LGMN Legumain Human Recombinant Protein | Boster PROTQ99538 product information

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product summary

company name :

Boster

product type :

protein

product name :

LGMN Legumain Human Recombinant Protein

catalog :

PROTQ99538

quantity :

2 ug, 10 ug, 1 mg

product information

sku :

PROTQ99538

status :

Enabled

name :

LGMN Legumain Human Recombinant Protein

gene name :

LGMN

price various sizes :

Sample: 2ug / $153 Regular: 10ug / $230 Bulk: 1mg / $4663

conjugate :

contents :

LGMN protein solution (1mg/ml) contains Phosphate buffered saline (pH7.4) and 10% glycerol.

description :

LGMN produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (18-433 a.a.) and fused to a 6 aa His Tag at C-terminus containing a total of 422 amino acids and having a molecular mass of 48.4kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa). LGMN is purified by proprietary chromatographic techniques.

short description :

description1 :

Introduction . Legumain, also known as LGMN, is a cysteine endopeptidase which demonstrates strict specificity for hydrolysis of asparaginyl bonds. Furthermore, LGMN can also cleave aspartyl bonds slowly, in particular under acidic conditions. LGMN plays an essential role in the endosomal/lysosomal degradation system as the Legumain deficiency causes the accumulation of pro cathepsins B, H L, another group of lysosomal cysteine proteases. Furthermore, over expression of LGMN in tumors is important for invasion/metastasis.

description2 :

Amino Acid Sequence VPIDDPEDGG KHWVVIVAGS NGWYNYRHQA DACHAYQIIH RNGIPDEQIV VMMYDDIAYS EDNPTPGIVI NRPNGTDVYQ GVPKDYTGED VTPQNFLAVL RGDAEAVKGI GSGKVLKSGP QDHVFIYFTD HGSTGILVFP NEDLHVKDLN ETIHYMYKHK MYRKMVFYIE ACESGSMMNH LPDNINVYAT TAANPRESSY ACYYDEKRST YLGDWYSVNW MEDSDVEDLT KETLHKQYHL VKSHTNTSHV MQYGNKTIST MKVMQFQGMK RKASSPVPLP PVTHLDLTPS PDVPLTIMKR KLMNTNDLEE SRQLTEEIQR HLDARHLIEK SVRKIVSLLA ASEAEVEQLL SERAPLTGHS CYPEALLHFR THCFNWHSPT YEYALRHLYV LVNLCEKPYP LHRIKLSMDH VCLGHYHHHH HH.

size :

2 ug, 10 ug, 1 mg

uniprot id :

Q99538

host :

form :

Sterile filtered colorless solution.

purification :

Greater than 95.0% as determined by SDS-PAGE.

storage :

Store in -20 C for long term storage. After reconstitution, store in 4 C for short term usage within a few days. Avoid freeze-thaw cycles.

applications :

Cell Culture

image labels :

Recombinant protein fun image

synonyms :

Legumain;3.4.22.34;Asparaginyl endopeptidase;Protease, cysteine 1;LGMN;PRSC1;

gene full name :

Legumain

protein function :

Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.

subcellular localization :

Lysosome

tissue specificity :

Ubiquitous. Particularly abundant in kidney, heart and placenta.

source :

Sf9, Baculovirus cells.

last modified :

4/18/19 6:56