B2M Beta-2 Microglobulin Human protein | Boster PROTP61769-1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

protein

product name :

B2M Beta-2 Microglobulin Human protein

catalog :

PROTP61769-1

quantity :

200 ug, 1 mg, 10 mg

product information

sku :

PROTP61769-1

status :

Enabled

name :

B2M Beta-2 Microglobulin Human protein

gene name :

B2M

price various sizes :

Sample: 200ug / $133.5 Regular: 1mg / $230 Bulk: 10mg / $1273.5

conjugate :

contents :

Lyophilized from 0.02M NH4HCO3.

description :

Human Beta-2 Microglobulin produced in Human urine from patients with tubular proteinuria having a molecular mass of 12KDa and pI of 5.6.

short description :

Human Beta-2 Microglobulin produced in Human urine from patients with tubular proteinuria having a molecular mass of 12KDa and pI of 5.6.

description1 :

Introduction . Beta 2 microglobulin is an 11 kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2 microglobulin associates with class I-like molecules such as CD1 and Qa as well as with the alpha chain of MHC class I molecules. Very limited amounts of MHC class I molecules can be found on the surface in the absence of Beta 2 microglobulin. CD8 T cells cannot develop in the absence of MHC class I. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinaemia, renal failure, or kidney transplants. Human Beta 2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumors and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy). Beta-2 microglobulin levels might also be elevated in multiple myeloma and lymphoma cases. Dialysis-related amyloidosis develops after a long-term hemodialysis, it can aggregate into amyloid fibers that deposit in joint spaces.

size :

200 ug, 1 mg, 10 mg

uniprot id :

P61769

host :

form :

Sterile Filtered White lyophilized (freeze-dried) powder.

purification :

Greater than 98.0%.

storage :

Store in -20 C for long term storage. After reconstitution, store in 4 C for short term usage within a few days. Avoid freeze-thaw cycles.

applications :

Cell Culture

image labels :

Recombinant protein fun image

synonyms :

Beta-2-microglobulin;Beta-2-microglobulin form pI 5.3;B2M;CDABP0092, HDCMA22P;

gene full name :

Beta-2-microglobulin

protein function :

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

subcellular localization :

Secreted

source :

Human urine from patients with tubular proteinuria.

last modified :

2/18/19 20:29