product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-ATM (Ser1981) (D25E5) Rabbit mAb
catalog :
13050
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D25E5
reactivity :
human, mouse
application :
western blot, immunocytochemistry
citations: 17
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig 3c
Kumar D, Das M, Oberg A, Sahoo D, Wu P, Sauceda C, et al. Hepatocyte Deletion of IGF2 Prevents DNA Damage and Tumor Formation in Hepatocellular Carcinoma. Adv Sci (Weinh). 2022;9:e2105120 pubmed publisher
  • western blot; human; fig 5a
Chesnokova V, Zonis S, Apostolou A, Estrada H, Knott S, Wawrowsky K, et al. Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage. Cell Rep. 2021;37:110068 pubmed publisher
  • western blot; human; 1:1500; loading ...; fig 5j
Xia R, Liu T, Li W, Xu X. RNA-binding protein RBM24 represses colorectal tumourigenesis by stabilising PTEN mRNA. Clin Transl Med. 2021;11:e383 pubmed publisher
  • western blot; human; loading ...; fig 4a
Ditano J, Donahue K, Tafe L, McCleery C, Eastman A. Sensitivity of cells to ATR and CHK1 inhibitors requires hyperactivation of CDK2 rather than endogenous replication stress or ATM dysfunction. Sci Rep. 2021;11:7077 pubmed publisher
  • western blot; human; loading ...; fig 3a
Moses N, Zhang M, Wu J, Hu C, Xiang S, Geng X, et al. HDAC6 Regulates Radiosensitivity of Non-Small Cell Lung Cancer by Promoting Degradation of Chk1. Cells. 2020;9: pubmed publisher
  • western blot; human; loading ...; fig 2b, 2f
Mallampalli R, Li X, Jang J, Kaminski T, Hoji A, Coon T, et al. Cigarette smoke exposure enhances transforming acidic coiled-coil-containing protein 2 turnover and thereby promotes emphysema. JCI Insight. 2020;5: pubmed publisher
  • western blot; human; loading ...; fig 3b
Li K, Meng Z, Jiang L, Xia C, Xu K, Yuan D, et al. CDKL1 promotes the chemoresistance of human oral squamous cell carcinoma cells to hydroxycamptothecin. Mol Cell Probes. 2019;44:57-62 pubmed publisher
  • western blot; human; loading ...; fig 2a, 2b
Karanika S, Karantanos T, Li L, Wang J, Park S, Yang G, et al. Targeting DNA Damage Response in Prostate Cancer by Inhibiting Androgen Receptor-CDC6-ATR-Chk1 Signaling. Cell Rep. 2017;18:1970-1981 pubmed publisher
  • western blot; human; loading ...; fig 6c
Chen Z, Liu B, Tang N, Xu Y, Ye X, Li Z, et al. FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response. Nucleic Acids Res. 2014;42:11560-9 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig s8
Wei F, Ojo D, Lin X, Wong N, He L, Yan J, et al. BMI1 attenuates etoposide-induced G2/M checkpoints via reducing ATM activation. Oncogene. 2015;34:3063-75 pubmed publisher
Guo R, Wang S, Jiang X, Zhang Y, Guo Y, Cui H, et al. CHK2 Promotes Metabolic Stress-Induced Autophagy through ULK1 Phosphorylation. Antioxidants (Basel). 2022;11: pubmed publisher
Batur T, Argundogan A, Keles U, Mutlu Z, Alotaibi H, Senturk S, et al. AXL Knock-Out in SNU475 Hepatocellular Carcinoma Cells Provides Evidence for Lethal Effect Associated with G2 Arrest and Polyploidization. Int J Mol Sci. 2021;22: pubmed publisher
Dahabieh M, Huang F, Goncalves C, Flores González R, Prabhu S, Bolt A, et al. Silencing PEX26 as an unconventional mode to kill drug-resistant cancer cells and forestall drug resistance. Autophagy. 2021;:1-19 pubmed publisher
Booth L, West C, Von Hoff D, Kirkwood J, Dent P. GZ17-6.02 Interacts With [MEK1/2 and B-RAF Inhibitors] to Kill Melanoma Cells. Front Oncol. 2021;11:656453 pubmed publisher
Booth L, West C, Hoff D, Dent P. GZ17-6.02 and Doxorubicin Interact to Kill Sarcoma Cells via Autophagy and Death Receptor Signaling. Front Oncol. 2020;10:1331 pubmed publisher
Wang J, Wang C, Yu H, Dela Ahator S, Wu X, Lv S, et al. Bacterial quorum sensing signal IQS induces host cell apoptosis by targeting POT1-p53 signalling pathway. Cell Microbiol. 2019;:e13076 pubmed publisher
Durant S, Zheng L, Wang Y, Chen K, Zhang L, Zhang T, et al. The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models. Sci Adv. 2018;4:eaat1719 pubmed publisher
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.