Recombinant Human SDF-1 Alpha (CXCL12) Protein | Boster PROTP48061-5 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

protein

product name :

Recombinant Human SDF-1 Alpha (CXCL12) Protein

catalog :

PROTP48061-5

quantity :

Various Sizes

product information

sku :

PROTP48061-5

status :

Enabled

name :

Recombinant Human SDF-1 Alpha (CXCL12) Protein

category name :

Proteins, Recombinant Proteins

gene name :

CXCL12

price various sizes :

2ug / $125 10ug / $230 50ug / $374 100ug / $590 250ug / $995 500ug / $1670 1mg / $2750

conjugate :

contents :

Protein concentration verified by UV Spectroscopy and/or SDS-PAGE gel.

description :

SDF-1 and are stromal derived CXC chemokines, and signal through the CXCR4 receptor. SDF-1 and chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV suppressive activity in cells expressing the CXCR4 receptor. Recombinant human SDF-1 is an 8.0 kDa protein containing 68 amino acid residues.

short description :

description2 :

Biological Activity And Protein Authenticity . Determined by its ability to chemoattract human peripheral T cells activated with PHA and IL-2 using a concentation of 20-80 ng/ml.

size :

Various Sizes

uniprot id :

P48061

host :

form :

Solid; white powder or thin/invisible film

storage :

Store in -20 C for long term storage. After reconstitution, store in 4 C for short term usage within a few days. Avoid freeze-thaw cycles.

applications :

Cell Culture

image labels :

Recombinant protein fun image

research category :

Chemokines, Host Virus Interaction, Immunology, Innate Immunity, Interspecies Interaction, Microbiology

synonyms :

Stromal cell-derived factor 1;SDF-1;hSDF-1;C-X-C motif chemokine 12;Intercrine reduced in hepatomas;IRH;hIRH;Pre-B cell growth-stimulating factor;PBSF;SDF-1-beta(3-72);SDF-1-alpha(3-67);CXCL12;SDF1, SDF1A, SDF1B; Stromal-Cell Derived Factor-1, CXCL12, PBSF

gene full name :

Stromal cell-derived factor 1

protein function :

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1- alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3- 67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T- cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

subcellular localization :

Secreted.

tissue specificity :

Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen.

source :

E. Coli

last modified :

2/15/19 23:59