MMP-9 Matrix Metalloproteinase-9 Rabbit Recombinant Protein | Boster PROTP41246 product information

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product summary

company name :

Boster

product type :

protein

product name :

MMP-9 Matrix Metalloproteinase-9 Rabbit Recombinant Protein

catalog :

PROTP41246

quantity :

2 ug, 10 ug, 100 ug

product information

SKU :

PROTP41246

Product Name :

MMP-9 Matrix Metalloproteinase-9 Rabbit Recombinant Protein

Product Page URL :

https://www.bosterbio.commmp-9-matrix-metalloproteinase-9-rabbit-recombinant-protein-protp41246-boster.html

Gene Name :

MMP9

Size :

2 ug, 10 ug, 100 ug

Reactivity :

Mouse

Applications :

Cell Culture

Introduction :

Introduction: Matrix metalloproteinases are a family of zinc and calcium-dependent endopeptidases that break down extracellular matrix proteins. The MMP9 is secreted as a 92kDa zymogen. Cleavage of ProMMP-9 results in the active enzyme, having a molecular weight of approximately 82kDa. MMP9 is composed of the following domains: a gelatin-binding domain consisting of three fibronectin type II units, a catalytic domain containing the zinc-binding site, a proline-rich type V collagen-homologous domain and a hemopexin-like domain. MMP9 is produced by the several cell types: monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts and endothelial cells. MMP9 is involved in inflammatory responses, tissue remodeling, wound healing, tumor growth and metastasis. MMP9 may also play an important part in local proteolysis of the extracellular matrix and in leukocyte migration, as well as in bone osteoclastic resorption. MMP9 cleaves type IV and type V collagens into large C-terminal three qu

Description :

MMP-9 Rabbit Recombinant is a full length secreted protein (688 amino acids - a.a. 20-707). The MMP-9 is expressed in insect cells and fused to a 30 aa C-terminal Myc-His tag, having a total MW of 79.94kDa. Purified MMP9 protein appears at 95kDa on SDS-PAGE gel due to protein modification.

Source :

Baculovirus system, insect cells.

Form :

Sterile Filtered clear solution.

Contents :

The MMP-9 solution (0.3mg/ml) contains 50mM Tris, 150mM NaCl, 10% Glycerol, pH 7.5.

AA Sequence and/or Biological Activity :

Sequence:APRRRQPTLVVFPGELRTRLTDRQLAEEYL
FRYGYTRVASMHGDSQSLRLPLLLLQKHLSLPETGELDN
ATLEAMRAPRCGVPDVGKFQTFEGDLKWHHHNITYWIQN
YSEDLPRDVIDDAFARAFALWSAVTPLTFTRVYSRDADI
VIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFD
DEELWSLGKGVVVPTYFGNADGAPCHFPFTFEGRSYTAC
TTDGRSDGMAWCSTTADYDTDRRFGFCPSERLYTQDGNA
DGKPCEFPFIFQGRTYSACTTDGRSDGHRWCATTASYDK
DKLYGFCPTRADSTVVGGNSAGELCVFPFVFLGKEYSSC
TSEGRRDGRLWCATTSNFDSDKKWGFCPDKGYSLFLVAA
HEFGHALGLDHSSVPERLMYPMYRYLEGSPLHEDDVRGI
QHLYGPNPNPQPPATTTPEPQPTAPPTACPTWPATVRPS
EHPTTSPTGAPSAGPTGPPTASPSAAPTASLDPAEDVCN
VNVFDAIAEIGNKLHVFKDGRYWRFSEGSGRRPQGPFLI
ADTWPALPAKLDSAFEEPLTKKLFFFSGRQVWVYTGASV
LGPRRLDKLGLGPEVPHVTGALPRAGGKVLLFGAQRFWR
FDVKTQTVDSRSGAPVDQMFPGVPLNTHDVFQYREKAYF
CQDRFFWRVSTRNEVNLVDQVGYVSFDILHCPEDENLYF
QGLEEQKLISEEDLNSAVDHHHHHH.
Amino Acid

Purification :

Greater than 85.0% as determined by SDS-PAGE.

Storage :

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Uniprot ID :

P41246

Gene Full Name :

Matrix metalloproteinase-9

Synonyms :

Matrix metalloproteinase-9;MMP-9;3.4.24.35;92 kDa gelatinase;92 kDa type IV collagenase;Gelatinase B;GELB;MMP9;

Protein Function :

Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).

Subcellular Localization :

Secreted, extracellular space, extracellular matrix

Tissue Specificity :

Osteoclasts