| Published Application/Species/Dilution | Reference |
|---|
- western blot (knockdown validation); human; fig 3
| Kline C, van den Heuvel A, Allen J, Prabhu V, Dicker D, El-Deiry W. ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases. Sci Signal. 2016;9:ra18 pubmed publisher |
- western blot (knockdown validation); human; fig s5c
- western blot (knockdown validation); mouse; fig s5b
| Ben-Sahra I, Hoxhaj G, Ricoult S, Asara J, Manning B. mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. Science. 2016;351:728-33 pubmed publisher |
- western blot (knockdown validation); human; 1:1000; fig 4
- western blot (knockdown validation); mouse; 1:1000; fig 4
| Cohen D, Won K, Nguyen N, Lazar M, Chen C, Steger D. ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis. elife. 2015;4:e06821 pubmed publisher |
- western blot; mouse; 1:1000; fig 2d
| Xu Z, Bu Y, Chitnis N, Koumenis C, Fuchs S, Diehl J. miR-216b regulation of c-Jun mediates GADD153/CHOP-dependent apoptosis. Nat Commun. 2016;7:11422 pubmed publisher |
- immunocytochemistry; human; 1:400; fig 8E
- western blot; human; 1:1000; fig 7A
| Zhou X, Wei Y, Qiu S, Xu Y, Zhang T, Zhang S. Propofol Decreases Endoplasmic Reticulum Stress-Mediated Apoptosis in Retinal Pigment Epithelial Cells. PLoS ONE. 2016;11:e0157590 pubmed publisher |
- chromatin immunoprecipitation; human; fig 6
| Mistry R, Murray T, Prysyazhna O, Martin D, Burgoyne J, Santos C, et al. Transcriptional Regulation of Cystathionine-γ-Lyase in Endothelial Cells by NADPH Oxidase 4-Dependent Signaling. J Biol Chem. 2016;291:1774-88 pubmed publisher |
- western blot; mouse; fig s2
| Krawczyk K, Ekman M, Rippe C, Grossi M, Nilsson B, Albinsson S, et al. Assessing the contribution of thrombospondin-4 induction and ATF6α activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction. Sci Rep. 2016;6:32449 pubmed publisher |
- western blot; human; 1:1000; fig 2
| Cormerais Y, Giuliano S, Lefloch R, Front B, Durivault J, Tambutte E, et al. Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth. Cancer Res. 2016;76:4481-92 pubmed publisher |
- immunohistochemistry; mouse; fig 3b
| Norlin S, Parekh V, Naredi P, Edlund H. Asna1/TRC40 Controls β-Cell Function and Endoplasmic Reticulum Homeostasis by Ensuring Retrograde Transport. Diabetes. 2016;65:110-9 pubmed publisher |
- western blot; human; fig 4
- western blot; mouse; fig 4
| Yuen K, Xu B, Krantz I, Gerton J. NIPBL Controls RNA Biogenesis to Prevent Activation of the Stress Kinase PKR. Cell Rep. 2016;14:93-102 pubmed publisher |
- immunohistochemistry; mouse; 1:100
| Ma Q, Ying M, Sui X, Zhang H, Huang H, Yang L, et al. Chronic copper exposure causes spatial memory impairment, selective loss of hippocampal synaptic proteins, and activation of PKR/eIF2α pathway in mice. J Alzheimers Dis. 2015;43:1413-27 pubmed publisher |
- western blot; human; 1:1000
| Ehnert S, Freude T, Ihle C, Mayer L, Braun B, Graeser J, et al. Factors circulating in the blood of type 2 diabetes mellitus patients affect osteoblast maturation - description of a novel in vitro model. Exp Cell Res. 2015;332:247-58 pubmed publisher |
- western blot; human; fig 5
| Sakabe I, Hu R, Jin L, Clarke R, Kasid U. TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling. Breast Cancer Res Treat. 2015;153:285-97 pubmed publisher |
- western blot; human; fig 2
| Sheng X, Arnoldussen Y, Storm M, Tesikova M, Nenseth H, Zhao S, et al. Divergent androgen regulation of unfolded protein response pathways drives prostate cancer. EMBO Mol Med. 2015;7:788-801 pubmed publisher |
| Willy J, Young S, Stevens J, Masuoka H, Wek R. CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis. Mol Biol Cell. 2015;26:2190-204 pubmed publisher |
- western blot; human; fig 3
| DeNicola G, Chen P, Mullarky E, Sudderth J, Hu Z, Wu D, et al. NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nat Genet. 2015;47:1475-81 pubmed publisher |
- western blot; human; 1:1000
| Nagelkerke A, Sweep F, Stegeman H, Grenman R, Kaanders J, Bussink J, et al. Hypoxic regulation of the PERK/ATF4/LAMP3-arm of the unfolded protein response in head and neck squamous cell carcinoma. Head Neck. 2015;37:896-905 pubmed publisher |
| Ost M, Werner F, Dokas J, Klaus S, Voigt A. Activation of AMPKα2 is not crucial for mitochondrial uncoupling-induced metabolic effects but required to maintain skeletal muscle integrity. PLoS ONE. 2014;9:e94689 pubmed publisher |
| Zhuo X, Wu Y, Ni Y, Liu J, Gong M, Wang X, et al. Isoproterenol instigates cardiomyocyte apoptosis and heart failure via AMPK inactivation-mediated endoplasmic reticulum stress. Apoptosis. 2013;18:800-10 pubmed publisher |
| Zhang X, Chen M, Zou P, Kanchana K, Weng Q, Chen W, et al. Curcumin analog WZ35 induced cell death via ROS-dependent ER stress and G2/M cell cycle arrest in human prostate cancer cells. BMC Cancer. 2015;15:866 pubmed publisher |
| Bagheri-Yarmand R, Sinha K, Gururaj A, Ahmed Z, Rizvi Y, Huang S, et al. A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis. J Biol Chem. 2015;290:11749-61 pubmed publisher |
| Herrmann U, Sonati T, Falsig J, Reimann R, Dametto P, O'Connor T, et al. Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways. PLoS Pathog. 2015;11:e1004662 pubmed publisher |
