PON1 Paraoxonase-1 Human Recombinant Protein | Boster PROTP27169 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

protein

product name :

PON1 Paraoxonase-1 Human Recombinant Protein

catalog :

PROTP27169

quantity :

2 ug, 10 ug, 1 mg

product information

SKU :

PROTP27169

Product Name :

PON1 Paraoxonase-1 Human Recombinant Protein

Product Page URL :

https://www.bosterbio.compon1-paraoxonase-1-human-recombinant-protein-protp27169-boster.html

Gene Name :

PON1

Size :

2 ug, 10 ug, 1 mg

Reactivity :

Mouse

Applications :

Cell Culture

Introduction :

Introduction: Paraoxonase 1 also called Esterase-A is involved in the detoxification of organophosphate insecticides such as parathion. Paraoxonase 1 may also confer protection against coronary artery disease by destroying proinflammatory oxidized lipids present in oxidized low-density lipoproteins (LDLs).

Description :

Paraoxonase-1 Isoform Human Recombinant is expressed in E. coli having a molecular weight of 42.9 kDa and fused to a 4.5kDa amino terminal hexahistidine tag. The PON1 purified by proprietary chromatographic techniques.

Source :

E. Coli

Form :

Sterile Filtered clear solution.

Contents :

PON1 is supplied in 20mM Tris-HCl pH 8.0 and 50% glycerol.

AA Sequence and/or Biological Activity :

Sequence:MAKLIALTLLGMGLALFRNHQSSYQTRLNA
LREVQPVELPNCNLVKGIETGSEDLEILPNGLAFISSGL
KYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFD
VSSFNPHGISTFTDEDNAMYLLVVNHPDAKSTVELFKFQ
EEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYGTNDHYF
LDPYLRSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANG
INISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDF
NTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPPASE
VLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLL
IGTVFHKALYCELZ.
Amino Acid

Purification :

Greater than 95% as determined by SDS-PAGE. Single band on Western Blot.

Storage :

Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.

Uniprot ID :

P27169

Gene Full Name :

Serum paraoxonase/arylesterase 1

Synonyms :

Serum paraoxonase/arylesterase 1;PON 1;3.1.1.2;3.1.1.81;3.1.8.1;Aromatic esterase 1;A-esterase 1;K-45;Serum aryldialkylphosphatase 1;PON1;PON;

Protein Function :

Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.

Subcellular Localization :

Secreted, extracellular space.

Tissue Specificity :

Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.