product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Phospho-Chk1 (Ser345) (133D3) Rabbit mAb (PE Conjugate)
catalog :
12268
clonality :
monoclonal
host :
domestic rabbit
conjugate :
PE
clone name :
133D3
reactivity :
human, mouse, rat
application :
flow cytometry
more info or order :
Cell Signaling Technology product webpage
citations: 9
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 5c
Salomè M, Magee A, Yalla K, Chaudhury S, Sarrou E, Carmody R, et al. A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling. Cell Death Dis. 2018;9:443 pubmed publisher
Leung W, Teater M, Durmaz C, Meydan C, Chivu A, Chadburn A, et al. SETD2 Haploinsufficiency Enhances Germinal Center-Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis. Cancer Discov. 2022;12:1782-1803 pubmed publisher
Oike T, Komachi M, Ogiwara H, Amornwichet N, Saitoh Y, Torikai K, et al. C646, a selective small molecule inhibitor of histone acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic catastrophe. Radiother Oncol. 2014;111:222-7 pubmed publisher
Kubota S, Fukumoto Y, Ishibashi K, Soeda S, Kubota S, Yuki R, et al. Activation of the prereplication complex is blocked by mimosine through reactive oxygen species-activated ataxia telangiectasia mutated (ATM) protein without DNA damage. J Biol Chem. 2014;289:5730-46 pubmed publisher
Neumann J, Boerries M, Kohler R, Giaisi M, Krammer P, Busch H, et al. The natural anticancer compound rocaglamide selectively inhibits the G1-S-phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints. Int J Cancer. 2014;134:1991-2002 pubmed publisher
Cai B, Lyu H, Huang J, Wang S, Lee C, Gao C, et al. Combination of bendamustine and entinostat synergistically inhibits proliferation of multiple myeloma cells via induction of apoptosis and DNA damage response. Cancer Lett. 2013;335:343-50 pubmed publisher
Cai B, Wang S, Huang J, Lee C, Gao C, Liu B. Cladribine and bendamustine exhibit inhibitory activity in dexamethasone-sensitive and -resistant multiple myeloma cells. Am J Transl Res. 2013;5:36-46 pubmed
Okita N, Minato S, Ohmi E, Tanuma S, Higami Y. DNA damage-induced CHK1 autophosphorylation at Ser296 is regulated by an intramolecular mechanism. FEBS Lett. 2012;586:3974-9 pubmed publisher
Oike T, Ogiwara H, Torikai K, Nakano T, Yokota J, Kohno T. Garcinol, a histone acetyltransferase inhibitor, radiosensitizes cancer cells by inhibiting non-homologous end joining. Int J Radiat Oncol Biol Phys. 2012;84:815-21 pubmed publisher
product information
SKU :
12268S
Product-Name :
Phospho-Chk1 (Ser345) (133D3) Rabbit mAb (PE Conjugate)
Size :
100 ul
Price-(USD) :
291 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Flow cytometry
Product-Category :
Cell Cycle / Checkpoint Control
Shipping-Temp :
COLD
Storage-Temp :
4°C
Product-Type :
Monoclonal Antibody
MW :
56
Host :
Rabbit
Target :
Chk1 (Ser345) phosphate
Primary-Protein :
Chk1
Alt-Names :
CHEK1,CHK1,CHK1 checkpoint homolog (S. pombe),Checkpoint, S. pombe, homolog of, 1,Serine/threonine-protein kinase Chk1
more info or order :
Cell Signaling Technology product webpage
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.