MCP-2 Monocyte Chemotactic Protein-2 Canine Recombinant Protein (CCL8)

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product summary

company name :

Boster

product type :

protein

product name :

MCP-2 Monocyte Chemotactic Protein-2 Canine Recombinant Protein (CCL8)

catalog :

PROTQ68AY9

quantity :

2 ug, 10 ug, 1 mg

product information

SKU :

PROTQ68AY9

Product Name :

MCP-2 Monocyte Chemotactic Protein-2 Canine Recombinant Protein (CCL8)

Product Page URL :

https://www.bosterbio.commcp-2-monocyte-chemotactic-protein-2-canine-recombinant-protein-ccl8-protq68ay9-boster.html

Gene Name :

CCL8

Size :

2 ug, 10 ug, 1 mg

Reactivity :

Mouse

Applications :

Cell Culture

Introduction :

Introduction: Chemokine (C-C motif) ligand 8 (CCL8) is a small cytokine belonging to the CC chemokine family that was once called monocyte chemotactic protein-2 (MCP-2). The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans. MCP-2 is chemotactic for and activates a many different immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors. These receptors include CCR1, CCR2B and CCR5.

Description :

MCP2 Canine Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 76 amino acids and having a molecular mass of 8.8kDa. The CCL8 is purified by proprietary chromatographic techniques.

Source :

E. Coli

Form :

Sterile Filtered White lyophilized (freeze-dried) powder.

AA Sequence and/or Biological Activity :

Amino Acid Sequence:QPDSVSIPIT CCFSMVKRKI PMQKLESYMR ITNSQCPQEA VIFKTKASRE ICADPKQKWV QDYMNHLDQK SQAQKP. Biological Activity: The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 10-100 ng/ml.

Purification :

Greater than 98.0% as determined by:. (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Storage :

Lyophilized MCP-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL8 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Uniprot ID :

Q68AY9

Gene Full Name :

C-C motif chemokine 8

Synonyms :

C-C motif chemokine 8;Monocyte chemoattractant protein 2;Monocyte chemotactic protein 2;MCP-2;Small-inducible cytokine A8;CCL8;MCP2;

Protein Function :

Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity).

Subcellular Localization :

Secreted