product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
xCT/SLC7A11 (D2M7A) Rabbit mAb
catalog :
12691
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D2M7A
reactivity :
human, mouse
application :
western blot, western blot knockout validation
citations: 20
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; 1:4000; loading ...; fig 1f
Zhang Y, Swanda R, Nie L, Liu X, Wang C, Lee H, et al. mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation. Nat Commun. 2021;12:1589 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5b
Stancic A, Velickovic K, Markelic M, Grigorov I, Saksida T, Savić N, et al. Involvement of Ferroptosis in Diabetes-Induced Liver Pathology. Int J Mol Sci. 2022;23: pubmed publisher
  • western blot; human; loading ...; fig 3a
von M xe4 ssenhausen A, Zamora Gonzalez N, Maremonti F, Belavgeni A, Tonnus W, Meyer C, et al. Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion. Sci Adv. 2022;8:eabl8920 pubmed publisher
  • western blot; human; loading ...; fig 1a
Koppula P, Olszewski K, Zhang Y, Kondiparthi L, Liu X, Lei G, et al. KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition. iScience. 2021;24:102649 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5g
Zeitler L, Fiore A, Meyer C, Russier M, Zanella G, Suppmann S, et al. Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism. elife. 2021;10: pubmed publisher
  • western blot; human; loading ...; fig s3a
Cao J, Chen X, Jiang L, Lu B, Yuan M, Zhu D, et al. DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase. Nat Commun. 2020;11:1251 pubmed publisher
  • western blot; human; loading ...; fig 3i
Lang X, Green M, Wang W, Yu J, Choi J, Jiang L, et al. Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11. Cancer Discov. 2019;9:1673-1685 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 4a
Bi J, Yang S, Li L, Dai Q, Borcherding N, Wagner B, et al. Metadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death Dis. 2019;10:682 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2g
Wang W, Green M, Choi J, Gijon M, Kennedy P, Johnson J, et al. CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019;569:270-274 pubmed publisher
  • western blot; human; 1:5000; loading ...; fig 2a
Shin C, Mishra P, Watrous J, Carelli V, D Aurelio M, Jain M, et al. The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility. Nat Commun. 2017;8:15074 pubmed publisher
  • western blot; human; fig 6a
Ma S, Henson E, Chen Y, Gibson S. Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells. Cell Death Dis. 2016;7:e2307 pubmed publisher
Gopal P, Yard B, Petty A, Lal J, Bera T, Hoang T, et al. The Mutational Landscape of Cancer's Vulnerability to Ionizing Radiation. Clin Cancer Res. 2022;28:5343-5358 pubmed publisher
Mej xed a Hern xe1 ndez J, Raghu D, Caramia F, Clemons N, Fujihara K, Riseborough T, et al. Targeting MDM4 as a Novel Therapeutic Approach in Prostate Cancer Independent of p53 Status. Cancers (Basel). 2022;14: pubmed publisher
Li Z, Ferguson L, Deol K, Roberts M, Magtanong L, Hendricks J, et al. Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability. Nat Chem Biol. 2022;18:751-761 pubmed publisher
Koch K, Hartmann R, Suwala A, Rios D, Kamp M, Sabel M, et al. Overexpression of Cystine/Glutamate Antiporter xCT Correlates with Nutrient Flexibility and ZEB1 Expression in Highly Clonogenic Glioblastoma Stem-like Cells (GSCs). Cancers (Basel). 2021;13: pubmed publisher
Hong T, Lei G, Chen X, Li H, Zhang X, Wu N, et al. PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer. Redox Biol. 2021;42:101928 pubmed publisher
Lei G, Zhang Y, Koppula P, Liu X, Zhang J, Lin S, et al. The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression. Cell Res. 2020;30:146-162 pubmed publisher
Zhu J, Berisa M, Schwörer S, Qin W, Cross J, Thompson C. Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation. Cell Metab. 2019;30:865-876.e5 pubmed publisher
Kim J, Kim H, Jung J, Song D, Park D, Lee H, et al. TM4SF5-mediated CD44v8-10 splicing variant promotes survival of type II alveolar epithelial cells during idiopathic pulmonary fibrosis. Cell Death Dis. 2019;10:645 pubmed publisher
Goji T, Takahara K, Negishi M, Katoh H. Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation. J Biol Chem. 2017;292:19721-19732 pubmed publisher
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.