product summary
company name :
Cell Signaling Technology
product type :
antibody
product name :
Glucocorticoid Receptor (D6H2L) XP® Rabbit mAb
catalog :
12041
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
D6H2L
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, western blot knockout validation, immunocytochemistry knockout validation
citations: 17
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; loading ...; fig 2c
von M xe4 ssenhausen A, Zamora Gonzalez N, Maremonti F, Belavgeni A, Tonnus W, Meyer C, et al. Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion. Sci Adv. 2022;8:eabl8920 pubmed publisher
  • immunocytochemistry knockout validation; human; 1:50; loading ...; fig s6a
  • chromatin immunoprecipitation; human; loading ...; fig 5b
  • western blot; human; 1:1000; loading ...; fig 1a, s2e
Prekovic S, Schuurman K, Mayayo Peralta I, Manjón A, Buijs M, Yavuz S, et al. Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer. Nat Commun. 2021;12:4360 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:400; loading ...; fig 1b
Ueki S, Fujishima F, Kumagai T, Ishida H, Okamoto H, Takaya K, et al. GR, Sgk1, and NDRG1 in esophageal squamous cell carcinoma: their correlation with therapeutic outcome of neoadjuvant chemotherapy. BMC Cancer. 2020;20:161 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:600; loading ...; fig 5d
  • chromatin immunoprecipitation; human; loading ...; fig 4g
Palit S, Vis D, Stelloo S, Lieftink C, Prekovic S, Bekers E, et al. TLE3 loss confers AR inhibitor resistance by facilitating GR-mediated human prostate cancer cell growth. elife. 2019;8: pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 4d
Lee B, Stallcup M. Glucocorticoid receptor binding to chromatin is selectively controlled by the coregulator Hic-5 and chromatin remodeling enzymes. J Biol Chem. 2017;292:9320-9334 pubmed publisher
  • immunoprecipitation; mouse
  • immunocytochemistry; mouse; 1:200; loading ...; fig 5b
  • western blot; mouse; loading ...; fig 3a
  • western blot; human; loading ...; fig 3a
Rimando M, Wu H, Liu Y, Lee C, Kuo S, Lo Y, et al. Glucocorticoid receptor and Histone deacetylase 6 mediate the differential effect of dexamethasone during osteogenesis of mesenchymal stromal cells (MSCs). Sci Rep. 2016;6:37371 pubmed publisher
  • western blot; human; 1:2000; fig 5
Lin S, Kao C, Lee H, Creighton C, Ittmann M, Tsai S, et al. Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer. Nat Commun. 2016;7:11418 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 1
Baker G, Murphy T, Block T, Nguyen D, Lynch F. Development and validation of an immunohistochemistry assay to assess glucocorticoid receptor expression for clinical trials of mifepristone in breast cancer. Cancer Manag Res. 2015;7:361-8 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig 1
Kroon J, Puhr M, Buijs J, van der Horst G, Hemmer D, Marijt K, et al. Glucocorticoid receptor antagonism reverts docetaxel resistance in human prostate cancer. Endocr Relat Cancer. 2016;23:35-45 pubmed publisher
  • chromatin immunoprecipitation; mouse
Gao L, Rabbitt E, Condon J, Renthal N, Johnston J, Mitsche M, et al. Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. J Clin Invest. 2015;125:2808-24 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Najm F, Madhavan M, Zaremba A, Shick E, Karl R, Factor D, et al. Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo. Nature. 2015;522:216-20 pubmed publisher
Lu H, Lei X, Winkler R, John S, Kumar D, Li W, et al. Crosstalk of hepatocyte nuclear factor 4a and glucocorticoid receptor in the regulation of lipid metabolism in mice fed a high-fat-high-sugar diet. Lipids Health Dis. 2022;21:46 pubmed publisher
Sager R, Woodford M, Backe S, Makedon A, Baker Williams A, DiGregorio B, et al. Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90. Cell Rep. 2019;26:1344-1356.e5 pubmed publisher
McNamara K, Guestini F, Sauer T, Touma J, Bukholm I, Lindstrøm J, et al. In breast cancer subtypes steroid sulfatase (STS) is associated with less aggressive tumour characteristics. Br J Cancer. 2018;118:1208-1216 pubmed publisher
Shah N, Wang P, Wongvipat J, Karthaus W, Abida W, Armenia J, et al. Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer. elife. 2017;6: pubmed publisher
Navarro A, Mandyam C. Protracted abstinence from chronic ethanol exposure alters the structure of neurons and expression of oligodendrocytes and myelin in the medial prefrontal cortex. Neuroscience. 2015;293:35-44 pubmed publisher
Ott M, Litzenburger U, Rauschenbach K, Bunse L, Ochs K, Sahm F, et al. Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway. Glia. 2015;63:78-90 pubmed publisher
product information
SKU :
12041P
Product-Name :
Glucocorticoid Receptor (D6H2L) XP® Rabbit mAb
Size :
40 ul
Price-(USD) :
135 USD
Species-x-Reactivity :
H, M, R, Mk
Applications :
Chromatin Immunoprecipitation
Product-Category :
Nuclear Receptor Signaling
Shipping-Temp :
AMBIENT
Storage-Temp :
-20°C
Product-Type :
Monoclonal Antibody
MW :
94, 91
Host :
Rabbit
Target :
Glucocorticoid Receptor
Primary-Protein :
GR
Alt-Names :
GCCR,GCR,GR,GRL,Glucocorticoid receptor,NR3C1,Nuclear receptor subfamily 3 group C member 1,nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
company information
Cell Signaling Technology
3 Trask Lane
Danvers, MA 01923
info@cellsignal.com
https://www.cellsignal.com
8776162355
headquarters: USA
Established in Beverly, MA in 1999, Cell Signaling Technology (CST) is a privately-owned company with over 400 employees worldwide. We are dedicated to providing innovative research tools that are used to help define mechanisms underlying cell function and disease. Since its inception, CST has become the world leader in the production of the highest quality activation-state and total protein antibodies utilized to expand knowledge of cell signaling pathways. Our mission is to deliver the world's highest quality research tools that accelerate progress in biological research and personalized medicine.