GHBP Growth Hormone Binding Protein Ovine Recombinant Protein

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product summary

company name :

Boster

product type :

protein

product name :

GHBP Growth Hormone Binding Protein Ovine Recombinant Protein

catalog :

PROTQ28575

quantity :

5 ug, 20 ug, 1 mg

product information

SKU :

PROTQ28575

Product Name :

GHBP Growth Hormone Binding Protein Ovine Recombinant Protein

Product Page URL :

https://www.bosterbio.comghbp-growth-hormone-binding-protein-ovine-recombinant-protein-protq28575-boster.html

Gene Name :

GHR

Size :

5 ug, 20 ug, 1 mg

Reactivity :

Mouse

Applications :

Cell Culture

Introduction :

Introduction: GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized.

Description :

Growth Hormone Binding Protein Ovine Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28 kDa. GHBP is purified by proprietary chromatographic techniques.

Source :

E. Coli

Form :

Sterile Filtered White lyophilized (freeze-dried) powder.

Contents :

GHBP was lyophilized from a concentrated (1mg/ml) solution with 0.0045mM NaHCO3.

AA Sequence and/or Biological Activity :

Amino Acid Sequence:The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Phe-Ser-Gly-Ser.

Purification :

Greater than 95.0% as determined by:. (a) Analysis by SEC-HPLC. (b) Analysis by SDS-PAGE.

Storage :

Lyophilized Growth Hormone Binding Protein although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GHBP should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Uniprot ID :

Q28575

Gene Full Name :

Growth hormone receptor

Synonyms :

Growth hormone receptor;GH receptor;Somatotropin receptor;Growth hormone-binding protein;GH-binding protein;GHBP;Serum-binding protein;GHR;

Protein Function :

Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).

Subcellular Localization :

Cell membrane