FGF-8 Fibroblast Growth Factor-8 Mouse Recombinant Protein | Boster PROTP37237 product information

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product summary

company name :

Boster

product type :

protein

product name :

FGF-8 Fibroblast Growth Factor-8 Mouse Recombinant Protein

catalog :

PROTP37237

quantity :

5 ug, 25 ug, 1 mg

product information

SKU :

PROTP37237

Product Name :

FGF-8 Fibroblast Growth Factor-8 Mouse Recombinant Protein

Product Page URL :

https://www.bosterbio.comfgf-8-fibroblast-growth-factor-8-mouse-recombinant-protein-protp37237-boster.html

Gene Name :

Fgf8

Size :

5 ug, 25 ug, 1 mg

Reactivity :

Mouse

Applications :

Cell Culture

Introduction :

Introduction: FGF8 is part of the fibroblast growth factor family. FGF family members have wide mitogenic and cell survival activities, and participate in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF8 supports androgen and anchorage independent growth of mammary tumor cells. FGF8 over expression increases tumor growth and angiogensis. The adult expression of FGF-8 gene is restricted to testes and ovaries. FGF8 functions as an embryonic epithelial factor. FGF8 takes part in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination.

Description :

FGF-8 Mouse Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 246 amino acids and having a molecular mass of 28.1kDa. The FGF-8 is purified by proprietary chromatographic techniques.

Source :

E. Coli

Form :

Sterile Filtered White lyophilized (freeze-dried) powder.

AA Sequence and/or Biological Activity :

Amino Acid Sequence:QVRSAAQKRG PGAGNPADTL GQGHEDRPFG QRSRAGKNFT NPAPNYPEEG SKEQRDSVLP KVTQRHVREQ SLVTDQLSRR LIRTYQLYSR TSGKHVQVLA NKRINAMAED GDPFAKLIVE TDTFGSRVRV RGAETGLYIC MNKKGKLIAK SNGKGKDCVF TEIVLENNYT ALQNAKYEGW YMAFTRKGRP RKGSKTRQHQ REVHFMKRLP RGHHTTEQSL RFEFLNYPPF TRSLRGSQRT WAPEPR.

Purification :

Greater than 95.0% as determined by: . (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Storage :

Lyophilized FGF-8 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FGF-8 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Uniprot ID :

P37237

Gene Full Name :

Fibroblast growth factor 8

Synonyms :

Fibroblast growth factor 8;FGF-8;Androgen-induced growth factor;AIGF;Heparin-binding growth factor 8;HBGF-8;Fgf8;Aigf;

Protein Function :

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells (By similarity). Cooperates with Wnt-1 in mouse mammary tumor virus- induced murine mammary tumorigenesis (PubMed:7884899).

Subcellular Localization :

Secreted.

Tissue Specificity :

Absent in normal mammary glands and detected only in adult testis and ovary and in midgestational embryos.