protein

Recombinant Human PDGF-AA, 2 μg

GFH16-2

Recombinant Human PDGF-AA, 2 μg

Growth Factors

Platelet-DerivedGrowth Factor (PDGF) is an important regulator of cellGrowth, proliferation, and angiogenesis. PDGF synthesis is induced by IL-1, IL-6, TNF-α, TGF-β and EGF signaling. PDGF functions as a mitogenicGrowth hormone on cells of mesenchymal lineage, such as smooth muscle andGlial cells. PDGF is also stored in the α-granules of platelets and is released upon adherence to traumatized tissues. PDGF is a dimericGlycoprotein formed by two A chains (AA), two B chains (BB), or as a heterodimer with an A and a B chain (AB). The PDGF dimer binds the cell surface receptor tyrosine kinases PDGFR-a and PDGFR-b.

Platelet-Derived Growth Factor, GDGF, ODGF, PDGF AA

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.