| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; 1:2000; loading ...; fig s1c
| Kang C, Song C, Kim N, Nam R, Choi S, Yu J, et al. The Enhanced Inhibitory Effect of Estrogen on PD-L1 Expression Following Nrf2 Deficiency in the AOM/DSS Model of Colitis-Associated Cancer. Front Oncol. 2021;11:679324 pubmed publisher |
- western blot knockout validation; human; loading ...; fig 1g
| Koppula P, Olszewski K, Zhang Y, Kondiparthi L, Liu X, Lei G, et al. KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition. iScience. 2021;24:102649 pubmed publisher |
- western blot knockout validation; mouse; 1:500; fig 2
| Deighton R, Márkus N, Al Mubarak B, Bell K, Papadia S, Meakin P, et al. Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes. Proc Natl Acad Sci U S A. 2014;111:E1818-20 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4b
| Li S, Jin H, Sun G, Zhang C, Wang J, Xu H, et al. Dietary Inorganic Nitrate Protects Hepatic Ischemia-Reperfusion Injury Through NRF2-Mediated Antioxidative Stress. Front Pharmacol. 2021;12:634115 pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 6b
| Shang L, Ren H, Wang S, Liu H, Hu A, Gou P, et al. SS-31 Protects Liver from Ischemia-Reperfusion Injury via Modulating Macrophage Polarization. Oxid Med Cell Longev. 2021;2021:6662156 pubmed publisher |
- western blot; rat; 1:1000; loading ...; fig 6c
| Zhou F, Zou X, Zhang J, Wang Z, Yang Y, Wang D. Jian-Pi-Yi-Shen Formula Ameliorates Oxidative Stress, Inflammation, and Apoptosis by Activating the Nrf2 Signaling in 5/6 Nephrectomized Rats. Front Pharmacol. 2021;12:630210 pubmed publisher |
- immunocytochemistry; human; 1:1000; fig s10
- western blot; human; 1:1000; fig s9e
| Goldfarb A, Freeman K, Sahu R, Elagib K, Holy M, Arneja A, et al. Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia. Nat Commun. 2021;12:1645 pubmed publisher |
- western blot; human; fig 6a
| Huang D, Dai C, Li S, Li X. Obacunone protects retinal pigment epithelium cells from ultra-violet radiation-induced oxidative injury. Aging (Albany NY). 2021;13:11010-11025 pubmed publisher |
- western blot; human; loading ...
| Brockway S, Wang G, Jackson J, Amici D, Takagishi S, Clutter M, et al. Quantitative and multiplexed chemical-genetic phenotyping in mammalian cells with QMAP-Seq. Nat Commun. 2020;11:5722 pubmed publisher |
- western blot; mouse; loading ...; fig s5a
| Li X, Wu Y, Zhao J, Wang H, Tan J, Yang M, et al. Distinct cardiac energy metabolism and oxidative stress adaptations between obese and non-obese type 2 diabetes mellitus. Theranostics. 2020;10:2675-2695 pubmed publisher |
- western blot; rat; loading ...; fig 4a
| Rafikova O, James J, Eccles C, Kurdyukov S, Niihori M, Varghese M, et al. Early progression of pulmonary hypertension in the monocrotaline model in males is associated with increased lung permeability. Biol Sex Differ. 2020;11:11 pubmed publisher |
- chromatin immunoprecipitation; mouse; loading ...; fig 3f
- western blot; mouse; 1:1000; loading ...; fig 1j
| Wei Y, Lu M, Mei M, Wang H, Han Z, Chen M, et al. Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection. Nat Commun. 2020;11:941 pubmed publisher |
- western blot; mouse; loading ...; fig 5c
| Casares L, Garcia V, Garrido Rodríguez M, Millán E, Collado J, Garcia Martin A, et al. Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020;28:101321 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3a
| Griñan Ferré C, Marsal García L, Bellver Sanchis A, Kondengaden S, Turga R, Vazquez S, et al. Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer's disease mouse model. Aging (Albany NY). 2019;11:11591-11608 pubmed publisher |
- western blot; human; 1:200; loading ...; fig s2r
| Wiel C, Le Gal K, Ibrahim M, Jahangir C, Kashif M, Yao H, et al. BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis. Cell. 2019;: pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 2e
| Lignitto L, LeBoeuf S, Homer H, Jiang S, Askenazi M, Karakousi T, et al. Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1. Cell. 2019;: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 1b
| Kang Y, Torrente L, Falzone A, Elkins C, Liu M, Asara J, et al. Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer. elife. 2019;8: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 3i
| Li C, Liu Q, Xie L. Suppressing NLRP2 expression accelerates hepatic steatosis: A mechanism involving inflammation and oxidative stress. Biochem Biophys Res Commun. 2018;507:22-29 pubmed publisher |
- western blot; mouse; loading ...; fig 1b
| Inouye S, Hatori Y, Kubo T, Saito S, Kitamura H, Akagi R. NRF2 and HSF1 coordinately regulate heme oxygenase-1 expression. Biochem Biophys Res Commun. 2018;506:7-11 pubmed publisher |
- western blot; human; 1:2000; loading ...; fig 6a
| Jena K, Kolapalli S, Mehto S, Nath P, Das B, Sahoo P, et al. TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. EMBO J. 2018;37: pubmed publisher |
- western blot; human; loading ...; fig 2b
| Zhu B, Tang L, Chen S, Yin C, Peng S, Li X, et al. Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy. Oncogene. 2018;37:4941-4954 pubmed publisher |
- western blot; mouse; loading ...; fig 3d
| Niwa Kawakita M, Ferhi O, Soilihi H, Le Bras M, Lallemand Breitenbach V, de Thé H. PML is a ROS sensor activating p53 upon oxidative stress. J Exp Med. 2017;214:3197-3206 pubmed publisher |
- western blot; human; loading ...; fig 3d
| Caino M, Seo J, Wang Y, Rivadeneira D, Gabrilovich D, Kim E, et al. Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer. J Clin Invest. 2017;127:3755-3769 pubmed publisher |
- western blot; human; loading ...; fig 4c
| Perez Leal O, Barrero C, Merali S. Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses. J Biol Chem. 2017;292:14108-14121 pubmed publisher |
- immunohistochemistry; human; 1:20
- western blot; human; 1:200; loading ...; fig 1a
| Wasik U, Milkiewicz M, Kempińska Podhorodecka A, Milkiewicz P. Protection against oxidative stress mediated by the Nrf2/Keap1 axis is impaired in Primary Biliary Cholangitis. Sci Rep. 2017;7:44769 pubmed publisher |
- western blot; human; loading ...; fig s8j
| Dey P, Baddour J, Muller F, Wu C, Wang H, Liao W, et al. Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. Nature. 2017;542:119-123 pubmed publisher |
- western blot; human; loading ...; fig 6C
| Cheng L, Li K, Yi N, Li X, Wang F, Xue B, et al. miRNA-141 attenuates UV-induced oxidative stress via activating Keap1-Nrf2 signaling in human retinal pigment epithelium cells and retinal ganglion cells. Oncotarget. 2017;8:13186-13194 pubmed publisher |
- western blot; human; loading ...; fig 5a
| Wang M, Li G, Yang Z, Wang L, Zhang L, Wang T, et al. Uncoupling protein 2 downregulation by hypoxia through repression of peroxisome proliferator-activated receptor γ promotes chemoresistance of non-small cell lung cancer. Oncotarget. 2017;8:8083-8094 pubmed publisher |
- western blot; human; loading ...; fig 7e
| Liu X, Xavier C, Jann J, Wu H. Salvianolic Acid B (Sal B) Protects Retinal Pigment Epithelial Cells from Oxidative Stress-Induced Cell Death by Activating Glutaredoxin 1 (Grx1). Int J Mol Sci. 2016;17: pubmed |
- western blot; human; 1:1000; loading ...; fig 2f
| Schlierf A, Altmann E, Quancard J, Jefferson A, Assenberg R, Renatus M, et al. Targeted inhibition of the COP9 signalosome for treatment of cancer. Nat Commun. 2016;7:13166 pubmed publisher |
- western blot; human; loading ...; fig 2b
| Zhang C, Wang H, Bao Q, Wang L, Guo T, Chen W, et al. NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction. Oncotarget. 2016;7:73593-73606 pubmed publisher |
- western blot; human; loading ...; fig 2g
| Ding S, Mooney N, Li B, Kelly M, Feng N, Loktev A, et al. Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex. PLoS Pathog. 2016;12:e1005929 pubmed publisher |
- chromatin immunoprecipitation; mouse; 1:250; fig 4
| Kobayashi E, Suzuki T, Funayama R, Nagashima T, Hayashi M, Sekine H, et al. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nat Commun. 2016;7:11624 pubmed publisher |
- immunocytochemistry; mouse; 1:250; fig 5
- western blot; mouse; fig 11
- immunocytochemistry; rat; 1:250; fig 5
- western blot; rat; fig 6
| Kim S, Choi K, Cho S, Yun S, Jeon J, Koh Y, et al. Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors. Sci Rep. 2016;6:24933 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 5h
- western blot; mouse; 1:1000; loading ...; fig 5h
| Zanotto Filho A, Dashnamoorthy R, Loranc E, de Souza L, Moreira J, Suresh U, et al. Combined Gene Expression and RNAi Screening to Identify Alkylation Damage Survival Pathways from Fly to Human. PLoS ONE. 2016;11:e0153970 pubmed publisher |
- western blot; human; 1:1000; fig 7
- immunoprecipitation; mouse; fig 8
- western blot; mouse; 1:1000; fig 7
| Yang Y, Huycke M, Herman T, Wang X. Glutathione S-transferase alpha 4 induction by activator protein 1 in colorectal cancer. Oncogene. 2016;35:5795-5806 pubmed publisher |
- ChIP-Seq; mouse; loading ...; fig 10a
| Uruno A, Yagishita Y, Katsuoka F, Kitajima Y, Nunomiya A, Nagatomi R, et al. Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism. Mol Cell Biol. 2016;36:1655-72 pubmed publisher |
- western blot; human; 1:500; fig 3, 4
| Tu G, Zhang Y, Wei W, Li L, Zhang Y, Yang J, et al. Allicin attenuates Hâ‚‚Oâ‚‚-induced cytotoxicity in retinal pigmented epithelial cells by regulating the levels of reactive oxygen species. Mol Med Rep. 2016;13:2320-6 pubmed publisher |
- western blot; human; loading ...; fig 8a
| Liu X, Ward K, Xavier C, Jann J, Clark A, Pang I, et al. The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation. Redox Biol. 2016;8:98-109 pubmed publisher |
- immunohistochemistry; human; loading ...; fig 4a
- western blot; human; loading ...; fig 4b
| Pettersen K, Monsen V, Hakvåg Pettersen C, Overland H, Pettersen G, Samdal H, et al. DHA-induced stress response in human colon cancer cells - Focus on oxidative stress and autophagy. Free Radic Biol Med. 2016;90:158-72 pubmed publisher |
- chromatin immunoprecipitation; human; fig 10
| Sekine H, Okazaki K, Ota N, Shima H, Katoh Y, Suzuki N, et al. The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression. Mol Cell Biol. 2016;36:407-20 pubmed publisher |
- western blot; mouse; loading ...; fig 2f
| Pehar M, Ball L, Sharma D, Harlan B, Comte Walters S, Neely B, et al. Changes in Protein Expression and Lysine Acetylation Induced by Decreased Glutathione Levels in Astrocytes. Mol Cell Proteomics. 2016;15:493-505 pubmed publisher |
| Lee S, Ha J, Park J, Kang E, Jeon S, Han S, et al. Antioxidant and Anti-Inflammatory Effects of Bischofia javanica (Blume) Leaf Methanol Extracts through the Regulation of Nrf2 and TAK1. Antioxidants (Basel). 2021;10: pubmed publisher |
| Mikac S, Rychłowski M, Dziadosz A, Szabelska Berȩsewicz A, Fahraeus R, Hupp T, et al. Identification of a Stable, Non-Canonically Regulated Nrf2 Form in Lung Cancer Cells. Antioxidants (Basel). 2021;10: pubmed publisher |
| Crinelli R, Zara C, Galluzzi L, Buffi G, Ceccarini C, Smietana M, et al. Activation of NRF2 and ATF4 Signaling by the Pro-Glutathione Molecule I-152, a Co-Drug of N-Acetyl-Cysteine and Cysteamine. Antioxidants (Basel). 2021;10: pubmed publisher |
| Täuber S, Sieckmann M, Erler K, Stahl W, Klotz L, Steinbrenner H. Activation of Nrf2 by Electrophiles Is Largely Independent of the Selenium Status of HepG2 Cells. Antioxidants (Basel). 2021;10: pubmed publisher |
| Cipak Gašparović A, Milković L, Dandachi N, Stanzer S, Pezdirc I, Vrančić J, et al. Chronic Oxidative Stress Promotes Molecular Changes Associated with Epithelial Mesenchymal Transition, NRF2, and Breast Cancer Stem Cell Phenotype. Antioxidants (Basel). 2019;8: pubmed publisher |
| Rezazadeh S, Yang D, Tombline G, Simon M, Regan S, Seluanov A, et al. SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170. Nucleic Acids Res. 2019;: pubmed publisher |
| Zou Y, Palte M, Deik A, Li H, Eaton J, Wang W, et al. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis. Nat Commun. 2019;10:1617 pubmed publisher |
| Zhang Y, Koppula P, Gan B. Regulation of H2A ubiquitination and SLC7A11 expression by BAP1 and PRC1. Cell Cycle. 2019;18:773-783 pubmed publisher |
| Doğan S, Cerutti R, Benincá C, Brea Calvo G, Jacobs H, Zeviani M, et al. Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy. Cell Metab. 2018;28:764-775.e5 pubmed publisher |
| McGann J, Mandel G. Neuronal activity induces glutathione metabolism gene expression in astrocytes. Glia. 2018;66:2024-2039 pubmed publisher |
| Pennington S, Klutho P, Xie L, Broadhurst K, Koval O, McCormick M, et al. Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription. Redox Biol. 2018;16:401-413 pubmed publisher |
| Muralimanoharan S, Kwak Y, Mendelson C. Redox-Sensitive Transcription Factor NRF2 Enhances Trophoblast Differentiation via Induction of miR-1246 and Aromatase. Endocrinology. 2018;159:2022-2033 pubmed publisher |
| Wang A, Wangensteen K, WANG Y, Zahm A, Moss N, Erez N, et al. TRAP-seq identifies cystine/glutamate antiporter as a driver of recovery from liver injury. J Clin Invest. 2018;128:2297-2309 pubmed publisher |
| Sabouny R, Fraunberger E, Geoffrion M, Ng A, Baird S, Screaton R, et al. The Keap1-Nrf2 Stress Response Pathway Promotes Mitochondrial Hyperfusion Through Degradation of the Mitochondrial Fission Protein Drp1. Antioxid Redox Signal. 2017;27:1447-1459 pubmed publisher |
| Alam M, Okazaki K, Nguyen L, Ota N, Kitamura H, Murakami S, et al. Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2. J Biol Chem. 2017;292:7519-7530 pubmed publisher |
| Liu M, Hu C, Xu Q, Chen L, Ma K, Xu N, et al. Methylseleninic acid activates Keap1/Nrf2 pathway via up-regulating miR-200a in human oesophageal squamous cell carcinoma cells. Biosci Rep. 2015;35: pubmed publisher |
