product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Bak (D4E4) Rabbit mAb
catalog :
12105
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D4E4
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, western blot knockout validation
citations: 20
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:1000; fig s1i
Giampazolias E, Zunino B, Dhayade S, Bock F, Cloix C, Cao K, et al. Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nat Cell Biol. 2017;19:1116-1129 pubmed publisher
  • western blot knockout validation; human; fig 4
Lopez J, Bessou M, Riley J, Giampazolias E, Todt F, Rochegüe T, et al. Mito-priming as a method to engineer Bcl-2 addiction. Nat Commun. 2016;7:10538 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3g
Kim J, Gupta R, Blanco L, Yang S, Shteinfer Kuzmine A, Wang K, et al. VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease. Science. 2019;366:1531-1536 pubmed publisher
  • western blot; human; loading ...; fig 4f
Pan C, Jin L, Wang X, Li Y, Chun J, Boese A, et al. Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance. J Clin Invest. 2019;129:2431-2445 pubmed publisher
  • western blot; mouse; loading ...; fig s3i
He M, Chaurushiya M, Webster J, Kummerfeld S, Reja R, Chaudhuri S, et al. Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1. Science. 2019;364:283-285 pubmed publisher
  • western blot; human; loading ...; fig 4c
Liu Y, Wang X, Deng L, Ping L, Shi Y, Zheng W, et al. ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma. Cancer Cell Int. 2019;19:32 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 8b
Yokoyama T, Kohn E, Brill E, Lee J. Apoptosis is augmented in high-grade serous ovarian cancer by the combined inhibition of Bcl-2/Bcl-xL and PARP. Int J Oncol. 2017;: pubmed publisher
  • western blot; human; loading ...; fig 5d
Klingbeil O, Lesche R, Gelato K, Haendler B, Lejeune P. Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated NSCLC to pro-apoptotic agents. Cell Death Dis. 2016;7:e2365 pubmed publisher
  • western blot; mouse; fig 2
Barroso González J, Auclair S, Luan S, Thomas L, Atkins K, Aslan J, et al. PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage. Cell Death Differ. 2016;23:1448-57 pubmed publisher
  • western blot; human; 1:1000; fig 1
Yu L, Wu W, Gu C, Zhong D, Zhao X, Kong Y, et al. Obatoclax impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cells. Oncotarget. 2016;7:14693-707 pubmed publisher
  • western blot; human
Sanders Y, Hagood J, Liu H, Zhang W, Ambalavanan N, Thannickal V. Histone deacetylase inhibition promotes fibroblast apoptosis and ameliorates pulmonary fibrosis in mice. Eur Respir J. 2014;43:1448-58 pubmed publisher
Zierhut C, Yamaguchi N, Paredes M, Luo J, Carroll T, Funabiki H. The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death. Cell. 2019;178:302-315.e23 pubmed publisher
Saunders I, Mir H, Kapur N, Singh S. Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways. Cancer Cell Int. 2019;19:98 pubmed publisher
Lin K, Xie A, Rutter J, Ahn Y, Lloyd Cowden J, Nichols A, et al. Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity. Cell Metab. 2019;29:1217-1231.e7 pubmed publisher
Moghadam A, da Silva Rosa S, Samiei E, Alizadeh J, Field J, Kawalec P, et al. Autophagy modulates temozolomide-induced cell death in alveolar Rhabdomyosarcoma cells. Cell Death Discov. 2018;4:52 pubmed publisher
Sirtl S, Knoll G, Trinh D, Lang I, Siegmund D, Gross S, et al. Hypertonicity-enforced BCL-2 addiction unleashes the cytotoxic potential of death receptors. Oncogene. 2018;37:4122-4136 pubmed publisher
Kong X, Xu P, Cai W, Wang H, Li B, Huang G, et al. ZBP-89 and Sp1 contribute to Bak expression in hepatocellular carcinoma cells. BMC Cancer. 2018;18:419 pubmed publisher
Kang T, Kim H, Lee B, Shin T, Choi S, Kim Y, et al. Mica Nanoparticle, STB-HO Eliminates the Human Breast Carcinoma Cells by Regulating the Interaction of Tumor with its Immune Microenvironment. Sci Rep. 2015;5:17515 pubmed publisher
Guo H, Cui H, Peng X, Fang J, Zuo Z, Deng J, et al. Modulation of the PI3K/Akt Pathway and Bcl-2 Family Proteins Involved in Chicken's Tubular Apoptosis Induced by Nickel Chloride (NiCl₂). Int J Mol Sci. 2015;16:22989-3011 pubmed publisher
Devereaux K, Dall Armi C, Alcazar Roman A, Ogasawara Y, Zhou X, Wang F, et al. Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis. PLoS ONE. 2013;8:e76405 pubmed publisher
product information
SKU :
12105S
Product-Name :
Bak (D4E4) Rabbit mAb
Size :
100 ul
Price-(USD) :
235 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Immunofluorescence (Immunocytochemistry)
Product-Category :
Apoptosis
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
25
Host :
Rabbit
Target :
Bak1
Primary-Protein :
Bak1
Alt-Names :
Apoptosis regulator BAK,BAK,BAK-LIKE,BAK1,BCL2-antagonist/killer 1,BCL2-like 7 protein,BCL2L7,Bcl-2 homologous antagonist/killer,Bcl-2-like protein 7,Bcl2-L-7,CDN1,MGC117255,MGC3887,pro-apoptotic protein BAK
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.