SirT6 (D8D12) Rabbit mAb | Cell Signaling Technology 12486 product information

product summary

company name :

Cell Signaling Technology

product type :

antibody

product name :

SirT6 (D8D12) Rabbit mAb

catalog :

12486

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

D8D12

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation, western blot knockout validation, immunocytochemistry knockout validation

more info or order :

Cell Signaling Technology product webpage

citations: 17

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry knockout validation; human; 1:100; fig 1 western blot knockout validation; human; 1:1000; fig 1 immunoprecipitation; human; 1:1000; fig s5	Pan H, Guan D, Liu X, Li J, Wang L, Wu J, et al. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Res. 2016;26:190-205 pubmed publisher
western blot knockout validation; mouse; loading ...; fig 4a western blot; human; loading ...; fig 2c	Zhang X, Spiegelman N, Nelson O, Jing H, Lin H. SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation. elife. 2017;6: pubmed publisher
western blot; mouse; 1:1000; loading ...; fig s10	Chen X, Zhi X, Wang J, Su J. RANKL signaling in bone marrow mesenchymal stem cells negatively regulates osteoblastic bone formation. Bone Res. 2018;6:34 pubmed publisher
western blot; mouse; 1:500; loading ...; fig s3s5	Sarikhani M, Mishra S, Maity S, Kotyada C, Wolfgeher D, Gupta M, et al. SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation. elife. 2018;7: pubmed publisher
western blot; human; loading ...; fig 8b	Jiang H, Zhang X, Lin H. Lysine fatty acylation promotes lysosomal targeting of TNF-?. Sci Rep. 2016;6:24371 pubmed publisher
western blot; human	Wang Y, Kuramitsu Y, Tokuda K, Baron B, Kitagawa T, Akada J, et al. Gemcitabine induces poly (ADP-ribose) polymerase-1 (PARP-1) degradation through autophagy in pancreatic cancer. PLoS ONE. 2014;9:e109076 pubmed publisher
	Naiman S, Huynh F, Gil R, Glick Y, Shahar Y, Touitou N, et al. SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα. Cell Rep. 2019;29:4127-4143.e8 pubmed publisher
	Zhou B, Qi F, Wu F, Nie H, Song Y, Shao L, et al. Endogenous Retrovirus-Derived Long Noncoding RNA Enhances Innate Immune Responses via Derepressing RELA Expression. MBio. 2019;10: pubmed publisher
	Zhao J, Wozniak A, Adams A, Cox J, Vittal A, Voss J, et al. SIRT7 regulates hepatocellular carcinoma response to therapy by altering the p53-dependent cell death pathway. J Exp Clin Cancer Res. 2019;38:252 pubmed publisher
	Hu J, Deng F, Hu X, Zhang W, Zeng X, Tian X. Histone deacetylase SIRT6 regulates chemosensitivity in liver cancer cells via modulation of FOXO3 activity. Oncol Rep. 2018;40:3635-3644 pubmed publisher
	Nicholatos J, Francisco A, Bender C, Yeh T, Lugay F, Salazar J, et al. Nicotine promotes neuron survival and partially protects from Parkinson's disease by suppressing SIRT6. Acta Neuropathol Commun. 2018;6:120 pubmed publisher
	Huang Z, Zhao J, Deng W, Chen Y, Shang J, Song K, et al. Identification of a cellularly active SIRT6 allosteric activator. Nat Chem Biol. 2018;14:1118-1126 pubmed publisher
	Strub T, Ghiraldini F, Carcamo S, Li M, Wroblewska A, Singh R, et al. SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling. Nat Commun. 2018;9:3440 pubmed publisher
	Zhang W, Wan H, Feng G, Qu J, Wang J, Jing Y, et al. SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature. 2018;560:661-665 pubmed publisher
	Ferrer C, Alders M, Postma A, Park S, Klein M, Cetinbaş M, et al. An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality. Genes Dev. 2018;32:373-388 pubmed publisher
	Jeng M, Hull P, Fei M, Kwon H, Tsou C, Kasler H, et al. Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1. J Exp Med. 2018;215:51-62 pubmed publisher
	Chen G, Zhang B, Xu H, Sun Y, Shi Y, Luo Y, et al. Suppression of Sirt1 sensitizes lung cancer cells to WEE1 inhibitor MK-1775-induced DNA damage and apoptosis. Oncogene. 2017;36:6863-6872 pubmed publisher

product information

SKU :

12486S

Product-Name :

SirT6 (D8D12) Rabbit mAb

Size :

100 ul

Price-(USD) :

235 USD

Species-x-Reactivity :

H, M, R, Mk

Applications :

Immunofluorescence (Immunocytochemistry)

Product-Category :

Chromatin Regulation / Nuclear Function

Shipping-Temp :

AMBIENT

Storage-Temp :

-20°C

Product-Type :

Monoclonal Antibody

MW :

42, 36

Host :

Rabbit

Target :

SirT6

Primary-Protein :

SIRT6

Alt-Names :

NAD-dependent deacetylase sirtuin-6,SIR2-like protein 6,SIR2L6,SIRT6,sir2-related protein type 6,sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae),sirtuin type 6

more info or order :

Cell Signaling Technology product webpage