FASLG Human, FAS Ligand Human Recombinant Protein, HEK | Boster PROTP48023 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

protein

product name :

FASLG Human, FAS Ligand Human Recombinant Protein, HEK

catalog :

PROTP48023

quantity :

2 ug, 10 ug, 1 mg

product information

SKU :

PROTP48023

Product Name :

FASLG Human, FAS Ligand Human Recombinant Protein, HEK

Product Page URL :

https://www.bosterbio.comfaslg-human-fas-ligand-human-recombinant-protein-hek-protp48023-boster.html

Gene Name :

FASLG

Size :

2 ug, 10 ug, 1 mg

Introduction :

Introduction: The type II transmembrane protein FASLG is a member of the tumor necrosis factor (TNF) superfamily. A fas ligand/receptor interaction has a significant part in the regulation of the immune system and the advancement of cancer. FASLG is expressed on the activated T cell surface as a nondisulfidelinked homotrimer. FASLG binding to Fas/CD95/TNFRSF6 on a nearby cell prompts apoptosis in the Fas expressing cell. FASLG is released from the cell surface by metalloproteinases as a soluble molecule that stays trimeric and is able to bind with Fas, but its capability to activate apoptosis is radically reduced. In addition, FASLG binds to DcR3 - a soluble trap receptor with no signal transduction capabilities. Flawed Fas-mediated apoptosis causes oncogenesis in addition to drug resistance in existing tumors. Constitutive expression of FASLG in a variety of tumors enables their immune evasion. Both mouse and human FASLG are active on mouse and human cells.

Description :

Recombinant Human FAS Ligand produced in HEK293 cells is a polypeptide chain containing 147 amino acids (134-281a.a). FASLG is fused to a 6 amino acid His-tag at N-terminus and purified by proprietary chromatographic techniques. Interleukin-119.1kDa. The Mouse IL-11 is purified by proprietary chromatographic techniques.

Source :

HEK293 cells.

Form :

Sterile Filtered colorless solution.

Contents :

The FASLG solution (0.6mg/ml) contains 1xPBS.

AA Sequence and/or Biological Activity :

Biological Activity: Fas ligand is biologically active as determined by its ability to induce cytotoxicity in Jurkat cells in the absence of any cross-linking.

Purification :

Greater than 95.0% as determined by: (a) Analysis by SEC-HPLC. (b) Analysis by SDS-PAGE.

Storage :

FASLG Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.

Uniprot ID :

P48023

Synonyms :

Tumor necrosis factor ligand superfamily member 6;Apoptosis antigen ligand;APTL;CD95 ligand;CD95-L;Fas antigen ligand;Fas ligand;FasL;CD178;Tumor necrosis factor ligand superfamily member 6, membrane form;Tumor necrosis factor ligand superfamily member 6, soluble form;Receptor-binding FasL ectodomain;Soluble Fas ligand;sFasL;ADAM10-processed FasL form;APL;FasL intracellular domain;FasL ICD;SPPL2A-processed FasL form;SPA;FASLG;APT1LG1, CD95L, FASL, TNFSF6;