product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Ki-67 (D3B5) Rabbit mAb (Mouse Specific; IHC Formulated)
catalog :
12202
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
D3B5
reactivity :
human, mouse
application :
immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
citations: 56
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 2a
Hoste E, Lecomte K, Annusver K, Vandamme N, Roels J, Maschalidi S, et al. OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity. Nat Commun. 2021;12:5913 pubmed publisher
  • immunohistochemistry; mouse; 1:250; fig 5a
Kitakaze K, Oyadomari M, Zhang J, Hamada Y, Takenouchi Y, Tsuboi K, et al. ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model. Mol Metab. 2021;54:101338 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 6b
Tian N, Hu L, Lu Y, Tong L, Feng M, Liu Q, et al. TKT maintains intestinal ATP production and inhibits apoptosis-induced colitis. Cell Death Dis. 2021;12:853 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 3s3
La Rocca G, King B, Shui B, Li X, Zhang M, Akat K, et al. Inducible and reversible inhibition of miRNA-mediated gene repression in vivo. elife. 2021;10: pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 3d
Saha J, Bae J, Wang S, Lu H, Chappell L, Gopal P, et al. Ablating putative Ku70 phosphorylation sites results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma. Nucleic Acids Res. 2021;49:9836-9850 pubmed publisher
  • immunohistochemistry; human; fig 6h
Zhang Y, Ma Y, Wu G, Xie M, Luo C, Huang X, et al. SENP1 promotes MCL pathogenesis through regulating JAK-STAT5 pathway and SOCS2 expression. Cell Death Discov. 2021;7:192 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...
Jiao L, Eickhoff R, Egners A, Jumpertz S, Roth J, Erdem M, et al. Deletion of mTOR in liver epithelial cells enhances hepatic metastasis of colon cancer. J Pathol. 2021;255:270-284 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s3d
Ortega Molina A, Lebrero Fernández C, Sanz A, Deleyto Seldas N, Plata Gómez A, Menéndez C, et al. Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs. Cell Rep. 2021;36:109372 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 2e
  • immunocytochemistry; mouse; 1:200; loading ...; fig 2c
Eyermann C, Li J, Alexandrova E. ΔN63 suppresses the ability of pregnancy-identified mammary epithelial cells (PIMECs) to drive HER2-positive breast cancer. Cell Death Dis. 2021;12:525 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 5a
Wu Y, Liu Y, Hu Y, Wang L, Bai F, Xu C, et al. Control of multiciliogenesis by miR-34/449 in the male reproductive tract through enforcing cell cycle exit. J Cell Sci. 2021;134: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig 5k
Malik N, Yan H, Yang H, Ayaz G, DuBois W, Tseng Y, et al. CBFB cooperates with p53 to maintain TAp73 expression and suppress breast cancer. PLoS Genet. 2021;17:e1009553 pubmed publisher
  • immunohistochemistry; mouse; 1:50; loading ...; fig 4a
Piñeiro Hermida S, Martinez P, Blasco M. Short and dysfunctional telomeres protect from allergen-induced airway inflammation. Aging Cell. 2021;20:e13352 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig s5a
Ni N, Fang X, Li Q. Functional similarity between TGF-beta type 2 and type 1 receptors in the female reproductive tract. Sci Rep. 2021;11:9294 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 2g
Yuan B, Yang J, Dubeau L, Hu Y, Li R. A Phosphotyrosine Switch in Estrogen Receptor β Is Required for Mouse Ovarian Function. Front Cell Dev Biol. 2021;9:649087 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 6i
Break T, Oikonomou V, Dutzan N, Desai J, Swidergall M, Freiwald T, et al. Aberrant type 1 immunity drives susceptibility to mucosal fungal infections. Science. 2021;371: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4g, s5b
Li X, Zhang M, Huang X, Liang W, Li G, Lu X, et al. Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners. Nat Commun. 2020;11:6364 pubmed publisher
  • immunohistochemistry; mouse; loading ...
Guo H, Chou W, Lai Y, Liang K, Tam J, Brickey W, et al. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science. 2020;370: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 1e
Peng Z, Aggarwal R, Zeng N, He L, Stiles E, Debebe A, et al. AKT1 Regulates Endoplasmic Reticulum Stress and Mediates the Adaptive Response of Pancreatic β Cells. Mol Cell Biol. 2020;40: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 5h, 2h
Liao Y, Zhao J, Bulek K, Tang F, Chen X, Cai G, et al. Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis. Nat Commun. 2020;11:900 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 6d
Sozen B, Cox A, De Jonghe J, Bao M, Hollfelder F, Glover D, et al. Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid. Dev Cell. 2019;51:698-712.e8 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 3a
Duhachek Muggy S, Bhat K, Medina P, Cheng F, He L, Alli C, et al. Radiation Mitigation of the Intestinal Acute Radiation Injury in Mice by 1-[(4-Nitrophenyl)Sulfonyl]-4-Phenylpiperazine. Stem Cells Transl Med. 2019;: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 1j
Merve A, Zhang X, Pomella N, Acquati S, Hoeck J, Dumas A, et al. c-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism. Acta Neuropathol Commun. 2019;7:2 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig s2k
Lee J, Stone M, Porrett P, Thomas S, Komar C, Li J, et al. Hepatocytes direct the formation of a pro-metastatic niche in the liver. Nature. 2019;567:249-252 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 1a
Jin C, Lagoudas G, Zhao C, Bullman S, Bhutkar A, Hu B, et al. Commensal Microbiota Promote Lung Cancer Development via γδ T Cells. Cell. 2019;176:998-1013.e16 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 6g
Mahmoud M, Evans I, Mehta V, Pellet Many C, Paliashvili K, Zachary I. Smooth muscle cell-specific knockout of neuropilin-1 impairs postnatal lung development and pathological vascular smooth muscle cell accumulation. Am J Physiol Cell Physiol. 2019;316:C424-C433 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 3f
Grohmann M, Wiede F, Dodd G, Gurzov E, Ooi G, Butt T, et al. Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC. Cell. 2018;175:1289-1306.e20 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 4a
Pinzon Guzman C, Meyer A, Wise R, Choi E, Muthupalani S, Wang T, et al. Evaluation of Lineage Changes in the Gastric Mucosa Following Infection With Helicobacter pylori and Specified Intestinal Flora in INS-GAS Mice. J Histochem Cytochem. 2018;:22155418785621 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 1a
Lyons J, Ghazi P, Starchenko A, Tovaglieri A, Baldwin K, Poulin E, et al. The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile. PLoS Biol. 2018;16:e2002417 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 7b
Andricovich J, Perkail S, Kai Y, Casasanta N, Peng W, Tzatsos A. Loss of KDM6A Activates Super-Enhancers to Induce Gender-Specific Squamous-like Pancreatic Cancer and Confers Sensitivity to BET Inhibitors. Cancer Cell. 2018;33:512-526.e8 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 5f
Otto T, Candido S, Pilarz M, Sicinska E, Bronson R, Bowden M, et al. Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Proc Natl Acad Sci U S A. 2017;114:10660-10665 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 3d
Capurro M, Izumikawa T, Suarez P, Shi W, Cydzik M, Kaneiwa T, et al. Glypican-6 promotes the growth of developing long bones by stimulating Hedgehog signaling. J Cell Biol. 2017;216:2911-2926 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 4a
Li N, Xue W, Yuan H, Dong B, Ding Y, Liu Y, et al. AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. J Clin Invest. 2017;127:1284-1302 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 3a
Junge H, Yung A, Goodrich L, Chen Z. Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord. Neural Dev. 2016;11:19 pubmed
  • immunohistochemistry; mouse; fig 3s1
Leggere J, Saito Y, Darnell R, Tessier Lavigne M, Junge H, Chen Z. NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord. elife. 2016;5: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig s2
Ravindran R, Loebbermann J, Nakaya H, Khan N, Ma H, Gama L, et al. The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature. 2016;531:523-527 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 2a
Payne S, Maher M, Tran N, Van De Hey D, Foley T, Yueh A, et al. PIK3CA mutations can initiate pancreatic tumorigenesis and are targetable with PI3K inhibitors. Oncogenesis. 2015;4:e169 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Kitajima S, Kohno S, Kondoh A, Sasaki N, Nishimoto Y, Li F, et al. Undifferentiated State Induced by Rb-p53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts. Stem Cells. 2015;33:1657-69 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig s9
Eikawa S, Nishida M, Mizukami S, Yamazaki C, Nakayama E, Udono H. Immune-mediated antitumor effect by type 2 diabetes drug, metformin. Proc Natl Acad Sci U S A. 2015;112:1809-14 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200
Chibly A, Querin L, Harris Z, Limesand K. Label-retaining cells in the adult murine salivary glands possess characteristics of adult progenitor cells. PLoS ONE. 2014;9:e107893 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400
Soares F, Tattoli I, Rahman M, Robertson S, Belcheva A, Liu D, et al. The mitochondrial protein NLRX1 controls the balance between extrinsic and intrinsic apoptosis. J Biol Chem. 2014;289:19317-30 pubmed publisher
Kubo C, Ogawa M, Uehara N, Katakura Y. Fisetin Promotes Hair Growth by Augmenting TERT Expression. Front Cell Dev Biol. 2020;8:566617 pubmed publisher
Kanayama M, Nakao K, Horie S, Aiba A. Generation of transgenic mouse line with prostate-specific expression of codon-improved Cre recombinase. Prostate Int. 2018;6:99-103 pubmed publisher
Best S, Harapas C, Kersbergen A, Rathi V, Asselin Labat M, Sutherland K. FGFR3-TACC3 is an oncogenic fusion protein in respiratory epithelium. Oncogene. 2018;37:6096-6104 pubmed publisher
Park S, Cui J, Yu W, Wu L, Carmon K, Liu Q. Differential activities and mechanisms of the four R-spondins in potentiating Wnt/β-catenin signaling. J Biol Chem. 2018;293:9759-9769 pubmed publisher
Pan P, Oshima K, Huang Y, Agle K, Drobyski W, Chen X, et al. Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors. Int J Cancer. 2018;143:886-896 pubmed publisher
Schmidt S, Schumacher N, Schwarz J, Tangermann S, Kenner L, Schlederer M, et al. ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling. J Exp Med. 2018;215:1205-1225 pubmed publisher
Pleiner T, Bates M, Gorlich D. A toolbox of anti-mouse and anti-rabbit IgG secondary nanobodies. J Cell Biol. 2018;217:1143-1154 pubmed publisher
Beirowski B, Wong K, Babetto E, Milbrandt J. mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells. Proc Natl Acad Sci U S A. 2017;114:E4261-E4270 pubmed publisher
Feng T, Dzieran J, Yuan X, Dropmann A, Maass T, Teufel A, et al. Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice. Oncogenesis. 2017;6:e294 pubmed publisher
Welker A, Jaros B, Puduvalli V, Imitola J, Kaur B, Beattie C. Standardized orthotopic xenografts in zebrafish reveal glioma cell-line-specific characteristics and tumor cell heterogeneity. Dis Model Mech. 2016;9:199-210 pubmed publisher
Howley B, Hussey G, Link L, Howe P. Translational regulation of inhibin βA by TGFβ via the RNA-binding protein hnRNP E1 enhances the invasiveness of epithelial-to-mesenchymal transitioned cells. Oncogene. 2016;35:1725-35 pubmed publisher
Holik A, Filby C, Pasquet J, Viitaniemi K, Ciciulla J, Sutherland K, et al. The LIM-domain only protein 4 contributes to lung epithelial cell proliferation but is not essential for tumor progression. Respir Res. 2015;16:67 pubmed publisher
Salvucci O, Ohnuki H, Maric D, Hou X, Li X, Yoon S, et al. EphrinB2 controls vessel pruning through STAT1-JNK3 signalling. Nat Commun. 2015;6:6576 pubmed publisher
Venkatraman G, Benesch M, Tang X, Dewald J, McMullen T, Brindley D. Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: implications for cancer treatment. FASEB J. 2015;29:772-85 pubmed publisher
Andl T, Le Bras G, Richards N, Allison G, Loomans H, Washington M, et al. Concerted loss of TGFβ-mediated proliferation control and E-cadherin disrupts epithelial homeostasis and causes oral squamous cell carcinoma. Carcinogenesis. 2014;35:2602-10 pubmed publisher
Engels M, Rajarajan K, Feistritzer R, Sharma A, Nielsen U, Schalij M, et al. Insulin-like growth factor promotes cardiac lineage induction in vitro by selective expansion of early mesoderm. Stem Cells. 2014;32:1493-502 pubmed publisher
product information
SKU :
12202S
Product-Name :
Ki-67 (D3B5) Rabbit mAb (Mouse Specific; IHC Formulated)
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
M
Applications :
Immunohistochemistry (Paraffin)
Product-Category :
Cell Cycle / Checkpoint Control
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
Host :
Mouse
Target :
KI-67
Primary-Protein :
KI-67
Alt-Names :
Antigen KI-67,KI67,KIA,MKI67,antigen identified by monoclonal antibody Ki-67,proliferation-related Ki-67 antigen
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.