EG-VEGF Endocrine Gland Vascular Endothelial Growth Factor Human Recombinant Protein

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product summary

company name :

Boster

product type :

protein

product name :

EG-VEGF Endocrine Gland Vascular Endothelial Growth Factor Human Recombinant Protein

catalog :

PROTP58294

quantity :

5 ug, 20 ug, 1 mg

product information

SKU :

PROTP58294

Product Name :

EG-VEGF Endocrine Gland Vascular Endothelial Growth Factor Human Recombinant Protein

Product Page URL :

https://www.bosterbio.comeg-vegf-endocrine-gland-vascular-endothelial-growth-factor-human-recombinant-protein-protp58294-boster.html

Gene Name :

PROK1

Size :

5 ug, 20 ug, 1 mg

Reactivity :

Mouse

Applications :

Cell Culture

Introduction :

Introduction: Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) induces proliferation, migration, and fenestration in capillary endothelial cells derived from endocrine glands. Its expression is induced by hypoxia and is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta). Its expression is often complementary to the expression of VEGF (MIM 192240), suggesting that these molecules function in a coordinated manner. EG-VEGF potently contracts gastrointestinal (gi) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types.

Description :

EG-VEGF Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 86 amino acids and having a molecular mass of 9.6kDa. The EG-VEGF is purified by proprietary chromatographic techniques.

Source :

E. Coli

Form :

Sterile Filtered White lyophilized (freeze-dried) powder.

Contents :

The protein was lyophilized from a concentrated (1mg/ml) solution with no additives.

AA Sequence and/or Biological Activity :

Amino Acid Sequence:AVITGACERD VQCGAGTCCA ISLWLRGLRM CTPLGREGEE CHPGSHKVPF FRKRKHHTCP CLPNLLCSRF PDGRYRCSMD LKNINF.

Purification :

Greater than 97.0% as determined by:. (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Storage :

Lyophilized EG-VEGF Human Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution EG-VEGF should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.

Uniprot ID :

P58294

Gene Full Name :

Prokineticin-1

Synonyms :

Prokineticin-1;Endocrine-gland-derived vascular endothelial growth factor;EG-VEGF;Mambakine;PROK1;UNQ600/PRO1186;

Protein Function :

Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.

Subcellular Localization :

Secreted.

Tissue Specificity :

Localizes to glandular epithelium, stroma and vascular epithelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands, ovary, testis, adrenal and placenta.