| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; mouse; loading ...; fig 4e
| Rock S, Jiang K, Wu Y, Liu Y, Li J, Weiss H, et al. Neurotensin Regulates Proliferation and Stem Cell Function in the Small Intestine in a Nutrient-Dependent Manner. Cell Mol Gastroenterol Hepatol. 2022;13:501-516 pubmed publisher |
- western blot; human; 1:1000; fig 3a
| Tang X, Li G, Shi L, Su F, Qian M, Liu Z, et al. Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis. Nat Commun. 2021;12:5058 pubmed publisher |
- western blot; mouse; loading ...; fig 5c
| Jiang L, Yang Q, Gao J, Yang J, He J, Xin H, et al. BK Channel Deficiency in Osteoblasts Reduces Bone Formation via the Wnt/β-Catenin Pathway. Mol Cells. 2021;44:557-568 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 6d
| Xu X, Lei Y, Chen L, Zhou H, Liu H, Jiang J, et al. Phosphorylation of NF-κBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target. J Exp Clin Cancer Res. 2021;40:253 pubmed publisher |
- western blot; human; loading ...; fig s4a
| Mygland L, Brinch S, Strand M, Olsen P, Aizenshtadt A, Lund K, et al. Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines. iScience. 2021;24:102807 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4a
| Guo J, Cheng J, Zheng N, Zhang X, Dai X, Zhang L, et al. Copper Promotes Tumorigenesis by Activating the PDK1-AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner. Adv Sci (Weinh). 2021;8:e2004303 pubmed publisher |
- western blot; human; 1:5000; loading ...; fig 1a
| Yin S, Liu L, Brobbey C, PALANISAMY V, Ball L, Olsen S, et al. PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis. Nat Commun. 2021;12:3444 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s4c
| López Gambero A, Rosell Valle C, Medina Vera D, Navarro J, Vargas A, Rivera P, et al. A Negative Energy Balance Is Associated with Metabolic Dysfunctions in the Hypothalamus of a Humanized Preclinical Model of Alzheimer's Disease, the 5XFAD Mouse. Int J Mol Sci. 2021;22: pubmed publisher |
- immunohistochemistry; mouse; 1:100; loading ...; fig 1
| Landin Malt A, Clancy S, Hwang D, Liu A, Smith C, Smith M, et al. Non-Canonical Wnt Signaling Regulates Cochlear Outgrowth and Planar Cell Polarity via Gsk3β Inhibition. Front Cell Dev Biol. 2021;9:649830 pubmed publisher |
- immunohistochemistry; human; loading ...; fig 1b
| Chen B, Wang P, Liang X, Jiang C, Ge Y, Dworkin L, et al. Permissive effect of GSK3β on profibrogenic plasticity of renal tubular cells in progressive chronic kidney disease. Cell Death Dis. 2021;12:432 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 6b
| Gao S, Gao L, Wang S, Shi X, Yue C, Wei S, et al. ATF3 Suppresses Growth and Metastasis of Clear Cell Renal Cell Carcinoma by Deactivating EGFR/AKT/GSK3β/β-Catenin Signaling Pathway. Front Cell Dev Biol. 2021;9:618987 pubmed publisher |
- western blot; human; 1:2000; loading ...; fig 5a
| Chang N, Yeh C, Lin Y, Kuo K, Fong I, Kounis N, et al. Garcinol Attenuates Lipoprotein(a)-Induced Oxidative Stress and Inflammatory Cytokine Production in Ventricular Cardiomyocyte through α7-Nicotinic Acetylcholine Receptor-Mediated Inhibition of the p38 MAPK and NF-κB Signaling Pathways. Antioxidants (Basel). 2021;10: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 6a, 6c
| Zhang L, Li M, Tian C, Wang T, Mi S. CCAAT enhancer binding protein α suppresses proliferation, metastasis, and epithelial-mesenchymal transition of ovarian cancer cells via suppressing the Wnt/β-catenin signaling. Neoplasma. 2021;68:602-612 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 5a
| Lu M, Qin X, Zhou Y, Li G, Liu Z, Geng X, et al. Long non-coding RNA LINC00665 promotes gemcitabine resistance of Cholangiocarcinoma cells via regulating EMT and stemness properties through miR-424-5p/BCL9L axis. Cell Death Dis. 2021;12:72 pubmed publisher |
- western blot; mouse; 1:500; loading ...; fig s2b
| Waaler J, Mygland L, Tveita A, Strand M, Solberg N, Olsen P, et al. Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models. Commun Biol. 2020;3:196 pubmed publisher |
- western blot; mouse; loading ...; fig s4a
| Li X, Wu Y, Zhao J, Wang H, Tan J, Yang M, et al. Distinct cardiac energy metabolism and oxidative stress adaptations between obese and non-obese type 2 diabetes mellitus. Theranostics. 2020;10:2675-2695 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2e
| Xu M, Ge C, Qin Y, Lou D, Li Q, Feng J, et al. Functional loss of inactive rhomboid-like protein 2 mitigates obesity by suppressing pro-inflammatory macrophage activation-triggered adipose inflammation. Mol Metab. 2020;34:112-123 pubmed publisher |
- western blot; mouse; loading ...; fig 5d
| Shi H, Wang Q, Zheng M, Hao S, Lum J, Chen X, et al. Supplement of microbiota-accessible carbohydrates prevents neuroinflammation and cognitive decline by improving the gut microbiota-brain axis in diet-induced obese mice. J Neuroinflammation. 2020;17:77 pubmed publisher |
- western blot; human; loading ...; fig 8b
| Tian S, Peng P, Li J, Deng H, Zhan N, Zeng Z, et al. SERPINH1 regulates EMT and gastric cancer metastasis via the Wnt/β-catenin signaling pathway. Aging (Albany NY). 2020;12:3574-3593 pubmed publisher |
- western blot; human; loading ...; fig 5e
| Aldonza M, Ku J, Hong J, Kim D, Yu S, Lee M, et al. Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms. Sci Adv. 2020;6:eaav7416 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4c
| Yan D, Wang J, Sun H, Zamani A, Zhang H, Chen W, et al. TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis. J Exp Med. 2020;217: pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s7d
| Quach C, Song Y, Guo H, Li S, Maazi H, Fung M, et al. A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. Nat Commun. 2019;10:5681 pubmed publisher |
- western blot; human; loading ...; fig 5a
- western blot; rat; loading ...; fig 5f
| Tian S, Jia W, Lu M, Zhao J, Sun X. Dual-specificity tyrosine phosphorylation-regulated kinase 1A ameliorates insulin resistance in neurons by up-regulating IRS-1 expression. J Biol Chem. 2019;: pubmed publisher |
- western blot; rat; 1:50; loading ...; fig 4g
| Presby D, Checkley L, Jackman M, Higgins J, Jones K, Giles E, et al. Regular exercise potentiates energetically expensive hepatic de novo lipogenesis during early weight regain. Am J Physiol Regul Integr Comp Physiol. 2019;317:R684-R695 pubmed publisher |
- western blot; human; loading ...; fig 4a
| Zhang H, Wang J, Wang Y, Gao C, Gu Y, Huang J, et al. Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats. Oxid Med Cell Longev. 2019;2019:2853534 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 3c
| Peng J, Liang S, Li L. sFRP1 exerts effects on gastric cancer cells through GSK3β/Rac1‑mediated restraint of TGFβ/Smad3 signaling. Oncol Rep. 2019;41:224-234 pubmed publisher |
- western blot; human; loading ...; fig 7e
| Lionnard L, Duc P, Brennan M, Kueh A, Pal M, Guardia F, et al. TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1. Cell Death Differ. 2019;26:902-917 pubmed publisher |
- western blot; mouse; loading ...; fig 4b
| Du X, de Almeida P, Manieri N, de Almeida Nagata D, Wu T, Harden Bowles K, et al. CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1. Proc Natl Acad Sci U S A. 2018;115:E11731-E11740 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; fig 4d
- western blot; human; loading ...; fig 1d
| Zheng C, Wang J, Lin M, Zhang P, Liu L, Lin J, et al. CDK5RAP3 suppresses Wnt/β-catenin signaling by inhibiting AKT phosphorylation in gastric cancer. J Exp Clin Cancer Res. 2018;37:59 pubmed publisher |
- western blot; mouse; loading ...; fig s3f
| Zhao Y, Wu X, Li X, Jiang L, Gui X, Liu Y, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 2018;97:1023-1031.e7 pubmed publisher |
- western blot; mouse; loading ...; fig 3d
| Markussen L, Winther S, Wicksteed B, Hansen J. GSK3 is a negative regulator of the thermogenic program in brown adipocytes. Sci Rep. 2018;8:3469 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 1c
| Xue C, Hong L, Lin J, Yao X, Wu D, Lin X, et al. β-Elemene inhibits the proliferation of primary human airway granulation fibroblasts by down-regulating canonical Wnt/β-catenin pathway. Biosci Rep. 2018;38: pubmed publisher |
- western blot; human; loading ...; fig s2
| Shuang W, Hou L, Zhu Y, Li Q, Hu W. Mcl-1 stabilization confers resistance to taxol in human gastric cancer. Oncotarget. 2017;8:82981-82990 pubmed publisher |
- western blot; mouse; loading ...; fig 2h
| Akiel M, Guo C, Li X, Rajasekaran D, Mendoza R, Robertson C, et al. IGFBP7 Deletion Promotes Hepatocellular Carcinoma. Cancer Res. 2017;77:4014-4025 pubmed publisher |
- western blot; mouse; loading ...; fig 7a
| Dong Q, Li J, Wu Q, Zhao N, Qian C, Ding D, et al. Blockage of transient receptor potential vanilloid 4 alleviates myocardial ischemia/reperfusion injury in mice. Sci Rep. 2017;7:42678 pubmed publisher |
- western blot; human; loading ...; fig s4j
| Zhao D, Lu X, Wang G, Lan Z, Liao W, Li J, et al. Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer. Nature. 2017;542:484-488 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 6a
| Li W, Liu M, Deng S, Liu Y, Shang L, Ding J, et al. ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion. Nat Commun. 2016;7:13770 pubmed publisher |
- western blot; human; loading ...; fig 4
| Song H, Li L, Zhong L, Yang R, Jiang K, Yang X, et al. NLS?RAR? modulates acute promyelocytic leukemia NB4 cell proliferation and differentiation via the PI3K/AKT pathway. Mol Med Rep. 2016;14:5495-5500 pubmed publisher |
- western blot; human; loading ...; fig 5a
| Nonomiya Y, Noguchi K, Tanaka N, Kasagaki T, Katayama K, Sugimoto Y. Effect of AKT3 expression on MYC- and caspase-8-dependent apoptosis caused by polo-like kinase inhibitors in HCT 116 cells. Cancer Sci. 2016;107:1877-1887 pubmed publisher |
- western blot; human; loading ...; fig 5a
| Lu W, Shi J, Zhang J, Lv Z, Guo F, Huang H, et al. CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model. Int J Mol Sci. 2016;17: pubmed |
- western blot; human; fig 5
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- western blot; human; loading ...; fig 1a
| Shriver M, Marimuthu S, Paul C, Geist J, Seale T, Konstantopoulos K, et al. Giant obscurins regulate the PI3K cascade in breast epithelial cells via direct binding to the PI3K/p85 regulatory subunit. Oncotarget. 2016;7:45414-45428 pubmed publisher |
- western blot; human; loading ...; fig 1c
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- western blot; rat; loading ...; fig 1a
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- western blot; human; 1:1000; fig 2
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- western blot; mouse; fig 3f
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- western blot; mouse; fig 1c
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- western blot; mouse; 1:1000; fig s9
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- western blot; human; fig 2
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| Moser B, Hochreiter B, Basílio J, Gleitsmann V, Panhuber A, Pardo Garcia A, et al. The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity. Mol Cancer. 2021;20:16 pubmed publisher |
| Ping M. Hyperin Controls the Development and Therapy of Gastric Cancer via Regulating Wnt/β-Catenin Signaling. Cancer Manag Res. 2020;12:11773-11782 pubmed publisher |
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