Anti-p53 Purified (PAb-1620) | Caprico Biotechnologies 102201 product information

product summary

company name :

Caprico Biotechnologies

product type :

antibody

product name :

Anti-p53 Purified (PAb-1620)

catalog :

102201

quantity :

100µg

price :

195.00 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PAb-1620

reactivity :

human

application :

flow cytometry

more info or order :

Caprico Biotechnologies product webpage

product information

Catalog Number :

102201

Product Name :

Anti-p53 Purified (PAb-1620)

Product Type :

Flow cytometry primary antibody

Host Species :

Mouse

Clonality :

monoclonal

Clone Name :

PAb-1620

Isotype :

IgG2a,k

Size :

100µg

List Price :

195.00 USD

Product Description :

p53 acts as a tumor suppressor in many tumor types; it induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator, p53 acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis

Immunogen :

Mouse VLM tumor cells

Buffer :

PBS pH 7.2, 0.09% sodium azide

Concentration :

0.5mg/mL

Uses :

Western Blot

Application Summary :

flow

Storage :

4°C

more info or order :

Caprico Biotechnologies product webpage