Bovine IGF-1 Recombinant Protein | Boster R00148 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

protein

product name :

Bovine IGF-1 Recombinant Protein

catalog :

R00148

quantity :

5 ug/vial

product information

sku :

R00148

status :

Enabled

name :

Bovine IGF-1 Recombinant Protein

category name :

Recombinant Proteins

gene name :

IGF1

conjugate :

contents :

Lyophilized without carrier protein.

description :

Insulin-like growth factor 1 (IGF-1) is a primary mediator of the effects of growth hormone (GH) and has growth-promoting effects on almost every cell in the body. IGF-1 can also regulate cell growth and development, especially in nerve cells, as well as cellular DNA synthesis. Bovine IGF-1 Recombinant Protein is purified insulin-like growth factor 1 (IGF-1) produced in yeast.

short description :

description2 :

Biological Activity . In testing. Amino Acid Sequence . GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA (70)

size :

5 ug/vial

uniprot id :

P07455

host :

form :

Lyophilized

purification :

Ion-exchange chromatography.

storage :

Stable for up to twelve months from date of receipt at -20 C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20 C. Avoid repeated freeze/thaw cycles.

applications :

Cell Culture

image labels :

Boster Kit Box

research category :

Cancer, Developmental Biology, Growth Factors, Growth Factors/Hormones, Signal Transduction

synonyms :

Insulin-like growth factor I; IGF-I; Somatomedin; IGF1

protein function :

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down- stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).

subcellular localization :

Secreted.

source :

Yeast

last modified :

2/11/19 19:30