product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
ARID1A/BAF250A (D2A8U) Rabbit mAb
catalog :
12354
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D2A8U
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunoprecipitation, chromatin immunoprecipitation, western blot knockout validation
citations: 18
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; 1:1000; loading ...; fig 1c, e1b, e2h
  • immunohistochemistry; human; 1:1000; fig 5f
Wu S, Fukumoto T, Lin J, Nacarelli T, Wang Y, Ong D, et al. Targeting glutamine dependence through GLS1 inhibition suppresses ARID1A-inactivated clear cell ovarian carcinoma. Nat Cancer. 2021;2:189-200 pubmed publisher
  • western blot knockout validation; human; 1:1000; loading ...; fig 1b
Wu S, Fatkhutdinov N, Rosin L, Luppino J, Iwasaki O, Tanizawa H, et al. ARID1A spatially partitions interphase chromosomes. Sci Adv. 2019;5:eaaw5294 pubmed publisher
  • western blot knockout validation; human; 1:1000; loading ...; fig s1
Goldman A, Bitler B, Schug Z, Conejo Garcia J, Zhang R, Speicher D. The Primary Effect on the Proteome of ARID1A-mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-transcriptional Level. Mol Cell Proteomics. 2016;15:3348-3360 pubmed
  • western blot; human; loading ...; fig 4a
  • immunohistochemistry; mouse; loading ...; fig 4d
Wilson M, Reske J, Holladay J, Neupane S, Ngo J, Cuthrell N, et al. ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation. Cell Rep. 2020;33:108366 pubmed publisher
  • western blot; human; 1:1000; loading ...
Asha K, Balfe N, Sharma Walia N. Concurrent Control of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle through Chromatin Modulation and Host Hedgehog Signaling: a New Prospect for the Therapeutic Potential of Lipoxin A4. J Virol. 2020;94: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s4r
Ballabio C, Anderle M, Gianesello M, Lago C, Miele E, Cardano M, et al. Modeling medulloblastoma in vivo and with human cerebellar organoids. Nat Commun. 2020;11:583 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4a,4b
Nastase A, Teo J, Heng H, Ng C, Myint S, Rajasegaran V, et al. Genomic and proteomic characterization of ARID1A chromatin remodeller in ampullary tumors. Am J Cancer Res. 2017;7:484-502 pubmed
  • chromatin immunoprecipitation; human; 1:1000; loading ...; fig s4d
  • immunoprecipitation; human; loading ...; fig 3g
  • western blot; human; 1:1000
Zhu P, Wang Y, Wu J, Huang G, Liu B, Ye B, et al. LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells. Nat Commun. 2016;7:13608 pubmed publisher
  • western blot; human; loading ...; fig 6a
Lund P, Elias J, Davis M. Global Analysis of O-GlcNAc Glycoproteins in Activated Human T Cells. J Immunol. 2016;197:3086-3098 pubmed
  • western blot; human; 1:500; loading ...; fig 5b
Nettersheim D, Jostes S, Fabry M, Honecker F, Schumacher V, Kirfel J, et al. A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment. Oncotarget. 2016;7:74931-74946 pubmed publisher
Zhou Q, Huang J, Zhang C, Zhao F, Kim W, Tu X, et al. The bromodomain containing protein BRD-9 orchestrates RAD51-RAD54 complex formation and regulates homologous recombination-mediated repair. Nat Commun. 2020;11:2639 pubmed publisher
Luo Q, Wu X, Chang W, Zhao P, Nan Y, Zhu X, et al. ARID1A prevents squamous cell carcinoma initiation and chemoresistance by antagonizing pRb/E2F1/c-Myc-mediated cancer stemness. Cell Death Differ. 2019;: pubmed publisher
Wilson M, Reske J, Holladay J, Wilber G, Rhodes M, Koeman J, et al. ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion. Nat Commun. 2019;10:3554 pubmed publisher
Witwicka H, Nogami J, Syed S, Maehara K, Padilla Benavides T, Ohkawa Y, et al. Calcineurin Broadly Regulates the Initiation of Skeletal Muscle-Specific Gene Expression by Binding Target Promoters and Facilitating the Interaction of the SWI/SNF Chromatin Remodeling Enzyme. Mol Cell Biol. 2019;39: pubmed publisher
Qu Y, Deng C, Luo Q, Shang X, Wu J, Shi Y, et al. Arid1a regulates insulin sensitivity and lipid metabolism. EBioMedicine. 2019;42:481-493 pubmed publisher
Ogiwara H, Takahashi K, Sasaki M, Kuroda T, Yoshida H, Watanabe R, et al. Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers. Cancer Cell. 2019;35:177-190.e8 pubmed publisher
Garczyk S, Schneider U, Lurje I, Becker K, Vögeli T, Gaisa N, et al. ARID1A-deficiency in urothelial bladder cancer: No predictive biomarker for EZH2-inhibitor treatment response?. PLoS ONE. 2018;13:e0202965 pubmed publisher
de Castro R, Previato L, Goitea V, Felberg A, Guiraldelli M, Filiberti A, et al. The chromatin-remodeling subunit Baf200 promotes homology-directed DNA repair and regulates distinct chromatin-remodeling complexes. J Biol Chem. 2017;292:8459-8471 pubmed publisher
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.