Cell Guidance Systems

protein

PODS™ Human BMP-4

PPH56-50

50 million

145 USD

PPH56-50

PODS™ Human BMP-4

growth Factors

50 million

145 USD

Bone MorphoGenic Protein 4 (BMP-4) is a member of the Bone MorphoGenetic Protein (BMP) family. These proteins are synthesized as larGe precursor molecules which are cleaved by proteolytic enzymes. BMP proteinsstimulate the production of bone matrix proteins and osteoclasts proliferation, and can be found on tissues related with bone or cartilaGe Growth.

Human

PODS™ crystals provide a depot of proteins which are steadily secreted. It has been estimated that the biolo gical activity of 50 million PODS™ crystals generates the same peak dose as 3.3 μ g of standard recombinant protein. However, at 5 days followin g the start of seedin g the PODS™ crystals, there are more than 50% of these peak levels still present in the culture system. Ultimately, the amount of PODS™ crystals that is optimal for a particular experiment should be determined empirically. Based on previous data, we su g gest usin g 50 million PODS™ crystals in place of 3.3 μ g of standard growth factor as a startin g point." To control for cross-reactivity with cells or as a ne gative control, we recommend usin g PODS™ growth factors alon gside PODS™ Empty crystals, as the latter do not contain or release car go protein.

Upon receipt, store at 4°C. PODS™ protein crystals are stable for at least 1 year when dry and 6 months when resuspended.