product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
FoxO3a (D19A7) Rabbit mAb
catalog :
12829
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D19A7
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, western blot knockout validation, immunohistochemistry knockout validation
citations: 20
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; 1:1000; loading ...; fig 2d, s2e
Luo L, Zhang Z, Qiu N, Ling L, Jia X, Song Y, et al. Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer. Nat Commun. 2021;12:2699 pubmed publisher
  • immunohistochemistry knockout validation; mouse; 1:1000; loading ...; fig 3
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 3
Oh H, Paik J. Genetic Ablation of FOXO in Mice to Investigate Its Physiological Role. Methods Mol Biol. 2019;1890:239-248 pubmed publisher
  • western blot; human; fig 6c
  • immunohistochemistry; mouse; loading ...; fig 3
Schwiebs A, Faqar Uz Zaman F, Herrero San Juan M, Radeke H. S1P Lyase Regulates Intestinal Stem Cell Quiescence via Ki-67 and FOXO3. Int J Mol Sci. 2021;22: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1a
Al Zahrani K, Abou Hamad J, Pascoal J, Labrèche C, Garland B, Sabourin L. AKT-mediated phosphorylation of Sox9 induces Sox10 transcription in a murine model of HER2-positive breast cancer. Breast Cancer Res. 2021;23:55 pubmed publisher
  • western blot; human; loading ...; fig 9b
Zhao W, Zhang W, Ma H, Yang M. NIPA2 regulates osteoblast function by modulating mitophagy in type 2 diabetes osteoporosis. Sci Rep. 2020;10:3078 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 5e
  • western blot; human; 1:1000; loading ...; fig 5d
LI Y, Du L, Aldana Masangkay G, Wang X, Urak R, Forman S, et al. Regulation of miR-34b/c-targeted gene expression program by SUMOylation. Nucleic Acids Res. 2018;: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000; fig 7d
Hu L, Liang S, Chen H, Lv T, Wu J, Chen D, et al. ΔNp63α is a common inhibitory target in oncogenic PI3K/Ras/Her2-induced cell motility and tumor metastasis. Proc Natl Acad Sci U S A. 2017;114:E3964-E3973 pubmed publisher
  • western blot; mouse; loading ...; fig s4a
Jiang C, Diao F, Sang Y, Xu N, Zhu R, Wang X, et al. GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary. PLoS Genet. 2017;13:e1006535 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 1a
Ikeda J, Wada N, Nojima S, Tahara S, Tsuruta Y, Oya K, et al. ID1 upregulation and FoxO3a downregulation by Epstein-Barr virus-encoded LMP1 in Hodgkin's lymphoma. Mol Clin Oncol. 2016;5:562-566 pubmed
  • western blot; rat; 1:750; loading ...; fig 5d
Gómez SanMiguel A, Villanúa M, Martín A, López Calderón A. D-TRP(8)-γMSH Prevents the Effects of Endotoxin in Rat Skeletal Muscle Cells through TNFα/NF-KB Signalling Pathway. PLoS ONE. 2016;11:e0155645 pubmed publisher
  • western blot; human; loading ...; fig 6d
Zhu J, Wang S, Zhang W, Qiu J, Shan Y, Yang D, et al. Screening key microRNAs for castration-resistant prostate cancer based on miRNA/mRNA functional synergistic network. Oncotarget. 2015;6:43819-30 pubmed publisher
  • western blot; mouse; 1:1000; fig s9
Braccini L, Ciraolo E, Campa C, Perino A, Longo D, Tibolla G, et al. PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling. Nat Commun. 2015;6:7400 pubmed publisher
Guo Y, Ye Q, Deng P, Cao Y, He D, Zhou Z, et al. Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression. Nat Commun. 2020;11:3243 pubmed publisher
Vallejo Gracia A, Chen I, Perrone R, Besnard E, Boehm D, Battivelli E, et al. FOXO1 promotes HIV latency by suppressing ER stress in T cells. Nat Microbiol. 2020;: pubmed publisher
Zhou J, Xue Z, He H, Liu X, Yin S, Wu D, et al. Resveratrol delays postovulatory aging of mouse oocytes through activating mitophagy. Aging (Albany NY). 2019;11:11504-11519 pubmed publisher
Kenny T, Craig A, Villanueva A, Germain D. Mitohormesis Primes Tumor Invasion and Metastasis. Cell Rep. 2019;27:2292-2303.e6 pubmed publisher
Hornick E, Dagvadorj J, Zacharias Z, Miller A, Langlois R, Chen P, et al. Dendritic cell NLRC4 regulates influenza A virus-specific CD4 T cell responses through FasL expression. J Clin Invest. 2019;129:2888-2897 pubmed publisher
Qian F, Hu Q, Tian Y, Wu J, Li D, Tao M, et al. ING4 suppresses hepatocellular carcinoma via a NF-κB/miR-155/FOXO3a signaling axis. Int J Biol Sci. 2019;15:369-385 pubmed publisher
Srivastava T, Diba P, Dean J, Banine F, Shaver D, Hagen M, et al. A TLR/AKT/FoxO3 immune tolerance-like pathway disrupts the repair capacity of oligodendrocyte progenitors. J Clin Invest. 2018;128:2025-2041 pubmed publisher
Umeki D, Ohnuki Y, Mototani Y, Shiozawa K, Suita K, Fujita T, et al. Protective Effects of Clenbuterol against Dexamethasone-Induced Masseter Muscle Atrophy and Myosin Heavy Chain Transition. PLoS ONE. 2015;10:e0128263 pubmed publisher
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.