hepatocellular carcinoma cells. BMC Cancer. 2020;20:332 pubmed publisher
Wang Q, Cao T, Guo K, Zhou Y, Liu H, Pan Y, et al. Regulation of Integrin Subunit Alpha 2 by miR-135b-5p Modulates Chemoresistance in Gastric Cancer. Front Oncol. 2020;10:308 pubmed publisher
Li Y, Tong K, Lu J, Lin J, Li Z, Sang Y, et al. PRMT5-TRIM21 interaction regulates the senescence of osteosarcoma cells by targeting the TXNIP/p21 axis. Aging (Albany NY). 2020;12:2507-2529 pubmed publisher
Wunderlich C, Ackermann P, Ostermann A, Adams Quack P, Vogt M, Tran M, et al. Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment. Nat Commun. 2018;9:1646 pubmed publisher
Choi M, Maruyama T, Chun C, Park Y. Alleviation of Murine Osteoarthritis by Cartilage-Specific Deletion of I?B?. Arthritis Rheumatol. 2018;70:1440-1449 pubmed publisher
Lee J, Shanina I, Chu Y, Horwitz M, Johnson J. Carbamazepine, a beta-cell protecting drug, reduces type 1 diabetes incidence in NOD mice. Sci Rep. 2018;8:4588 pubmed publisher
Elenbaas J, Bragazzi Cunha J, Azuero Dajud R, Nelson B, Oral E, Williams J, et al. Lamin A/C Maintains Exocrine Pancreas Homeostasis by Regulating Stability of RB and Activity of E2F. Gastroenterology. 2018;154:1625-1629.e8 pubmed publisher
Sen A, Sharma A, Greenberg H. Rotavirus Degrades Multiple Interferon (IFN) Type Receptors To Inhibit IFN Signaling and Protects against Mortality from Endotoxin in Suckling Mice. J Virol. 2018;92: pubmed publisher
Gruber W, Peer E, Elmer D, Sternberg C, Tesanovic S, Del Burgo P, et al. Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC-202 blocks oncogenic hedgehog-GLI signaling and overcomes smoothened inhibitor resistance. Int J Cancer. 2018;142:968-975 pubmed publisher
El Zowalaty A, Li R, Zheng Y, Lydon J, DeMayo F, Ye X. Deletion of RhoA in Progesterone Receptor-Expressing Cells Leads to Luteal Insufficiency and Infertility in Female Mice. Endocrinology. 2017;158:2168-2178 pubmed publisher
Chiang H, Zhao Y, Song J, Liu S, Wang N, Terhorst C, et al. GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses. Nat Immunol. 2014;15:63-71 pubmed publisher
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.