FGF-8 Fibroblast Growth Factor-8 Human Recombinant Protein | Boster PROTP55075 product information

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product summary

company name :

Boster

product type :

protein

product name :

FGF-8 Fibroblast Growth Factor-8 Human Recombinant Protein

catalog :

PROTP55075

quantity :

2 ug, 10 ug, 1 mg

product information

SKU :

PROTP55075

Product Name :

FGF-8 Fibroblast Growth Factor-8 Human Recombinant Protein

Product Page URL :

https://www.bosterbio.comfgf-8-fibroblast-growth-factor-8-human-recombinant-protein-protp55075-boster.html

Gene Name :

FGF8

Size :

2 ug, 10 ug, 1 mg

Reactivity :

Mouse

Applications :

Cell Culture

Introduction :

Introduction: FGF8 is part of the fibroblast growth factor family. FGF family members have wide mitogenic and cell survival activities, and participate in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF8 supports androgen and anchorage independent growth of mammary tumor cells. FGF8 over expression increases tumor growth and angiogensis. The adult expression of FGF-8 gene is restricted to testes and ovaries. FGF8 functions as an embryonic epithelial factor. FGF8 takes part in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination.

Description :

FGF-8 Human Recombinant produced in HEK cells is a glycosylated monomer, having a molecular weight range of 30-45kDa due to glycosylation. The FGF8 is purified by proprietary chromatographic techniques.

Source :

HEK.

Form :

Sterile Filtered White lyophilized (freeze-dried) powder.

Contents :

The FGF-8 was lyophilized in 10mM Tris-HCl pH 7.4 and 800mM NaCl.

AA Sequence and/or Biological Activity :

Biological Activity: The specific activity was determined by the dose-dependent stimulation of the proliferation of the Balb/3T3 cell line.

Purification :

Greater than 95% as obsereved by SDS-PAGE.

Storage :

Lyophilized FGF-8 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FGF8 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Uniprot ID :

P55075

Gene Full Name :

Fibroblast growth factor 8

Synonyms :

Fibroblast growth factor 8;FGF-8;Androgen-induced growth factor;AIGF;Heparin-binding growth factor 8;HBGF-8;FGF8;AIGF;

Protein Function :

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (PubMed:16384934, PubMed:16597617, PubMed:8663044). Plays a role in neurite outgrowth in hippocampal cells (PubMed:21576111).

Subcellular Localization :

Secreted.